| Utestående aktier | 38,581,863 shares |
| Insideraktier | 19 077 130 shares |
| Insynsägande | 49,45 % |
| Totalt antal insynspersoner | 60 |
Insider Sentiment Score
Insider sentiment score hittar de företag som köps av foretagsinsynspersoner.
Det är resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av insiderackumulation. Poängmodellen använder en kombination av nettoantalet insiders som köpt de föregående 90 dagarna, det totala antalet aktier som köpts i procent av aktiekapitalet och det totala antalet aktier som ägs av insiders. Siffran sträcker sig från 0 till 100, med högre siffror som indikerar en högre nivå av ackumulering för sina kamrater, och 50 är genomsnittet.
Uppdateringsfrekvens: Dagligen
Se Insiders Top Picks, som ger en lista över företag med högsta insiderackumulation.
Office Sentiment Score
Officersentiment Score hittar företag som köps av Corporate Officers.
Per definition Corporate Officers är Corporate Insiders, men till skillnad från vissa av de andra Insiders (10 % aktieägare och styrelseledamöter), arbetar ämbetsmän för företaget dagligen och de använder sina egna pengar när de handlar . (10 % aktieägare och styrelseledamöter är ofta fondförvaltare som förvaltar andras pengar.) Som sådan är insideraffärer som görs av tjänstemän mycket mer betydelsefulla och bör behandlas på lämpligt sätt.
Liksom Insider Sentiment Score är Officer Sentiment Score resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av officersackumulering.
Uppdateringsfrekvens: Dagligen
Se insiderns bästa val, vilket ger en lista över företag med högsta insider sentiment.
Viktiga insidernyckeltal
Denna kort visar hur företaget rankas längs olika insidernyckeltal. Procenttilrankningen visar hur detta företag jämförs med andra företag på USA-marknaden. Högre rankingar indikerar bättre situationer.
Till exempel anses det allmänt att insiderköp är en positiv indikator, så företag med mer insiderköp skulle rankas högre än företag med mindre insiderköp (eller til och med insiderförsäljning).
Procent av flytande köpta av insiders (ranking)
0.000 %( )
5210 out of 11218Procentandelen av aktier köpta av insiders är det totala antalet aktier som köpts av insiders minus det totala antalet aktier som sålts av insiders under de senaste 90 dagarna, dividerat med det totala antalet aktier och multiplicerat med 100.
Insiderhandelsdiagram
Protara Therapeutics, Inc. insideraffärer visas i följande diagram. Insiders är tjänstemän, styrelseledamöter eller betydande investerare i ett företag. I allmänhet är det i allmänhet olagligt för insiders att göra affärer i sina företag baserat på väsentlig, icke-offentlig information. Detta betyder inte att det är olagligt för dem att göra några affärer i sina egna företag. De måste dock rapportera alla affärer till SEC via ett formulär 4.
Insiderlista och lönsamhetsstatistik
Den här tabellen visar listan över kända insiders och genereras automatiskt från anmälningar som avslöjas till SEC. Förutom namnen, den senaste titeln och direktören, tjänstemannen eller ägarbeteckningen på 10 %, tillhandahåller vi de senaste avslöjade innehaven. Dessutom, när det är möjligt tillhandahåller vi insiderns historiska handelsresultat. Det historiska handelsresultatet är ett vägt genomsnitt av resultatet för faktiska köptransaktioner på den öppna marknaden som insidern gjort. För mer information om hur detta beräknas, titta på detta YouTube-webinarium.
See our leaderboard of most profitable insider traders.
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
| LLP Abingworth - | 2 144 517 | 2 144 517 | |
| Luke M Beshar Director - [D] | 198 000 | 198 000 | |
| Garen G Bohlin Director - [D] | 53 312 | 53 312 | |
| Jathin Bandari Chief Medical Officer - [O] | 56 704 | 56 704 | |
|
Hubert Birner
Director, 10% Owner -
[D]
|
12 700 | ||
| Scott Braunstein Director - [D] | 26 500 | 26 500 | |
| Steven Keith Burke SVP and Chief Medical Officer - [O] | 26 332 | 26 332 | |
| William Conkling Chief Commercial Officer - [O] | 50 000 | 50 000 | |
| Scott A Canute | 12 700 | ||
| Julio Casoy Chief Medical Officer - [O] | 45 500 | 45 500 | |
|
Management Co Deerfield
10% Owner -
|
12 700 | 0 | |
| Deerfield Partners, L.p. Director - [D] | 0 | 0 | |
| Blaine Davis Chief Financial Officer - [O] | 20 662 | 20 662 | |
| Deerfield International Master Fund, L.P. Director - [D] | 0 | 0 | |
|
Deerfield Mgmt III, L.P.
10% Owner -
|
1 311 766 | 1 311 766 | |
| Deerfield Mgmt IV, L.P. Director - [D] | 1 311 766 | 1 311 766 | |
|
Deerfield Mgmt L.P.
10% Owner -
|
0 | 0 | |
|
Deerfield Private Design Fund III, L.P.
10% Owner -
|
1 311 766 | 1 311 766 | |
| Deerfield Private Design Fund IV, L.P. Director - [D] | 1 311 766 | 1 311 766 | |
|
Deerfield Special Situations Fund, L.P.
10% Owner -
|
1 311 766 | 1 311 766 |
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
|
Deerfield Special Situations International Master Fund, L.P.
10% Owner -
|
170 371 | 170 371 | |
| George Arthur Eldridge, Sr VP, CFO, Treasr, Asst Secy - [O] | 29 132 | 29 132 | |
| Patrick Fabbio Chief Financial Officer - [O] | 45 500 | 45 500 | |
|
Stefan Fischer
10% Owner -
|
500 | 1 943 059 | |
| Barry P Flannelly | 26 250 | ||
| James E Flynn Director - [D] | 0 | 0 | |
|
John Gordon Freund
10% Owner -
|
2 175 882 | 2 175 882 | |
| Hannah Fry VP, Controller - [O] | 38 942 | 38 942 | |
| Roger Garceau Director - [D] | 33 000 | 33 000 | |
|
Alexandra Goll
10% Owner -
|
1 943 059 | 1 943 059 | |
| Daniel Philip Gottlieb VP Corporate Development - [O] | 244 | 244 | |
| Paul J Hastings Director - [D] | 13 272 | 13 272 | |
| Timothy Haines - | 2 144 517 | 2 144 517 | |
| Bradley J Hartman | 70 000 | ||
|
Yasunori Kaneko
10% Owner -
|
1 432 930 | 1 432 930 | |
| Stuart A Kingsley | 12 700 | ||
|
Dmitry Kobyzev
Director, 10% Owner -
[D]
|
1 165 344 | 1 165 344 | |
| Matthew Paul Kowalsky VP, Legal and Secretary - [O] | 29 479 | 29 479 | |
| Jonathan S Leff Director - [D] | 0 | 0 | |
| Richard S Levy Director - [D] | 51 000 | 51 000 |
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
| Randall Marshall - | 585 600 | 585 600 | |
| Timothy P Noyes President and CEO, Director - [D] [O] | 0 | 0 | |
| Leonardo Viana Nicacio Chief Medical Officer - [O] | 52 181 | 52 181 | |
| Brendan O'Leary Director - [D] | 1 387 198 | 1 387 198 | |
| Martin Sebastian Olivo Chief Medical Officer - [O] | 14 344 | 14 344 | |
|
Opaleye Management Inc.
10% Owner -
|
45 000 | 45 000 | |
|
Opaleye, L.P.
10% Owner -
|
9 206 | 9 206 | |
| Gregory D Phelps | 6 666 | ||
|
Pharmstandard International S.A.
10% Owner -
|
1 165 344 | 1 165 344 | |
|
Joint Stock Co Pharmstandard Public
10% Owner -
|
1 165 344 | 1 165 344 | |
| Gregory Sargen Director - [D] | 31 000 | 31 000 | |
|
Helmut Schuhsler
10% Owner -
|
500 | 1 943 059 | |
| Jesse Shefferman CEO and President, Director - [D] [O] | 659 886 | 659 886 | |
|
Skyline Venture Management IV, LLC
10% Owner -
|
1 432 930 | 1 432 930 | |
|
Skyline Venture Partners Qualified Purchaser Fund IV L P
10% Owner -
|
1 432 930 | 1 432 930 | |
| Michael Edward Solomon Director - [D] | 26 500 | 26 500 | |
|
TVM Life Science Ventures VI GmbH & Co KG
10% Owner -
|
1 943 059 | 1 943 059 | |
|
TVM Life Science Ventures VI LP
10% Owner -
|
500 | 1 943 059 | |
| Toner E. Scott Senior VP of Commercial - [O] | 23 357 | 23 357 | |
| Jacqueline Zummo Chf Scientific Operations Off - [O] | 98 861 | 98 861 |
Report errors via our new Insider Auditing Tool
Track Records av insiderköp - Kortsiktig vinstanalys
I denna sektion analyserar vi lönsamheten för varje oplanerat, öppet-marknads insiderköp gjorda i TARA / Protara Therapeutics, Inc.. Denna analys hjälper till att förstå om insidern konsekvent genererar onormala avkastningar och är värd att följa. Denna analys är för ett år efter varje handel, och resultaten är teoretiska .
Tabellen nedan visar de senaste köpen på öppna marknaden som inte var en del av en automatisk handelsplan.
Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.
Track Records av insiderförsäljning - Kortsiktig förlustanalys
I denna sektion analyserar vi lönsamheten för varje oplanerat, öppet-marknads insiderköp gjorda i TARA / Protara Therapeutics, Inc.. Denna analys hjälper till att förstå om insidern konsekvent genererar onormala avkastningar och är värd att följa. Denna analys är för ett år efter varje handel, och resultaten är teoretiska .
Tabellen nedan visar de senaste försäljningarna på öppna marknaden som inte var en del av en automatisk handelsplan.
Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.
Transaktionshistorik
Klicka på länkikonen för att se hela transaktionshistoriken. Transaktioner som rapporteras som en del av en automatisk handelsplan 10b5-1 kommer att ha ett X i kolumnen markerad 10b-5.
| Fil datum |
Handel datum |
Schema | Insider | Ticker | Värdepappertitel | Kod | Direkta | Utövningspris | Enhet pris |
Enheter ändrad |
Värde ändrad (1K) |
Kvarvarande Optioner |
Kvarvarande Aktier |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-07-07 | 2025-06-24 | 4 | Shefferman Jesse | TARA | Common Stock | D | −300 000 | 659 886 | ||||||
| 2025-06-30 | 2025-06-27 | 4 | Shefferman Jesse | TARA | Common Stock | D | −3 367 | 959 886 | ||||||
| 2025-06-30 | 2025-06-27 | 4 | Shefferman Jesse | TARA | Common Stock | D | −10 200 | 963 253 | ||||||
| 2025-06-30 | 2025-06-26 | 4 | Shefferman Jesse | TARA | Common Stock | D | −3 400 | 973 453 | ||||||
| 2025-06-30 | 2025-06-26 | 4 | Shefferman Jesse | TARA | Common Stock | D | −1 700 | 976 853 | ||||||
| 2025-06-04 | 2025-06-02 | 4 | CONKLING WILLIAM | TARA | Common Stock | D | 50 000 | 50 000 | ||||||
| 2025-05-19 | 2025-05-14 | 4/A | Levy Richard S | TARA | Common Stock | D | 3,1900 | 20 000 | 64 | 51 000 | ||||
| 2025-05-16 | 2025-05-14 | 4 | Levy Richard S | TARA | Common Stock | D | 3,1900 | 20 000 | 64 | 51 000 | ||||
| 2025-04-17 | 2025-04-15 | 4 | Nicacio Leonardo Viana | TARA | Common Stock | D | 50 000 | 52 181 | ||||||
| 2025-04-17 | 3 | Nicacio Leonardo Viana | TARA | Common Stock | D | 2 181 | ||||||||
| 2025-03-28 | 2025-03-26 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 4,5300 | −21 224 | −96 | 98 861 | ||||
| 2025-01-28 | 2025-01-24 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 24 500 | 126 639 | ||||||
| 2025-01-28 | 2025-01-24 | 4 | Shefferman Jesse | TARA | Common Stock | D | 65 000 | 994 022 | ||||||
| 2025-01-28 | 2025-01-24 | 4 | Fabbio Patrick | TARA | Common Stock | D | 23 500 | 45 500 | ||||||
| 2025-01-28 | 2025-01-24 | 4 | Fry Hannah | TARA | Common Stock | D | 9 500 | 38 942 | ||||||
| 2025-01-23 | 2025-01-21 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 4,7600 | −6 554 | −31 | 95 585 | ||||
| 2025-01-23 | 2025-01-21 | 4 | Fry Hannah | TARA | Common Stock | D | 4,7600 | −2 130 | −10 | 27 312 | ||||
| 2025-01-23 | 2025-01-21 | 4 | Fabbio Patrick | TARA | Common Stock | D | 4,7600 | −3 061 | −15 | 18 939 | ||||
| 2025-01-23 | 2025-01-21 | 4 | Shefferman Jesse | TARA | Common Stock | D | 4,7600 | −15 469 | −74 | 913 553 | ||||
| 2025-01-07 | 2025-01-03 | 4 | Fry Hannah | TARA | Common Stock | D | 6,1400 | −394 | −2 | 29 442 | ||||
| 2025-01-07 | 2025-01-03 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 6,1400 | −2 157 | −13 | 102 139 | ||||
| 2025-01-07 | 2025-01-03 | 4 | Shefferman Jesse | TARA | Common Stock | D | 6,1400 | −6 479 | −40 | 929 022 | ||||
| 2024-09-12 | 2024-09-12 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 1,7089 | −6 500 | −11 | 45 000 | ||||
| 2024-09-12 | 2024-09-12 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 1,7089 | −119 801 | −205 | 1 944 134 | ||||
| 2024-09-12 | 2024-09-11 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 1,7141 | −1 600 | −3 | 51 500 | ||||
| 2024-09-12 | 2024-09-11 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 1,7141 | −31 000 | −53 | 2 063 935 | ||||
| 2024-09-10 | 2024-09-10 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 1,7690 | −1 500 | −3 | 53 100 | ||||
| 2024-09-10 | 2024-09-10 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 1,7690 | −24 000 | −42 | 2 094 935 | ||||
| 2024-09-10 | 2024-09-09 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 1,8947 | −1 900 | −4 | 54 600 | ||||
| 2024-09-10 | 2024-09-09 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 1,8947 | −34 592 | −66 | 2 118 935 | ||||
| 2024-08-30 | 2024-08-28 | 4 | Shefferman Jesse | TARA | Common Stock | D | −3 300 | 935 501 | ||||||
| 2024-08-30 | 2024-08-28 | 4 | Shefferman Jesse | TARA | Common Stock | D | −5 263 | 938 801 | ||||||
| 2024-07-18 | 2024-07-16 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,4419 | −3 500 | −9 | 56 500 | ||||
| 2024-07-18 | 2024-07-16 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,4419 | −7 896 | −19 | 2 153 527 | ||||
| 2024-07-11 | 2024-07-11 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,4034 | −15 000 | −36 | 60 000 | ||||
| 2024-07-11 | 2024-07-11 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,4034 | −32 993 | −79 | 2 161 423 | ||||
| 2024-07-11 | 2024-07-10 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,3080 | −5 000 | −12 | 75 000 | ||||
| 2024-07-11 | 2024-07-10 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,3080 | −13 061 | −30 | 2 194 416 | ||||
| 2024-07-11 | 2024-07-09 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,2138 | −2 500 | −6 | 80 000 | ||||
| 2024-07-11 | 2024-07-09 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,2138 | −5 997 | −13 | 2 207 477 | ||||
| 2024-07-03 | 2024-07-01 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,1233 | −2 500 | −5 | 87 500 | ||||
| 2024-07-03 | 2024-07-01 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,1233 | −5 788 | −12 | 2 213 474 | ||||
| 2024-06-28 | 2024-06-28 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,0748 | −5 000 | −10 | 85 000 | ||||
| 2024-06-28 | 2024-06-28 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,0748 | −12 994 | −27 | 2 219 262 | ||||
| 2024-06-28 | 2024-06-27 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,2581 | −12 471 | −28 | 90 000 | ||||
| 2024-06-28 | 2024-06-27 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,2581 | −34 103 | −77 | 2 232 256 | ||||
| 2024-06-27 | 2024-06-25 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,2581 | −6 225 | −14 | 102 471 | ||||
| 2024-06-27 | 2024-06-25 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,2581 | −6 500 | −15 | 2 266 359 | ||||
| 2024-05-31 | 2024-05-31 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,9009 | −5 824 | −17 | 108 696 | ||||
| 2024-05-31 | 2024-05-30 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,9375 | −9 230 | −27 | 114 520 | ||||
| 2024-05-23 | 2024-05-22 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,0021 | −500 | −2 | 123 750 | ||||
| 2024-05-23 | 2024-05-22 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,0210 | −9 300 | −28 | 2 272 859 | ||||
| 2024-05-23 | 2024-05-21 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,0557 | −1 800 | −6 | 124 250 | ||||
| 2024-05-23 | 2024-05-21 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,0557 | −31 200 | −95 | 2 282 159 | ||||
| 2024-05-17 | 2024-05-17 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,0606 | −1 200 | −4 | 126 050 | ||||
| 2024-05-17 | 2024-05-17 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,3281 | −2 750 | −9 | 127 250 | ||||
| 2024-05-17 | 2024-05-17 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,0606 | −19 685 | −60 | 2 313 359 | ||||
| 2024-05-17 | 2024-05-17 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,3281 | −47 250 | −157 | 2 333 044 | ||||
| 2024-05-10 | 2024-05-10 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,1142 | −151 700 | −472 | 2 380 294 | ||||
| 2024-05-10 | 2024-05-09 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,0891 | −30 600 | −95 | 2 531 994 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Fry Hannah | TARA | Common Stock | D | 1,9100 | −904 | −2 | 29 836 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Fry Hannah | TARA | Common Stock | D | 8 000 | 30 740 | ||||||
| 2024-01-23 | 2024-01-19 | 4 | Fabbio Patrick | TARA | Common Stock | D | 22 000 | 22 000 | ||||||
| 2024-01-23 | 2024-01-19 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 1,9100 | −3 049 | −6 | 104 296 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 23 000 | 107 345 | ||||||
| 2024-01-23 | 2024-01-19 | 4 | Bandari Jathin | TARA | Common Stock | D | 1,9100 | −2 879 | −5 | 56 704 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Bandari Jathin | TARA | Common Stock | D | 23 000 | 59 583 | ||||||
| 2024-01-23 | 2024-01-19 | 4 | Shefferman Jesse | TARA | Common Stock | D | 1,9100 | −7 803 | −15 | 944 064 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Shefferman Jesse | TARA | Common Stock | D | 59 000 | 951 867 | ||||||
| 2024-01-12 | 2024-01-10 | 4 | Bandari Jathin | TARA | Common Stock | D | 2,3900 | −1 877 | −4 | 36 583 | ||||
| 2024-01-12 | 2024-01-10 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 2,3900 | −5 229 | −12 | 84 345 | ||||
| 2024-01-12 | 2024-01-10 | 4 | Shefferman Jesse | TARA | Common Stock | D | 2,3900 | −5 746 | −14 | 892 867 | ||||
| 2024-01-05 | 2024-01-03 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 2,1700 | −1 899 | −4 | 89 574 | ||||
| 2024-01-05 | 2024-01-03 | 4 | Shefferman Jesse | TARA | Common Stock | D | 2,1700 | −5 840 | −13 | 898 613 | ||||
| 2024-01-05 | 2024-01-03 | 4 | Fry Hannah | TARA | Common Stock | D | 2,1700 | −324 | −1 | 22 740 | ||||
| 2023-07-18 | 2023-07-17 | 4 | Fry Hannah | TARA | Common Stock | D | 2,5600 | −10 075 | −26 | 23 064 | ||||
| 2023-07-05 | 2023-07-03 | 4 | Bandari Jathin | TARA | Common Stock | D | 2,4600 | −682 | −2 | 38 460 | ||||
| 2023-06-27 | 2023-06-27 | 4 | Shefferman Jesse | TARA | Common Stock | D | −7 420 | 904 453 | ||||||
| 2023-06-27 | 2023-06-23 | 4 | Shefferman Jesse | TARA | Common Stock | D | −1 890 | 911 873 | ||||||
| 2023-02-10 | 2022-06-27 | 5 | Shefferman Jesse | TARA | Common Stock | D | −4 519 | 913 763 | ||||||
| 2023-01-20 | 2023-01-19 | 4 | Bandari Jathin | TARA | Common Stock | D | 20 700 | 39 142 | ||||||
| 2023-01-20 | 2023-01-19 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 19 900 | 91 473 | ||||||
| 2023-01-20 | 2023-01-19 | 4 | Fry Hannah | TARA | Common Stock | D | 5 900 | 33 139 | ||||||
| 2023-01-20 | 2023-01-19 | 4 | Shefferman Jesse | TARA | Common Stock | D | 51 300 | 918 282 | ||||||
| 2023-01-11 | 2023-01-10 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 3,0000 | −5 225 | −16 | 71 573 | ||||
| 2023-01-11 | 2023-01-10 | 4 | Bandari Jathin | TARA | Common Stock | D | 3,0000 | −1 876 | −6 | 18 442 | ||||
| 2023-01-11 | 2023-01-10 | 4 | Shefferman Jesse | TARA | Common Stock | D | 3,0000 | −5 855 | −18 | 866 982 | ||||
| 2023-01-04 | 2023-01-03 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 2,8000 | −2 159 | −6 | 76 798 | ||||
| 2023-01-04 | 2023-01-03 | 4 | Shefferman Jesse | TARA | Common Stock | D | 2,8000 | −6 604 | −18 | 872 837 | ||||
| 2023-01-04 | 2023-01-03 | 4 | Fry Hannah | TARA | Common Stock | D | 2,8000 | −361 | −1 | 27 239 | ||||
| 2022-12-30 | 2022-12-30 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 2,7111 | 2 300 | 6 | 130 000 | ||||
| 2022-12-30 | 2022-12-30 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,7111 | 13 173 | 36 | 2 562 594 | ||||
| 2022-09-15 | 2022-09-15 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 3,8000 | 2 300 | 9 | 132 300 | ||||
| 2022-09-15 | 2022-09-15 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,8000 | 5 000 | 19 | 2 575 777 | ||||
| 2022-09-15 | 2022-09-14 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 3,9800 | 2 500 | 10 | 130 000 | ||||
| 2022-09-15 | 2022-09-14 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,9800 | 14 100 | 56 | 2 570 777 | ||||
| 2022-08-15 | 2022-08-11 | 4 | Shefferman Jesse | TARA | Common Stock | D | 3,8400 | 9 065 | 35 | 879 441 | ||||
| 2022-07-19 | 2022-07-15 | 4 | Davis Blaine | TARA | Common Stock | D | 3,1300 | −5 081 | −16 | 20 662 | ||||
| 2022-07-19 | 2022-07-16 | 4 | Fry Hannah | TARA | Common Stock | D | 25 000 | 27 600 | ||||||
| 2022-07-19 | 3 | Fry Hannah | TARA | Common Stock | D | 2 600 | ||||||||
| 2022-07-05 | 2022-06-30 | 4 | BESHAR LUKE M | TARA | Common Stock | D | 3,1000 | 10 000 | 31 | 198 000 | ||||
| 2022-07-05 | 2022-07-01 | 4 | Bandari Jathin | TARA | Common Stock | D | 3,2200 | −682 | −2 | 20 318 | ||||
| 2022-04-15 | 2022-04-08 | 4/A | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,7958 | 2 469 | 12 | 127 500 | ||||
| 2022-04-15 | 2022-04-08 | 4/A | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,7958 | 5 322 | 26 | 2 556 667 | ||||
| 2022-04-15 | 2022-04-07 | 4/A | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,7432 | 1 000 | 5 | 125 031 | ||||
| 2022-04-15 | 2022-04-07 | 4/A | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,7432 | 1 345 | 6 | 2 551 345 | ||||
| 2022-04-08 | 2022-04-08 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,7958 | 2 469 | 12 | 128 | ||||
| 2022-04-08 | 2022-04-08 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,7958 | 5 322 | 26 | 2 556 667 | ||||
| 2022-04-08 | 2022-04-07 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,7432 | 1 000 | 5 | 125 031 | ||||
| 2022-04-08 | 2022-04-07 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,7432 | 1 345 | 6 | 2 551 345 | ||||
| 2022-03-16 | 2022-03-14 | 4 | BESHAR LUKE M | TARA | Common Stock | D | 4,2500 | 10 000 | 42 | 188 000 | ||||
| 2022-03-14 | 2022-03-10 | 4 | BESHAR LUKE M | TARA | Common Stock | D | 4,4555 | 10 000 | 45 | 178 000 | ||||
| 2022-02-11 | 2021-06-29 | 5 | Shefferman Jesse | TARA | Common Stock | D | −513 | 870 376 | ||||||
| 2022-02-11 | 2021-06-29 | 5 | Shefferman Jesse | TARA | Common Stock | D | −1 536 | 870 889 | ||||||
| 2022-01-31 | 2022-01-28 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,9632 | 4 031 | 20 | 124 031 | ||||
| 2022-01-31 | 2022-01-28 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,9632 | 20 000 | 99 | 2 550 000 | ||||
| 2022-01-12 | 2022-01-10 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 6,2700 | −4 603 | −29 | 78 957 | ||||
| 2022-01-12 | 2022-01-10 | 4 | Shefferman Jesse | TARA | Common Stock | D | 6,2700 | −5 080 | −32 | 872 425 | ||||
| 2022-01-12 | 2022-01-10 | 4 | Bandari Jathin | TARA | Stock Option (Right to Buy) | D | 6,27 | 81 000 | 81 000 | |||||
| 2022-01-12 | 2022-01-10 | 4 | Bandari Jathin | TARA | Common Stock | D | 13 500 | 13 500 | ||||||
| 2022-01-12 | 3 | Bandari Jathin | TARA | Common Stock | D | 7 500 | ||||||||
| 2022-01-05 | 2022-01-03 | 4 | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 6,90 | 253 500 | 253 500 | |||||
| 2022-01-05 | 2022-01-03 | 4 | Shefferman Jesse | TARA | Common Stock | D | 42 300 | 877 505 | ||||||
| 2022-01-05 | 2022-01-03 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 6,90 | 84 800 | 84 800 | |||||
| 2022-01-05 | 2022-01-03 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 14 100 | 83 560 | ||||||
| 2022-01-05 | 2022-01-03 | 4 | Davis Blaine | TARA | Stock Option (Right to Buy) | D | 6,90 | 84 800 | 84 800 | |||||
| 2022-01-05 | 2022-01-03 | 4 | Davis Blaine | TARA | Common Stock | D | 14 100 | 15 581 | ||||||
| 2021-12-29 | 2021-12-29 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,9795 | 4 500 | 31 | 120 000 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,3588 | 5 500 | 35 | 115 500 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,3588 | 1 591 | 10 | 2 530 000 | ||||
| 2021-12-27 | 2021-12-27 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,5317 | 5 000 | 33 | 110 000 | ||||
| 2021-12-27 | 2021-12-27 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,5317 | 31 700 | 207 | 2 528 409 | ||||
| 2021-12-27 | 2021-12-23 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,6000 | 800 | 5 | 105 000 | ||||
| 2021-12-27 | 2021-12-23 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,6000 | 500 | 3 | 2 496 709 | ||||
| 2021-12-22 | 2021-12-20 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,4900 | 703 | 5 | 2 496 209 | ||||
| 2021-12-20 | 2021-12-17 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,6000 | 490 | 3 | 104 200 | ||||
| 2021-12-20 | 2021-12-17 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,6000 | 2 300 | 15 | 2 495 506 | ||||
| 2021-12-20 | 2021-12-16 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,4108 | 1 063 | 7 | 103 710 | ||||
| 2021-12-20 | 2021-12-16 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,4108 | 6 500 | 42 | 2 493 206 | ||||
| 2021-11-19 | 2021-11-18 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,9795 | 1 000 | 7 | 102 647 | ||||
| 2021-11-19 | 2021-11-18 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,9795 | 14 206 | 99 | 2 486 706 | ||||
| 2021-11-19 | 2021-11-17 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,9800 | 1 090 | 8 | 101 647 | ||||
| 2021-11-19 | 2021-11-17 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,9800 | 8 028 | 56 | 2 472 500 | ||||
| 2021-11-08 | 2021-11-04 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,5000 | 557 | 4 | 100 557 | ||||
| 2021-11-08 | 2021-11-04 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,5000 | 6 000 | 39 | 2 464 472 | ||||
| 2021-06-14 | 2021-06-10 | 4 | Olivo Martin Sebastian | TARA | Common Stock | D | 10,1300 | 4 934 | 50 | 14 344 | ||||
| 2021-06-14 | 2021-06-10 | 4 | Olivo Martin Sebastian | TARA | Common Stock | D | 10,0800 | 4 959 | 50 | 9 410 | ||||
| 2021-06-10 | 2021-06-09 | 4 | Huang Jane | TARA | Stock Option (Right to Buy) | D | 10,51 | 10 000 | 10 000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Huang Jane | TARA | Stock Option (Right to Buy) | D | 10,51 | 20 000 | 20 000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Flannelly Barry P | TARA | Stock Option (Right to Buy) | D | 10,51 | 10 000 | 10 000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Smith Cynthia | TARA | Stock Option (Right to Buy) | D | 10,51 | 10 000 | 10 000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Levy Richard S | TARA | Stock Option (Right to Buy) | D | 10,51 | 10 000 | 10 000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 10,51 | 10 000 | 10 000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | SARGEN GREGORY | TARA | Stock Option (Right to Buy) | D | 10,51 | 10 000 | 10 000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 10,51 | 10 000 | 10 000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 10,51 | 10 000 | 10 000 | |||||
| 2021-04-20 | 2021-04-19 | 4 | Olivo Martin Sebastian | TARA | Stock Option (Right to Buy) | D | 15,30 | 120 000 | 120 000 | |||||
| 2021-04-20 | 3 | Olivo Martin Sebastian | TARA | Common Stock | D | 4 451 | ||||||||
| 2021-02-01 | 2021-01-29 | 4 | Smith Cynthia | TARA | Stock Option (Right to Buy) | D | 17,98 | 3 750 | 21 750 | |||||
| 2021-02-01 | 2021-01-29 | 4 | Smith Cynthia | TARA | Stock Option (Right to Buy) | D | 17,98 | 18 000 | 18 000 | |||||
| 2021-01-21 | 2021-01-19 | 4 | Davis Blaine | TARA | Stock Option (Right to Buy) | D | 19,82 | 75 000 | 75 000 | |||||
| 2021-01-21 | 2021-01-19 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 19,82 | 75 000 | 75 000 | |||||
| 2021-01-21 | 2021-01-19 | 4 | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 19,82 | 202 000 | 202 000 | |||||
| 2021-01-13 | 2021-01-11 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 21,1600 | −4 653 | −98 | 69 460 | ||||
| 2021-01-13 | 2021-01-11 | 4 | Shefferman Jesse | TARA | Common Stock | D | 21,1600 | −5 069 | −107 | 835 205 | ||||
| 2020-10-02 | 2020-09-30 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 16,0000 | 50 000 | 800 | 2 458 472 | ||||
| 2020-09-25 | 2020-09-24 | 4 | Opaleye Management Inc. By Opaleye, L.P. | "TARA" | Common Stock, par value $0.001 per share | I | 16,8700 | 200 000 | 3 374 | 2 408 472 | ||||
| 2020-09-25 | 2020-09-24 | 4 | Opaleye Management Inc. By Managed Account | "TARA" | Common Stock, par value $0.001 per share | I | 16,8700 | 100 000 | 1 687 | 100 000 | ||||
| 2020-09-23 | 2020-09-22 | 4 | Davis Blaine | TARA | Common Stock | D | 16,9060 | 1 481 | 25 | 1 481 | ||||
| 2020-09-15 | 2020-09-14 | 4 | Marshall Randall | TARA | Common Stock | D | 20,0000 | −474 | −9 | 585 600 | ||||
| 2020-09-15 | 2020-09-14 | 4 | Marshall Randall | TARA | Common Stock | D | 19,2600 | −2 080 | −40 | 586 074 | ||||
| 2020-09-14 | 2020-09-10 | 4 | Marshall Randall | TARA | Common Stock | D | 18,0000 | −239 | −4 | 588 154 | ||||
| 2020-09-10 | 2020-09-09 | 4 | Marshall Randall | TARA | Common Stock | D | 19,2700 | −4 913 | −95 | 588 393 | ||||
| 2020-09-10 | 2020-09-09 | 4 | Marshall Randall | TARA | Common Stock | D | 18,1000 | −5 309 | −96 | 593 306 | ||||
| 2020-09-10 | 2020-09-08 | 4 | Marshall Randall | TARA | Common Stock | D | 18,9400 | −3 108 | −59 | 598 615 | ||||
| 2020-09-04 | 2020-09-03 | 4 | Marshall Randall | TARA | Common Stock | D | 20,1900 | −52 | −1 | 601 723 | ||||
| 2020-09-04 | 2020-09-02 | 4 | Marshall Randall | TARA | Common Stock | D | 20,6800 | −207 | −4 | 601 775 | ||||
| 2020-09-01 | 2020-08-28 | 4 | Marshall Randall | TARA | Common Stock | D | 22,0900 | −771 | −17 | 601 982 | ||||
| 2020-08-28 | 2020-08-27 | 4 | Marshall Randall | TARA | Common Stock | D | 22,3700 | −616 | −14 | 602 753 | ||||
| 2020-08-28 | 2020-08-26 | 4 | Marshall Randall | TARA | Common Stock | D | 22,4000 | −1 418 | −32 | 603 369 | ||||
| 2020-08-26 | 2020-08-25 | 4 | Marshall Randall | TARA | Common Stock | D | 22,7300 | −2 461 | −56 | 604 787 | ||||
| 2020-08-26 | 2020-08-24 | 4 | Marshall Randall | TARA | Common Stock | D | 23,1600 | −974 | −23 | 607 248 | ||||
| 2020-08-24 | 2020-08-20 | 4 | Marshall Randall | TARA | Common Stock | D | 24,1830 | −510 | −12 | 608 222 | ||||
| 2020-08-20 | 2020-08-18 | 4 | Marshall Randall | TARA | Common Stock | D | 25,1900 | −200 | −5 | 608 732 | ||||
| 2020-08-18 | 2020-08-17 | 4 | Marshall Randall | TARA | Common Stock | D | 25,1100 | −1 548 | −39 | 608 932 | ||||
| 2020-08-18 | 2020-08-14 | 4 | Marshall Randall | TARA | Common Stock | D | 25,0900 | −700 | −18 | 610 480 | ||||
| 2020-07-31 | 2020-07-30 | 4 | Marshall Randall | TARA | Common Stock | D | 26,1400 | −1 317 | −34 | 611 180 | ||||
| 2020-07-31 | 2020-07-29 | 4 | Marshall Randall | TARA | Common Stock | D | 28,4500 | −100 | −3 | 612 497 | ||||
| 2020-07-31 | 2020-07-29 | 4 | Marshall Randall | TARA | Common Stock | D | 27,2800 | −600 | −16 | 612 597 | ||||
| 2020-07-31 | 2020-07-29 | 4 | Marshall Randall | TARA | Common Stock | D | 26,0300 | −1 816 | −47 | 613 197 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 35,4500 | −600 | −21 | 615 013 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 33,7900 | −1 650 | −56 | 615 613 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 33,0900 | −1 200 | −40 | 617 263 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 31,5300 | −3 493 | −110 | 618 463 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 30,4200 | −14 243 | −433 | 621 956 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 28,6300 | −1 811 | −52 | 636 199 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 26,8500 | −2 600 | −70 | 638 010 | ||||
| 2020-07-29 | 2020-07-27 | 4 | Marshall Randall | TARA | Common Stock | D | 26,0800 | −338 | −9 | 640 610 | ||||
| 2020-07-27 | 2020-07-23 | 4 | Flannelly Barry P | TARA | Stock Option (Right to Buy) | D | 26,70 | 8 250 | 26 250 | |||||
| 2020-07-27 | 2020-07-23 | 4 | Flannelly Barry P | TARA | Stock Option (Right to Buy) | D | 26,70 | 18 000 | 18 000 | |||||
| 2020-07-27 | 2020-07-24 | 4 | Marshall Randall | TARA | Common Stock | D | 26,0000 | −300 | −8 | 640 948 | ||||
| 2020-07-27 | 2020-07-23 | 4 | Marshall Randall | TARA | Common Stock | D | 27,2900 | −93 | −3 | 641 248 | ||||
| 2020-07-27 | 2020-07-23 | 4 | Marshall Randall | TARA | Common Stock | D | 26,5800 | −1 950 | −52 | 641 341 | ||||
| 2020-07-23 | 2020-07-22 | 4 | Marshall Randall | TARA | Common Stock | D | 27,4450 | −75 | −2 | 643 291 | ||||
| 2020-07-23 | 2020-07-22 | 4 | Marshall Randall | TARA | Common Stock | D | 26,6900 | −1 297 | −35 | 643 366 | ||||
| 2020-07-23 | 2020-07-21 | 4 | Marshall Randall | TARA | Common Stock | D | 26,5600 | −223 | −6 | 644 663 | ||||
| 2020-07-21 | 2020-07-20 | 4 | Marshall Randall | TARA | Common Stock | D | 27,6800 | −472 | −13 | 644 886 | ||||
| 2020-07-21 | 2020-07-20 | 4 | Marshall Randall | TARA | Common Stock | D | 26,7000 | −2 257 | −60 | 645 358 | ||||
| 2020-07-21 | 2020-07-17 | 4 | Marshall Randall | TARA | Common Stock | D | 26,6600 | −1 601 | −43 | 647 615 | ||||
| 2020-07-14 | 2020-07-13 | 4 | Marshall Randall | TARA | Common Stock | D | 27,1300 | −2 145 | −58 | 649 216 | ||||
| 2020-07-14 | 2020-07-10 | 4 | Marshall Randall | TARA | Common Stock | D | 27,4100 | −2 659 | −73 | 651 361 | ||||
| 2020-07-13 | 2020-07-10 | 4 | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 27,42 | 111 250 | 111 250 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 6 676 | 6 676 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 12 399 | 12 399 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 15 641 | 15 641 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 16 214 | 16 214 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 2 861 | 2 861 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 9,18 | 12 399 | 12 399 | |||||
| 2020-06-11 | 2020-01-10 | 4/A | Solomon Michael Edward | TARA | Common Stock | D | 26 500 | 26 500 | ||||||
| 2020-06-11 | 2020-01-09 | 4/A | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 6 676 | 6 676 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 2 861 | 2 861 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 35,00 | 9 000 | 9 000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | SARGEN GREGORY | TARA | Stock Option (Right to Buy) | D | 35,00 | 9 000 | 9 000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Levy Richard S | TARA | Stock Option (Right to Buy) | D | 35,00 | 9 000 | 9 000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 35,00 | 9 000 | 9 000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 35,00 | 9 000 | 9 000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 35,00 | 9 000 | 9 000 | |||||
| 2020-02-18 | 2020-01-10 | 4/A | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 30,00 | 111 250 | 111 250 | |||||
| 2020-02-11 | 2020-02-11 | 4 | Davis Blaine | TARA | Stock Option (Right to Buy) | D | 37,30 | 94 000 | 94 000 | |||||
| 2020-01-13 | 2020-01-10 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 45 500 | 74 113 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 9,18 | 9 537 | 9 537 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 9,18 | 9 537 | 9 537 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 9,18 | 19 075 | 19 075 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 28 613 | 28 613 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | Levy Richard S | TARA | Common Stock | D | 31 000 | 31 000 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | Solomon Michael Edward | TARA | Common Stock | D | 26 500 | 26 500 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 10 491 | 10 491 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 6 676 | 6 676 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 2 861 | 2 861 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 9 537 | 9 537 | |||||
| 2020-01-13 | 2020-01-10 | 4 | GARCEAU ROGER | TARA | Common Stock | D | 33 000 | 33 000 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 9,18 | 10 491 | 10 491 | |||||
| 2020-01-13 | 2020-01-09 | 4 | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 9,18 | 12 399 | 12 399 | |||||
| 2020-01-13 | 2020-01-10 | 4 | SARGEN GREGORY | TARA | Common Stock | D | 31 000 | 31 000 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | Braunstein Scott | TARA | Common Stock | D | 26 500 | 26 500 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 15 737 | 15 737 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 6 676 | 6 676 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 9 537 | 9 537 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 9 537 | 9 537 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 2 861 | 2 861 | |||||
| 2020-01-13 | 2020-01-10 | 4 | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 31,50 | 111 250 | 111 250 | |||||
| 2020-01-13 | 2020-01-10 | 4 | Shefferman Jesse | TARA | Common Stock | D | 50 000 | 840 274 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Shefferman Jesse | TARA | Common Stock | D | 790 274 | 790 274 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Marshall Randall | TARA | Common Stock | D | 654 020 | 654 020 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | Casoy Julio | TARA | Common Stock | D | 45 500 | 45 500 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Casoy Julio | TARA | Stock Option (Right to Buy) | D | 9,18 | 38 151 | 38 151 | |||||
| 2020-01-13 | 3 | Opaleye, L.P. | TARA | Common Stock | D | 9 206 | ||||||||
| 2020-01-13 | 3 | Opaleye, L.P. | TARA | Common Stock | D | 9 206 | ||||||||
| 2020-01-13 | 3 | Opaleye, L.P. | TARA | Common Stock | D | 9 206 | ||||||||
| 2020-01-13 | 2020-01-09 | 4 | Opaleye, L.P. | TARA | Common Stock | D | 7,0100 | 1 426 234 | 9 998 | 2 208 472 | ||||
| 2020-01-13 | 2020-01-09 | 4 | Opaleye, L.P. | TARA | Common Stock | D | 777 635 | 782 238 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | BESHAR LUKE M | TARA | Common Stock | D | 168 000 | 168 000 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 10 491 | 10 491 | |||||
| 2020-01-13 | 2020-01-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 6 676 | 6 676 | |||||
| 2020-01-13 | 2020-01-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 12 399 | 12 399 | |||||
| 2019-11-14 | 2019-11-12 | 4 | Abingworth LLP | PRTO | Series A Convertible Preferred Stock | I | 0,99 | −126 | 2 400 | |||||
| 2019-11-14 | 2019-11-12 | 4 | Abingworth LLP | PRTO | Common Stock, $0.001 par value | I | 0,9949 | 126 645 | 126 | 2 144 517 | ||||
| 2019-11-14 | 2019-11-12 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Series A Convertible Preferred Stock | I | 0,99 | −126 | 2 400 | |||||
| 2019-11-14 | 2019-11-12 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Common Stock, $0.001 par value | I | 0,9949 | 126 645 | 126 | 2 144 517 | ||||
| 2019-11-12 | 2019-11-08 | 4 | Freund John Gordon | PRTO | Series A Convertible Preferred Stock | I | 0,99 | −700 | 354 | |||||
| 2019-11-12 | 2019-11-08 | 4 | Freund John Gordon | PRTO | Common Stock | D | 0,9949 | 703 588 | 700 | 2 175 882 | ||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 7 333 | 26 332 | ||||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 7 333 | 26 332 | ||||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −7 333 | 101 917 | ||||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −7 333 | 101 917 | ||||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −7 334 | 116 584 | ||||||
| 2019-02-04 | 2019-01-31 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 2,70 | 350 000 | 350 000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 2,64 | 145 000 | 145 000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 2,64 | 145 000 | 145 000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Hartman Bradley J | PRTO | Stock Option (Right to Buy) | D | 2,64 | 70 000 | 70 000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Kowalsky Matthew Paul | PRTO | Stock Option (Right to Buy) | D | 2,64 | 60 000 | 60 000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 2,64 | 60 000 | 60 000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 2,64 | 60 000 | 60 000 | |||||
| 2019-01-03 | 2018-12-31 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,9300 | 2 448 | 5 | 123 917 | ||||
| 2019-01-03 | 2018-12-31 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 1,9300 | 2 448 | 5 | 29 132 | ||||
| 2019-01-03 | 2018-12-31 | 4 | Kowalsky Matthew Paul | PRTO | Common Stock | D | 1,9300 | 2 448 | 5 | 29 479 | ||||
| 2019-01-03 | 2018-12-31 | 4 | Toner E. Scott | PRTO | Common Stock | D | 1,9300 | 4 117 | 8 | 23 357 | ||||
| 2018-08-02 | 2018-08-01 | 4 | Hartman Bradley J | PRTO | Stock Option (Right to Buy) | D | 2,12 | 150 000 | 150 000 | |||||
| 2018-07-03 | 2018-06-29 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,6150 | −10 000 | −16 | 121 469 | ||||
| 2018-07-03 | 2018-06-29 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 1,6150 | 10 000 | 16 | 26 684 | ||||
| 2018-07-03 | 2018-06-29 | 4 | Kowalsky Matthew Paul | PRTO | Common Stock | D | 1,6150 | 10 000 | 16 | 27 031 | ||||
| 2018-07-03 | 2018-06-29 | 4 | Toner E. Scott | PRTO | Common Stock | D | 1,6150 | 4 856 | 8 | 19 240 | ||||
| 2018-06-12 | 2018-06-08 | 4 | Flynn James E Through Deerfield Management Company, L.P. | PRTO | Stock Option (Right to Buy) | I | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-12 | 2018-06-08 | 4 | LEFF JONATHAN S | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Abingworth LLP By affiliate | PRTO | Stock Option (Right to Buy) | I | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Birner Hubert | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | BOHLIN GAREN G | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Canute Scott A | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Freund John Gordon | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Haines Timothy | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | HASTINGS PAUL J | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12 700 | 12 700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Kingsley Stuart A | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12 700 | 12 700 | |||||
| 2018-02-20 | 2018-02-16 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,1100 | −2 997 | −6 | 0 | ||||
| 2018-02-16 | 2018-02-15 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,1520 | −2 245 | −5 | 2 997 | ||||
| 2018-02-16 | 2018-02-14 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,2000 | −3 500 | −8 | 5 242 | ||||
| 2018-02-09 | 2018-02-08 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 2,15 | 500 000 | 500 000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 2,85 | 200 000 | 200 000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 2,85 | 200 000 | 200 000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 2,85 | 110 000 | 110 000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Kowalsky Matthew Paul | PRTO | Stock Option (Right to Buy) | D | 2,85 | 110 000 | 110 000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 2,85 | 110 000 | 110 000 | |||||
| 2018-01-17 | 2018-01-16 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,3570 | −10 000 | −24 | 8 742 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,2960 | −3 934 | −5 | 111 469 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 1,2960 | 3 934 | 5 | 16 684 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Kowalsky Matthew Paul | PRTO | Common Stock | D | 1,2960 | 3 934 | 5 | 17 031 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Toner E. Scott | PRTO | Common Stock | D | 1,2960 | 5 531 | 7 | 14 384 | ||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 3 333 | 11 666 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 3 333 | 11 666 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −3 333 | 107 535 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −3 333 | 107 535 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −3 334 | 114 201 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,8800 | 12 000 | 23 | 117 535 | ||||
| 2017-12-15 | 2017-12-14 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,8540 | −10 000 | −19 | 18 742 | ||||
| 2017-12-04 | 2017-11-30 | 4 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1,7500 | −110 557 | −193 | 0 | ||||
| 2017-12-04 | 2017-11-30 | 4 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1,7500 | 110 557 | 193 | 197 424 | ||||
| 2017-11-16 | 2017-11-15 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,7020 | −5 650 | −10 | 28 742 | ||||
| 2017-11-16 | 2017-11-14 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,6870 | −4 350 | −7 | 34 392 | ||||
| 2017-11-14 | 2017-11-14 | 4 | BOHLIN GAREN G | PRTO | Common Stock | D | 1,8890 | 3 812 | 7 | 53 312 | ||||
| 2017-11-14 | 2017-11-13 | 4 | BOHLIN GAREN G | PRTO | Common Stock | D | 1,9180 | 25 700 | 49 | 49 500 | ||||
| 2017-11-14 | 2017-11-10 | 4 | BOHLIN GAREN G | PRTO | Common Stock | D | 1,9630 | 23 800 | 47 | 23 800 | ||||
| 2017-11-14 | 2017-11-14 | 4 | Eldridge, George Arthur As custodian for child's UTMA account | PRTO | Common Stock | I | 1,6900 | 295 | 0 | 1 545 | ||||
| 2017-10-17 | 2017-10-16 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,3120 | −10 000 | −23 | 38 742 | ||||
| 2017-09-18 | 2017-09-15 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,4790 | −5 146 | −8 | 48 742 | ||||
| 2017-09-18 | 2017-09-14 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,4540 | −4 854 | −7 | 53 888 | ||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1 335 456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2 102 698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1 374 575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1 311 766 | ||||||||
| 2017-08-04 | 3 | LEFF JONATHAN S | PRTO | Common Stock | D | 0 | ||||||||
| 2017-08-04 | 2017-08-02 | 4 | Flynn James E Through Deerfield Management Company, L.P. | PRTO | Stock Option (Right to Buy) | I | 1,30 | 13 333 | 13 333 | |||||
| 2017-08-04 | 2017-08-02 | 4 | LEFF JONATHAN S | PRTO | Stock Option (Right to Buy) | D | 1,30 | 13 333 | 13 333 | |||||
| 2017-07-05 | 2017-06-30 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,2960 | −10 000 | −13 | 105 535 | ||||
| 2017-07-05 | 2017-06-30 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 1,2960 | 10 000 | 13 | 12 750 | ||||
| 2017-07-05 | 2017-06-30 | 4 | Kowalsky Matthew Paul | PRTO | Common Stock | D | 1,2960 | 10 000 | 13 | 13 097 | ||||
| 2017-07-05 | 2017-06-30 | 4 | Toner E. Scott | PRTO | Common Stock | D | 1,2960 | −8 718 | −11 | 8 853 | ||||
| 2017-06-30 | 2017-06-22 | 4/A | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A Convertible Preferred Stock | D | 0,99 | 1 000,0000 | 372 | 372 | 500 | |||
| 2017-06-26 | 2017-06-22 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A Convertible Preferred Stock | D | 0,99 | 1 000,0000 | 128 | 128 | 500 | |||
| 2017-06-26 | 2017-06-22 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A Convertible Preferred Stock | D | 0,99 | 1 000,0000 | 372 | 372 | 500 | |||
| 2017-06-26 | 2017-06-22 | 4 | Freund John Gordon By Skyline Venture Partners | PRTO | Series A Convertible Preferred Stock | I | 0,99 | 1 000,0000 | 1 054 | 1 054 | 1 054 | |||
| 2017-06-26 | 2017-06-22 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Series A Convertible Preferred Stock | I | 0,99 | 1 000,0000 | 2 526 | 2 526 | 2 526 | |||
| 2017-06-26 | 2017-06-22 | 4 | Abingworth LLP | PRTO | Series A Convertible Preferred Stock | I | 0,99 | 1 000,0000 | 2 526 | 2 526 | 2 526 | |||
| 2017-06-21 | 2017-06-20 | 4 | Canute Scott A | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6 666 | 6 666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | HASTINGS PAUL J | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6 666 | 6 666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Kingsley Stuart A | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6 666 | 6 666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Abingworth LLP By affiliate | PRTO | Stock Option (Right to Buy) | I | 1,30 | 6 666 | 6 666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Birner Hubert | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6 666 | 6 666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Freund John Gordon | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6 666 | 6 666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Haines Timothy | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6 666 | 6 666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | BOHLIN GAREN G | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6 666 | 6 666 | |||||
| 2017-05-05 | 3 | Kowalsky Matthew Paul | PRTO | Common Stock, $0.001 par value | D | 6 194 | ||||||||
| 2017-05-05 | 3 | Kowalsky Matthew Paul | PRTO | Common Stock, $0.001 par value | D | 6 194 | ||||||||
| 2017-03-13 | 2017-03-10 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 1,27 | −57 934 | 0 | |||||
| 2017-03-13 | 2017-03-10 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 2,38 | −12 287 | 0 | |||||
| 2017-03-13 | 2017-03-10 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,2700 | 57 934 | 74 | 95 535 | ||||
| 2017-03-13 | 2017-03-10 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 2,3800 | 12 287 | 29 | 37 601 | ||||
| 2017-01-26 | 2017-01-24 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 2,05 | 122 838 | 122 838 | |||||
| 2017-01-26 | 2017-01-24 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 2,05 | 29 215 | 29 215 | |||||
| 2017-01-26 | 2017-01-24 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 2,05 | 53 119 | 53 119 | |||||
| 2017-01-26 | 2017-01-24 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 2,05 | 53 119 | 53 119 | |||||
| 2017-01-26 | 2017-01-24 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 2,05 | 73 039 | 73 039 | |||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 2 500 | 5 000 | ||||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 2 500 | 5 000 | ||||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −2 500 | 25 314 | ||||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −2 500 | 25 314 | ||||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | D | −2 500 | 25 314 | ||||||
| 2016-10-20 | 3 | HASTINGS PAUL J | PRTO | Common Stock, $0.001 par value | I | 13 272 | ||||||||
| 2016-10-20 | 3 | HASTINGS PAUL J | PRTO | Common Stock, $0.001 par value | I | 13 272 | ||||||||
| 2016-10-20 | 2016-10-18 | 4 | HASTINGS PAUL J | PRTO | Stock Option (Right to Buy) | D | 9,00 | 13 333 | 13 333 | |||||
| 2016-09-01 | 2016-08-31 | 4 | Toner E. Scott | PRTO | Common Stock | D | −50 | 135 | ||||||
| 2016-06-15 | 2016-06-09 | 4 | Birner Hubert | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6 666 | 6 666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Canute Scott A | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6 666 | 6 666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | BOHLIN GAREN G | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6 666 | 6 666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Freund John Gordon | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6 666 | 6 666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Kingsley Stuart A | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6 666 | 6 666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Abingworth LLP By affiliate | PRTO | Stock Option (Right to Buy) | I | 5,90 | 6 666 | 6 666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | O'Leary Brendan | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6 666 | 6 666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Haines Timothy | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6 666 | 6 666 | |||||
| 2016-06-07 | 2016-06-06 | 4 | Eldridge, George Arthur As custodian for child's UTMA account | PRTO | Common Stock | I | 5,7800 | 400 | 2 | 400 | ||||
| 2016-06-07 | 2016-06-06 | 4 | Eldridge, George Arthur As custodian for child's UTMA account | PRTO | Common Stock | I | 5,7760 | 425 | 2 | 425 | ||||
| 2016-06-07 | 2016-06-06 | 4 | Eldridge, George Arthur As custodian for child's UTMA account | PRTO | Common Stock | I | 5,7600 | 425 | 2 | 425 | ||||
| 2016-06-07 | 2016-06-06 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 5,7800 | 2 750 | 16 | 2 750 | ||||
| 2016-04-13 | 2016-04-12 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | −58 742 | 0 | |||||
| 2016-04-13 | 2016-04-12 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 58 742 | 112 | 58 742 | ||||
| 2016-01-05 | 2015-12-31 | 4 | Toner E. Scott | PRTO | Common Stock | D | 13,1800 | 185 | 2 | 185 | ||||
| 2016-01-05 | 2015-12-31 | 4 | Gottlieb Daniel Philip | PRTO | Common Stock | D | 13,1800 | 244 | 3 | 244 | ||||
| 2016-01-05 | 2016-01-04 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | −5 000 | 58 742 | |||||
| 2016-01-05 | 2016-01-04 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 13,8800 | −5 000 | −69 | 0 | ||||
| 2016-01-05 | 2016-01-04 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5 000 | 10 | 5 000 | ||||
| 2015-12-10 | 2015-12-08 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 14,70 | −22 000 | 22 000 | |||||
| 2015-12-10 | 2015-12-08 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 14,70 | −125 000 | 125 000 | |||||
| 2015-12-10 | 2015-12-08 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 14,70 | −22 000 | 22 000 | |||||
| 2015-12-10 | 2015-12-08 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 14,70 | −33 000 | 33 000 | |||||
| 2015-12-10 | 2015-12-08 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 14,70 | −57 000 | 57 000 | |||||
| 2015-12-02 | 2015-12-01 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | −5 000 | 63 742 | |||||
| 2015-12-02 | 2015-12-01 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 14,9700 | −5 000 | −75 | 0 | ||||
| 2015-12-02 | 2015-12-01 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5 000 | 10 | 5 000 | ||||
| 2015-11-03 | 2015-11-02 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | −5 000 | 68 742 | |||||
| 2015-11-03 | 2015-11-02 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 13,5000 | −5 000 | −68 | 0 | ||||
| 2015-11-03 | 2015-11-02 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5 000 | 10 | 5 000 | ||||
| 2015-10-19 | 2015-10-16 | 4 | Kingsley Stuart A | PRTO | Stock Option (Right to Buy) | D | 15,21 | 13 333 | 13 333 | |||||
| 2015-10-02 | 2015-10-01 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | −5 000 | 73 742 | |||||
| 2015-10-02 | 2015-10-01 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 13,3300 | −5 000 | −67 | 0 | ||||
| 2015-10-02 | 2015-10-01 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5 000 | 10 | 5 000 | ||||
| 2015-09-10 | 2015-09-08 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | −5 000 | 78 742 | |||||
| 2015-09-10 | 2015-09-08 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 13,5500 | −5 000 | −68 | 0 | ||||
| 2015-09-10 | 2015-09-08 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5 000 | 10 | 5 000 | ||||
| 2015-07-23 | 2015-07-21 | 4 | Canute Scott A | PRTO | Stock Option (Right to Buy) | D | 18,25 | 13 333 | 13 333 | |||||
| 2015-07-08 | 2015-06-30 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 8,8400 | 2 403 | 21 | 32 814 | ||||
| 2015-07-08 | 2015-07-07 | 4 | Gottlieb Daniel Philip | PRTO | Common Stock | D | 16,8600 | −1 965 | −33 | 0 | ||||
| 2015-07-08 | 2015-06-30 | 4 | Gottlieb Daniel Philip | PRTO | Common Stock | D | 8,8400 | 1 965 | 17 | 1 965 | ||||
| 2015-06-03 | 2015-06-02 | 4 | BOHLIN GAREN G | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6 666 | 6 666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Freund John Gordon | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6 666 | 6 666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | PHELPS GREGORY D | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6 666 | 6 666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Abingworth LLP By affiliate | PRTO | Stock Option (Right to Buy) | I | 17,59 | 6 666 | 6 666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Birner Hubert | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6 666 | 6 666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | O'Leary Brendan | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6 666 | 6 666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Haines Timothy | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6 666 | 6 666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Kobyzev Dmitry | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6 666 | 6 666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 17,59 | 50 000 | 50 000 | |||||
| 2015-01-08 | 2015-01-07 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 10,61 | 26 699 | 26 699 | |||||
| 2015-01-08 | 2015-01-07 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 10,61 | 53 808 | 53 808 | |||||
| 2015-01-08 | 2015-01-07 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 10,61 | 134 333 | 134 333 | |||||
| 2015-01-08 | 2015-01-07 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 10,61 | 69 813 | 69 813 | |||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Option (Right to Purchase) | I | −451 276 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Option (Right to Purchase) | I | −1 316 683 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Warrants (Right to Buy) | I | 4,60 | −39 932 | 0 | |||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Warrants (Right to Buy) | I | 4,60 | −116 511 | 0 | |||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series D Convertible Preferred Stock | I | −1 277 663 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series D Convertible Preferred Stock | I | −3 727 823 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series C Convertible Preferred Stock | I | −799 043 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series C Convertible Preferred Stock | I | −2 331 391 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series B Convertible Preferred Stock | I | −835 121 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series B Convertible Preferred Stock | I | −2 436 618 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series A-1 Convertible Preferred Stock | I | −717 260 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series A-1 Convertible Preferred Stock | I | −2 092 735 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series A Convertible Preferred Stock | I | −1 531 518 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series A Convertible Preferred Stock | I | −4 468 482 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P.(3) | PRTO | Common Stock | I | 4,6023 | 39 932 | 184 | 1 943 059 | ||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Common Stock | I | 4,6023 | 116 511 | 536 | 1 903 127 | ||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 379 462 | 1 786 616 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Common Stock | I | 1 107 154 | 1 407 154 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 10,0000 | 76 590 | 766 | 300 000 | ||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Common Stock | I | 10,0000 | 223 410 | 2 234 | 223 410 | ||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Option (Right to Purchase) | I | −451 276 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Option (Right to Purchase) | D | −1 316 683 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Warrants (Right to Buy) | I | 4,60 | −39 932 | 0 | |||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Warrants (Right to Buy) | D | 4,60 | −116 511 | 0 | |||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series D Convertible Preferred Stock | I | −1 277 663 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series D Convertible Preferred Stock | D | −3 727 823 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series C Convertible Preferred Stock | I | −799 043 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series C Convertible Preferred Stock | D | −2 331 391 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series B Convertible Preferred Stock | I | −835 121 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series B Convertible Preferred Stock | D | −2 436 618 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series A-1 Convertible Preferred Stock | I | −717 260 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A-1 Convertible Preferred Stock | D | −2 092 735 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series A Convertible Preferred Stock | I | −1 531 518 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A Convertible Preferred Stock | D | −4 468 482 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 4,6023 | 39 932 | 184 | 1 943 059 | ||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Common Stock | D | 4,6023 | 116 511 | 536 | 1 903 127 | ||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 379 462 | 1 786 616 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Common Stock | D | 1 107 154 | 1 407 154 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 10,0000 | 76 590 | 766 | 300 000 | ||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Common Stock | D | 10,0000 | 223 410 | 2 234 | 223 410 | ||||
| 2014-10-29 | 3/A | Burke Steven Keith | PRTO | Common Stock | D | 30 411 | ||||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Option (Right to Purchase) | I | −1 389 064 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Warrants (Right to Buy) | I | 4,60 | −121 760 | 0 | |||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series D Convertible Preferred Stock | I | −3 932 747 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series C Convertible Preferred Stock | I | −2 436 437 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series B Convertible Preferred Stock | I | −2 173 913 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series A-1 Convertible Preferred Stock | I | −2 341 664 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series A Convertible Preferred Stock | I | −5 000 000 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Common Stock | I | 10,0000 | −56 038 | −560 | 1 432 930 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Common Stock | I | 4,6023 | 121 760 | 560 | 1 488 968 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Common Stock | I | 1 167 208 | 1 367 208 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Common Stock | I | 10,0000 | 200 000 | 2 000 | 200 000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Option (Right to Purchase) | D | −1 389 064 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Warrants (Right to Buy) | D | 4,60 | −121 760 | 0 | |||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series D Convertible Preferred Stock | D | −3 932 747 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series C Convertible Preferred Stock | D | −2 436 437 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series B Convertible Preferred Stock | D | −2 173 913 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series A-1 Convertible Preferred Stock | D | −2 341 664 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series A Convertible Preferred Stock | D | −5 000 000 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Common Stock | D | 10,0000 | −56 038 | −560 | 1 432 930 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Common Stock | D | 4,6023 | 121 760 | 560 | 1 488 968 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Common Stock | D | 1 167 208 | 1 367 208 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Common Stock | D | 10,0000 | 200 000 | 2 000 | 200 000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Abingworth LLP See Note | PRTO | Option (Right to Purchase) | I | −12 835 264 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Abingworth LLP See Note | PRTO | Series D Convertible Preferred Stock | I | −16 044 081 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Abingworth LLP See Note | PRTO | Common Stock | I | 1 067 872 | 2 017 872 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Abingworth LLP See Note | PRTO | Common Stock | I | 10,0000 | 950 000 | 9 500 | 950 000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock Warrants | I | −1 965 454 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series D Convertible Preferred Stock | I | −4 000 070 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series C Convertible Preferred Stock | I | −2 478 183 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series B Convertible Preferred Stock | I | −2 336 956 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series A-1 Convertible Preferred Stock | I | −2 341 664 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series A Convertible Preferred Stock | I | −5 000 000 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 10,0000 | 83 170 | 832 | 1 387 198 | ||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 123 846 | 1 304 028 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 252 052 | 1 180 182 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 192 070 | 928 130 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 181 125 | 736 060 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 180 014 | 554 935 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 374 921 | 374 921 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Option (Right to Purchase) | I | −12 835 264 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Series D Convertible Preferred Stock | I | −16 044 081 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Common Stock | I | 1 067 872 | 2 017 872 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Common Stock | I | 10,0000 | 950 000 | 9 500 | 950 000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Pharmstandard International S.A. | PRTO | Option (Right to Purchase) | D | −6 795 140 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Pharmstandard International S.A. | PRTO | Series D Convertible Preferred Stock | D | −8 493 925 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Pharmstandard International S.A. | PRTO | Common Stock | D | 565 344 | 1 165 344 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Pharmstandard International S.A. | PRTO | Common Stock | D | 10,0000 | 600 000 | 6 000 | 600 000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Kobyzev Dmitry By Pharmstandard International S.A | PRTO | Option (Right to Purchase) | I | −6 795 140 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Kobyzev Dmitry By Pharmstandard International S.A | PRTO | Series D Convertible Preferred Stock | I | −8 493 925 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Kobyzev Dmitry By Pharmstandard International S.A | PRTO | Common Stock | I | 565 344 | 1 165 344 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Kobyzev Dmitry By Pharmstandard International S.A | PRTO | Common Stock | I | 10,0000 | 600 000 | 6 000 | 600 000 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Series D Purchase Right | I | −838 067 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Series D Purchase Right | I | −1 049 472 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Series D Purchase Right | I | −4 907 601 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Series D Preferred Stock | I | −1 047 584 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Series D Preferred Stock | I | −1 311 840 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Series D Preferred Stock | I | −6 134 501 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 45 | 0 | 170 371 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 55 | 1 | 208 345 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 272 | 3 | 170 326 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 328 | 3 | 208 290 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 12 819 | 128 | 170 054 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 15 417 | 154 | 207 962 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 5 801 | 58 | 157 235 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 6 976 | 70 | 192 545 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 81 949 | 819 | 151 434 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 98 556 | 986 | 185 569 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 10,0000 | 469 495 | 4 695 | 876 391 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 69 485 | 69 485 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 87 013 | 87 013 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 406 896 | 406 896 |
P
Köp på öppna marknaden eller privat köp av icke-derivatsäkerhet
S
Köp på öppna marknaden eller privat försäljning av icke-derivatsäkerhet
A
Bevilja, tilldelning eller annat förvärv av värdepapper från företaget (såsom en option)
C
Omvandling av derivat
D
Försäljning eller överföring av värdepapper tillbaka til företaget
F
Betalning av lösenpris eller skatteskuld med del av värdepapper som erhållits från bolaget
G
Överlåtelse av värdepapper från eller till insidern
K
Aktieswappar och liknande säkringsaffärer
M
Utövande eller omvandling av derivatsäkerhet som erhållits från företaget (som en option)
V
En transaktion friviligt rapporterad på schema 4
J
Andra (med en fotnot som beskriver transaktionen)
