Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionSicart Associates LLC
Latest Disclosed Ownership159,412 shares
Latest Disclosed Value $ 11,970,247
Sicart Associates LLC reports 2.53% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On April 21, 2026 - Sicart Associates LLC filed a 13F-HR form disclosing ownership of 159,412 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $11,970,247 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 14, 2026 disclosing 163,557 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -2.53% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

Upgrade to unlock premium data and export to Excel .

Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-21 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 159,412 -4,145 -2.53 11,970 -7.48 3.0750
2026-01-14 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 163,557 -761 -0.46 12,939 20.36 3.4331
2025-10-07 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 164,318 -20,978 -11.32 10,750 46.82 2.9124
2025-07-18 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 185,296 -350 -0.19 7,321 30.73 2.5615
2025-04-25 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 185,646 -175 -0.09 5,601 -13.79 1.9371
2025-01-15 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 185,821 -5,702 -2.98 6,496 -15.33 2.3237
2024-10-25 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 191,523 0 0.00 7,672 -15.94 2.6943
2024-08-05 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 191,523 -2,470 -1.27 9,128 8.54 3.5031
2024-05-03 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 193,993 -300 -0.15 8,410 -14.45 3.0803
2024-01-19 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 194,293 -8,839 -4.35 9,829 6.67 3.7591
2023-10-26 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 203,132 -1,815 -0.89 9,214 9.59 3.6136
2023-07-28 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 204,947 -5,751 -2.73 8,409 11.66 3.2661
2023-05-09 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 210,698 -35,560 -14.44 7,530 -19.04 2.9282
2023-01-27 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 246,258 -7,718 -3.04 9,301 -17.20 3.2792
2022-11-02 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 253,976 -34,775 -12.04 11,233 5.08 3.9835
2022-08-05 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 288,751 -16,031 -5.26 10,690 -5.31 3.3272
2022-05-06 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 304,782 22,251 7.88 11,289 30.84 2.9209
2022-01-31 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 282,531 -8,723 -2.99 8,628 -11.68 2.2518
2021-10-22 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 291,254 -77,155 -20.94 9,769 -33.53 2.6621
2021-07-23 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 368,409 -1,889 -0.51 14,696 -11.73 3.4986
2021-05-10 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 370,298 -32,610 -8.09 16,649 -26.91 4.4025
2021-01-22 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 402,908 -15,387 -3.68 22,780 14.77 5.6247
2020-10-14 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 418,295 -1,077 -0.26 19,848 -19.73 5.9264
2020-07-30 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 419,372 -10,380 -2.42 24,726 21.69 7.9082
2020-04-22 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 429,752 18,940 4.61 20,319 -18.12 7.7355
2020-01-30 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 410,812 275 0.07 24,817 0.90 8.2677
2019-10-21 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 410,537 -2,835 -0.69 24,595 -7.42 8.0731
2019-07-23 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 413,372 -3,613 -0.87 26,567 -21.51 10.7958
2019-05-01 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 416,985 -104,974 -20.11 33,847 19.95 14.3015
2019-01-22 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 521,959 -1,885 -0.36 28,217 4.43 13.6553
2018-10-19 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 523,844 -50 -0.01 27,020 23.77 12.9602
2018-07-19 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 523,894 177,082 51.06 21,831 42.81 11.4463
2018-04-12 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 346,812 -51,260 -12.88 15,287 -23.65 9.1307
2018-01-17 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 398,072 9,050 2.33 20,023 1.52 10.5706
2017-11-06 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 389,022 1,700 0.44 19,724 0.11 14.1060
2017-08-04 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 387,322 19,962 5.43 19,703 33.42 14.3191
2017-04-10 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 367,360 87,045 31.05 14,768 10.15 10.6718
2017-02-07 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 280,315 280,315 13,407 9.2546
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.