MTFB / Motif Bio plc ADRs - SEC-arkiveringar, Årsredovisning, Fullmaktsutlåtande

Motif Bio plc ADRs
US ˙ NASDAQ
DENNA SYMBOL ÄR INTE LÄNGRE AKTIV

Grundläggande statistik
CIK 1674657
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Motif Bio plc ADRs
SEC Filings (Chronological Order)
Denna sida innehåller en komplett, kronologisk lista över SEC-arkiveringar, exklusive ägande-arkiveringar som vi tillhandahåller på andra ställen.
March 26, 2020 15-12B

MTFB / Motif Bio plc ADRs 15-12B - - FORM 15-12B

15-12B 1 f1512b032620.htm FORM 15-12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number: 001-37847 MOTIF BIO PLC (Exact name o

March 18, 2020 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Corporate Update

Exhibit 99.1 18 March 2020 Motif Bio plc ("Motif Bio" or the "Company") Corporate Update Motif Bio plc (AIM: MTFB), which has been reclassified as an AIM Rule 15 cash shell, provides an update on corporate developments. As announced on 28 January 2020, Motif Inc. ceased all operations and engaged Tamarack Associates to facilitate the sale of iclaprim and other assets of Motif Inc. It remains the c

March 18, 2020 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: March 2020 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exec

March 5, 2020 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: March 2020 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exec

January 29, 2020 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: January 2020 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal ex

January 29, 2020 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Corporate Update Agreement with Hercules Capital, Inc Reclassification as a Rule 15 Cash Shell

Exhibit 99.1 28 January 2020 Motif Bio plc ("Motif Bio" or the "Company") Corporate Update Agreement with Hercules Capital, Inc Reclassification as a Rule 15 Cash Shell Motif Bio plc (AIM/Nasdaq: MTFB) today provided an update on recent corporate developments following the General Meeting held on 14 November 2019 (the “General Meeting”). Agreement with Hercules Capital, Inc The Company and its who

December 23, 2019 POS AM

MTFB / Motif Bio plc ADRs POS AM - - POS AM

As filed with the Securities and Exchange Commission on December 23, 2019 Registration No.

December 23, 2019 POS AM

MTFB / Motif Bio plc ADRs POS AM - - POS AM

As filed with the Securities and Exchange Commission on December 23, 2019 Registration No.

December 9, 2019 25

MTFB / Motif Bio plc ADRs 25 - - FORM 25

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-37847 MOTIF BIO PLC The Nasdaq Stock Market LLC (Exact name of Issuer as specified in its charter, and name of Exchange where security is listed and/or registered) 125 Park Ave

November 27, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: November 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal e

November 27, 2019 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") American Depositary Shares (“ADS”) Program and Warrant Agent Agreement

EX-99.1 2 exh991.htm EXHIBIT 99.1 Exhibit 99.1 27 November 2019 Motif Bio plc ("Motif Bio" or the "Company") American Depositary Shares (“ADS”) Program and Warrant Agent Agreement Motif Bio plc (AIM/Nasdaq: MTFB) announces, that further to the announcement yesterday of the Company’s intention to voluntarily delist its American Depository Shares (ADSs), it has given notice on November 26, 2019 to T

November 26, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of November 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive

November 26, 2019 EX-99.1

Motif Bio plc Announces Voluntary Delisting from the Nasdaq Capital Market

EX-99.1 2 exh991.htm PRESS RELEASE EXHIBIT 99.1 Motif Bio plc Announces Voluntary Delisting from the Nasdaq Capital Market NEW YORK, Nov. 26, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB) ("Motif Bio" or the "Company") announces that formal notice was given by the Company to Nasdaq on November 25, 2019 of the intention to voluntarily delist the Company’s American Depository Shares (ADSs

November 18, 2019 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Directorate Changes

Exhibit 99.1 18 November 2019 Motif Bio plc ("Motif Bio" or the "Company") Directorate Changes Motif Bio plc (AIM/Nasdaq: MTFB) announces that the following Non-Executive Directors have offered their resignations as of the close of business US time on Friday 15 November 2019 and will stand down from the board with immediate effect: Dr. Craig Albanese, Charlotta Ginman, Zaki Hosny, Dr. Mary Lake Po

November 18, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: November 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal e

November 15, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: November 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal e

November 15, 2019 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Result of General Meeting

EX-99.1 2 exh991.htm EXHIBIT 99.1 Exhibit 99.1 14 November 2019 Motif Bio plc ("Motif Bio" or the "Company") Result of General Meeting Motif Bio plc (AIM/Nasdaq: MTFB announces that at the General Meeting (“GM”) of the Company held earlier today in New York, all resolutions put to shareholders were duly passed. The results of the poll, incorporating the proxy votes lodged in advance of the meeting

November 12, 2019 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Settlement Agreement

Exhibit 99.1 11 November 2019 Motif Bio plc ("Motif Bio" or the "Company") Settlement Agreement Motif Bio plc (AIM/Nasdaq: MTFB) announces that its subsidiary Motif BioSciences Inc., has reached agreement with its former clinical research organisation to settle all obligations without further payment. This will result in the reversal of a previously recognised expense and the reduction of the Moti

November 12, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: November 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal e

October 28, 2019 SC 13D/A

MTFB / Motif Bio plc ADRs / Invesco Ltd. Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (AMENDMENT NO. 5) UNDER THE SECURITIES EXCHANGE ACT OF 1934 Motif Bio plc (Name of Issuer) Ordinary Shares, par value £0.01 per share (Title of Class of Securities) 619784101 (CUSIP Number) Nancy Tomassone Invesco Ltd. 1555 Peachtree Street, N.E., Suite 1800 Atlanta, Georgia 30309 Telephone Number: (404) 892-0896

October 25, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: October 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal ex

October 25, 2019 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Posting of Circular and Notice of General Meeting

Exhibit 99.1 25 October 2019 Motif Bio plc ("Motif Bio" or the "Company") Posting of Circular and Notice of General Meeting Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, further to its announcements of 2 October 2019 and 21 October 2019, confirmed today that a Circular incorporating a formal Notice of General Meeting (‘Ge

October 3, 2019 EX-99.1

Motif Bio plc (“Motif Bio”, or “the Company”) Change of Adviser

Exhibit 99.1 3 October 2019 Motif Bio plc (“Motif Bio”, or “the Company”) Change of Adviser Motif Bio plc (AIM/NASDAQ: MTFB) is pleased to announce the appointment of SP Angel Corporate Finance LLP as nominated adviser and sole corporate broker with immediate effect. AIM Rule 17 Disclosure In accordance with AIM Rule 17 and Schedule Two (g) sub-paragraph (v) of the AIM Rules for Companies (the “AI

October 3, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

6-K 1 f6k100319.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: October 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 1

October 2, 2019 EX-99.1

Motif Bio plc (“Motif Bio”, or “the Company”) Conditional Placing to raise gross proceeds of £600,000 (US$0.73 million)

EX-99.1 2 exh991.htm EXHIBIT 99.1 Exhibit 99.1 2 October 2019 The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain. NOT FOR RE

October 2, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

6-K 1 f6k100219.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: October 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 1

September 30, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: September 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal

September 30, 2019 EX-99.1

September 30, 2019

Exhibit 99.1 September 30, 2019 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Commissioners: We have read the statements made by Motif Bio plc (copy attached), which we understand will be filed with the Securities and Exchange Commission, pursuant to the Form 6-K of Motif Bio plc dated September 30, 2019. We agree with the statements concerning our Firm contained there

September 30, 2019 EX-99.1

Motif Bio plc and subsidiary (“Motif Bio”, or “the Group”) Motif Bio Reports Half-Year 2019 Financial Results, Operational Progress and Proposed Initiatives

Exhibit 99.1 30 September 2019 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART DIRECTLY OR INDIRECTLY IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION. Motif Bio plc and subsidiary (“Motif Bio”, or “the Group”) Motif Bio Reports Half-Year 2019 Financial Results, Operational Progress and Proposed

September 30, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: September 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal

September 3, 2019 EX-99.2

FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT

EX-99.2 3 exh992.htm PRESS RELEASE EXHIBIT 99.2 FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “FifthAmendment”) is made as of this 30th day of August 2019, by and between MOTIF BIOSCIENCES INC., a Delaware corporation (“Borrower”) and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent and collateral age

September 3, 2019 EX-99.1

Motif Bio and Hercules Capital Amend Loan and Security Agreement

EXHIBIT 99.1 Motif Bio and Hercules Capital Amend Loan and Security Agreement NEW YORK, Sept. 02, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB) ("Motif Bio" or the "Company"), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announces that its lender, Hercules Capital, Inc. (“Hercules”), has agreed to amend the Company’s loan and security agreemen

September 3, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 September 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive office) Indicat

August 1, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of August 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive o

August 1, 2019 EX-99.1

Motif Bio and Hercules Capital Amend Loan and Security Agreement

EXHIBIT 99.1 Motif Bio and Hercules Capital Amend Loan and Security Agreement NEW YORK, Aug. 01, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announced today that its Lender, Hercules Capital, Inc., has agreed to amend the Company’s loan and security agreement such that the next amortization date

August 1, 2019 EX-99.2

FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT

EX-99.2 3 exh992.htm EXHIBIT 99.2 Exhibit 99.2 FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Fourth Amendment”) is made as of this 30th day of July 2019, by and between MOTIF BIOSCIENCES INC., a Delaware corporation (“Borrower”) and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent and collateral ag

July 26, 2019 EX-99.1

Motif Bio Confirms Meeting Date with U.S. FDA regarding Iclaprim

EXHIBIT 99.1 Motif Bio Confirms Meeting Date with U.S. FDA regarding Iclaprim NEW YORK, July 26, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announced today that the U.S. Food & Drug Administration (FDA) has granted the Company’s request for a Type B meeting related to a proposed clinical study f

July 26, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of July 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive off

July 26, 2019 EX-99.1

Motif Bio Confirms Receipt of Deficiency Notice from Nasdaq

EX-99.1 2 exh991.htm PRESS RELEASE EXHIBIT 99.1 Motif Bio Confirms Receipt of Deficiency Notice from Nasdaq NEW YORK, July 26, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that it has received a deficiency notice from Nasdaq indicating that, based upon a review of Motif Bio’s tradi

July 26, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of July 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive off

July 19, 2019 EX-99.1

Motif Bio Announces Receipt of Deficiency Notice from Nasdaq

EXHIBIT 99.1 Motif Bio Announces Receipt of Deficiency Notice from Nasdaq NEW YORK, July 19, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that it has received a deficiency notice from Nasdaq indicating that, based upon a review of Motif Bio’s Market Value of Listed Securities (MVLS

July 19, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

6-K 1 f6k071919.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: July 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Addr

July 15, 2019 EX-99.1

Motif Bio Submits Meeting Request and Package to the U.S. FDA for Iclaprim

EXHIBIT 99.1 Motif Bio Submits Meeting Request and Package to the U.S. FDA for Iclaprim NEW YORK, July 15, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that it has submitted a meeting request and package to the U.S. Food & Drug Administration (FDA) related to the Company’s lead pro

July 15, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of July 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive off

June 6, 2019 EX-99.1

Motif Bio Announces Path Forward for Iclaprim following Receipt of FDA Meeting Minutes Conference call scheduled for Thursday, June 6, 2019 at 8:00 AM EDT/1:00 PM BST/2:00 PM CET

EXHIBIT 99.1 Motif Bio Announces Path Forward for Iclaprim following Receipt of FDA Meeting Minutes Conference call scheduled for Thursday, June 6, 2019 at 8:00 AM EDT/1:00 PM BST/2:00 PM CET NEW YORK, June 06, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that the Company has recei

June 6, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of June 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive off

May 31, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: May 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive off

May 31, 2019 EX-99.1

Result of Annual General Meeting

EX-99.1 2 exh991.htm PRESS RELEASE EXHIBIT 99.1 Result of Annual General Meeting NEW YORK, May 31, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announces that at the Annual General Meeting held earlier today, all but one of the resolutions proposed were duly passed by the shareholders on a poll. T

May 22, 2019 EX-99.1

Motif Bio plc AGM Statement

EXHIBIT 99.1 Motif Bio plc AGM Statement NEW YORK, May 22, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announces that at the Company’s AGM held earlier today the Company provided the following review of key aspects of its business and growth strategy. Iclaprim for treating ABSSSI (acute bacterial

May 22, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of May 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive offi

May 3, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K Current Report of Foreign Issuer FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of May 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal executive offi

May 3, 2019 EX-99.1

Motif Bio meeting with U.S. FDA held as planned

EXHIBIT 99.1 Motif Bio meeting with U.S. FDA held as planned NEW YORK, May 03, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, confirms that the Company met with the U.S. Food & Drug Administration (FDA) on May 3, 2019 as expected. The Type A meeting was held to discuss the points raised in the Compl

April 26, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer) FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: April 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exec

April 26, 2019 EX-99.4

MOTIF BIO PLC Proxy Form

EXHIBIT 99.4 MOTIF BIO PLC Proxy Form I/We, (insert full name in BLOCK CAPITALS) of (insert address in BLOCK CAPITALS) POSTCODE being (a) holder(s) of ordinary shares in Motif Bio plc appoint the Chairman of the meeting or the following person: Name Number of Shares as my/our proxy to attend, speak and vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held at 1

April 26, 2019 EX-99.5

MOTIF BIO PLC 125 Park Avenue, 25th Floor, New York, NY 10017 USA Registered Office: 201 Temple Chambers, 3-7 Temple Avenue, London, EC4Y 0DT Incorporated in England/Wales No. 09320890 www.motifbio.com

EXHIBIT 99.5 Dear Shareholder, NOTICE OF AGM / ANNUAL REPORT & ACCOUNTS We hereby notify you that the Annual Report and Financial Statements for the year ended 2018, Notice of the Annual General Meeting to be held on 22 May 2019, and the form of proxy for the Annual General Meeting are now available on the Company’s website www.motifbio.com under the tab https://www.motifbio.com/aim-investors/. Yo

April 26, 2019 EX-99.1

Motif Bio Announces Appointment of Andrew Powell to Board of Directors

EXHIBIT 99.1 Motif Bio Announces Appointment of Andrew Powell to Board of Directors NEW YORK, April 26, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB) ("Motif Bio" or the "Company"), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced the appointment of Andrew Powell, J.D. as Non-executive Director, effective immediately. Mr. Powell ha

April 26, 2019 EX-99.2

Motif Bio plc: Notice of Annual General Meeting

EXHIBIT 99.2 Motif Bio plc: Notice of Annual General Meeting NEW YORK, April 26, 2019 (GLOBE NEWSWIRE) - Motif Bio plc ("Motif Bio" or the "Company") (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that its notice of its Annual General Meeting (AGM) have been posted to shareholders and will shortly be available for downlo

April 26, 2019 EX-99.3

Motif Bio PLC (incorporated and registered in England and Wales under number 09320890) NOTICE OF ANNUAL GENERAL MEETING

EXHIBIT 99.3 THIS DOCUMENT IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION. If you are in any doubt as to what action you should take, you are recommended to seek financial advice from your stockbroker or other independent adviser authorized under the Financial Services and Market Act 2000 (as amended). If you have recently sold or transferred all of your shares in Motif Bio plc, please forward

April 15, 2019 20-F

MTFB / Motif Bio plc ADRs 20-F

20-F 1 a19-2933120f.htm 20-F Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F (Mark One) o REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2018 OR o TRANSITION REPORT PURSUA

April 15, 2019 EX-15.2

CONSENT OF BAL PHARMA CONSULTING, LLC

Exhibit 15.2 CONSENT OF BAL PHARMA CONSULTING, LLC BAL Pharma Consulting, LLC hereby consents to all references to the market research survey it was commissioned to prepare on behalf of Motif Bio plc entitled “Assessment of Iclaprim Commercial Opportunity in the Gram Positive Antibiotic Hospital Market” and to the results of such survey (collectively, the “BAL Information”) included in this Annual

April 15, 2019 EX-15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statement on Form F-3 (Nos. 333-222042, 333-222614) of Motif Bio plc of our report dated April 15, 2019 relating to the financial statements, which appears in this Form 20-F. /s/ PricewaterhouseCoopers LLP Florham Park, New Jersey April 15, 2019

April 15, 2019 EX-13.2

Certification by the Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the annual report of Motif Bio plc (the “Company”) on Form 20-F for the fiscal year ended December 31, 2018 as filed with the Securities and Exchange Commission on the date hereof, I, Jonathan Gold Chief Financial

April 15, 2019 EX-15.3

CONSENT OF JMI LABORATORIES

Exhibit 15.3 CONSENT OF JMI LABORATORIES JMI Laboratories hereby consents to all references to the worldwide microbiological survey (protocol #15-MOT-01) it was commissioned to prepare on behalf of Motif Bio plc and to the results of such survey (collectively, the “JMI Information”) included in this Annual Report on Form 20-F of Motif Bio plc for the year ending December 31, 2018, and to all refer

April 15, 2019 EX-15.4

CONSENT OF IHMA LABORATORIES

Exhibit 15.4 CONSENT OF IHMA LABORATORIES IHMA Laboratories hereby consents to all references to the US and Europe microbiological survey it was commissioned to prepare on behalf of Motif Bio plc and to the results of such survey (collectively, the “IHMA Information”) included Annual Report on Form 20-F of Motif Bio plc for the year ending December 31, 2018, and to all references to IHMA Laborator

April 15, 2019 EX-12.2

Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Jonathan Gold, certify that: 1. I have reviewed this annual report on Form 20-F of Motif Bio plc (the “Company”) or the fiscal year ended December 31, 2018; 2. Based on my knowledge, this annual repor

April 15, 2019 EX-12.1

Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Dr. Graham Lumsden, certify that: 1. I have reviewed this annual report on Form 20-F of Motif Bio plc (the “Company”) or the fiscal year ended December 31, 2018; 2. Based on my knowledge, this annual

April 15, 2019 EX-13.1

Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the annual report of Motif Bio plc (the “Company”) on Form 20-F for the fiscal year ended December 31, 2018 as filed with the Securities and Exchange Commission on the date hereof, I, Dr. Graham Lumsden, Chief Exec

April 15, 2019 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio Reports Fiscal Year 2018 Results

Exhibit 99.1 April 15, 2019 Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio Reports Fiscal Year 2018 Results Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced financial results for the year ended December 31, 2018. Dr. Graham Lumsden, Chief Executive Officer, said: “Motif Bio had an incredibly productiv

April 15, 2019 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: April 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exec

April 15, 2019 EX-99.2

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio Reports Fiscal Year 2018 Results

Exhibit 99.2 15 April 2019 Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio Reports Fiscal Year 2018 Results Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced financial results for the year ended December 31, 2018. Dr. Graham Lumsden, Chief Executive Officer, said: “Motif Bio had an incredibly productive

April 2, 2019 SC 13D/A

MTFB / Motif Bio plc ADRs / Invesco Ltd. Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (AMENDMENT NO. 4) UNDER THE SECURITIES EXCHANGE ACT OF 1934 Motif Bio plc (Name of Issuer) Ordinary Shares, par value £0.01 per share (Title of Class of Securities) 619784101 (CUSIP Number) Nancy Tomassone Invesco Ltd. 1555 Peachtree Street, N.E., Suite 1800 Atlanta, Georgia 30309 Telephone Number: (404) 892-0896

March 26, 2019 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: March 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exec

March 26, 2019 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Motif Bio Raises £2.7m (US$3.55m)

Exhibit 99.1 26 March 2019 The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain. NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION,

March 26, 2019 EX-99.2

Exhibit 99.2

Exhibit 99.2

March 25, 2019 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: March 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exec

March 25, 2019 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Proposed Equity Fundraise

Exhibit 99.1 25 March 2019 The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain. Motif Bio plc ("Motif Bio" or the "Company")

March 20, 2019 EX-99.1

Motif Bio Granted Meeting with U.S. FDA regarding Iclaprim

EXHIBIT 99.1 Motif Bio Granted Meeting with U.S. FDA regarding Iclaprim NEW YORK, March 20, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announced today that the U.S. Food & Drug Administration (FDA) has granted the Company’s request for a Type A meeting to discuss the points raised in the Complet

March 20, 2019 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of March 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Address of principal executive o

March 18, 2019 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

6-K 1 f6k031819.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of March 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Add

March 18, 2019 EX-99.1

Motif Bio Announces Appointment of Bruce Williams as Interim Chairman and Resignation of Richard Morgan from the Board

EXHIBIT 99.1 Motif Bio Announces Appointment of Bruce Williams as Interim Chairman and Resignation of Richard Morgan from the Board NEW YORK, March 18, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that Richard C. E. Morgan has tendered his resignation as Non-executive Chairman and

February 19, 2019 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: February 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal e

February 19, 2019 EX-99.1

Motif BioSciences Enters into Amendment Agreement with Hercules Capital

EXHIBIT 99.1 Motif BioSciences Enters into Amendment Agreement with Hercules Capital NEW YORK, Feb. 18, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that Motif BioSciences Inc. (a wholly owned subsidiary) has entered into an amendment agreement with its lender Hercules Capital, Inc

February 19, 2019 EX-99.2

SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT

EXHIBIT 99.2 Execution Version SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Agreement”) is made this 17th day of February, 2019, by and between MOTIF BIOSCIENCES INC., a Delaware corporation (“Borrower”) and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and the L

February 15, 2019 SC 13D/A

MTFB / Motif Bio plc ADRs / Invesco Ltd. - MOTIF BIO PLC Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (AMENDMENT NO. 3) UNDER THE SECURITIES EXCHANGE ACT OF 1934 Motif Bio plc (Name of Issuer) Ordinary Shares, par value £0.01 per share (Title of Class of Securities) 619784101 (CUSIP Number) Nancy Tomassone Invesco Ltd. 1555 Peachtree Street, N.E., Suite 1800 Atlanta, Georgia 30309 Telephone Number: (404) 892-0896

February 14, 2019 EX-99.1

Motif Bio Receives Complete Response Letter from the FDA

EXHIBIT 99.1 Motif Bio Receives Complete Response Letter from the FDA NEW YORK, Feb. 14, 2019 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announced today that the Company has received a Complete Response Letter (CRL) from the U.S. Food & Drug Administration (FDA) regarding the New Drug Application (ND

February 14, 2019 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of February 2019 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Address of principal executiv

February 13, 2019 SC 13G/A

MTFB / Motif Bio plc ADRs / BANK OF AMERICA CORP /DE/ - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Motif Bio plc (Name of Issuer) Ordinary Shares (Title of Class of Securities) 619784101 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whic

February 11, 2019 SC 13D

MTFB / Motif Bio plc ADRs / Invesco Ltd. - MOTIF BIO PLC Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (AMENDMENT NO. 2) UNDER THE SECURITIES EXCHANGE ACT OF 1934 Motif Bio plc (Name of Issuer) Ordinary Shares, par value £0.01 per share (Title of Class of Securities) 619784101 (CUSIP Number) Nancy Tomassone Invesco Ltd. 1555 Peachtree Street, N.E., Suite 1800 Atlanta, Georgia 30309 Telephone Number: (404) 892-0896

February 5, 2019 SC 13G

MTFB / Motif Bio plc ADRs / M&G INVESTMENT MANAGEMENT LTD - MOTIF BIO PLC Passive Investment

SC 13G 1 d625312dsc13g.htm MOTIF BIO PLC UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Motif Bio plc (Name of Issuer) Ordinary Shares (Title of Class of Securities) G62924108 (CUSIP Number) 31st December 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designa

September 25, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: September 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal

September 25, 2018 EX-99.1

Motif Bio plc and subsidiary (“Motif Bio”, or “the Group”) Motif Bio Reports Half-Year 2018 Financial Results and Operational Progress

Exhibit 99.1 25 September 2018 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART DIRECTLY OR INDIRECTLY IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION. Motif Bio plc and subsidiary (“Motif Bio”, or “the Group”) Motif Bio Reports Half-Year 2018 Financial Results and Operational Progress Motif Bio

August 21, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: August 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exe

August 21, 2018 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio notes statement from Amphion Innovations

Exhibit 99.1 21 August 2018 Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio notes statement from Amphion Innovations Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, notes the announcement made today via RNS by Amphion Innovations plc (“Amphion”), a substantial shareholder in the Company, relating to its sale of share

August 14, 2018 EX-99.1

Motif Bio Announces FDA Acceptance of New Drug Application with Priority Review for Iclaprim for Treatment of Acute Bacterial Skin and Skin Structure Infections PDUFA action date set for February 13, 2019

EXHIBIT 99.1 Motif Bio Announces FDA Acceptance of New Drug Application with Priority Review for Iclaprim for Treatment of Acute Bacterial Skin and Skin Structure Infections PDUFA action date set for February 13, 2019 NEW YORK, Aug. 14, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced

August 14, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

6-K 1 f6k081418.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: August 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (A

August 8, 2018 EX-99.1

Motif Bio Announces Notice of Allowance for Two U.S. Iclaprim Patents with Expiration in 2037

EXHIBIT 99.1 Motif Bio Announces Notice of Allowance for Two U.S. Iclaprim Patents with Expiration in 2037 NEW YORK, Aug. 08, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM/NASDAQ: MTFB) ("Motif Bio" or the "Company"), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that the Company has received a Notice of Allowance from the United States Paten

August 8, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of August 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Address of principal executive

July 3, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of July 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Address of principal executive of

July 3, 2018 EX-99.1

Motif Bio Announces Resignation of Robert Bertoldi from Board of Directors

EXHIBIT 99.1 Motif Bio Announces Resignation of Robert Bertoldi from Board of Directors NEW YORK, July 03, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM:MTFB) (NASDAQ:MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that Robert Bertoldi has informed the Company of his decision to resign from the Board of Directors, effective July 16, 2018

June 19, 2018 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Result of Annual General Meeting

Exhibit 99.1 19 June 2018 Motif Bio plc (“Motif Bio” or the “Company”) Result of Annual General Meeting Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announces that at the Annual General Meeting held earlier today, all resolutions proposed were duly passed by the shareholders on a poll. The results of the poll, incorporat

June 19, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

6-K 1 a18-1562416k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011

June 14, 2018 EX-99.1

Motif Bio Submits NDA for Iclaprim

EXHIBIT 99.1 Motif Bio Submits NDA for Iclaprim NEW YORK, June 14, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM:MTFB) (NASDAQ:MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced the completion of its rolling submission of a New Drug Application (NDA) to the U.S. Food & Drug Administration (FDA) for iclaprim, a targeted, Gram-positive invest

June 14, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Address of principal executive o

May 23, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: May 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal execut

May 23, 2018 EX-99.1

Motif Bio plc ("Motif Bio" or the "Company") Motif Bio notes statement from Amphion Innovations

Exhibit 99.1 23 May 2018 Motif Bio plc ("Motif Bio" or the "Company") Motif Bio notes statement from Amphion Innovations Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, notes the announcement made today via RNS by Amphion Innovations plc ("Amphion"), a substantial shareholder in the Company, relating to its sale of shares i

May 17, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: May 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal execut

May 17, 2018 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Proposed Placing to raise approximately £10m (US$14m)

Exhibit 99.1 17 May 2018 The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain. NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, D

May 17, 2018 EX-99.2

Motif Bio plc (“Motif Bio” or the “Company”) Result of Placing

Exhibit 99.2 17 May 2018 The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain. NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, D

May 9, 2018 EX-99.1

Motif Bio Appoints Stephanie Noviello, MD, MPH as Vice President, Clinical Development

EXHIBIT 99.1 Motif Bio Appoints Stephanie Noviello, MD, MPH as Vice President, Clinical Development NEW YORK, May 09, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM:MTFB) (NASDAQ:MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that Stephanie Noviello, MD, MPH has joined the Company as Vice President, Clinical Development. She will report

May 9, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

6-K 1 f6k050818.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of May 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Addre

April 19, 2018 EX-99.1

Motif Bio Announces New Iclaprim Data being Presented at ECCMID 2018

EXHIBIT 99.1 Motif Bio Announces New Iclaprim Data being Presented at ECCMID 2018 NEW YORK, April 19, 2018 (GLOBE NEWSWIRE) - Positive efficacy and safety highlights from Phase 3 REVIVE-2 trial in ABSSSI Potential to avoid costs related to vancomycin-associated acute kidney injury in ABSSSI Data continue to support iclaprim activity against MRSA and other drug-resistant pathogens Motif Bio plc (AI

April 19, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

6-K 1 f6k041918.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of April 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Add

April 17, 2018 EX-99.5

MOTIF BIO PLC Proxy Form

Exhibit 99.5 MOTIF BIO PLC Proxy Form I/We, (insert full name in BLOCK CAPITALS) of (insert address in BLOCK CAPITALS) POSTCODE being (a) holder(s) of ordinary shares in Motif Bio plc appoint the Chairman of the meeting or the following person: Name Number of Shares as my/our proxy to attend, speak and vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held at 1

April 17, 2018 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Posting of UK Annual Report and Accounts & Notice of AGM

Exhibit 99.1 17 April 2018 Motif Bio plc (“Motif Bio” or the “Company”) Posting of UK Annual Report and Accounts & Notice of AGM Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that its 2017 UK Annual Report and Accounts and notice of its Annual General Meeting have been posted to shareholders and will short

April 17, 2018 EX-99.4

Notice of Annual General Meeting

Exhibit 99.4 Notice of Annual General Meeting THIS DOCUMENT IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION If you are in any doubt as to what action you should take, you are recommended to seek financial advice from your stockbroker or other independent adviser authorized under the Financial Services and Market Act 2000. If you have recently sold or transferred all of your shares in Motif Bio

April 17, 2018 EX-99.3

MOTIF BIO PLC 125 Park Avenue, 25th Floor, Suite 2622, New York, NY 10017 USA Registered Office: 27/28 Eastcastle Street, London W1W 8DH, UK Incorporated in England/Wales No. 09320890

Exhibit 99.3 Dear Shareholder, NOTICE OF AGM / ANNUAL REPORT & ACCOUNTS We hereby notify you that the Annual Report and Financial Statements for the year ended 2017, Notice of the Annual General Meeting to be held on 19 June 2018, and the form of proxy for the Annual General Meeting are now available on the Company’s website www.motifbio.com under the tab https://www.motifbio.com/aim-investors/. Y

April 17, 2018 EX-99.2

Motif Bio plc (“Motif Bio” or the “Company”) Posting of UK Annual Report and Accounts & Notice of AGM

Exhibit 99.2 17 April 2018 Motif Bio plc (“Motif Bio” or the “Company”) Posting of UK Annual Report and Accounts & Notice of AGM Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that its 2017 UK Annual Report and Accounts and notice of its Annual General Meeting have been posted to shareholders and will short

April 17, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: April 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exec

April 10, 2018 EX-99.1

Motif Bio Reports Fiscal Year 2017 Results

Exhibit 99.1 Motif Bio Reports Fiscal Year 2017 Results New York, NY, April 10, 2018 - Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced financial results for the year ended December 31, 2017. Dr. Graham Lumsden, Chief Executive Officer, said: “Motif Bio made tremendous progress in 2017, accomplishing several

April 10, 2018 EX-99.2

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio Reports Fiscal Year 2017 Results

Exhibit 99.2 10 April 2018 Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio Reports Fiscal Year 2017 Results Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced financial results for the year ended December 31, 2017. Dr. Graham Lumsden, Chief Executive Officer, said: “Motif Bio made tremendous progress in

April 10, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: April 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal exec

April 10, 2018 EX-4.25

CONSULTING AGREEMENT Effective Date: February 2, 2018

Exhibit 4.25 CONSULTING AGREEMENT Effective Date: February 2, 2018 THIS CONSULTING AGREEMENT (this “Agreement”) is entered into by and between Motif Biosciences, Inc., a Delaware corporation (the “Company”), and Robert Dickey IV, an individual (“Consultant”), as of the date set forth above (the “Effective Date”). WHEREAS, the Consultant was previously the Chief Financial Officer of the Company (“C

April 10, 2018 EX-12.1

Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Dr. Graham Lumsden, certify that: 1. I have reviewed this annual report on Form 20-F of Motif Bio plc (the “Company”) for the fiscal year ended December 31, 2017; 2. Based on my knowledge, this annual

April 10, 2018 EX-13.2

Certification by the Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the annual report of Motif Bio plc (the “Company”) on Form 20-F for the fiscal year ended December 31, 2017 as filed with the Securities and Exchange Commission on the date hereof, I, Jonathan Gold, Chief Financial

April 10, 2018 EX-15.2

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.2 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statements on Form F-3 (Nos. 333-222042, 333-222614) of Motif Bio plc of our report dated May 16, 2016 relating to the financial statements, which appears in this Form 20-F. /s/ PricewaterhouseCoopers LLP Aberdeen, United Kingdom April 10, 2018

April 10, 2018 EX-15.3

CONSENT OF BAL PHARMA CONSULTING, LLC

Exhibit 15.3 CONSENT OF BAL PHARMA CONSULTING, LLC BAL Pharma Consulting, LLC hereby consents to all references to the market research survey it was commissioned to prepare on behalf of Motif Bio plc entitled “Assessment of Iclaprim Commercial Opportunity in the Gram Positive Antibiotic Hospital Market” and to the results of such survey (collectively, the “BAL Information”) included in this Annual

April 10, 2018 EX-4.22

WARRANT AGREEMENT To Purchase American Depositary Shares of MOTIF BIO PLC Dated as of November 14, 2017 (the “Effective Date”)

EX-4.22 3 a18-73371ex4d22.htm EX-4.22 Exhibit 4.22 EXECUTION COPY THIS WARRANT AND THE SHARES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR, SUBJECT TO SECTION 11 HER

April 10, 2018 EX-4.21

LOAN AND SECURITY AGREEMENT

Exhibit 4.21 EXECUTION COPY LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT is made and dated as of November 14, 2017 and is entered into by and among MOTIF BIOSCIENCES INC., a Delaware corporation, and each of its Qualified Subsidiaries (hereinafter collectively referred to herein as the “Borrower”), the several banks and other financial institutions or entities from time to time par

April 10, 2018 EX-4.24

STOCK PLEDGE AGREEMENT

Exhibit 4.24 EXECUTION COPY STOCK PLEDGE AGREEMENT This Stock Pledge Agreement (this “Agreement”) is entered into as of November 14, 2017, by and between HERCULES CAPITAL, INC., as administrative agent and collateral agent (in such capacity, “Agent”) for a syndicate of secured parties (together with Agent, collectively, “Secured Parties”) and MOTIF BIO PLC, a public limited company organized under

April 10, 2018 EX-15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statements on Form F-3 (Nos. 333-222042, 333-222614) of Motif Bio plc of our report dated April 10, 2018 relating to the financial statements, which appears in this Form 20-F. /s/ PricewaterhouseCoopers LLP Florham Park, New Jersey, United States of America

April 10, 2018 EX-13.1

Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the annual report of Motif Bio plc (the “Company”) on Form 20-F for the fiscal year ended December 31, 2017 as filed with the Securities and Exchange Commission on the date hereof, I, Dr. Graham Lumsden, Chief Exec

April 10, 2018 20-F

MTFB / Motif Bio plc ADRs 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F (Mark One) o REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2017 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF

April 10, 2018 EX-15.4

CONSENT OF JMI LABORATORIES

Exhibit 15.4 CONSENT OF JMI LABORATORIES JMI Laboratories hereby consents to all references to the worldwide microbiological survey (protocol #15-MOT-01) it was commissioned to prepare on behalf of Motif Bio plc and to the results of such survey (collectively, the “JMI Information”) included in this Annual Report on Form 20-F of Motif Bio plc for the year ending December 31, 2017, and to all refer

April 10, 2018 EX-4.26

CONFIDENTIAL SEPARATION AGREEMENT AND RELEASE

Exhibit 4.26 CONFIDENTIAL SEPARATION AGREEMENT AND RELEASE THIS CONFIDENTIAL SEPARATION AGREEMENT AND RELEASE (the “Agreement”) is made and entered into by and between Robert Dickey IV (“Dickey”) and Motif BioSciences, Inc. (the “Company”) (collectively, the “Parties”). WHEREAS, Dickey was employed by the Company pursuant to an employment agreement, dated January 16, 2017 (the “Employment Agreemen

April 10, 2018 EX-15.5

CONSENT OF IHMA LABORATORIES

Exhibit 15.5 CONSENT OF IHMA LABORATORIES IHMA Laboratories hereby consents to all references to the US and Europe microbiological survey it was commissioned to prepare on behalf of Motif Bio plc and to the results of such survey (collectively, the “IHMA Information”) included Annual Report on Form 20-F of Motif Bio plc for the year ending December 31, 2017, and to all references to IHMA Laborator

April 10, 2018 EX-12.2

Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Jonathan Gold, certify that: 1. I have reviewed this annual report on Form 20-F of Motif Bio plc (the “Company”) for the fiscal year ended December 31, 2017; 2. Based on my knowledge, this annual repo

April 10, 2018 EX-4.23

REGISTRATION AGREEMENT

Exhibit 4.23 EXECUTION COPY REGISTRATION AGREEMENT THIS REGISTRATION AGREEMENT is entered into as of November 14, 2017 by and between Motif Bio Plc, a public limited company incorporated in England and Wales (the “Company”), and Hercules Capital, Inc., a Maryland corporation (“Hercules”). RECITALS WHEREAS, in connection with the transactions contemplated by that certain Loan and Security Agreement

April 3, 2018 EX-99.1

Motif Bio Initiates NDA Rolling Submission for Iclaprim and Provides Business Update

EXHIBIT 99.1 Motif Bio Initiates NDA Rolling Submission for Iclaprim and Provides Business Update NEW YORK, April 03, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM:MTFB) (NASDAQ:MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced the initiation of a rolling submission of a New Drug Application (NDA) to the U.S. Food & Drug Administration (FD

April 3, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

6-K 1 f6k040218.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of April 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Add

March 20, 2018 6-K/A

MTFB / Motif Bio plc ADRs FORM 6-K/A (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K/A REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: March 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10017 (Address of principal ex

March 20, 2018 EX-99.1

Exhibit 99.1

EXHIBIT 99.1 Motif Bio Update on NDA Submission for Iclaprim NEW YORK, March 20, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM:MTFB) (NASDAQ:MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today provided an update on the status and timeline for submission of its New Drug Application (NDA) to the U.S. Food & Drug Administration (FDA) for its targeted, Gr

March 20, 2018 EX-99.1

Motif Bio Update on NDA Submission for Iclaprim

EXHIBIT 99.1 Motif Bio Update on NDA Submission for Iclaprim NEW YORK, March 20, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM:MTFB) (NASDAQ:MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today provided an update on the status and timeline for submission of its New Drug Application (NDA) to the U.S. Food & Drug Administration (FDA) for its targeted, Gr

March 20, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of March 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10017 (Address of principal executive o

March 19, 2018 EX-99.1

Motif Bio to present at upcoming investor and scientific conferences

EXHIBIT 99.1 Motif Bio to present at upcoming investor and scientific conferences NEW YORK, March 19, 2018 (GLOBE NEWSWIRE) - Motif Bio plc (AIM:MTFB) (NASDAQ:MTFB), a clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that the Company will present at the following conferences in March. Superbugs & Superdrugs 2018 March 19-20, 2018 London, UK David Hua

March 19, 2018 6-K

MTFB / Motif Bio plc ADRs FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of March 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Translation of registrant's name into English) 125 Park Avenue 25th Floor New York , New York 10011 (Address of principal executive o

March 1, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: March 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal exec

March 1, 2018 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Grant of share options to senior management

Exhibit 99.1 1 March 2018 Motif Bio plc (?Motif Bio? or the ?Company?) Grant of share options to senior management Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, announces that the Company has granted a total of 4,750,000 options to purchase ordinary shares of 1 pence each of Motif Bio (?Ordinary Shares?) under the Company

February 21, 2018 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio to Present Iclaprim Data at ECCMID 2018

Exhibit 99.1 21 February 2018 Motif Bio plc (?Motif Bio? or the ?Company?) Motif Bio to Present Iclaprim Data at ECCMID 2018 ? Phase 3 trial results for REVIVE-2 in patients with ABSSSI ? Potential cost savings opportunities with iclaprim versus vancomycin ? Iclaprim in vitro susceptibility data Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing

February 21, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: February 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal e

February 14, 2018 SC 13G

MTFB / Motif Bio plc ADRs / BANK OF AMERICA CORP /DE/ - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. n/a )* Motif Bio plc (Name of Issuer) Ordinary Shares (Title of Class of Securities) 619784101 (CUSIP Number) December 29, 2017 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to w

February 5, 2018 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Appointment of Jonathan E. Gold as Interim Chief Financial Officer

Exhibit 99.1 2 February 2018 Motif Bio plc (?Motif Bio? or the ?Company?) Appointment of Jonathan E. Gold as Interim Chief Financial Officer Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that Robert Dickey IV has informed the Company of his intention to resign from his role as Chief Financial Officer (CFO)

February 5, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: February 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal e

February 2, 2018 SC 13D

MTFB / Motif Bio plc ADRs / Invesco Ltd. - MOTIF BIO PLC Activist Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES ACT OF 1934 (Amendment No. 1) Motif Bio plc (Name of Issuer) Ordinary Shares, par value £0.01 per share (Title and Class of Securities) 619784101 (CUSIP Number) Nancy Tomassone Invesco Ltd. 1555 Peachtree Street, N.E., Suite 1800 Atlanta, Georgia 30309 Telephone number: (404) 892-0896 (Name, Address and Tel

January 29, 2018 CORRESP

MTFB / Motif Bio plc ADRs CORRESP

MOTIF BIO PLC 125 Park Avenue 25th Floor New York, New York 10011 (646) 880-3050 January 29, 2018 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F.

January 19, 2018 EX-99.1

Motif Bio Announces Filing of U.S. Shelf Registration

Exhibit 99.1 Motif Bio Announces Filing of U.S. Shelf Registration New York, NY, January 19, 2018. Motif Bio? plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that the Company has filed a ?universal? shelf registration statement on Form F-3 with the U.S. Securities and Exchange Commission (the ?SEC?). The filing of a s

January 19, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: January 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal ex

January 18, 2018 F-3

MTFB / Motif Bio plc ADRs F-3

Use these links to rapidly review the document TABLE OF CONTENTS INDEX TO INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTS Table of Contents As filed with the Securities and Exchange Commission on January 18, 2018 Registration No.

January 5, 2018 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: January 2018 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal ex

January 5, 2018 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio to participate in panel discussion at upcoming Cantor Antibiotics Summit

Exhibit 99.1 5 January 2018 Motif Bio plc (?Motif Bio? or the ?Company?) Motif Bio to participate in panel discussion at upcoming Cantor Antibiotics Summit Motif Bio plc (AIM/NASDAQ: MTFB), a clinical stage biopharmaceutical company specialising in developing novel antibiotics, announced today that the Company will participate in the following event: Cantor Antibiotics Summit January 17, 2018 Omni

January 3, 2018 424B3

1,202,902 American Depositary Shares Each Representing 20 Ordinary Shares Issuable Upon the Exercise of Warrants 11,181,714 Ordinary Shares Issuable Upon the Exercise of Warrants

Table of Contents Filed pursuant to Rule 424(b)(3) Registration No. 333-222042 PROSPECTUS 1,202,902 American Depositary Shares Each Representing 20 Ordinary Shares Issuable Upon the Exercise of Warrants 11,181,714 Ordinary Shares Issuable Upon the Exercise of Warrants This prospectus relates to (i) the offer and sale by us of 1,202,902 American Depositary Shares, or ADSs, each representing 20 of o

January 3, 2018 424B3

11,099,220 Ordinary Shares Including 1,469,040 Ordinary Shares in the Form of 73,452 American Depositary Shares

Table of Contents Filed pursuant to Rule 424(b)(3) Registration No. 333-222042 PROSPECTUS 11,099,220 Ordinary Shares Including 1,469,040 Ordinary Shares in the Form of 73,452 American Depositary Shares This prospectus relates to the resale of up to 11,099,220 ordinary shares, nominal value of ?0.01 per share of Motif Bio plc, that may be sold from time to time by the selling shareholders named in

December 28, 2017 CORRESP

MTFB / Motif Bio plc ADRs ESP

MOTIF BIO PLC 125 Park Avenue 25th Floor New York, New York 10011 (646) 880-3050 December 28, 2017 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F.

December 22, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio notes statement from Amphion Innovations

Exhibit 99.1 22 December 2017 Motif Bio plc (?Motif Bio? or the ?Company?) Motif Bio notes statement from Amphion Innovations Motif Bio plc (AIM/NASDAQ: MTFB), a clinical stage biopharmaceutical company specialising in developing novel antibiotics, notes the announcement made today via RNS by Amphion Innovations plc (?Amphion?), a substantial shareholder in the Company, relating to the successful

December 22, 2017 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: December 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal e

December 21, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio REVIVE-1 Phase 3 Study Results with Iclaprim Published in Peer-reviewed Journal, Clinical Infectious Diseases

Exhibit 99.1 21 December 2017 Motif Bio plc (?Motif Bio? or the ?Company?) Motif Bio REVIVE-1 Phase 3 Study Results with Iclaprim Published in Peer-reviewed Journal, Clinical Infectious Diseases ? Iclaprim met the primary endpoint ? Iclaprim was well tolerated in the study ? Additional data from the previously announced topline results are included in the publication Motif Bio plc (AIM/NASDAQ: MTF

December 21, 2017 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: December 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal e

December 14, 2017 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: December 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal e

December 14, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Filing of SEC Form F-3

Exhibit 99.1 14 December 2017 This announcement shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws or any such state or jurisdiction. Motif Bio plc (?Motif Bio? or the

December 13, 2017 F-3

MTFB / Motif Bio plc ADRs F-3

Table of Contents As filed with the Securities and Exchange Commission on December 13, 2017 Registration No.

November 15, 2017 6-K

MTFB / Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: November 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal e

November 15, 2017 EX-99.1

The information contained within this announcement is deemed by Motif Bio plc to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information

Exhibit 99.1 15 November 2017 The information contained within this announcement is deemed by Motif Bio plc to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain Motif Bio plc (?Motif Bio? or the ?Compan

October 6, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: October 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal ex

October 6, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio Presents New Pre-Clinical Data for Iclaprim at IDWeek 2017™ 1. Pre-Clinical Data Support the Potential Use of Iclaprim in the Treatment of Staphylococcus aureus Pneumonia in Cystic Fibrosis Patie

Exhibit 99.1 6 October 2017 Motif Bio plc (?Motif Bio? or the ?Company?) Motif Bio Presents New Pre-Clinical Data for Iclaprim at IDWeek 2017? 1. Pre-Clinical Data Support the Potential Use of Iclaprim in the Treatment of Staphylococcus aureus Pneumonia in Cystic Fibrosis Patients 2. Iclaprim Demonstrates Potent In Vitro Suppression of Exotoxins in MRSA Isolates Motif Bio plc (AIM/NASDAQ: MTFB), a

October 4, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: October 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal ex

October 4, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio Announces Positive Topline Results for iclaprim in the REVIVE-2 Phase 3 Study

Exhibit 99.1 4 October 2017 The information contained within this announcement is deemed by Motif Bio plc to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain. Motif Bio plc (?Motif Bio? or the ?Company

September 29, 2017 EX-99.1

Motif Bio plc and subsidiary Interim Results Half-Year 2017 Financial Results and Operational Progress

Exhibit 99.1 September 29, 2017 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART DIRECTLY OR INDIRECTLY IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION The information contained within this announcement is deemed by Motif Bio plc to constitute inside information as stipulated under the Market Abu

September 29, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: September 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal

September 25, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: September 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal

September 25, 2017 EX-99.1

Motif Bio plc (“Motif” or the “Group”) Holding(s) in the Company

Exhibit 99.1 25 September 2017 Motif Bio plc (?Motif? or the ?Group?) Holding(s) in the Company Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that it was informed on 22 September 2017 by Amphion Innovations plc (?Amphion?) that a total of 4,390,000 ordinary shares in the Company had been sold in respect of a partial

September 15, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

6-K 1 a17-2214216k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: September 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 1

September 15, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio announces iclaprim granted Orphan Drug Designation by US FDA for treatment of Staphylococcus aureus lung infections in patients with cystic fibrosis

Exhibit 99.1 15 September 2017 Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio announces iclaprim granted Orphan Drug Designation by US FDA for treatment of Staphylococcus aureus lung infections in patients with cystic fibrosis Motif Bio plc (AIM/NASDAQ: MTFB), a clinical stage biopharmaceutical company specialising in developing novel antibiotics, announced today that the US Food and Drug

September 8, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: September 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal

September 8, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio to Host Investor and Analyst Event on September 20, 2017 in New York

Exhibit 99.1 08 September 2017 Motif Bio plc (“Motif Bio” or the “Company”) Motif Bio to Host Investor and Analyst Event on September 20, 2017 in New York Motif Bio plc (AIM/NASDAQ: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announces that the Company will host an Investor and Analyst Event on Wednesday, September 20, 2017, in New York fro

September 6, 2017 SC 13G

MTFB / Motif Bio plc ADRs / Morgan Richard C E - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Motif Bio plc (Name of Issuer) Ordinary Shares, par value £0.

September 6, 2017 SC 13G

Motif Bio plc ADRs SC 13G (Passive Acquisition of More Than 5% of Shares)

SC 13G 1 a17-213432sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Motif Bio plc (Name of Issuer) Ordinary Shares, par value £0.01 per share (Title of Class of Securities) 619784 101 (CUSIP Number) December 31, 2016 (Date of Event That Requires Filing of this Statement) Check the appropriate box to design

September 6, 2017 SC 13G

Motif Bio plc ADRs SC 13G (Passive Acquisition of More Than 5% of Shares)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Motif Bio plc (Name of Issuer) Ordinary Shares, par value ?0.

August 31, 2017 EX-99.1

Motif Bio plc (“Motif” or the “Company”) Motif Bio to present at upcoming investor and scientific conferences

Exhibit 99.1 31 August 2017 Motif Bio plc (?Motif? or the ?Company?) Motif Bio to present at upcoming investor and scientific conferences Motif Bio plc (AIM/NASDAQ: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announced today that the Company will present at the following conferences in September. Rodman & Renshaw 19th Annual Global Investment C

August 31, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: August 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal exe

August 9, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: August 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal exe

August 9, 2017 EX-99.1

Motif Bio plc (“Motif” or the “Company”) Motif Bio’s second Phase 3 clinical trial in ABSSSI finishes patient treatment phase

EX-99.1 2 a17-198951ex99d1.htm EX-99.1 Exhibit 99.1 9 August 2017 Motif Bio plc (“Motif” or the “Company”) Motif Bio’s second Phase 3 clinical trial in ABSSSI finishes patient treatment phase Motif Bio plc (AIM/NASDAQ: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announced today that the last patient has completed the treatment phase in REVIVE-2

July 18, 2017 EX-99.1

Motif Bio plc (“Motif” or the “Company”) Amendment to Amphion Innovations Consultancy Agreement

Exhibit 99.1 18 July 2017 Motif Bio plc (?Motif? or the ?Company?) Amendment to Amphion Innovations Consultancy Agreement Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that it has amended the terms of its consultancy agreement with Amphion Innovations plc. On April 1, 2015, the Group entered into a consultancy agreem

July 18, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: July 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

July 6, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: July 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

July 6, 2017 EX-99.1

MOTIF BIO TO PRESENT THREE POSTERS AT IDWEEK 2017

Exhibit 99.1 MOTIF BIO TO PRESENT THREE POSTERS AT IDWEEK 2017 NEW YORK, July 6, 2017 (GLOBE NEWSWIRE) ? Motif Bio plc (NASDAQ: MTFB; AIM: MTFB.LN), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, today announced that three abstracts have been accepted for poster presentations at the Infectious Diseases Week Annual Meeting in San Diego 4-8 October 2017. The

June 23, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

June 23, 2017 EX-99.1

Motif Bio Announces Result of General Meeting and Total Voting Rights

Exhibit 99.1 Motif Bio Announces Result of General Meeting and Total Voting Rights THIS ANNOUNCEMENT DOES NOT CONSTITUTE AN OFFERING OF ANY SECURITIES. ANY OFFERING OF SECURITIES BY THE COMPANY IS NOT ADDRESSED TO ANY PERSON WITH A REGISTERED ADDRESS IN, OR WHO IS RESIDENT IN, THE UNITED STATES OR ANY U.S. PERSON, AND NO SUCH PERSONS ARE ENTITLED TO PARTICIPATE IN ANY SUCH OFFERING. This announcem

June 22, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

June 22, 2017 EX-99.1

Motif Bio Invited to Present at Infectious Diseases Conference

Exhibit 99.1 Motif Bio Invited to Present at Infectious Diseases Conference NEW YORK, June 22, 2017 (GLOBE NEWSWIRE) ? Motif Bio plc (NASDAQ: MTFB; AIM: MTFB.LN), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, today announced that Dr. David Huang, Chief Medical Officer at Motif Bio, has been invited to present a clinical development overview of iclaprim du

June 16, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

June 16, 2017 EX-99.1

Motif Bio plc (the “Company”) Results of Annual General Meeting

Exhibit 99.1 15 June 2017 Motif Bio plc (the ?Company?) Results of Annual General Meeting Motif Bio plc (LSE: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that at the Annual General Meeting of Motif Bio plc held earlier today, all resolutions proposed were duly passed by the shareholders on a poll. The results of the poll, incorporatin

June 14, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

June 14, 2017 EX-99.1

Motif Bio to Present at BIO International Convention

Exhibit 99.1 Motif Bio to Present at BIO International Convention NEW YORK, June 14, 2017 (GLOBE NEWSWIRE) — Motif Bio plc (NASDAQ: MTFB; AIM: MTFB.LN), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, today announced that the Company will present at BIO 2017 being held at the San Diego Convention Center, 111 West Harbor Drive, San Diego from 19-22 June 2017

June 9, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

June 9, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Notification of change in holding of significant shareholder

Exhibit 99.1 8 June 2017 Motif Bio plc (?Motif Bio? or the ?Company?) Notification of change in holding of significant shareholder Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that it was informed on 7 June 2017 by Aviva plc & its subsidiaries (?Aviva?) that as at 6 June 2017 Aviva?s direct interest in shares in the

June 6, 2017 EX-99.2

Proof 3: 03-06-2017 Motif Bio PLC Form of Proxy I/We ................................................................................................................................................................ (block capitals please) of .........

Exhibit 99.2 Proof 3: 03-06-2017 Motif Bio PLC Form of Proxy I/We ................................................................................................................................................................ (block capitals please) of ..................................................................................................................................................

June 6, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

June 6, 2017 EX-99.1

Motif Bio plc (Incorporated and registered in England and Wales with registered No. 09320890) Notice of General Meeting in relation to a Placing of 66,666,667 New Ordinary Shares at 30 pence per share Nominated Adviser and Joint Broker Peel Hunt LLP

Exhibit 99.1 NOT FOR ONWARD RELEASE, PUBLICATION OR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, AUSTRALIA, CANADA, JAPAN OR THE REPUBLIC OF SOUTH AFRICA THIS DOCUMENT DOES NOT CONSTITUTE AN OFFERING OF ANY SECURITIES. ANY OFFERING OF SECURITIES BY THE COMPANY IS NOT ADDRESSED TO ANY PERSON WITH A REGISTERED ADDRESS IN, OR WHO IS RESIDENT IN, THE UNITED

June 2, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: June 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execu

June 2, 2017 EX-99.2

Motif Bio plc (“Motif Bio” or the “Company”) Result of Placing

Exhibit 99.2 2 June 2017 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, AUSTRALIA, CANADA, JAPAN OR THE REPUBLIC OF SOUTH AFRICA. THIS ANNOUNCEMENT DOES NOT CONSTITUTE AN OFFERING OF ANY SECURITIES. ANY OFFERING OF SECURITIES BY THE COMPANY IS NOT ADDRESSED TO ANY PERSON WITH A REGISTERED ADDRESS IN, OR WHO IS RESIDENT IN, T

June 2, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Proposed Placing to raise approximately £19.4m (US$25m)

Exhibit 99.1 2 June 2017 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, AUSTRALIA, CANADA, JAPAN OR THE REPUBLIC OF SOUTH AFRICA. THIS ANNOUNCEMENT (INCLUDING THE APPENDIX) DOES NOT CONSTITUTE AN OFFERING OF ANY SECURITIES. ANY OFFERING OF SECURITIES BY THE COMPANY IS NOT ADDRESSED TO ANY PERSON WITH A REGISTERED ADDRESS IN,

May 18, 2017 EX-99.2

Motif Bio plc (“Motif Bio” or the “Company”) Publication of UK Annual Report and Accounts & Notice of AGM

Exhibit 99.2 18 May 2017 Motif Bio plc (?Motif Bio? or the ?Company?) Publication of UK Annual Report and Accounts & Notice of AGM Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces its 2016 UK Annual Report and Accounts and notice of its Annual General Meeting have been posted to shareholders and will shortly be availabl

May 18, 2017 EX-99.1

Publication of UK Annual Report and Accounts & Notice of AGM

Exhibit 99.1 Publication of UK Annual Report and Accounts & Notice of AGM NEW YORK, May 18, 2017 (GLOBE NEWSWIRE) ? Motif Bio plc (NASDAQ: MTFB; AIM: MTFB.LN), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, today announced its 2016 UK Annual Report and Accounts and notice of its Annual General Meeting have been posted to shareholders and will shortly be av

May 18, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: May 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execut

May 10, 2017 EX-99.1

Motif Bio Appoints Scientific Opinion Leaders to Advisory Board

Exhibit 99.1 Motif Bio Appoints Scientific Opinion Leaders to Advisory Board NEW YORK, May 10, 2017 (GLOBE NEWSWIRE) ? Motif Bio plc (NASDAQ: MTFB; AIM: MTFB.LN), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, today announced the appointment of Dr.Thomas Lodise, Dr.Thomas Holland and Dr. William O?Riordan to the Clinical Advisory Board. The three new advis

May 10, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

6-K 1 a17-1283116k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: May 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (

May 5, 2017 EX-99.1

Motif Bio Appoints Dr. Craig Albanese as Non-Executive Director

Exhibit 99.1 Motif Bio Appoints Dr. Craig Albanese as Non-Executive Director NEW YORK, May 5, 2017 (GLOBE NEWSWIRE) — Motif Bio plc (NASDAQ: MTFB; AIM: MTFB.LN), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, today announced the appointment of Dr. Craig T. Albanese to the Company’s Board as Non-Executive Director with immediate effect. Dr. Albanese has 25

May 5, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: May 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execut

May 1, 2017 EX-99.1

Motif Bio Reports Year-End 2016 Financial Results

Exhibit 99.1 Motif Bio Reports Year-End 2016 Financial Results NEW YORK, May 1, 2017 (GLOBE NEWSWIRE) ? Motif Bio plc (NASDAQ: MTFB; AIM: MTFB.LN), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, today announced financial results for the year ended December 31, 2016. ?Motif Bio made significant progress in 2016 towards our goal of bringing our novel antibio

May 1, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: May 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor New York, New York 10011 (Address of principal execut

May 1, 2017 20-F

Motif Bio plc ADRs 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F (Mark One) o REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2016 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF

April 18, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: April 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor, Suite 2622 New York, New York 10011 (Address of pr

April 18, 2017 EX-99.1

Motif Bio Announces Positive Results for Iclaprim, in the REVIVE-1 Phase 3 Study

Exhibit 99.1 Motif Bio Announces Positive Results for Iclaprim, in the REVIVE-1 Phase 3 Study ? Iclaprim met the primary endpoint ? Iclaprim was well tolerated in the study ? Data from the second Phase 3 ABSSSI Trial, REVIVE-2, expected in the second half of 2017 ? NDA submission expected in the first half of 2018 Company to host conference call today at 8:00 am EDT, 1:00 pm BST NEW YORK, April 18

April 12, 2017 EX-99.1

Class/type of shares

Exhibit 99.1 TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ii Motif Bio plc 2. Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights An acquisition or disposal of qualifying financial instruments which may result in the acquisiti

April 12, 2017 6-K

Motif Bio plc ADRs 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: April 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor, Suite 2622 New York, New York 10011 (Address of pr

April 12, 2017 EX-99.2

Class/type of shares

Exhibit 99.2 TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ii Motif Bio plc 2. Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights An acquisition or disposal of qualifying financial instruments which may result in the acquisiti

February 8, 2017 6-K

MOTIF BIO 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: February 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor, Suite 2622 New York, New York 10011 (Address of

February 8, 2017 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Director and PDMR dealing - grant of options

Exhibit 99.1 8 February 2017 This announcement contains inside information Motif Bio plc (“Motif Bio” or the “Company”) Director and PDMR dealing - grant of options Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that the Company has granted options to purchase ordinary shares of 1 pence each of Motif Bio (“Ordinary Sh

January 30, 2017 EX-99.1

Motif Bio Phase 3 clinical trial finishes patient treatment phase

Exhibit 99.1 Motif Bio Phase 3 clinical trial finishes patient treatment phase NEW YORK, January 30, 2017 (GLOBE NEWSWIRE) ? Motif Bio plc (Motif)(NASDAQ: MTFB), (NASDAQ: MTFBW), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, today announced that the last patient has finished the treatment phase in REVIVE-1, the Phase 3 clinical trial investigating the saf

January 30, 2017 6-K

MOTIF BIO 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: January 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor, Suite 2622 New York, New York 10011 (Address of

January 17, 2017 EX-99.1

Appointment of Chief Financial Officer

Exhibit 99.1 Appointment of Chief Financial Officer NEW YORK, January 17, 2017 (GLOBE NEWSWIRE) — Motif Bio plc (Motif)(NASDAQ: MTFB), (NASDAQ: MTFBW), a clinical stage biopharmaceutical company specializing in developing novel antibiotics, announces that Robert Dickey IV has been appointed as Chief Financial Officer. Mr. Dickey is an accomplished financial professional with senior leadership expe

January 17, 2017 6-K

MOTIF BIO 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the Month of: January 2017 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of registrant as specified in its charter) 125 Park Avenue 25th Floor, Suite 2622 New York, New York 10011 (Address of

December 22, 2016 EX-99.2

Motif Bio plc Announces Conversion of Convertible Promissory Notes, PDMR Dealing and Total Voting Rights

Exhibit 99.2 Motif Bio plc Announces Conversion of Convertible Promissory Notes, PDMR Dealing and Total Voting Rights NEW YORK, December 22, 2016 (GLOBE NEWSWIRE) ?Motif Bio plc (Motif)(NASDAQ: MTFB), (NASDAQ: MTFBW), a clinical stage biopharmaceutical company specializing in developing novel antibiotics announced, that it has issued, in aggregate, 14,510,770 new ordinary shares in the Company (?O

December 22, 2016 6-K

MOTIF BIO 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Section 13a-16 or 15d-16 of the Securities Exchange Act of 1934 For the Month of: December 2016 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of Registrant as specified in its charter) 125 Park Avenue 25th Floor, Suite 2622 New York, New York 10011 (Address of

December 22, 2016 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”) Result of GM

Exhibit 99.1 21 December 2016 Motif Bio plc (“Motif Bio” or the “Company”) Result of GM Motif Bio plc (AIM: MTFB) the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that all resolutions put to shareholders at the Company’s General Meeting held earlier today were duly passed. For further information please contact: Motif Bio plc [email protected] Gr

December 5, 2016 EX-99.1

Motif Bio plc (“Motif Bio” or the “Company”)

Exhibit 99.1 Motif Bio plc (“Motif Bio” or the “Company”) 5 December 2016 PUBLICATION OF CIRCULAR AND NOTICE OF GENERAL MEETING Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that on Friday 2 December 2016 it sent to Shareholders a circular and notice of General Meeting to be held at the offices of Reed Smith LLP at T

December 5, 2016 6-K

MOTIF BIO 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER Pursuant to Section 13a-16 or 15d-16 of the Securities Exchange Act of 1934 For the Month of: December 2016 Commission File Number: 001-37847 MOTIF BIO PLC (Exact name of Registrant as specified in its charter) 125 Park Avenue 25th Floor, Suite 2622 New York, New York 10011 (Address of

November 29, 2016 SC 13D

MTFB / Motif Bio plc ADRs / Invesco Ltd. - MOTIF BIO PLC 11292016 Activist Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES ACT OF 1934 Motif Bio plc (Name of Issuer) Ordinary Shares, par value £0.01 per share (Title and Class of Securities) 619784101 (CUSIP Number) Nancy Tomassone Invesco Ltd. 1555 Peachtree Street, N.E., Suite 1800 Atlanta, Georgia 30309 Telephone number: (404) 892-0896 (Name, Address and Telephone Number of P

November 21, 2016 424B4

71,633,248 Ordinary Shares Including 48,769,820 Ordinary Shares in the Form of 2,438,491 American Depositary Shares together with Warrants to Purchase 1,219,246 American Depositary Shares in a U.S. Offering and 22,863,428 Ordinary Shares together wit

Use these links to rapidly review the document TABLE OF CONTENTS INDEX TO FINANCIAL STATEMENTS Table of Contents Filed Pursuant to Rule 424(B)(4) Registration No.

November 17, 2016 FWP

MOTIF BIO PLC FREE WRITING PROSPECTUS

Filed Pursuant to Rule 433 of the Securities Act of 1933 Issuer Free Writing Prospectus dated November 17, 2016 Relating to Preliminary Prospectus dated November 14, 2016 Registration No.

November 15, 2016 CORRESP

Motif Bio plc ADRs ESP

Motif Bio plc 125 Park Avenue 25th Floor, Suite 2622 New York, NY 10011 United States November 16, 2016 VIA EDGAR United States Securities and Exchange Commission 100 F Street, NE Washington, D.

November 15, 2016 CORRESP

Motif Bio plc ADRs ESP

November 16, 2016 VIA FACSIMILE AND EDGAR U.S. Securities and Exchange Commission Division of Corporate Finance Washington, DC 20549 Re: MOTIF BIO PLC Registration Statement on Form F-1 (Registration No. 333-212491) - Concurrence in Acceleration Request Ladies and Gentlemen: H.C. Wainwright & Co., LLC (?Wainwright?), as managing underwriter for the referenced offering, hereby concurs in the reques

November 14, 2016 F-1/A

MOTIF BIO F-1/A

F-1/A 1 a2230255zf-1a.htm F-1/A Use these links to rapidly review the document TABLE OF CONTENTS INDEX TO FINANCIAL STATEMENTS Table of Contents As filed with the Securities and Exchange Commission on November 14, 2016 Registration No. 333-212491 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 10 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1

November 14, 2016 CORRESP

Motif Bio plc ADRs ESP

599 Lexington Avenue New York, NY 10022-7650 +1 212 521 5400 Fax +1 212 521 5450 reedsmith.

November 4, 2016 F-1/A

MOTIF BIO F-1/A

QuickLinks - Click here to rapidly navigate through this document As filed with the Securities and Exchange Commission on November 4, 2016 Registration No.

November 4, 2016 EX-1.1

AMERICAN DEPOSITARY SHARES, EACH REPRESENTING 20 ORDINARY SHARES, £0.01 PAR VALUE, AND WARRANTS TO PURCHASE AMERICAN DEPOSITARY SHARES MOTIF BIO PLC UNDERWRITING AGREEMENT

Exhibit 1.1 AMERICAN DEPOSITARY SHARES, EACH REPRESENTING 20 ORDINARY SHARES, ?0.01 PAR VALUE, AND WARRANTS TO PURCHASE AMERICAN DEPOSITARY SHARES MOTIF BIO PLC UNDERWRITING AGREEMENT , 2016 H.C. Wainwright & Co., LLC As Representative of the Several Underwriters, if any, listed on Schedule I hereto 430 Park Avenue, 4th Floor New York, New York 10022 Ladies and Gentlemen: Motif Bio plc, a public l

November 4, 2016 EX-4.3

Form of Warrant Agent Agreement, between Motif Bio plc and The Bank of New York Mellon, as warrant agent; incorporated by reference to Exhibit 4.3 to the Registrant’s Registration Statement on Form F-1 (SEC File No. 333-212491)

Exhibit 4.3 WARRANT AGENT AGREEMENT WARRANT AGENT AGREEMENT (this ?Warrant Agreement?) dated as of , 2016 (the ?Issuance Date?) between Motif Bio plc, a company incorporated under the laws of England and Wales (the ?Company?), and The Bank of New York Mellon (the ?Warrant Agent?). WHEREAS, pursuant to the terms of that certain Underwriting Agreement (?Underwriting Agreement?), dated , 2016, betwee

November 4, 2016 EX-4.5

Form of Ordinary Share Warrant; incorporated by reference to Exhibit 4.5 to the Registrant’s Registration Statement on Form F-1 (SEC File No. 333-212491).

Exhibit 4.5 MOTIF BIO PLC WARRANT INSTRUMENT DATED: [?] 2016 Reed Smith LLP The Broadgate Tower 20 Primrose Street London EC2A 2RS Phone: +44 (0) 20 3116 3000 Fax: +44 (0) 20 3116 3999 DX1066 City / DX18 London reedsmith.com CONTENTS 1 DEFINITIONS AND INTERPRETATION 2 2 SUBSCRIPTION RIGHTS 5 3 WARRANT CERTIFICATES 6 4 EXERCISE OF WARRANTS 7 5 BENEFICIAL OWNERSHIP LIMITATION 10 6 CASHLESS EXERCISE

November 1, 2016 8-A12B/A

MOTIF BIO 8-A12B/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A/A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 MOTIF BIO PLC (Exact name of registrant as specified in its charter) United Kingdom Not Applicable (State of incorporation or organization) (I.R.S. Employer Identification No.) 125 Park Avenue 25

October 31, 2016 FWP

Motif Bio plc (?Motif Bio? or the ?Company?)

Filed Pursuant to Rule 433 Issuer Free Writing Prospectus Registration No. 333-212491 October 31, 2016 31 October 2016 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART DIRECTLY OR INDIRECTLY IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION Motif Bio plc (?Motif Bio? or the ?Company?) UPDATE ON TIM

October 31, 2016 F-1/A

MOTIF BIO F-1/A

Use these links to rapidly review the document TABLE OF CONTENTS INDEX TO FINANCIAL STATEMENTS Table of Contents As filed with the Securities and Exchange Commission on October 31, 2016 Registration No.

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