PRTA Insider Trading - Prothena Corporation plc

Utestående aktier	53,829,982 shares
Insideraktier	25 026 707 shares
Insynsägande	46,49 %
Totalt antal insynspersoner	31

Insider Sentiment Score

Insider sentiment score hittar de företag som köps av foretagsinsynspersoner.

Det är resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av insiderackumulation. Poängmodellen använder en kombination av nettoantalet insiders som köpt de föregående 90 dagarna, det totala antalet aktier som köpts i procent av aktiekapitalet och det totala antalet aktier som ägs av insiders. Siffran sträcker sig från 0 till 100, med högre siffror som indikerar en högre nivå av ackumulering för sina kamrater, och 50 är genomsnittet.

Uppdateringsfrekvens: Dagligen

Se Insiders Top Picks, som ger en lista över företag med högsta insiderackumulation.

Se Högst rankade aktier

Office Sentiment Score

Officersentiment Score hittar företag som köps av Corporate Officers.

Per definition Corporate Officers är Corporate Insiders, men till skillnad från vissa av de andra Insiders (10 % aktieägare och styrelseledamöter), arbetar ämbetsmän för företaget dagligen och de använder sina egna pengar när de handlar . (10 % aktieägare och styrelseledamöter är ofta fondförvaltare som förvaltar andras pengar.) Som sådan är insideraffärer som görs av tjänstemän mycket mer betydelsefulla och bör behandlas på lämpligt sätt.

Liksom Insider Sentiment Score är Officer Sentiment Score resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av officersackumulering.

Uppdateringsfrekvens: Dagligen

Se insiderns bästa val, vilket ger en lista över företag med högsta insider sentiment.

Se Högst rankade aktier

Viktiga insidernyckeltal

Denna kort visar hur företaget rankas längs olika insidernyckeltal. Procenttilrankningen visar hur detta företag jämförs med andra företag på USA-marknaden. Högre rankingar indikerar bättre situationer.

Till exempel anses det allmänt att insiderköp är en positiv indikator, så företag med mer insiderköp skulle rankas högre än företag med mindre insiderköp (eller til och med insiderförsäljning).

Nettoantalet insiders som köper (rankning)

0 ( )

5294 out of 11305

Nettoantalet insiders som köper är den totala mängden insiders som säljer minus det totala antalet insiders som säljer under de senaste 90 dagarna. Percentilrankningen visas här (intervall från 0 till 100%).

Procent av flytande köpta av insiders (ranking)

0.000 %( )

5262 out of 11221

Procentandelen av aktier köpta av insiders är det totala antalet aktier som köpts av insiders minus det totala antalet aktier som sålts av insiders under de senaste 90 dagarna, dividerat med det totala antalet aktier och multiplicerat med 100.

Insiderhandelsdiagram

Prothena Corporation plc insideraffärer visas i följande diagram. Insiders är tjänstemän, styrelseledamöter eller betydande investerare i ett företag. I allmänhet är det i allmänhet olagligt för insiders att göra affärer i sina företag baserat på väsentlig, icke-offentlig information. Detta betyder inte att det är olagligt för dem att göra några affärer i sina egna företag. De måste dock rapportera alla affärer till SEC via ett formulär 4.

Insiderlista och lönsamhetsstatistik

Den här tabellen visar listan över kända insiders och genereras automatiskt från anmälningar som avslöjas till SEC. Förutom namnen, den senaste titeln och direktören, tjänstemannen eller ägarbeteckningen på 10 %, tillhandahåller vi de senaste avslöjade innehaven. Dessutom, när det är möjligt tillhandahåller vi insiderns historiska handelsresultat. Det historiska handelsresultatet är ett vägt genomsnitt av resultatet för faktiska köptransaktioner på den öppna marknaden som insidern gjort. För mer information om hur detta beräknas, titta på detta YouTube-webinarium.

See our leaderboard of most profitable insider traders.

Insider	Aktier Ägda	Delad Justerad
Richard T Collier Director - [D]	1 219	1 219
Paula K Cobb	15 000
Shane Cooke Director - [D]	0	0
Corp Plc Elan 10% Owner - [10%]	0	0
EcoR1 Capital, LLC 10% Owner - [10%]	5 304 596	5 304 596
Lars Ekman Director - [D]	243	243
John Randall Fawcett Controller - [O]	336	336
Hideki Garren Chief Medical Officer - [O]	0	0
Christopher S Henney Director - [D]	0	0
Arthur W Homan Chief Legal Officer - [O]	0	0

Insider	Aktier Ägda	Delad Justerad
Karl Anders Olof Harfstrand	15 000
Karp Carol D. Chief Regulatory Officer - [O]	0	0
Kinney Gene G. President and CEO, Director - [D] [O]	152 793	152 793
Martin Koller Chief Medical Officer - [O]	0	0
Michael J Malecek Chief Legal Officer - [O]	80 000	80 000
McNinch David B.	100 000
Oleg Nodelman Director, 10% Owner - [D] [10%]	18 853 280	18 853 280
Tran Nguyen Chief Strategy Officer and CFO - [O]	97 205	97 205
Tara Nickerson Chief Business Officer - [O]	2 000	2 000
Noonberg Sarah B.	0

Insider	Aktier Ägda	Delad Justerad
Co plc PERRIGO 10% Owner - [10%]	0	0
Perrigo Science One Ltd. 10% Owner - [10%]	0	0
Sanjiv Patel	15 000
William P Scully 10% Owner - [10%]	190 950	190 950
Schenk Dale B. President and CEO, Director - [D] [O]	14 877	14 877
Selkoe Dennis J. Director - [D]	4 208	4 208
Smith Brandon S. Chief Operating Officer - [O]	130 000	130 000
Swanson Chad J. Chief Development Officer - [O]	85 000	85 000
Radhika Tripuraneni	50 000
Karin L Walker Chief Accounting Officer - [O]	25 000	25 000
Zago Wagner M. Chief Scientific Officer - [O]	85 000	85 000

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Track Records av insiderköp - Kortsiktig vinstanalys

I denna sektion analyserar vi lönsamheten för varje oplanerat, öppet-marknads insiderköp gjorda i PRTA / Prothena Corporation plc. Denna analys hjälper till att förstå om insidern konsekvent genererar onormala avkastningar och är värd att följa. Denna analys är för ett år efter varje handel, och resultaten är teoretiska .

Tabellen nedan visar de senaste köpen på öppna marknaden som inte var en del av en automatisk handelsplan.

Handelsdatum	Insider	Rapporterade aktier	Rapporterat pris	Justerade aktier	Justerat pris	Kostnadsbasis	Dagar til Max	Pris vid Max	Maximal vinst ($)	Maximal avkastning (%)
2025-01-14	SCULLY WILLIAM P	100 000	12,7904	100 000	12,7904	1 279 040	13	16.0400	324 960	25,41
2024-12-31	SCULLY WILLIAM P	1 200	13,3652	1 200	13,3652	16 038
2024-12-31	SCULLY WILLIAM P	800	13,3940	800	13,3940	10 715
2024-12-31	SCULLY WILLIAM P	30 000	12,9880	30 000	12,9880	389 640
2024-12-20	SCULLY WILLIAM P	2 000	15,9065	2 000	15,9065	31 813
2024-12-18	SCULLY WILLIAM P	73 436	13,9260	73 436	13,9260	1 022 670
2022-05-05	EcoR1 Capital, LLC	1 062 736	29,0200	1 062 736	29,0200	30 840 599
2022-01-12	EcoR1 Capital, LLC	300 000	37,5010	300 000	37,5010	11 250 300
2021-03-24	EcoR1 Capital, LLC	875 000	20,7500	875 000	20,7500	18 156 250

Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.

PRTA / Prothena Corporation plc Insider Trades

Track Records av insiderförsäljning - Kortsiktig förlustanalys

Tabellen nedan visar de senaste försäljningarna på öppna marknaden som inte var en del av en automatisk handelsplan.

Handelsdatum	Insider	Rapporterade aktier	Rapporterat pris	Justerade aktier	Justerat pris	Kostnadsbasis	Dagar til Min	Pris vid Min	Maximal förlust undvikits ($)	Maximal förlust undvikits ($)
2025-05-06	EcoR1 Capital, LLC	1 984 053	7,6433	1 984 053	7,6433	15 164 712	21	4.5800	−6 077 749	−40,08
2025-05-05	EcoR1 Capital, LLC	977 693	8,1111	977 693	8,1111	7 930 166
2025-05-02	EcoR1 Capital, LLC	3 317 938	8,3621	3 317 938	8,3621	27 744 929
2022-05-05	EcoR1 Capital, LLC	1 062 736	29,0200	1 062 736	29,0200	30 840 599
2021-06-25	HENNEY CHRISTOPHER S	1 736	48,7308	1 736	48,7308	84 597
2021-06-25	HENNEY CHRISTOPHER S	10 264	47,5665	10 264	47,5665	488 223
2015-11-25	Ekman Lars	16 588	72,9602	16 588	72,9602	1 210 264
2015-11-25	Ekman Lars	1 910	74,4349	1 910	74,4349	142 171
2015-11-25	Ekman Lars	11 502	73,7262	11 502	73,7262	847 999

Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.

Transaktionshistorik

Klicka på länkikonen för att se hela transaktionshistoriken. Transaktioner som rapporteras som en del av en automatisk handelsplan 10b5-1 kommer att ha ett X i kolumnen markerad 10b-5.

Fil datum	Handel datum	Schema	Insider	Ticker	Värdepappertitel	Kod	Direkta	Utövningspris	Enhet pris	Enheter ändrad	Värde ändrad (1K)	Kvarvarande Optioner	Kvarvarande Aktier
2025-07-30	2025-07-28	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	A - Award	D			130 000			130 000
2025-07-30	2025-07-28	4	Swanson Chad J.	PRTA	Ordinary Shares, par value $0.01 per share	A - Award	D			85 000			85 000
2025-07-30	2025-07-28	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	A - Award	D			85 000			85 000
2025-07-30	2025-07-28	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	A - Award	D			25 000			25 000
2025-07-30	2025-07-28	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	A - Award	D			80 000			80 000
2025-07-30	2025-07-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	A - Award	D			140 000			152 793
2025-07-30	2025-07-28	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	A - Award	D			95 000			97 205
2025-05-06	2025-05-06	4	EcoR1 Capital, LLC See Note	PRTA	Ordinary Shares	S - Sale	I		7,6433	−1 984 053	−15 165		5 304 596
2025-05-06	2025-05-05	4	EcoR1 Capital, LLC See Note	PRTA	Ordinary Shares	S - Sale	I		8,1111	−977 693	−7 930		7 288 649
2025-05-06	2025-05-02	4	EcoR1 Capital, LLC See Note	PRTA	Ordinary Shares	S - Sale	I		8,3621	−3 317 938	−27 745		8 266 342
2025-05-02	2025-01-15	4	SCULLY WILLIAM P By Spouse	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	I			−12 000			47 000
2025-05-02	2025-01-14	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		12,7904	100 000	1 279		735 993
2025-05-02	2025-01-03	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	D			−1 000			635 993
2025-05-02	2025-01-02	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	D			−13 200			636 993
2025-05-02	2024-12-31	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		12,9880	30 000	390		650 193
2025-05-02	2024-12-31	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		13,3940	800	11		620 193
2025-05-02	2024-12-31	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		13,3652	1 200	16		619 393
2025-05-02	2024-12-20	4	SCULLY WILLIAM P By Spouse	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	I			−40 000			59 000
2025-05-02	2024-12-20	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	D			−500			618 193
2025-05-02	2024-12-20	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		15,9065	2 000	32		618 693
2025-05-02	2024-12-19	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	D			−681 000			616 693
2025-05-02	2024-12-18	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		13,9260	73 436	1 023		1 297 693
2025-05-02	2024-12-18	4	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	D			430 000			1 224 257
2025-05-01		3	SCULLY WILLIAM P By Manatee Equity Fund LLC	PRTA	Ordinary Shares, par value $0.01 per share		I						75 950
2025-05-01		3	SCULLY WILLIAM P By Spouse	PRTA	Ordinary Shares, par value $0.01 per share		I						99 000
2025-05-01		3	SCULLY WILLIAM P By Self as Trustee for The 2012 Randolph Scully Family Trust	PRTA	Ordinary Shares, par value $0.01 per share		I						68 000
2025-05-01		3	SCULLY WILLIAM P	PRTA	Ordinary Shares, par value $0.01 per share		D						794 257
2025-02-14	2020-04-08	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	J - Other	D			−995			2 205
2024-01-24	2024-01-24	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		34,0000	−5 000	−170		0
2024-01-24	2024-01-24	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		13,5300	5 000	68		5 000
2023-12-20	2023-12-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		37,4499	−3 322	−124		0
2023-12-20	2023-12-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		36,6765	−1 678	−62		3 322
2023-12-20	2023-12-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		13,5300	5 000	68		5 000
2023-11-30	2023-11-30	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		34,0000	−5 000	−170		0
2023-11-30	2023-11-30	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		13,5300	5 000	68		5 000
2023-10-25	2023-10-25	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		42,2793	−294	−12		0
2023-10-25	2023-10-25	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		41,3843	−2 917	−121		294
2023-10-25	2023-10-25	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		40,2701	−1 789	−72		3 211
2023-10-25	2023-10-25	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		13,5300	5 000	68		5 000
2023-10-11	2023-10-11	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		47,7437	−444	−21		0
2023-10-11	2023-10-11	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		46,6216	−3 556	−166		444
2023-10-11	2023-10-11	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,1200	4 000	44		4 000
2023-10-04	2023-10-04	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		47,2930	−663	−31		0
2023-10-04	2023-10-04	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		46,5135	−4 337	−202		663
2023-10-04	2023-10-04	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		12,1500	5 000	61		5 000
2023-09-27	2023-09-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,3148	−404	−20		0
2023-09-27	2023-09-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		47,2945	−4 596	−217		404
2023-09-27	2023-09-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	5 000	51		5 000
2023-09-19	2023-09-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,3614	−5 000	−262		0
2023-09-19	2023-09-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	5 000	75		5 000
2023-09-13	2023-09-13	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,4761	−2 000	−111		0
2023-09-13	2023-09-13	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	2 000	50		2 000
2023-09-13	2023-09-13	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,9563	−114	−6		0
2023-09-13	2023-09-13	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,4771	−3 886	−216		114
2023-09-13	2023-09-13	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,1200	4 000	44		4 000
2023-09-06	2023-09-06	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,2700	−6	−0		0
2023-09-06	2023-09-06	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,7601	−4 994	−273		6
2023-09-06	2023-09-06	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		12,1500	5 000	61		5 000
2023-08-30	2023-08-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,2100	−14	−1		0
2023-08-30	2023-08-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,3871	−2 664	−148		14
2023-08-30	2023-08-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,5770	−2 322	−127		2 678
2023-08-30	2023-08-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	5 000	51		5 000
2023-08-18	2023-08-18	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,1845	−5 000	−286		0
2023-08-18	2023-08-18	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	5 000	75		5 000
2023-08-16	2023-08-16	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,9134	−401	−24		0
2023-08-16	2023-08-16	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,1527	−1 373	−81		401
2023-08-16	2023-08-16	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,2220	−2 226	−130		1 774
2023-08-16	2023-08-16	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,1200	4 000	44		4 000
2023-08-16	2023-08-16	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,7365	−374	−22		0
2023-08-16	2023-08-16	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,9294	−748	−44		374
2023-08-16	2023-08-16	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,1542	−878	−51		1 122
2023-08-16	2023-08-16	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	2 000	50		2 000
2023-08-02	2023-08-02	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,0726	−229	−16		0
2023-08-02	2023-08-02	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,9830	−3 771	−253		229
2023-08-02	2023-08-02	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		12,1500	4 000	49		4 000
2023-08-02	2023-08-02	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,9515	−328	−22		0
2023-08-02	2023-08-02	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,9486	−4 672	−313		328
2023-08-02	2023-08-02	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		12,1500	5 000	61		5 000
2023-07-26	2023-07-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		63,4017	−620	−39		0
2023-07-26	2023-07-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,6891	−1 903	−119		620
2023-07-26	2023-07-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,7811	−2 477	−153		2 523
2023-07-26	2023-07-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	5 000	51		5 000
2023-07-19	2023-07-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,0764	−1 034	−72		0
2023-07-19	2023-07-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,9572	−3 966	−273		1 034
2023-07-19	2023-07-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	5 000	75		5 000
2023-07-12	2023-07-12	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,9480	−800	−54		0
2023-07-12	2023-07-12	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,3960	−3 200	−216		800
2023-07-12	2023-07-12	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,1200	4 000	44		4 000
2023-07-12	2023-07-12	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,1957	−92	−6		0
2023-07-12	2023-07-12	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,4804	−1 908	−129		92
2023-07-12	2023-07-12	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	2 000	50		2 000
2023-07-05	2023-07-05	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,6874	−1 009	−69		0
2023-07-05	2023-07-05	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,9847	−2 991	−203		1 009
2023-07-05	2023-07-05	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		12,1500	4 000	49		4 000
2023-07-05	2023-07-05	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,6919	−1 034	−71		0
2023-07-05	2023-07-05	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,9800	−3 966	−270		1 034
2023-07-05	2023-07-05	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		12,1500	5 000	61		5 000
2023-07-03	2023-07-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,4300	−5 000	−337		2 845
2023-07-03	2023-07-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,3300	5 000	57		7 845
2023-06-28	2023-06-28	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,8386	−710	−50		0
2023-06-28	2023-06-28	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,8944	−3 050	−213		710
2023-06-28	2023-06-28	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,0680	−1 240	−86		3 760
2023-06-28	2023-06-28	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	5 000	51		5 000
2023-06-20	2023-06-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,9941	−529	−37		0
2023-06-20	2023-06-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,4856	−2 471	−172		529
2023-06-20	2023-06-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,8842	−2 000	−136		3 000
2023-06-20	2023-06-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	5 000	75		5 000
2023-06-16	2023-06-16	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		74,0000	−7 331	−542		0
2023-06-16	2023-06-16	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	7 331	183		7 331
2023-06-14	2023-06-14	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		75,4858	−655	−49		0
2023-06-14	2023-06-14	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		74,5895	−2 534	−189		655
2023-06-14	2023-06-14	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		73,3098	−971	−71		3 189
2023-06-14	2023-06-14	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		72,4539	−509	−37		4 160
2023-06-14	2023-06-14	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	4 669	116		4 669
2023-06-14	2023-06-14	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		75,5582	−1 362	−103		0
2023-06-14	2023-06-14	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		74,6863	−959	−72		1 362
2023-06-14	2023-06-14	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		73,3542	−1 914	−140		2 321
2023-06-14	2023-06-14	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		72,5205	−1 098	−80		4 235
2023-06-14	2023-06-14	4	Smith Brandon S.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,1200	5 333	59		5 333
2023-06-07	2023-06-07	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		72,9300	−361	−26		0
2023-06-07	2023-06-07	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		71,9682	−3 811	−274		361
2023-06-07	2023-06-07	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,9979	−12 782	−907		4 172
2023-06-07	2023-06-07	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,9001	−3 046	−213		16 954
2023-06-07	2023-06-07	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		13,5300	15 000	203		20 000
2023-06-07	2023-06-07	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		12,1500	5 000	61		5 000
2023-06-07	2023-06-07	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		73,1400	−294	−22		0
2023-06-07	2023-06-07	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		71,9551	−3 759	−270		294
2023-06-07	2023-06-07	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,9914	−12 004	−852		4 053
2023-06-07	2023-06-07	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,0173	−2 943	−206		16 057
2023-06-07	2023-06-07	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		12,1500	4 000	49		19 000
2023-06-07	2023-06-07	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	15 000	447		15 000
2023-05-31	2023-05-31	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,9813	−711	−47		0
2023-05-31	2023-05-31	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,2001	−1 078	−70		711
2023-05-31	2023-05-31	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,1621	−3 211	−206		1 789
2023-05-31	2023-05-31	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	5 000	51		5 000
2023-05-19	2023-05-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		74,4732	−2 177	−162		0
2023-05-19	2023-05-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		73,6274	−2 823	−208		2 177
2023-05-19	2023-05-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	5 000	75		5 000
2023-05-17	2023-05-17	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		74,4945	−14 934	−1 113		12 793
2023-05-17	2023-05-17	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		73,6040	−19 864	−1 462		27 727
2023-05-17	2023-05-17	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		72,7035	−10 202	−742		47 591
2023-05-17	2023-05-17	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	45 000	1 341		57 793
2023-05-17	2023-05-17	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		76,0400	−100	−8		3 200
2023-05-17	2023-05-17	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		75,4429	−9 215	−695		3 300
2023-05-17	2023-05-17	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		74,5458	−37 044	−2 761		12 515
2023-05-17	2023-05-17	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		73,5367	−34 640	−2 547		49 559
2023-05-17	2023-05-17	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		72,6609	−14 001	−1 017		84 199
2023-05-17	2023-05-17	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,8500	50 000	1 142		98 200
2023-05-17	2023-05-17	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	45 000	1 341		48 200
2023-05-05	2023-05-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,0000	−15 000	−855		2 845
2023-05-05	2023-05-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		23,9700	9 000	216		17 845
2023-05-05	2023-05-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,2300	6 000	55		8 845
2023-04-28	2023-04-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,2524	−320	−17		0
2023-04-28	2023-04-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,4042	−4 680	−250		320
2023-04-28	2023-04-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	5 000	51		5 000
2023-04-21	2023-04-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,2487	−2 083	−111		0
2023-04-21	2023-04-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,6441	−2 917	−154		2 083
2023-04-21	2023-04-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	5 000	75		5 000
2023-03-31	2023-03-29	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		49,2794	−2 266	−112		0
2023-03-31	2023-03-29	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,8135	−2 734	−133		2 266
2023-03-31	2023-03-29	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	5 000	51		5 000
2023-03-22	2023-03-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,4653	−1 097	−53		0
2023-03-22	2023-03-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		47,5130	−3 903	−185		1 097
2023-03-22	2023-03-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	5 000	75		5 000
2023-03-17	2023-03-15	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,6642	−10 569	−514		0
2023-03-17	2023-03-15	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,1406	−9 431	−454		10 569
2023-03-17	2023-03-15	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	20 000	301		20 000
2023-03-17	2023-03-15	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,6781	−5 198	−253		3 200
2023-03-17	2023-03-15	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,1644	−4 802	−231		8 398
2023-03-17	2023-03-15	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		13 200
2023-03-17	2023-03-15	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,6688	−8 564	−417		0
2023-03-17	2023-03-15	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,1343	−6 436	−310		8 564
2023-03-17	2023-03-15	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	15 000	154		15 000
2023-03-17	2023-03-15	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,6616	−6 000	−292		0
2023-03-17	2023-03-15	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,1610	−6 000	−289		6 000
2023-03-17	2023-03-15	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	12 000	299		12 000
2023-02-17	2023-02-15	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,8715	−664	−36		3 200
2023-02-17	2023-02-15	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,3019	−9 336	−498		3 864
2023-02-17	2023-02-15	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		13 200
2023-01-20	2023-01-18	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,9709	−638	−36		3 200
2023-01-20	2023-01-18	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,3242	−2 085	−117		3 838
2023-01-20	2023-01-18	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,1770	−7 277	−402		5 923
2023-01-20	2023-01-18	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		13 200
2023-01-12	2023-01-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,9216	−5 000	−265		0
2023-01-12	2023-01-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		5 000
2023-01-05	2023-01-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,6700	−5 000	−263		1 219
2023-01-05	2023-01-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		6 219
2023-01-05	2023-01-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,8467	−69	−4		243
2023-01-05	2023-01-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,4600	−10	−1		312
2023-01-05	2023-01-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,6692	−1 523	−89		322
2023-01-05	2023-01-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,9789	−1 303	−74		1 845
2023-01-05	2023-01-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,3314	−6 621	−373		3 148
2023-01-05	2023-01-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,3472	−2 897	−160		9 769
2023-01-05	2023-01-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,1503	−3 411	−185		12 666
2023-01-05	2023-01-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	15 834	101		16 077
2022-12-23	2022-12-21	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,2059	−6 845	−405		3 200
2022-12-23	2022-12-21	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,4551	−3 155	−184		10 045
2022-12-23	2022-12-21	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		13 200
2022-12-12	2022-12-12	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,4113	−3 887	−239		0
2022-12-12	2022-12-12	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,0781	−781	−47		3 887
2022-12-12	2022-12-12	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,9295	−332	−20		4 668
2022-12-12	2022-12-12	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		5 000
2022-12-05	2022-12-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,0170	−949	−62		1 219
2022-12-05	2022-12-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		63,8267	−647	−41		2 168
2022-12-05	2022-12-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,7103	−576	−36		2 815
2022-12-05	2022-12-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,1266	−913	−56		3 391
2022-12-05	2022-12-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,2764	−1 915	−115		4 304
2022-12-05	2022-12-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		6 219
2022-12-02	2022-12-01	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,1190	−6 021	−374		243
2022-12-02	2022-12-01	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,2848	−9 813	−601		6 264
2022-12-02	2022-12-01	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	15 834	101		16 077
2022-12-02	2022-11-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,8659	−176	−12		0
2022-12-02	2022-11-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,9577	−411	−27		176
2022-12-02	2022-11-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,1262	−494	−32		587
2022-12-02	2022-11-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,8530	−456	−29		1 081
2022-12-02	2022-11-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,0633	−1 625	−101		1 537
2022-12-02	2022-11-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,9584	−1 696	−103		3 162
2022-12-02	2022-11-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,9172	−142	−9		4 858
2022-12-02	2022-11-30	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	5 000	51		5 000
2022-12-02	2022-12-01	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,5100	−4 000	−250		0
2022-12-02	2022-12-01	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	4 000	100		4 000
2022-11-25	2022-11-23	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,2788	−1 469	−91		3 200
2022-11-25	2022-11-23	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,2764	−3 984	−244		4 669
2022-11-25	2022-11-23	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,5324	−4 547	−275		8 653
2022-11-25	2022-11-23	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		13 200
2022-11-18	2022-11-18	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,2745	−226	−13		0
2022-11-18	2022-11-18	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,0431	−9 774	−558		226
2022-11-18	2022-11-18	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	10 000	150		10 000
2022-11-10	2022-11-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,8518	−875	−50		0
2022-11-10	2022-11-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,1402	−3 870	−217		875
2022-11-10	2022-11-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,1951	−255	−14		4 745
2022-11-10	2022-11-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		5 000
2022-11-09	2022-11-07	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,8947	−826	−47		1 219
2022-11-09	2022-11-07	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,7068	−2 688	−150		2 045
2022-11-09	2022-11-07	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,7431	−1 486	−81		4 733
2022-11-09	2022-11-07	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		6 219
2022-11-03	2022-11-01	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,9414	−1 661	−108		243
2022-11-03	2022-11-01	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,2586	−3 312	−213		1 904
2022-11-03	2022-11-01	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,9079	−1 717	−108		5 216
2022-11-03	2022-11-01	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,0095	−9 143	−567		6 933
2022-11-03	2022-11-01	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	15 833	101		16 076
2022-11-03	2022-11-01	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,4109	−511	−32		0
2022-11-03	2022-11-01	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,8179	−3 489	−216		511
2022-11-03	2022-11-01	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	4 000	100		4 000
2022-10-28	2022-10-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,0002	−20 000	−1 240		0
2022-10-28	2022-10-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	20 000	205		20 000
2022-10-28	2022-10-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,1170	−19 720	−1 205		0
2022-10-28	2022-10-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,2710	−29 572	−1 782		19 720
2022-10-28	2022-10-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,3701	−15 708	−933		49 292
2022-10-28	2022-10-26	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	65 000	668		65 000
2022-10-26	2022-10-24	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,9806	−1 164	−69		0
2022-10-26	2022-10-24	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,2534	−3 785	−220		1 164
2022-10-26	2022-10-24	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,3352	−7 144	−410		4 949
2022-10-26	2022-10-24	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,3890	−7 907	−446		12 093
2022-10-26	2022-10-24	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	20 000	301		20 000
2022-10-21	2022-10-19	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,1746	−171	−10		3 200
2022-10-21	2022-10-19	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,3029	−4 541	−260		3 371
2022-10-21	2022-10-19	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,3037	−2 520	−142		7 912
2022-10-21	2022-10-19	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,0360	−2 768	−152		10 432
2022-10-21	2022-10-19	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		13 200
2022-10-12	2022-10-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,3786	−2 676	−151		0
2022-10-12	2022-10-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,3705	−2 324	−129		2 676
2022-10-12	2022-10-10	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		5 000
2022-10-07	2022-10-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,9486	−354	−21		1 219
2022-10-07	2022-10-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,9418	−352	−21		1 573
2022-10-07	2022-10-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,9711	−3 404	−197		1 925
2022-10-07	2022-10-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,5380	−890	−50		5 329
2022-10-07	2022-10-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		6 219
2022-10-05	2022-10-03	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,9000	−4 000	−244		0
2022-10-05	2022-10-03	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	4 000	100		4 000
2022-10-05	2022-10-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,9609	−1 693	−107		243
2022-10-05	2022-10-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,1050	−6 355	−395		1 936
2022-10-05	2022-10-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,0726	−4 277	−261		8 291
2022-10-05	2022-10-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,3204	−3 508	−212		12 568
2022-10-05	2022-10-03	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	15 833	101		16 076
2022-09-30	2022-09-28	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,0900	−31 666	−1 523		243
2022-09-30	2022-09-28	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	31 666	203		31 909
2022-09-30	2022-09-28	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,0900	−10 000	−481		0
2022-09-30	2022-09-28	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	10 000	64		10 000
2022-09-30	2022-09-28	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,0900	−25 000	−1 202		1 219
2022-09-30	2022-09-28	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	25 000	160		26 219
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,9300	−129	−8		12 793
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,7031	−243	−14		12 922
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,1915	−40	−2		13 165
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,3236	−1 342	−74		13 205
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,3760	−4 748	−258		14 547
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,3966	−5 852	−312		19 295
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,4397	−2 333	−122		25 147
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		51,2999	−552	−28		27 480
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		49,4100	−128	−6		28 032
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,0900	−1 045	−50		28 160
2022-09-30	2022-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	16 412	105		29 205
2022-09-23	2022-09-21	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		30,7496	−10 000	−307		3 200
2022-09-23	2022-09-21	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		13 200
2022-09-23	2022-09-21	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,0183	−2 720	−87		12 793
2022-09-23	2022-09-21	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	2 720	17		15 513
2022-09-16	2022-09-15	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		30,0000	−4 000	−120		0
2022-09-16	2022-09-15	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	4 000	100		4 000
2022-08-26	2022-08-24	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		30,1672	−10 000	−302		3 200
2022-08-26	2022-08-24	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		13 200
2022-08-19	2022-08-17	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,0287	−2 181	−70		12 793
2022-08-19	2022-08-17	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	2 181	14		14 974
2022-08-12	2022-08-12	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,1579	−20 284	−652		12 793
2022-08-12	2022-08-12	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	20 284	130		33 077
2022-08-12	2022-08-11	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,1561	−13 650	−439		12 793
2022-08-12	2022-08-11	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	13 650	87		26 443
2022-08-12	2022-08-10	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,0118	−991	−32		12 793
2022-08-12	2022-08-10	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	991	6		13 784
2022-08-05	2022-08-05	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		33,0633	−4 673	−155		12 793
2022-08-05	2022-08-05	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,7665	−16 833	−552		17 466
2022-08-05	2022-08-05	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	21 506	138		34 299
2022-08-05	2022-08-04	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,1808	−20 954	−674		12 793
2022-08-05	2022-08-04	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	20 954	134		33 747
2022-08-03	2022-08-01	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		30,5200	−4 000	−122		0
2022-08-03	2022-08-01	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	4 000	100		4 000
2022-07-29	2022-07-27	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,0000	−376	−12		12 793
2022-07-29	2022-07-27	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	376	2		13 169
2022-07-22	2022-07-22	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,5483	−7 320	−238		3 200
2022-07-22	2022-07-22	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	7 320	49		10 520
2022-07-22	2022-07-21	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		33,6900	−5	−0		3 200
2022-07-22	2022-07-21	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,6405	−20 555	−671		3 205
2022-07-22	2022-07-21	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	20 560	138		23 760
2022-07-22	2022-07-20	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,7321	−16 984	−556		3 200
2022-07-22	2022-07-20	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,3249	−25 136	−813		20 184
2022-07-22	2022-07-20	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	42 120	283		45 320
2022-07-22	2022-07-20	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		32,9000	−15 000	−494		0
2022-07-22	2022-07-20	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	15 000	96		15 000
2022-07-08	2022-07-06	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		30,0000	−8 000	−240		0
2022-07-08	2022-07-06	4	Garren Hideki	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		24,9000	8 000	199		8 000
2022-05-27	2022-05-18	4	COLLIER RICHARD T	PRTA	Stock Option (Right to Buy)	A - Award	D	25,60		15 000		15 000
2022-05-27	2022-05-18	4	Cooke Shane	PRTA	Stock Option (Right to Buy)	A - Award	D	25,60		15 000		15 000
2022-05-27	2022-05-18	4	Cobb Paula K	PRTA	Stock Option (Right to Buy)	A - Award	D	25,60		15 000		15 000
2022-05-27	2022-05-18	4	Harfstrand Karl Anders Olof	PRTA	Stock Option (Right to Buy)	A - Award	D	25,60		15 000		15 000
2022-05-27	2022-05-18	4	Patel Sanjiv	PRTA	Stock Option (Right to Buy)	A - Award	D	25,60		15 000		15 000
2022-05-27	2022-05-18	4	Ekman Lars	PRTA	Stock Option (Right to Buy)	A - Award	D	25,60		15 000		15 000
2022-05-27	2022-05-18	4	Selkoe Dennis J.	PRTA	Stock Option (Right to Buy)	A - Award	D	25,60		15 000		15 000
2022-05-09	2022-05-05	4	EcoR1 Capital, LLC See Note	PRTA	Ordinary Shares	S - Sale	I		29,0200	−1 062 736	−30 841		11 584 280
2022-05-09	2022-05-05	4	EcoR1 Capital, LLC See Notes	PRTA	Ordinary Shares	P - Purchase	I		29,0200	1 062 736	30 841		11 584 280
2022-04-13	2022-04-11	4	Cooke Shane	PRTA	Stock Option (Right to Buy)	M - Exercise	D	6,41		−5 000		45 000
2022-04-13	2022-04-11	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		36,5996	−514	−19		0
2022-04-13	2022-04-11	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		35,7568	−1 484	−53		514
2022-04-13	2022-04-11	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		34,4791	−3 002	−104		1 998
2022-04-13	2022-04-11	4	Cooke Shane	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		5 000
2022-04-07	2022-04-05	4	COLLIER RICHARD T	PRTA	Stock Option (Right to Buy)	M - Exercise	D	6,41		−5 000		45 000
2022-04-07	2022-04-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		39,6598	−2 369	−94		1 219
2022-04-07	2022-04-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		39,1762	−2 631	−103		3 588
2022-04-07	2022-04-05	4	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 000	32		6 219
2022-02-25	2022-02-23	4	Karp Carol D.	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		85 000		85 000
2022-02-25	2022-02-23	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		85 000		85 000
2022-02-25	2022-02-23	4	Kinney Gene G.	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		250 000		250 000
2022-02-25	2022-02-23	4	Malecek Michael J	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		85 000		85 000
2022-02-25	2022-02-23	4	Smith Brandon S.	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		85 000		85 000
2022-02-25	2022-02-23	4	Tripuraneni Radhika	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		50 000		50 000
2022-02-25	2022-02-23	4	Garren Hideki	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		85 000		85 000
2022-02-25	2022-02-23	4	Nguyen Tran	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		85 000		85 000
2022-02-25	2022-02-23	4	Walker Karin L	PRTA	Stock Option (Right to Buy)	A - Award	D	32,45		45 500		45 500
2022-01-12	2022-01-12	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		37,5010	300 000	11 250		11 584 280
2022-01-05	2022-01-03	4	Selkoe Dennis J.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	9,23		5 000		6 000
2022-01-05	2022-01-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		49,4773	−492	−24		2 845
2022-01-05	2022-01-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		47,6017	−2 375	−113		3 337
2022-01-05	2022-01-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		46,8054	−2 133	−100		5 712
2022-01-05	2022-01-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,2300	5 000	46		7 845
2021-11-26	2021-11-23	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	15,04		−4 519		85 481
2021-11-26	2021-11-23	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,4310	−1 819	−106		0
2021-11-26	2021-11-23	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,5137	−2 700	−155		1 819
2021-11-26	2021-11-23	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	4 519	68		4 519
2021-11-19	2021-11-19	4	Malecek Michael J	PRTA	Stock Option (Right to Buy)	M - Exercise	D	10,27		−10 000		230 000
2021-11-19	2021-11-19	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,0000	−10 000	−550		0
2021-11-19	2021-11-19	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	10 000	103		10 000
2021-11-03	2021-11-01	4	Karp Carol D.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	15,04		−10 000		120 000
2021-11-03	2021-11-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,5080	−4 937	−289		0
2021-11-03	2021-11-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,6529	−2 725	−154		4 937
2021-11-03	2021-11-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,9980	−2 338	−129		7 662
2021-11-03	2021-11-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	10 000	150		10 000
2021-10-29	2021-10-27	4	Malecek Michael J	PRTA	Stock Option (Right to Buy)	M - Exercise	D	10,27		−10 000		240 000
2021-10-29	2021-10-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,8850	−20	−1		0
2021-10-29	2021-10-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,0307	−1 066	−64		20
2021-10-29	2021-10-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,8839	−2 950	−174		1 086
2021-10-29	2021-10-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,0704	−5 964	−346		4 036
2021-10-29	2021-10-27	4	Malecek Michael J	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		10,2700	10 000	103		10 000
2021-10-22	2021-10-20	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	29,81		−3 000		0
2021-10-22	2021-10-20	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	15,04		−20 000		90 000
2021-10-22	2021-10-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,9407	−2 185	−135		0
2021-10-22	2021-10-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,9082	−1 700	−104		2 185
2021-10-22	2021-10-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,0020	−19 115	−1 147		3 885
2021-10-22	2021-10-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	3 000	89		23 000
2021-10-22	2021-10-20	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	20 000	301		20 000
2021-10-01	2021-10-01	4	Selkoe Dennis J.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	9,23		−5 000		11 000
2021-10-01	2021-10-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,6907	−706	−49		2 845
2021-10-01	2021-10-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,7449	−1 237	−85		3 551
2021-10-01	2021-10-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,9637	−1 300	−88		4 788
2021-10-01	2021-10-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,3542	−1 757	−117		6 088
2021-10-01	2021-10-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,2300	5 000	46		7 845
2021-10-01	2021-10-01	4	Karp Carol D.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	15,04		−10 000		130 000
2021-10-01	2021-10-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,4400	−213	−15		0
2021-10-01	2021-10-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,6142	−2 600	−181		213
2021-10-01	2021-10-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,6756	−1 967	−135		2 813
2021-10-01	2021-10-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,9763	−2 620	−178		4 780
2021-10-01	2021-10-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,5971	−2 600	−173		7 400
2021-10-01	2021-10-01	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	10 000	150		10 000
2021-10-01	2021-09-29	4	Smith Brandon S.	PRTA	Stock Option (Right to Buy)	A - Award	D	70,81		25 000		25 000
2021-09-10	2021-09-09	4	Karp Carol D.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	15,04		−10 000		140 000
2021-09-10	2021-09-09	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		72,6299	−4 542	−330		0
2021-09-10	2021-09-09	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		71,4477	−5 458	−390		4 542
2021-09-10	2021-09-09	4	Karp Carol D.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	10 000	150		10 000
2021-07-30	2021-07-30	4	Selkoe Dennis J.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	9,23		−1 500		16 000
2021-07-30	2021-07-30	4	Selkoe Dennis J.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	16,42		−3 500		0
2021-07-30	2021-07-30	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		49,8840	−2 718	−136		2 845
2021-07-30	2021-07-30	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,9876	−2 282	−112		5 563
2021-07-30	2021-07-30	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,2300	1 500	14		7 845
2021-07-30	2021-07-30	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 500	57		6 345
2021-07-16	2021-07-14	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	M - Exercise	D	11,33		−11 108		0
2021-07-16	2021-07-14	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,1315	−2 000	−112		0
2021-07-16	2021-07-14	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,3093	−9 108	−504		2 000
2021-07-16	2021-07-14	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,3300	11 108	126		11 108
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	M - Exercise	D	11,33		6 392		11 108
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	M - Exercise	D	9,23		17 500		0
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,2500	−177	−11		0
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,2500	−177	−11		0
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,4467	−300	−18		177
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,6550	−800	−47		477
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,8543	−700	−40		1 277
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,5557	−2 100	−119		1 977
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,2572	−2 315	−128		4 077
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,3300	6 392	72		6 392
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,2450	−600	−36		177
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,2120	−500	−29		777
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,8751	−1 634	−93		1 277
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,9499	−2 475	−138		2 911
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,5540	−5 886	−321		5 386
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,8430	−6 228	−335		11 272
2021-07-13	2021-07-12	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,2300	17 500	162		17 500
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	M - Exercise	D	11,33		6 392		11 108
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	M - Exercise	D	9,23		17 500		0
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,2500	−177	−11		0
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,2500	−177	−11		0
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,4467	−300	−18		177
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,6550	−800	−47		477
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,8543	−700	−40		1 277
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,5557	−2 100	−119		1 977
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,2572	−2 315	−128		4 077
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		11,3300	6 392	72		6 392
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,2450	−600	−36		177
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,2120	−500	−29		777
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,8751	−1 634	−93		1 277
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,9499	−2 475	−138		2 911
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,5540	−5 886	−321		5 386
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,8430	−6 228	−335		11 272
2021-07-12	2021-07-12	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,2300	17 500	162		17 500
2021-06-29	2021-06-25	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	M - Exercise	D	16,43		12 000		0
2021-06-29	2021-06-25	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		48,7308	−1 736	−85		0
2021-06-29	2021-06-25	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		47,5665	−10 264	−488		1 736
2021-06-29	2021-06-25	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4300	12 000	197		12 000
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	15,04		−81 250		68 750
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	27,81		−19 000		0
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	20,17		−15 000		0
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		49,0074	−5 203	−255		0
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		47,8149	−18 101	−865		5 203
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		46,2743	−26 106	−1 208		23 304
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		45,4169	−65 840	−2 990		49 410
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		15,0400	81 250	1 222		115 250
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		27,8100	19 000	528		34 000
2021-06-24	2021-06-22	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		20,1700	15 000	303		15 000
2021-06-22	2021-06-18	4	EcoR1 Capital, LLC See Note 1	PRTA	Call Option (Right to Purchase)	X - Other	I	30,00		−2 500		0
2021-06-22	2021-06-18	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	X - Other	I		30,0000	250 000	7 500		11 284 280
2021-05-21	2021-05-19	4	Cooke Shane	PRTA	Stock Option (Right to Buy)	A - Award	D	23,97		15 000		15 000
2021-05-21	2021-05-19	4	COLLIER RICHARD T	PRTA	Stock Option (Right to Buy)	A - Award	D	23,97		15 000		15 000
2021-05-21	2021-05-19	4	Patel Sanjiv	PRTA	Stock Option (Right to Buy)	A - Award	D	23,97		30 000		30 000
2021-05-21	2021-05-19	4	Ekman Lars	PRTA	Stock Option (Right to Buy)	A - Award	D	23,97		15 000		15 000
2021-05-21	2021-05-19	4	Cobb Paula K	PRTA	Stock Option (Right to Buy)	A - Award	D	23,97		15 000		15 000
2021-05-21	2021-05-19	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	A - Award	D	23,97		15 000		15 000
2021-05-21	2021-05-19	4	Selkoe Dennis J.	PRTA	Stock Option (Right to Buy)	A - Award	D	23,97		15 000		15 000
2021-05-21	2021-05-19	4	Harfstrand Karl Anders Olof	PRTA	Stock Option (Right to Buy)	A - Award	D	23,97		15 000		15 000
2021-04-07	2021-04-05	4	Garren Hideki	PRTA	Stock Option (Right to Buy)	A - Award	D	24,90		250 000		250 000
2021-03-25	2021-03-24	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		20,7500	875 000	18 156		11 034 280
2021-02-26	2021-02-25	4	Smith Brandon S.	PRTA	Stock Option (Right to Buy)	A - Award	D	22,60		56 000		56 000
2021-02-26	2021-02-25	4	Kinney Gene G.	PRTA	Stock Option (Right to Buy)	A - Award	D	12,15		50 000		50 000
2021-02-26	2021-02-25	4	Kinney Gene G.	PRTA	Stock Option (Right to Buy)	A - Award	D	22,60		250 000		250 000
2021-02-26	2021-02-25	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,60		28 000		28 000
2021-02-26	2021-02-25	4	Karp Carol D.	PRTA	Stock Option (Right to Buy)	A - Award	D	22,60		56 000		56 000
2021-02-26	2021-02-25	4	Tripuraneni Radhika	PRTA	Stock Option (Right to Buy)	A - Award	D	22,60		56 000		56 000
2021-02-26	2021-02-25	4	Nguyen Tran	PRTA	Stock Option (Right to Buy)	A - Award	D	22,60		84 000		84 000
2021-02-26	2021-02-25	4	Malecek Michael J	PRTA	Stock Option (Right to Buy)	A - Award	D	22,60		56 000		56 000
2021-02-26	2021-02-25	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	A - Award	D	22,60		56 000		56 000
2021-02-25	2021-02-24	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		22,0247	10 800	238		10 159 280
2021-02-25	2021-02-23	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		21,0477	44 400	935		10 148 480
2021-02-23	2021-02-18	4/A	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		23,6525	44 100	1 043		10 104 080
2021-02-22	2021-02-18	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		3,6758	44 100	162		10 104 080
2021-02-19	2021-02-18	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	6,41		−7 540		0
2021-02-19	2021-02-18	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		25,5000	−7 540	−192		0
2021-02-19	2021-02-18	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	7 540	48		7 540
2021-02-17	2021-02-17	4	EcoR1 Capital, LLC See Note 1	PRTA	Call Option	P - Purchase	I	30,00	3,6758	2 500	9	2 500
2021-02-17	2021-02-17	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		23,4638	198 840	4 666		10 059 980
2021-02-17	2021-02-16	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		22,7799	89 200	2 032		9 861 140
2021-02-17	2021-02-12	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		20,0796	282 800	5 679		9 771 940
2021-02-17	2021-02-12	4	EcoR1 Capital, LLC See Note 1	PRTA	Ordinary Shares	P - Purchase	I		20,5000	62 500	1 281		9 489 140
2021-02-17	2021-02-12	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	13,53		−18 750		31 250
2021-02-17	2021-02-12	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	6,41		−7 560		7 540
2021-02-17	2021-02-12	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		20,0004	−18 750	−375		0
2021-02-17	2021-02-12	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		13,5300	18 750	254		18 750
2021-02-17	2021-02-12	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		17,0700	−7 560	−129		0
2021-02-17	2021-02-12	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	7 560	48		7 560
2021-02-17	2021-02-12	4	Nguyen Tran	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		60 150		60 150
2021-02-17	2021-02-12	4	Nguyen Tran	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	33,10		−80 000		0
2021-02-17	2021-02-12	4	Nguyen Tran	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		39 062		39 062
2021-02-17	2021-02-12	4	Nguyen Tran	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	55,00		−75 000		0
2021-02-17	2021-02-12	4	Nguyen Tran	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		40 625		40 625
2021-02-17	2021-02-12	4	Nguyen Tran	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	34,61		−65 000		0
2021-02-17	2021-02-12	4	Nguyen Tran	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		50 000		50 000
2021-02-17	2021-02-12	4	Nguyen Tran	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	27,81		−55 000		0
2021-02-17	2021-02-12	4	Cooke Shane	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		6 315		6 315
2021-02-17	2021-02-12	4	Cooke Shane	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	56,23		−12 000		0
2021-02-17	2021-02-12	4	Cooke Shane	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		8 426		8 426
2021-02-17	2021-02-12	4	Cooke Shane	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	34,04		−15 000		0
2021-02-17	2021-02-12	4	Cooke Shane	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	42,50		−15 000		0
2021-02-17	2021-02-12	4	Cooke Shane	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		9 803		9 803
2021-02-17	2021-02-12	4	COLLIER RICHARD T	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		6 315		6 315
2021-02-17	2021-02-12	4	COLLIER RICHARD T	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	56,23		−12 000		0
2021-02-17	2021-02-12	4	COLLIER RICHARD T	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		8 426		8 426
2021-02-17	2021-02-12	4	COLLIER RICHARD T	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	42,50		−15 000		0
2021-02-17	2021-02-12	4	COLLIER RICHARD T	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	34,04		−15 000		0
2021-02-17	2021-02-12	4	COLLIER RICHARD T	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		9 803		9 803
2021-02-17	2021-02-12	4	Tripuraneni Radhika	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		37 037		37 037
2021-02-17	2021-02-12	4	Tripuraneni Radhika	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	35,24		−50 000		0
2021-02-17	2021-02-12	4	Ekman Lars	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		6 315		6 315
2021-02-17	2021-02-12	4	Ekman Lars	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	56,23		−12 000		0
2021-02-17	2021-02-12	4	Ekman Lars	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		8 426		8 426
2021-02-17	2021-02-12	4	Ekman Lars	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	34,04		−15 000		0
2021-02-17	2021-02-12	4	Ekman Lars	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	42,50		−15 000		0
2021-02-17	2021-02-12	4	Ekman Lars	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		9 803		9 803
2021-02-17	2021-02-12	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		18 796		18 796
2021-02-17	2021-02-12	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	33,10		−25 000		0
2021-02-17	2021-02-12	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	34,61		−25 000		0
2021-02-17	2021-02-12	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		15 625		15 625
2021-02-17	2021-02-12	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		15 625		15 625
2021-02-17	2021-02-12	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	55,00		−30 000		0
2021-02-17	2021-02-12	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		15 909		15 909
2021-02-17	2021-02-12	4	Walker Karin L	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	27,81		−17 500		0
2021-02-17	2021-02-12	4	Harfstrand Karl Anders Olof	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		6 315		6 315
2021-02-17	2021-02-12	4	Harfstrand Karl Anders Olof	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	56,23		−12 000		0
2021-02-17	2021-02-12	4	Harfstrand Karl Anders Olof	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		8 426		8 426
2021-02-17	2021-02-12	4	Harfstrand Karl Anders Olof	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	42,50		−15 000		0
2021-02-17	2021-02-12	4	Harfstrand Karl Anders Olof	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		15 873		15 873
2021-02-17	2021-02-12	4	Harfstrand Karl Anders Olof	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	49,60		−30 000		0
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		140 601		140 601
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	33,10		−187 000		0
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		62 500		62 500
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	55,00		−120 000		0
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		16 759		16 759
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	45,13		−30 000		0
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		25 125		25 125
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	52,21		−50 000		0
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		40 625		40 625
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	27,81		−65 000		0
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	34,61		−65 000		0
2021-02-17	2021-02-12	4	Kinney Gene G.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		59 090		59 090
2021-02-17	2021-02-12	4	Selkoe Dennis J.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		6 315		6 315
2021-02-17	2021-02-12	4	Selkoe Dennis J.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	56,23		−12 000		0
2021-02-17	2021-02-12	4	Selkoe Dennis J.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		8 426		8 426
2021-02-17	2021-02-12	4	Selkoe Dennis J.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	34,04		−15 000		0
2021-02-17	2021-02-12	4	Selkoe Dennis J.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	42,50		−15 000		0
2021-02-17	2021-02-12	4	Selkoe Dennis J.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		9 803		9 803
2021-02-17	2021-02-12	4	HENNEY CHRISTOPHER S	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		6 315		6 315
2021-02-17	2021-02-12	4	HENNEY CHRISTOPHER S	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	56,23		−12 000		0
2021-02-17	2021-02-12	4	HENNEY CHRISTOPHER S	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		8 426		8 426
2021-02-17	2021-02-12	4	HENNEY CHRISTOPHER S	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	34,04		−15 000		0
2021-02-17	2021-02-12	4	HENNEY CHRISTOPHER S	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	42,50		−15 000		0
2021-02-17	2021-02-12	4	HENNEY CHRISTOPHER S	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		9 803		9 803
2021-02-17	2021-02-12	4	Karp Carol D.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		45 112		45 112
2021-02-17	2021-02-12	4	Karp Carol D.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	33,10		−60 000		0
2021-02-17	2021-02-12	4	Karp Carol D.	PRTA	Employee Stock Option (Right to Buy)	A - Award	D	22,85		51 282		51 282
2021-02-17	2021-02-12	4	Karp Carol D.	PRTA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	52,78		−100 000		0
2020-08-19	2020-08-17	4	Kinney Gene G.	PRTA	Stock Option (Right to Buy)	M - Exercise	D	6,41		−10 000		99 074
2020-08-19	2020-08-17	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	10 000	64		12 793
2020-05-22	2020-05-20	4	Ekman Lars	PRTA	Stock Option (Right to Buy)	A - Award	D	11,33		17 500		17 500
2020-05-22	2020-05-20	4	Cooke Shane	PRTA	Stock Option (Right to Buy)	A - Award	D	11,33		17 500		17 500
2020-05-22	2020-05-20	4	COLLIER RICHARD T	PRTA	Stock Option (Right to Buy)	A - Award	D	11,33		17 500		17 500
2020-05-22	2020-05-20	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	A - Award	D	11,33		17 500		17 500
2020-05-22	2020-05-20	4	Selkoe Dennis J.	PRTA	Stock Option (Right to Buy)	A - Award	D	11,33		17 500		17 500
2020-05-22	2020-05-20	4	Harfstrand Karl Anders Olof	PRTA	Stock Option (Right to Buy)	A - Award	D	11,33		17 500		17 500
2020-05-22	2020-05-20	4	Cobb Paula K	PRTA	Stock Option (Right to Buy)	A - Award	D	11,33		17 500		17 500
2020-03-04	2020-03-02	4	Smith Brandon S.	PRTA	Stock Option (Right to Buy)	A - Award	D	11,12		240 000		240 000
2020-02-27	2020-02-25	4	Kinney Gene G.	PRTA	Stock Option (Right to Buy)	A - Award	D	12,15		200 000		200 000
2020-02-27	2020-02-25	4	Nguyen Tran	PRTA	Stock Option (Right to Buy)	A - Award	D	12,15		105 000		105 000
2020-02-27	2020-02-25	4	Zago Wagner M.	PRTA	Stock Option (Right to Buy)	A - Award	D	12,15		70 000		70 000
2020-02-27	2020-02-25	4	Karp Carol D.	PRTA	Stock Option (Right to Buy)	A - Award	D	12,15		70 000		70 000
2020-02-27	2020-02-25	4	Tripuraneni Radhika	PRTA	Stock Option (Right to Buy)	A - Award	D	12,15		70 000		70 000
2020-02-27	2020-02-25	4	Malecek Michael J	PRTA	Stock Option (Right to Buy)	A - Award	D	12,15		70 000		70 000
2020-02-27	2020-02-25	4	Walker Karin L	PRTA	Stock Option (Right to Buy)	A - Award	D	12,15		40 000		40 000
2019-12-13		3	NODELMAN OLEG See Note	PRTA	Ordinary Shares		I						18 853 280
2019-12-13		3	NODELMAN OLEG See Note	PRTA	Ordinary Shares		I						18 853 280
2019-12-13		3	NODELMAN OLEG See Note	PRTA	Ordinary Shares		I						18 853 280
2019-08-27		3	EcoR1 Capital, LLC See Note	PRTA	Ordinary Shares		I						18 853 280
2019-08-27		3	EcoR1 Capital, LLC See Note	PRTA	Ordinary Shares		I						18 853 280
2019-08-27		3	EcoR1 Capital, LLC See Note	PRTA	Ordinary Shares		I						18 853 280
2019-07-03	2019-07-01	4	Malecek Michael J	PRTA	Stock Option (Right to Buy)	A - Award	D	10,27		250 000		250 000
2019-07-03	2019-07-02	4	Cobb Paula K	PRTA	Stock Option (Right to Buy)	A - Award	D	10,02		35 000		35 000
2019-05-24	2019-05-22	4	Ekman Lars	PRTA	Stock Option (Right to Buy)	A - Award	D	9,23		17 500		17 500
2019-05-24	2019-05-22	4	Selkoe Dennis J.	PRTA	Stock Option (Right to Buy)	A - Award	D	9,23		17 500		17 500
2019-05-24	2019-05-22	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (Right to Buy)	A - Award	D	9,23		17 500		17 500
2019-05-24	2019-05-22	4	Harfstrand Karl Anders Olof	PRTA	Stock Option (Right to Buy)	A - Award	D	9,23		17 500		17 500
2019-05-24	2019-05-22	4	COLLIER RICHARD T	PRTA	Stock Option (Right to Buy)	A - Award	D	9,23		17 500		17 500
2019-05-24	2019-05-22	4	Cooke Shane	PRTA	Stock Option (Right to Buy)	A - Award	D	9,23		17 500		17 500
2019-03-01	2019-02-27	4	Walker Karin L	PRTA	Stock Option (right to buy)	A - Award	D	13,53		35 000		35 000
2019-03-01	2019-02-27	4	Tripuraneni Radhika	PRTA	Stock Option (right to buy)	A - Award	D	13,53		50 000		50 000
2019-03-01	2019-02-27	4	Zago Wagner M.	PRTA	Stock Option (right to buy)	A - Award	D	13,53		50 000		50 000
2019-03-01	2019-02-27	4	Karp Carol D.	PRTA	Stock Option (right to buy)	A - Award	D	13,53		50 000		50 000
2019-03-01	2019-02-27	4	Nguyen Tran	PRTA	Stock Option (right to buy)	A - Award	D	13,53		95 000		95 000
2019-03-01	2019-02-27	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	13,53		245 000		245 000
2018-12-13	2018-12-11	4	Tripuraneni Radhika	PRTA	Stock Option (right to buy)	A - Award	D	11,63		35 000		35 000
2018-06-25	2018-06-21	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	15,04		620 000		620 000
2018-06-25	2018-06-21	4	Walker Karin L	PRTA	Stock Option (right to buy)	A - Award	D	15,04		110 000		110 000
2018-06-25	2018-06-21	4	Zago Wagner M.	PRTA	Stock Option (right to buy)	A - Award	D	15,04		150 000		150 000
2018-06-25	2018-06-21	4	Karp Carol D.	PRTA	Stock Option (right to buy)	A - Award	D	15,04		150 000		150 000
2018-06-25	2018-06-21	4	Nguyen Tran	PRTA	Stock Option (right to buy)	A - Award	D	15,04		250 000		250 000
2018-06-25	2018-06-21	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	A - Award	D	15,04		150 000		150 000
2018-05-18	2018-05-16	4	Cooke Shane	PRTA	Stock Option (right to buy)	A - Award	D	16,43		12 000		12 000
2018-05-18	2018-05-16	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	A - Award	D	16,43		12 000		12 000
2018-05-18	2018-05-16	4	Harfstrand Karl Anders Olof	PRTA	Stock Option (right to buy)	A - Award	D	16,43		12 000		12 000
2018-05-18	2018-05-16	4	COLLIER RICHARD T	PRTA	Stock Option (right to buy)	A - Award	D	16,43		12 000		12 000
2018-05-18	2018-05-16	4	Ekman Lars	PRTA	Stock Option (right to buy)	A - Award	D	16,43		12 000		12 000
2018-05-18	2018-05-16	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	A - Award	D	16,43		12 000		12 000
2018-02-23	2018-02-21	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	A - Award	D	33,10		60 000		60 000
2018-02-23	2018-02-21	4	Karp Carol D.	PRTA	Stock Option (right to buy)	A - Award	D	33,10		60 000		60 000
2018-02-23	2018-02-21	4	Zago Wagner M.	PRTA	Stock Option (right to buy)	A - Award	D	33,10		60 000		60 000
2018-02-23	2018-02-21	4	Nguyen Tran	PRTA	Stock Option (right to buy)	A - Award	D	33,10		80 000		80 000
2018-02-23	2018-02-21	4	Nickerson Tara	PRTA	Stock Option (right to buy)	A - Award	D	33,10		45 000		45 000
2018-02-23	2018-02-21	4	Walker Karin L	PRTA	Stock Option (right to buy)	A - Award	D	33,10		25 000		25 000
2018-02-23	2018-02-21	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	33,10		187 000		187 000
2017-10-04	2017-10-02	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−3 500		3 500
2017-10-04	2017-10-02	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,7700	−201	−13		2 845
2017-10-04	2017-10-02	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,1298	−3 299	−212		3 046
2017-10-04	2017-10-02	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 500	57		6 345
2017-09-29	2017-09-28	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	M - Exercise	D	6,65		−900		14 100
2017-09-29	2017-09-28	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,0000	−900	−63		0
2017-09-29	2017-09-28	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,6500	900	6		900
2017-09-29	2017-09-28	4	Zago Wagner M.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−900		15 100
2017-09-29	2017-09-28	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,0000	−900	−63		0
2017-09-29	2017-09-28	4	Zago Wagner M.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	900	6		900
2017-09-29	2017-09-28	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−2 800		109 074
2017-09-29	2017-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,0000	−2 800	−196		2 793
2017-09-29	2017-09-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	2 800	18		5 593
2017-09-29	2017-09-28	4	Walker Karin L	PRTA	Stock Option(right to buy)	M - Exercise	D	27,81		−1 500		17 500
2017-09-29	2017-09-28	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		70,0000	−1 500	−105		0
2017-09-29	2017-09-28	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		27,8100	1 500	42		1 500
2017-09-29	2017-09-28	4	Nickerson Tara	PRTA	Stock Option (right to buy)	M - Exercise	D	6,73		−12 776		18 500
2017-09-29	2017-09-28	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,1966	−12 776	−884		2 000
2017-09-29	2017-09-28	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	12 776	86		14 776
2017-09-29	2017-09-27	4	Nickerson Tara	PRTA	Stock Option (right to buy)	M - Exercise	D	6,73		−4 724		31 276
2017-09-29	2017-09-27	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,0494	−4 724	−326		2 000
2017-09-29	2017-09-27	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	4 724	32		6 724
2017-09-27	2017-09-25	4	Nickerson Tara	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−17 500		1 500
2017-09-27	2017-09-25	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,3273	−3 783	−243		2 000
2017-09-27	2017-09-25	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		63,3944	−13 717	−870		5 783
2017-09-27	2017-09-25	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	17 500	112		19 500
2017-07-19	2017-07-17	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	M - Exercise	D	6,65		−5 000		15 000
2017-07-19	2017-07-17	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,1341	−5 000	−331		0
2017-07-19	2017-07-17	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,6500	5 000	33		5 000
2017-07-19	2017-07-17	4	Walker Karin L	PRTA	Stock Option(right to buy)	M - Exercise	D	9,75		−5 000		0
2017-07-19	2017-07-17	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,2097	−3 600	−235		0
2017-07-19	2017-07-17	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,0604	−1 400	−90		3 600
2017-07-19	2017-07-17	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	5 000	49		5 000
2017-07-07	2017-07-07	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−3 500		7 000
2017-07-07	2017-07-07	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,5480	−500	−29		2 845
2017-07-07	2017-07-07	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		58,0416	−3 000	−174		3 345
2017-07-07	2017-07-07	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 500	57		6 345
2017-06-13	2017-06-09	4	Zago Wagner M.	PRTA	Stock Option (right to buy)	A - Award	D	51,32		20 000		20 000
2017-05-19	2017-05-18	4	Cooke Shane	PRTA	Stock Option (right to buy)	A - Award	D	56,23		12 000		12 000
2017-05-19	2017-05-18	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	A - Award	D	56,23		12 000		12 000
2017-05-19	2017-05-18	4	COLLIER RICHARD T	PRTA	Stock Option (right to buy)	A - Award	D	56,23		12 000		12 000
2017-05-19	2017-05-18	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	A - Award	D	56,23		12 000		12 000
2017-05-19	2017-05-18	4	Harfstrand Karl Anders Olof	PRTA	Stock Option (right to buy)	A - Award	D	56,23		12 000		12 000
2017-05-19	2017-05-18	4	Ekman Lars	PRTA	Stock Option (right to buy)	A - Award	D	56,23		12 000		12 000
2017-05-18	2017-05-16	4	Noonberg Sarah B.	PRTA	Stock Option (right to buy)	A - Award	D	56,37		100 000		100 000
2017-04-19	2017-04-17	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	29,81		−2 000		3 000
2017-04-19	2017-04-17	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−3 000		5 000
2017-04-19	2017-04-17	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,2908	−2 000	−105		0
2017-04-19	2017-04-17	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	2 000	60		2 000
2017-04-19	2017-04-17	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,7000	−100	−5		0
2017-04-19	2017-04-17	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,2105	−2 900	−151		100
2017-04-19	2017-04-17	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	3 000	29		3 000
2017-04-05	2017-04-03	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−3 500		10 500
2017-04-05	2017-04-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,8637	−3 500	−196		2 845
2017-04-05	2017-04-03	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 500	57		6 345
2017-03-09	2017-03-09	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		51,3172	1 000	51		3 200
2017-03-03	2017-03-01	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−3 500		14 000
2017-03-03	2017-03-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,2469	−3 500	−207		2 845
2017-03-03	2017-03-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 500	57		6 345
2017-03-03	2017-03-01	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−3 125		68 750
2017-03-03	2017-03-01	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		59,2824	−3 125	−185		0
2017-03-03	2017-03-01	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	3 125	69		3 125
2017-03-03	2017-03-01	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−25 163		111 874
2017-03-03	2017-03-01	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,2444	−12 822	−785		2 793
2017-03-03	2017-03-01	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,2846	−12 341	−744		15 615
2017-03-03	2017-03-01	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	25 163	161		27 956
2017-03-02	2017-02-28	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−3 796		137 037
2017-03-02	2017-02-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,0000	−3 796	−228		2 793
2017-03-02	2017-02-28	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	3 796	24		6 589
2017-03-01	2017-02-27	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	M - Exercise	D	6,65		−5 989		20 000
2017-03-01	2017-02-27	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,1632	−5 989	−342		0
2017-03-01	2017-02-27	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,6500	5 989	40		5 989
2017-02-24	2017-02-22	4	Nguyen Tran	PRTA	Stock Option (right to buy)	A - Award	D	55,00		75 000		75 000
2017-02-24	2017-02-22	4	Walker Karin L	PRTA	Stock Option (right to buy)	A - Award	D	55,00		30 000		30 000
2017-02-24	2017-02-22	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	55,00		120 000		120 000
2017-02-24	2017-02-22	4	Nickerson Tara	PRTA	Stock Option (right to buy)	A - Award	D	55,00		45 000		45 000
2017-02-24	2017-02-22	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	A - Award	D	55,00		55 000		55 000
2017-02-22	2017-02-17	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	M - Exercise	D	6,65		−4 011		25 989
2017-02-22	2017-02-17	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,0632	−4 011	−229		0
2017-02-22	2017-02-17	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,6500	4 011	27		4 011
2017-01-05	2017-01-04	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−2 712		71 875
2017-01-05	2017-01-04	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,2687	−2 712	−142		0
2017-01-05	2017-01-04	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	2 712	60		2 712
2017-01-05	2017-01-03	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−413		74 587
2017-01-05	2017-01-03	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,1500	−413	−22		0
2017-01-05	2017-01-03	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	413	9		413
2016-12-16	2016-12-14	4	Karp Carol D.	PRTA	Stock Option (right to buy)	A - Award	D	52,78		100 000		100 000
2016-11-30	2016-11-28	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−5 000		17 500
2016-11-30	2016-11-28	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		63,5911	−900	−57		2 845
2016-11-30	2016-11-28	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,1674	−4 100	−255		3 745
2016-11-30	2016-11-28	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	5 000	82		7 845
2016-11-10	2016-11-09	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−3 125		75 000
2016-11-10	2016-11-09	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,1861	−3 125	−163		0
2016-11-10	2016-11-09	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	3 125	69		3 125
2016-11-10	2016-11-09	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−8 548		140 833
2016-11-10	2016-11-09	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,3235	−8 548	−473		2 793
2016-11-10	2016-11-09	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	8 548	55		11 341
2016-11-04	2016-11-02	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	45,13		30 000		30 000
2016-10-21	2016-10-21	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−5 834		149 381
2016-10-21	2016-10-21	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,1500	−5 834	−322		2 793
2016-10-21	2016-10-21	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	5 834	37		8 627
2016-10-21	2016-10-20	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−14 785		155 215
2016-10-21	2016-10-20	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,0800	−14 785	−814		2 793
2016-10-21	2016-10-20	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	14 785	95		17 578
2016-10-14	2016-10-13	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	29,81		−2 000		5 000
2016-10-14	2016-10-13	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−3 000		8 000
2016-10-14	2016-10-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,7133	−900	−49		0
2016-10-14	2016-10-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,6082	−1 100	−59		900
2016-10-14	2016-10-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	2 000	60		2 000
2016-10-14	2016-10-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,7369	−1 800	−99		0
2016-10-14	2016-10-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		53,6963	−1 200	−64		1 800
2016-10-14	2016-10-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	3 000	29		3 000
2016-09-21	2016-09-19	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	27,81		−5 000		19 000
2016-09-21	2016-09-19	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−7 000		11 000
2016-09-21	2016-09-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,8342	−4 500	−278		0
2016-09-21	2016-09-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,0100	−500	−30		4 500
2016-09-21	2016-09-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		27,8100	5 000	139		5 000
2016-09-21	2016-09-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,8305	−2 700	−167		0
2016-09-21	2016-09-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		60,0006	−4 300	−258		2 700
2016-09-21	2016-09-19	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	7 000	68		7 000
2016-09-06	2016-09-01	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	52,21		50 000		50 000
2016-09-02	2016-09-01	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−3 125		78 125
2016-09-02	2016-09-01	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,1570	−3 125	−163		0
2016-09-02	2016-09-01	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	3 125	69		3 125
2016-08-24	2016-08-22	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−5 000		22 500
2016-08-24	2016-08-22	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,0531	−1 700	−94		2 845
2016-08-24	2016-08-22	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,3895	−3 300	−179		4 545
2016-08-24	2016-08-22	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	5 000	82		7 845
2016-08-05	2015-08-07	4/A	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	M - Exercise	D	6,65		−10 000		40 000
2016-08-05	2015-08-07	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,0301	−1 040	−67		0
2016-08-05	2015-08-07	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		63,2523	−4 560	−288		1 040
2016-08-05	2015-08-07	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,3356	−4 400	−274		5 600
2016-08-05	2015-08-07	4/A	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,6500	10 000	66		10 000
2016-07-22	2016-07-20	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−9 375		81 250
2016-07-22	2016-07-20	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,1400	−9 375	−489		0
2016-07-22	2016-07-20	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	9 375	208		9 375
2016-05-25	2016-05-24	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−4 820		27 500
2016-05-25	2016-05-24	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		45,0000	−4 820	−217		2 845
2016-05-25	2016-05-24	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	4 820	79		7 665
2016-05-25	2016-05-23	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−180		32 320
2016-05-25	2016-05-23	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		45,0000	−180	−8		2 845
2016-05-25	2016-05-23	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	180	3		3 025
2016-05-24	2016-05-20	4	Cooke Shane	PRTA	Stock Option (right to buy)	A - Award	D	42,50		15 000		15 000
2016-05-24	2016-05-20	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	A - Award	D	42,50		15 000		15 000
2016-05-24	2016-05-20	4	Ekman Lars	PRTA	Stock Option (right to buy)	A - Award	D	42,50		15 000		15 000
2016-05-24	2016-05-20	4	COLLIER RICHARD T	PRTA	Stock Option (right to buy)	A - Award	D	42,50		15 000		15 000
2016-05-24	2016-05-20	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	A - Award	D	42,50		15 000		15 000
2016-05-24	2016-05-20	4	Harfstrand Karl Anders Olof	PRTA	Stock Option (right to buy)	A - Award	D	42,50		15 000		15 000
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	27,81		−1 000		24 000
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	29,81		−1 000		24 000
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−2 000		18 000
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		45,2875	−1 000	−45		0
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		27,8100	1 000	28		1 000
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		45,2825	−1 000	−45		0
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	1 000	30		1 000
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		45,5900	−400	−18		0
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		44,7769	−1 600	−72		400
2016-04-15	2016-04-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	2 000	20		2 000
2016-04-06	2016-04-04	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−5 000		32 500
2016-04-06	2016-04-04	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		45,0000	−5 000	−225		2 845
2016-04-06	2016-04-04	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	5 000	82		7 845
2016-02-26	2016-02-24	4	HOMAN ARTHUR W	PRTA	Stock Option(right to buy)	A - Award	D	34,61		45 000		45 000
2016-02-26	2016-02-24	4	Nguyen Tran	PRTA	Stock Option (right to buy)	A - Award	D	34,61		65 000		65 000
2016-02-26	2016-02-24	4	Walker Karin L	PRTA	Stock Option (right to buy)	A - Award	D	34,61		25 000		25 000
2016-02-26	2016-02-24	4	Schenk Dale B.	PRTA	Stock Option (right to buy)	A - Award	D	34,61		200 000		200 000
2016-02-26	2016-02-24	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	34,61		65 000		65 000
2016-02-26	2016-02-24	4	Nickerson Tara	PRTA	Stock Option (right to buy)	A - Award	D	34,61		35 000		35 000
2016-02-26	2016-02-24	4	Koller Martin	PRTA	Stock Option (right to buy)	A - Award	D	34,61		50 000		50 000
2016-02-26	2016-02-24	4	McNinch David B.	PRTA	Stock Option(right to buy)	A - Award	D	34,61		100 000		100 000
2016-01-15	2016-01-13	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−2 000		8 000
2016-01-15	2016-01-13	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	29,81		−2 000		8 000
2016-01-15	2016-01-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		51,8180	−500	−26		0
2016-01-15	2016-01-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		50,6907	−1 500	−76		500
2016-01-15	2016-01-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	2 000	60		2 000
2016-01-15	2016-01-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		51,8000	−500	−26		0
2016-01-15	2016-01-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		50,6733	−1 500	−76		500
2016-01-15	2016-01-13	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	2 000	20		2 000
2016-01-06	2016-01-04	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−3 125		90 625
2016-01-06	2016-01-04	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,5460	−600	−40		0
2016-01-06	2016-01-04	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,4581	−1 138	−74		600
2016-01-06	2016-01-04	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,5066	−1 387	−89		1 738
2016-01-06	2016-01-04	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	3 125	69		3 125
2015-12-11	2015-12-09	4	Nickerson Tara	PRTA	Stock Option (right to buy)	M - Exercise	D	6,73		−10 000		36 000
2015-12-11	2015-12-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,9433	−600	−40		2 000
2015-12-11	2015-12-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,3980	−6 695	−445		2 600
2015-12-11	2015-12-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,4163	−2 705	−177		9 295
2015-12-11	2015-12-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	10 000	67		12 000
2015-12-11	2015-12-09	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−30 000		170 000
2015-12-11	2015-12-09	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,0517	−1 360	−91		2 793
2015-12-11	2015-12-09	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,3724	−20 439	−1 357		4 153
2015-12-11	2015-12-09	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,4616	−8 201	−537		24 592
2015-12-11	2015-12-09	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	30 000	192		32 793
2015-12-11	2015-12-09	4	Nguyen Tran	PRTA	Stock Option (right to buy)	M - Exercise	D	6,73		−30 000		150 000
2015-12-11	2015-12-09	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,0021	−2 100	−141		2 200
2015-12-11	2015-12-09	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,3684	−19 731	−1 310		4 300
2015-12-11	2015-12-09	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,4616	−8 169	−535		24 031
2015-12-11	2015-12-09	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	30 000	202		32 200
2015-12-03	2015-12-01	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−3 125		37 500
2015-12-03	2015-12-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,6850	−200	−14		2 845
2015-12-03	2015-12-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,1212	−1 519	−105		3 045
2015-12-03	2015-12-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,1870	−1 406	−96		4 564
2015-12-03	2015-12-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 125	51		5 970
2015-12-01	2015-11-27	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	M - Exercise	D	6,65		−5 000		30 000
2015-12-01	2015-11-27	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		75,0000	−5 000	−375		0
2015-12-01	2015-11-27	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,6500	5 000	33		5 000
2015-11-25	2015-11-25	4	Ekman Lars	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−30 000		95 000
2015-11-25	2015-11-25	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		74,4349	−1 910	−142		243
2015-11-25	2015-11-25	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		73,7262	−11 502	−848		2 153
2015-11-25	2015-11-25	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		72,9602	−16 588	−1 210		13 655
2015-11-25	2015-11-25	4	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	30 000	192		30 243
2015-11-19	2015-11-19	4	Schenk Dale B. By Trust	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	I			3 333			14 877
2015-11-19	2015-11-19	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	D			−3 333			0
2015-11-19	2015-11-17	4	Schenk Dale B.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,03		−33 333		383 334
2015-11-19	2015-11-17	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		69,3667	−300	−21		3 333
2015-11-19	2015-11-17	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		68,6541	−7 200	−494		3 633
2015-11-19	2015-11-17	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		67,8910	−7 374	−501		10 833
2015-11-19	2015-11-17	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		66,8283	−9 826	−657		18 207
2015-11-19	2015-11-17	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,7780	−5 300	−349		28 033
2015-11-19	2015-11-17	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,0300	33 333	201		33 333
2015-11-19	2015-08-31	4	Schenk Dale B. By Trust	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	I			3 333			11 544
2015-11-19	2015-08-31	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	D			−3 333			0
2015-11-13	2015-11-13	4	Koller Martin	PRTA	Stock Option (right to buy)	M - Exercise	D	6,73		−30 000		65 000
2015-11-13	2015-11-13	4	Koller Martin	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		65,0324	−30 000	−1 951		0
2015-11-13	2015-11-13	4	Koller Martin	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	30 000	202		30 000
2015-11-04	2015-11-02	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−3 125		93 750
2015-11-04	2015-11-02	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		52,1400	−3 125	−163		0
2015-11-04	2015-11-02	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	3 125	69		3 125
2015-10-30	2015-10-29	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	M - Exercise	D	6,65		−5 000		35 000
2015-10-30	2015-10-29	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,0000	−5 000	−275		0
2015-10-30	2015-10-29	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,6500	5 000	33		5 000
2015-09-11	2015-09-09	4	Nickerson Tara	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−10 000		19 000
2015-09-11	2015-09-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,3200	−200	−11		2 000
2015-09-11	2015-09-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,5186	−4 000	−226		2 200
2015-09-11	2015-09-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,6931	−5 800	−323		6 200
2015-09-11	2015-09-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	10 000	64		12 000
2015-09-03	2015-09-02	4	Koller Martin	PRTA	Stock Option (right to buy)	M - Exercise	D	6,73		−5 400		95 000
2015-09-03	2015-09-02	4	Koller Martin	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,1702	−5 400	−298		0
2015-09-03	2015-09-02	4	Koller Martin	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	5 400	36		5 400
2015-09-03	2015-09-01	4	Koller Martin	PRTA	Stock Option (right to buy)	M - Exercise	D	6,73		−24 600		100 400
2015-09-03	2015-09-01	4	Koller Martin	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,1752	−2 950	−166		0
2015-09-03	2015-09-01	4	Koller Martin	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,5787	−21 650	−1 203		2 950
2015-09-03	2015-09-01	4	Koller Martin	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,7300	24 600	166		24 600
2015-09-03	2015-09-01	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−3 125		40 625
2015-09-03	2015-09-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,7578	−2 025	−113		2 845
2015-09-03	2015-09-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,8823	−1 100	−60		4 870
2015-09-03	2015-09-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 125	51		5 970
2015-09-03	2015-09-01	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	M - Exercise	D	22,14		−3 125		96 875
2015-09-03	2015-09-01	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,7655	−2 025	−113		0
2015-09-03	2015-09-01	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		54,8477	−1 100	−60		2 025
2015-09-03	2015-09-01	4	HOMAN ARTHUR W	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		22,1400	3 125	69		3 125
2015-08-21	2015-08-20	4	Schenk Dale B.	PRTA	Stock Option (right to buy)	M - Exercise	D	6,03		−33 333		416 667
2015-08-21	2015-08-20	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		57,5946	−7 100	−409		3 333
2015-08-21	2015-08-20	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		56,7272	−13 600	−771		10 433
2015-08-21	2015-08-20	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		55,8210	−9 300	−519		24 033
2015-08-21	2015-08-20	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,0300	33 333	201		33 333
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	29,81		−2 000		10 000
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−5 000		22 000
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,3341	−1 100	−69		0
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,5094	−900	−55		1 100
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		29,8100	2 000	60		2 000
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		63,2724	−324	−21		0
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,4285	−2 176	−136		324
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		61,6544	−2 500	−154		2 500
2015-08-14	2015-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	5 000	49		5 000
2015-08-07	2015-08-07	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	M - Exercise	D	6,65		−10 000		40 000
2015-08-07	2015-08-07	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		64,0301	−1 040	−67		0
2015-08-07	2015-08-07	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		63,2523	−4 560	−288		1 040
2015-08-07	2015-08-07	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		62,3356	−4 400	−274		5 600
2015-08-07	2015-08-07	4	HENNEY CHRISTOPHER S	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	10 000	64		10 000
2015-06-30	2015-06-29	4	Harfstrand Karl Anders Olof	PRTA	Stock Option (right to buy)	A - Award	D	49,60		30 000		30 000
2015-06-09	2015-06-09	4	Nickerson Tara	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−12 000		29 000
2015-06-09	2015-06-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		45,1691	−2 760	−125		2 000
2015-06-09	2015-06-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		44,1864	−9 240	−408		4 760
2015-06-09	2015-06-09	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	12 000	77		14 000
2015-06-03	2015-06-01	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−3 125		43 750
2015-06-03	2015-06-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		40,8092	−325	−13		2 845
2015-06-03	2015-06-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		39,4181	−1 100	−43		3 170
2015-06-03	2015-06-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		38,3993	−1 700	−65		4 270
2015-06-03	2015-06-01	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 125	51		5 970
2015-05-26	2015-05-22	4	COLLIER RICHARD T	PRTA	Stock Option (right to buy)	A - Award	D	34,04		15 000		15 000
2015-05-26	2015-05-22	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	A - Award	D	34,04		15 000		15 000
2015-05-26	2015-05-22	4	Ekman Lars	PRTA	Stock Option (right to buy)	A - Award	D	34,04		15 000		15 000
2015-05-26	2015-05-22	4	Cooke Shane	PRTA	Stock Option (right to buy)	A - Award	D	34,04		15 000		15 000
2015-05-26	2015-05-22	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	A - Award	D	34,04		15 000		15 000
2015-03-20	2015-03-20	4	Nickerson Tara	PRTA	Stock Option (right to buy)	M - Exercise	D	6,41		−13 000		41 000
2015-03-20	2015-03-20	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		39,9900	−13 000	−520		2 000
2015-03-20	2015-03-20	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		6,4100	13 000	83		15 000
2015-03-12	2015-03-11	4	Koller Martin	PRTA	Stock Option (right to buy)	A - Award	D	27,81		50 000		50 000
2015-03-12	2015-03-11	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	27,81		65 000		65 000
2015-03-12	2015-03-11	4	Nickerson Tara	PRTA	Stock Option (right to buy)	A - Award	D	27,81		37 500		37 500
2015-03-12	2015-03-11	4	Walker Karin L	PRTA	Stock Option (right to buy)	A - Award	D	27,81		25 000		25 000
2015-03-12	2015-03-11	4	Schenk Dale B.	PRTA	Stock Option (right to buy)	A - Award	D	27,81		150 000		150 000
2015-03-12	2015-03-11	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	A - Award	D	27,81		42 500		42 500
2015-03-12	2015-03-11	4	Nguyen Tran	PRTA	Stock Option (right to buy)	A - Award	D	27,81		55 000		55 000
2015-03-10	2015-03-09	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	M - Exercise	D	16,42		−3 125		46 875
2015-03-10	2015-03-09	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		25,5573	−3 125	−80		2 845
2015-03-10	2015-03-09	4	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		16,4200	3 125	51		5 970
2015-02-13	2014-11-24	5	Schenk Dale B. By Trust	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	I			8 161			8 211
2015-02-13	2014-11-24	5	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	G - Gift	D			−8 161			0
2015-02-12	2015-02-10	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−2 500		27 000
2015-02-12	2015-02-10	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		21,5265	−2 500	−54		0
2015-02-12	2015-02-10	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	2 500	24		2 500
2014-12-11	2014-12-09	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−2 500		29 500
2014-12-11	2014-12-09	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		20,0011	−2 500	−50		0
2014-12-11	2014-12-09	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	2 500	24		2 500
2014-10-23	2014-10-16	4/A	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−2 500		32 000
2014-10-23	2014-10-16	4/A	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		20,0873	−2 500	−50		0
2014-10-23	2014-10-16	4/A	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	2 500	24		2 500
2014-10-20	2014-10-16	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−2 500		32 000
2014-10-20	2014-10-16	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		20,0873	−2 500	−50		0
2014-10-20	2014-10-16	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	2 500	24		2 500
2014-08-13	2014-08-12	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−2 500		34 500
2014-08-13	2014-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		20,7368	−2 500	−52		0
2014-08-13	2014-08-12	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	2 500	24		2 500
2014-08-07	2014-08-07	4	HOMAN ARTHUR W By Trust	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	I		19,1210	2 000	38		2 000
2014-06-06	2014-06-06	4	Walker Karin L	PRTA	Stock Option (right to buy)	M - Exercise	D	9,75		−8 000		37 000
2014-06-06	2014-06-06	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	S - Sale	D		21,5785	−8 000	−173		0
2014-06-06	2014-06-06	4	Walker Karin L	PRTA	Ordinary Shares, par value $0.01 per share	M - Exercise	D		9,7500	8 000	78		8 000
2014-05-12	2014-05-09	4	Nguyen Tran	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		19,6064	2 200	43		2 200
2014-05-12	2014-05-12	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		20,9878	5 900	124		8 161
2014-05-12	2014-05-12	4	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		20,2348	2 100	42		2 261
2014-05-12	2014-05-09	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		19,5399	2 500	49		2 793
2014-05-12	2014-05-12	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	P - Purchase	D		21,0000	1 656	35		2 000
2014-05-02	2014-05-01	4	HOMAN ARTHUR W	PRTA	Stock Option (right to buy)	A - Award	D	22,14		100 000		100 000
2014-04-03	2014-04-01	4	Koller Martin	PRTA	Stock Option (right to buy)	A - Award	D	37,02		25 000		25 000
2014-03-19		3/A	Schenk Dale B. By Trust	PRTA	Ordinary Shares, par value $0.01 per share		I						50
2014-03-19		3/A	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share		D						161
2014-03-19	2013-01-29	4/A	Schenk Dale B.	PRTA	Stock Option (right to buy)	A - Award	D	6,03		450 000		450 000
2014-03-19	2014-02-04	4/A	Schenk Dale B.	PRTA	Stock Option (right to buy)	A - Award	D	29,81		105 000		105 000
2014-02-06	2014-02-04	4	Nguyen Tran	PRTA	Stock Option (right to buy)	A - Award	D	29,81		45 000		45 000
2014-02-06	2014-02-04	4	Walker Karin L	PRTA	Stock Option (right to buy)	A - Award	D	29,81		12 000		12 000
2014-02-06	2014-02-04	4	Schenk Dale B.	PRTA	Stock Option (right to buy)	A - Award	D	29,81		105 000		105 000
2014-02-06	2014-02-04	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	29,81		45 000		45 000
2014-02-06	2014-02-04	4	Nickerson Tara	PRTA	Stock Option (right to buy)	A - Award	D	29,81		50 000		50 000
2014-02-06	2014-02-04	4	Koller Martin	PRTA	Stock Option (right to buy)	A - Award	D	29,81		40 000		40 000
2014-02-04	2014-02-03	4	PERRIGO Co plc Indirect	PRTA	Ordinary Shares	S - Sale	I		24,9600	−3 182 253	−79 429		0
2014-01-27		3	PERRIGO Co plc Indirect	PRTA	Ordinary Shares		I						3 182 253
2013-07-24		3	Selkoe Dennis J.	PRTA	Ordinary Shares, par value $0.01 per share		D						2 845
2013-07-24		3	Selkoe Dennis J. By wife	PRTA	Ordinary Shares, par value $0.01 per share		I						1 363
2013-07-24	2013-07-22	4	Selkoe Dennis J.	PRTA	Stock Option (right to buy)	A - Award	D	16,42		50 000		50 000
2013-06-05	2013-06-03	4	Walker Karin L	PRTA	Stock Option (right to buy)	A - Award	D	9,75		45 000		45 000
2013-04-02	2013-04-01	4	Nguyen Tran	PRTA	Stock Option (right to buy)	A - Award	D	6,73		180 000		180 000
2013-04-02	2013-04-01	4	Nickerson Tara	PRTA	Stock Option (right to buy)	A - Award	D	6,73		46 000		46 000
2013-04-02	2013-04-01	4	Koller Martin	PRTA	Stock Option (right to buy)	A - Award	D	6,73		125 000		125 000
2013-03-19	2013-03-18	4	HENNEY CHRISTOPHER S	PRTA	Stock Option (right to buy)	A - Award	D	6,65		50 000		50 000
2013-01-31	2013-01-29	4	Ekman Lars	PRTA	Stock Option (right to buy)	A - Award	D	6,41		125 000		125 000
2013-01-31	2013-01-29	4	COLLIER RICHARD T	PRTA	Stock Option (right to buy)	A - Award	D	6,41		50 000		50 000
2013-01-31	2013-01-29	4	Cooke Shane	PRTA	Stock Option (right to buy)	A - Award	D	6,41		50 000		50 000
2013-01-31	2013-01-29	4	Schenk Dale B.	PRTA	Stock Option (right to buy)	A - Award	D	6,03		450 000		450 000
2013-01-31	2013-01-30	4	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share	J - Other	D			25			293
2013-01-31	2013-01-29	4	Kinney Gene G.	PRTA	Stock Option (right to buy)	A - Award	D	6,41		200 000		200 000
2013-01-31	2013-01-29	4	Fawcett John Randall	PRTA	Stock Option (right to buy)	A - Award	D	6,41		36 000		36 000
2013-01-31	2013-01-30	4	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share	J - Other	D			79			344
2013-01-31	2013-01-29	4	Nickerson Tara	PRTA	Stock Option (right to buy	A - Award	D	6,41		54 000		54 000
2012-12-28		3	PERRIGO SCIENCE ONE LTD. Indirect	PRTA	Ordinary Shares		I						3 182 253
2012-12-21		3	Ekman Lars	PRTA	Ordinary Shares, par value $0.01 per share		D						243
2012-12-21		3	COLLIER RICHARD T	PRTA	Ordinary Shares, par value $0.01 per share		D						1 219
2012-12-21		3	Schenk Dale B.	PRTA	Ordinary Shares, par value $0.01 per share		D						211
2012-12-21		3	Kinney Gene G.	PRTA	Ordinary Shares, par value $0.01 per share		D						268
2012-12-21		3	Fawcett John Randall	PRTA	Ordinary Shares, par value $0.01 per share		D						336
2012-12-21		3	Nickerson Tara	PRTA	Ordinary Shares, par value $0.01 per share		D						265

Köp på öppna marknaden eller privat köp av icke-derivatsäkerhet

Köp på öppna marknaden eller privat försäljning av icke-derivatsäkerhet

Bevilja, tilldelning eller annat förvärv av värdepapper från företaget (såsom en option)

Omvandling av derivat

Försäljning eller överföring av värdepapper tillbaka til företaget

Betalning av lösenpris eller skatteskuld med del av värdepapper som erhållits från bolaget

Överlåtelse av värdepapper från eller till insidern

Aktieswappar och liknande säkringsaffärer

Utövande eller omvandling av derivatsäkerhet som erhållits från företaget (som en option)

En transaktion friviligt rapporterad på schema 4

Andra (med en fotnot som beskriver transaktionen)

GB:0Y3M	8,75 US$
DE:0PT	6,90 €

PRTA / Prothena Corporation plc - Insider Trading and Ownership Report - SEC Form 3, 4, 5