| Utestående aktier | 44,656,906 shares |
| Insideraktier | 1 602 359 shares |
| Insynsägande | 3,59 % |
| Totalt antal insynspersoner | 36 |
Insider Sentiment Score
Insider sentiment score hittar de företag som köps av foretagsinsynspersoner.
Det är resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av insiderackumulation. Poängmodellen använder en kombination av nettoantalet insiders som köpt de föregående 90 dagarna, det totala antalet aktier som köpts i procent av aktiekapitalet och det totala antalet aktier som ägs av insiders. Siffran sträcker sig från 0 till 100, med högre siffror som indikerar en högre nivå av ackumulering för sina kamrater, och 50 är genomsnittet.
Uppdateringsfrekvens: Dagligen
Se Insiders Top Picks, som ger en lista över företag med högsta insiderackumulation.
Office Sentiment Score
Officersentiment Score hittar företag som köps av Corporate Officers.
Per definition Corporate Officers är Corporate Insiders, men till skillnad från vissa av de andra Insiders (10 % aktieägare och styrelseledamöter), arbetar ämbetsmän för företaget dagligen och de använder sina egna pengar när de handlar . (10 % aktieägare och styrelseledamöter är ofta fondförvaltare som förvaltar andras pengar.) Som sådan är insideraffärer som görs av tjänstemän mycket mer betydelsefulla och bör behandlas på lämpligt sätt.
Liksom Insider Sentiment Score är Officer Sentiment Score resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av officersackumulering.
Uppdateringsfrekvens: Dagligen
Se insiderns bästa val, vilket ger en lista över företag med högsta insider sentiment.
Viktiga insidernyckeltal
Denna kort visar hur företaget rankas längs olika insidernyckeltal. Procenttilrankningen visar hur detta företag jämförs med andra företag på USA-marknaden. Högre rankingar indikerar bättre situationer.
Till exempel anses det allmänt att insiderköp är en positiv indikator, så företag med mer insiderköp skulle rankas högre än företag med mindre insiderköp (eller til och med insiderförsäljning).
Procent av flytande köpta av insiders (ranking)
0.034 %( )
337 out of 11226Procentandelen av aktier köpta av insiders är det totala antalet aktier som köpts av insiders minus det totala antalet aktier som sålts av insiders under de senaste 90 dagarna, dividerat med det totala antalet aktier och multiplicerat med 100.
Insiderhandelsdiagram
Iterum Therapeutics plc insideraffärer visas i följande diagram. Insiders är tjänstemän, styrelseledamöter eller betydande investerare i ett företag. I allmänhet är det i allmänhet olagligt för insiders att göra affärer i sina företag baserat på väsentlig, icke-offentlig information. Detta betyder inte att det är olagligt för dem att göra några affärer i sina egna företag. De måste dock rapportera alla affärer till SEC via ett formulär 4.
Insiderlista och lönsamhetsstatistik
Den här tabellen visar listan över kända insiders och genereras automatiskt från anmälningar som avslöjas till SEC. Förutom namnen, den senaste titeln och direktören, tjänstemannen eller ägarbeteckningen på 10 %, tillhandahåller vi de senaste avslöjade innehaven. Dessutom, när det är möjligt tillhandahåller vi insiderns historiska handelsresultat. Det historiska handelsresultatet är ett vägt genomsnitt av resultatet för faktiska köptransaktioner på den öppna marknaden som insidern gjort. För mer information om hur detta beräknas, titta på detta YouTube-webinarium.
See our leaderboard of most profitable insider traders.
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
| Brenton Karl Ahrens Director - [D] | 0 | 0 | |
|
Canaan X L.p.
Director, 10% Owner -
[D]
|
1 733 170 | 115 545 | |
|
Canaan Partners X LLC
Director, 10% Owner -
[D]
|
0 | 115 545 | |
| Mark Chin Director - [D] | 18 306 | 18 306 | |
|
Alexander J Denner
10% Owner -
|
0 | 0 | |
| Dunne Michael W. Director - [D] | 235 001 | 235 001 | |
| Paul R Edick Director - [D] | 31 390 | 2 093 | |
|
Fhm Vii, L.l.c.
10% Owner -
|
333 000 | 22 744 | |
|
Fhm Vii, L.p.
10% Owner -
|
333 000 | 22 744 | |
| Fishman Corey N. Chief Executive Officer, Director - [D] [O] | 137 062 | 137 062 | |
|
Frazier Healthcare VII, L.P.
10% Owner -
|
333 000 | 22 744 | |
|
Frazier Healthcare VII-A, L.P.
10% Owner -
|
333 000 | 22 744 |
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
|
James Healy
10% Owner -
|
1 226 514 | 81 768 | |
| Ronald Hunt Director - [D] | 91 122 | 91 122 | |
| Beth Hecht Director - [D] | 18 839 | 18 839 | |
| Patrick J Heron Director - [D] | 9 006 | 600 | |
| David George Kelly Director - [D] | 37 108 | 2 474 | |
|
Peter Kolchinsky
10% Owner -
|
11 651 597 | 776 773 | |
|
Vijay K Lathi
10% Owner -
|
384 615 | 25 641 | |
| Shahzad Malik Director - [D] | 838 325 | 55 888 | |
| Matthews Judith M. Chief Financial Officer - [O] | 8 135 | 8 135 | |
|
Anand Mehra
10% Owner -
|
1 726 514 | 115 101 | |
|
Michael Powell
10% Owner -
|
1 226 514 | 81 768 | |
| Sailaja Puttagunta Chief Medical Officer - [O] | 10 369 | 10 369 |
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
|
Ra Capital Management, Llc
10% Owner -
|
11 651 597 | 776 773 | |
|
RA Capital Healthcare Fund LP
10% Owner -
|
11 651 597 | 776 773 | |
|
Liam Ratcliffe
10% Owner -
|
384 615 | 25 641 | |
|
Sarissa Capital Catapult Fund LLC
10% Owner -
|
0 | 0 | |
|
Sarissa Capital Hawkeye Fund LP
10% Owner -
|
0 | 0 | |
|
Sarissa Capital Management LP
10% Owner -
|
0 | 0 | |
|
Sarissa Capital Master Fund II LP
10% Owner -
|
0 | 0 | |
|
Sarissa Capital Offshore Master Fund LP
10% Owner -
|
0 | 0 | |
| Schaffnit Jeffrey R. Chief Commercial Officer - [O] | 0 | 0 | |
|
Shah Rajeev M.
10% Owner -
|
11 651 597 | 776 773 | |
|
Sofinnova Management IX, L.L.C.
10% Owner -
|
1 226 514 | 81 768 | |
|
Sofinnova Venture Partners IX, L.P.
10% Owner -
|
1 226 514 | 81 768 |
Report errors via our new Insider Auditing Tool
Track Records av insiderköp - Kortsiktig vinstanalys
I denna sektion analyserar vi lönsamheten för varje oplanerat, öppet-marknads insiderköp gjorda i ITRM / Iterum Therapeutics plc. Denna analys hjälper till att förstå om insidern konsekvent genererar onormala avkastningar och är värd att följa. Denna analys är för ett år efter varje handel, och resultaten är teoretiska .
Tabellen nedan visar de senaste köpen på öppna marknaden som inte var en del av en automatisk handelsplan.
Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.
Track Records av insiderförsäljning - Kortsiktig förlustanalys
I denna sektion analyserar vi lönsamheten för varje oplanerat, öppet-marknads insiderköp gjorda i ITRM / Iterum Therapeutics plc. Denna analys hjälper till att förstå om insidern konsekvent genererar onormala avkastningar och är värd att följa. Denna analys är för ett år efter varje handel, och resultaten är teoretiska .
Tabellen nedan visar de senaste försäljningarna på öppna marknaden som inte var en del av en automatisk handelsplan.
Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.
Transaktionshistorik
Klicka på länkikonen för att se hela transaktionshistoriken. Transaktioner som rapporteras som en del av en automatisk handelsplan 10b5-1 kommer att ha ett X i kolumnen markerad 10b-5.
| Fil datum |
Handel datum |
Schema | Insider | Ticker | Värdepappertitel | Kod | Direkta | Utövningspris | Enhet pris |
Enheter ändrad |
Värde ändrad (1K) |
Kvarvarande Optioner |
Kvarvarande Aktier |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-08-12 | 2025-08-08 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 0,7236 | 15 000 | 11 | 235 001 | ||||
| 2024-08-12 | 2024-08-06 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 82 613 | 137 062 | ||||||
| 2024-08-12 | 2024-08-06 | 4 | HUNT RONALD By New Leaf Biopharma Opportunities II, L.P. | ITRM | Ordinary Shares | I | 65 481 | 91 122 | ||||||
| 2024-08-12 | 2024-08-06 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 182 453 | 253 898 | ||||||
| 2024-08-12 | 2024-08-06 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 106 247 | 220 001 | ||||||
| 2023-12-27 | 2023-12-22 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 1,4000 | 25 000 | 35 | 113 754 | ||||
| 2023-12-19 | 2023-12-18 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 1,8442 | 10 000 | 18 | 88 754 | ||||
| 2023-12-04 | 2023-12-01 | 4 | Puttagunta Sailaja | ITRM | Ordinary Shares | D | 2,1200 | −2 933 | −6 | 10 369 | ||||
| 2023-12-04 | 2023-12-01 | 4 | Puttagunta Sailaja | ITRM | Ordinary Shares | D | 8 333 | 13 302 | ||||||
| 2023-11-27 | 2023-11-22 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 2,0345 | 20 000 | 41 | 78 754 | ||||
| 2023-11-20 | 2023-11-20 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 1,5863 | 10 000 | 16 | 54 449 | ||||
| 2023-10-02 | 2023-10-01 | 4 | HUNT RONALD | ITRM | Ordinary Shares | D | 5 479 | 14 346 | ||||||
| 2023-10-02 | 2023-10-01 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 3 487 | 58 754 | ||||||
| 2023-07-03 | 2023-07-01 | 4 | HUNT RONALD | ITRM | Ordinary Shares | D | 2 796 | 8 867 | ||||||
| 2023-07-03 | 2023-07-01 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 1 779 | 55 267 | ||||||
| 2023-06-15 | 2023-06-15 | 4 | Hecht Beth | ITRM | Ordinary Shares | D | 15 853 | 18 839 | ||||||
| 2023-06-15 | 2023-06-15 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 15 853 | 53 488 | ||||||
| 2023-06-15 | 2023-06-15 | 4 | Chin Mark | ITRM | Ordinary Shares | D | 15 853 | 18 306 | ||||||
| 2023-06-05 | 2023-04-01 | 4/A | Dunne Michael W. | ITRM | Ordinary Shares | D | 1 299 | 37 635 | ||||||
| 2023-04-03 | 2023-04-01 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 1 299 | 37 636 | ||||||
| 2023-04-03 | 2023-04-01 | 4 | HUNT RONALD | ITRM | Ordinary Shares | D | 2 041 | 6 071 | ||||||
| 2023-03-14 | 2023-03-11 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 0,9600 | −2 883 | −3 | 8 135 | ||||
| 2023-03-14 | 2023-03-11 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 6 666 | 11 018 | ||||||
| 2023-03-14 | 2023-03-11 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 0,9600 | −5 683 | −5 | 44 449 | ||||
| 2023-03-14 | 2023-03-11 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 14 333 | 50 132 | ||||||
| 2023-01-04 | 2023-01-01 | 4 | HUNT RONALD | ITRM | Ordinary Shares | D | 1 197 | 4 030 | ||||||
| 2023-01-04 | 2023-01-01 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 761 | 36 337 | ||||||
| 2022-12-05 | 2022-12-02 | 4 | Puttagunta Sailaja | ITRM | Ordinary Shares | D | 1,3200 | −3 365 | −4 | 4 969 | ||||
| 2022-12-05 | 2022-12-01 | 4 | Puttagunta Sailaja | ITRM | Ordinary Shares | D | 8 334 | 8 334 | ||||||
| 2022-09-20 | 2022-09-20 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 1,7817 | −7 246 | −13 | 0 | ||||
| 2022-09-20 | 2022-09-19 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 1,7652 | −15 000 | −26 | 7 246 | ||||
| 2022-09-20 | 2022-09-16 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 1,9028 | −15 000 | −29 | 22 246 | ||||
| 2022-09-15 | 2022-09-15 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 2,0181 | −15 000 | −30 | 37 246 | ||||
| 2022-09-15 | 2022-09-14 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 2,0971 | −15 000 | −31 | 52 246 | ||||
| 2022-09-15 | 2022-09-13 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 2,1412 | −15 000 | −32 | 67 246 | ||||
| 2022-09-12 | 2022-09-12 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 2,3072 | −15 000 | −35 | 82 246 | ||||
| 2022-09-12 | 2022-09-09 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 2,3153 | −15 000 | −35 | 97 246 | ||||
| 2022-09-12 | 2022-09-08 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | I | 2,2635 | −3 298 | −7 | 112 246 | ||||
| 2022-09-09 | 2022-09-07 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 2,2200 | 10 000 | 22 | 35 576 | ||||
| 2022-06-24 | 2022-06-23 | 4 | Hecht Beth | ITRM | Ordinary Shares | D | 36 798 | 44 805 | ||||||
| 2022-06-24 | 2022-06-23 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 36 798 | 383 647 | ||||||
| 2022-06-24 | 2022-06-23 | 4 | Chin Mark | ITRM | Ordinary Shares | D | 36 798 | 36 798 | ||||||
| 2022-06-24 | 2022-06-23 | 4 | HUNT RONALD | ITRM | Ordinary Shares | D | 36 798 | 42 501 | ||||||
| 2022-03-29 | 2022-03-25 | 4 | Dunne Michael W. | ITRM | Restricted Share Units | D | 11 426 | 11 426 | ||||||
| 2022-03-29 | 2022-03-25 | 4 | Dunne Michael W. | ITRM | Restricted Share Units | D | −10 494 | 0 | ||||||
| 2022-03-29 | 2022-03-25 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 10 494 | 346 849 | ||||||
| 2022-03-29 | 2022-03-25 | 4 | Ahrens Brenton Karl | ITRM | Stock Option (Right to Buy) | D | 0,45 | 47 436 | 47 436 | |||||
| 2022-03-29 | 2022-03-25 | 4 | HUNT RONALD | ITRM | Restricted Share Units | D | 17 955 | 17 955 | ||||||
| 2022-03-22 | 2022-03-18 | 4 | Hecht Beth | ITRM | Restricted Share Units | D | −7 642 | 0 | ||||||
| 2022-03-22 | 2022-03-18 | 4 | Hecht Beth | ITRM | Ordinary Shares | D | 7 642 | 8 007 | ||||||
| 2022-03-15 | 2022-03-14 | 4/A | Matthews Judith M. | ITRM | Ordinary Shares | D | 0,3100 | −63 340 | −20 | 65 292 | ||||
| 2022-03-15 | 2022-03-14 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 0,3800 | −47 132 | −18 | 81 500 | ||||
| 2022-03-15 | 2022-03-11 | 4 | Matthews Judith M. | ITRM | Restricted Share Units | D | −100 000 | 100 000 | ||||||
| 2022-03-15 | 2022-03-11 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 100 000 | 128 632 | ||||||
| 2022-03-15 | 2022-03-11 | 4 | Fishman Corey N. | ITRM | Restricted Share Units | D | −215 000 | 215 000 | ||||||
| 2022-03-15 | 2022-03-11 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 215 000 | 537 008 | ||||||
| 2021-12-14 | 2021-12-10 | 4 | Puttagunta Sailaja | ITRM | Restricted Share Units | D | 500 000 | 500 000 | ||||||
| 2021-12-14 | 2021-12-10 | 4 | Puttagunta Sailaja | ITRM | Share Option (Right to Buy) | D | 0,48 | 1 800 000 | 1 800 000 | |||||
| 2021-07-27 | 2021-07-25 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 80 000 | 336 355 | ||||||
| 2021-06-25 | 2021-06-23 | 4 | Kelly David George | ITRM | Stock Option (Right to Buy) | D | 2,01 | 64 706 | 64 706 | |||||
| 2021-06-25 | 2021-06-23 | 4 | Chin Mark | ITRM | Restricted Stock Units | D | 36 798 | 36 798 | ||||||
| 2021-06-25 | 2021-06-23 | 4 | Matthews Judith M. | ITRM | Stock Option (Right to Buy) | D | 2,01 | 1 936 000 | 1 936 000 | |||||
| 2021-06-25 | 2021-06-23 | 4 | Hecht Beth | ITRM | Restricted Stock Units | D | 36 798 | 36 798 | ||||||
| 2021-06-25 | 2021-06-23 | 4 | HUNT RONALD | ITRM | Restricted Stock Units | D | 36 798 | 36 798 | ||||||
| 2021-06-25 | 2021-06-23 | 4 | Dunne Michael W. | ITRM | Restricted Stock Units | D | 36 798 | 36 798 | ||||||
| 2021-06-25 | 2021-06-23 | 4 | Ahrens Brenton Karl | ITRM | Stock Option (Right to Buy) | D | 2,01 | 64 706 | 64 706 | |||||
| 2021-06-25 | 2021-06-23 | 4 | Fishman Corey N. | ITRM | Stock Option (Right to Buy) | D | 2,01 | 5 280 000 | 5 280 000 | |||||
| 2021-04-21 | 3 | Hecht Beth | ITRM | Ordinary Shares | D | 365 | ||||||||
| 2021-03-29 | 2021-03-25 | 4 | Dunne Michael W. | ITRM | Restricted Stock Units | D | 10 494 | 10 494 | ||||||
| 2021-03-19 | 2021-03-18 | 4 | Hecht Beth | ITRM | Restricted Stock Units | D | 7 642 | 7 642 | ||||||
| 2021-03-15 | 2021-03-11 | 4 | Fishman Corey N. | ITRM | Restricted Share Units | D | 430 000 | 430 000 | ||||||
| 2021-03-15 | 2021-03-11 | 4 | Matthews Judith M. | ITRM | Restricted Share Units | D | 200 000 | 200 000 | ||||||
| 2021-03-03 | 2020-07-28 | 4 | Chin Mark | ITRM | Ordinary Shares | D | −11 857 | 0 | ||||||
| 2021-02-12 | 2021-02-12 | 4 | DENNER ALEXANDER J See footnotes | ITRM | Ordinary Shares | I | 2,2700 | −10 619 949 | −24 107 | 0 | ||||
| 2021-02-12 | 2021-02-11 | 4 | DENNER ALEXANDER J See Footnotes | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | −15 000 000 | 0 | ||||||
| 2021-02-12 | 2021-02-11 | 4 | DENNER ALEXANDER J See footnotes | ITRM | Ordinary Shares | I | 2,5900 | −10 000 000 | −25 900 | 10 619 949 | ||||
| 2021-02-12 | 2021-02-11 | 4 | DENNER ALEXANDER J See footnotes | ITRM | Ordinary Shares | I | 20 619 949 | 20 616 949 | ||||||
| 2021-02-08 | 2021-02-04 | 4 | RA CAPITAL MANAGEMENT, LLC See Footnotes | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | −8 486 000 | 0 | ||||||
| 2021-02-08 | 2021-02-04 | 4 | RA CAPITAL MANAGEMENT, LLC See Footnotes | ITRM | Ordinary Shares | I | 11 651 597 | 11 651 597 | ||||||
| 2021-01-27 | 2021-01-26 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 1,7300 | −85 445 | −148 | 322 008 | ||||
| 2021-01-27 | 2021-01-25 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 167 500 | 407 453 | ||||||
| 2021-01-27 | 2021-01-26 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 1,7300 | −33 868 | −59 | 28 632 | ||||
| 2021-01-27 | 2021-01-25 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 62 500 | 62 500 | ||||||
| 2021-01-27 | 2021-01-26 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 1,7300 | −33 143 | −57 | 256 355 | ||||
| 2021-01-27 | 2021-01-25 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 80 000 | 289 498 | ||||||
| 2020-10-28 | 2020-10-27 | 4 | Dunne Michael W. | ITRM | Warrants (right to buy) | D | 0,65 | 46 155 | 46 155 | |||||
| 2020-10-28 | 2020-10-27 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 61 540 | 209 498 | ||||||
| 2020-10-02 | 2020-09-30 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 1,6400 | −56 130 | −92 | 0 | ||||
| 2020-07-06 | 2020-07-01 | 4 | Heron Patrick J | ITRM | Restricted Stock Units | D | −2 852 | 0 | ||||||
| 2020-07-06 | 2020-07-01 | 4 | Heron Patrick J | ITRM | Ordinary Shares | D | 2 852 | 9 006 | ||||||
| 2020-07-02 | 2020-07-01 | 4 | HUNT RONALD | ITRM | Restricted Stock Units | D | −5 703 | 0 | ||||||
| 2020-07-02 | 2020-07-01 | 4 | HUNT RONALD | ITRM | Ordinary Shares | D | 5 703 | 5 703 | ||||||
| 2020-07-02 | 2020-07-01 | 4 | Chin Mark | ITRM | Restricted Stock Units | D | −5 703 | 0 | ||||||
| 2020-07-02 | 2020-07-01 | 4 | Chin Mark | ITRM | Ordinary Shares | D | 5 703 | 11 857 | ||||||
| 2020-06-16 | 2020-06-13 | 4 | Kelly David George | ITRM | Restricted Stock Units | D | −11 406 | 0 | ||||||
| 2020-06-16 | 2020-06-13 | 4 | Kelly David George | ITRM | Ordinary Shares | D | 11 406 | 37 108 | ||||||
| 2020-06-12 | 2020-06-10 | 4 | Kelly David George | ITRM | Stock Option (Right to Buy) | D | 1,68 | 62 840 | 62 840 | |||||
| 2020-06-03 | 2020-06-02 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | D | 1,6074 | −400 000 | −643 | 1 226 514 | ||||
| 2020-06-03 | 2020-06-01 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | D | 1,6912 | −100 000 | −169 | 1 626 514 | ||||
| 2020-04-09 | 2020-04-07 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 0 | |||||||
| 2020-04-09 | 2020-04-07 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | Ordinary Shares | I | −1 089 903 | 0 | ||||||
| 2020-01-23 | 2020-01-21 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | D | 1 750 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | CANAAN X L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | D | 2 000 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | Frazier Healthcare VII, L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | D | 333 000,0000 | 333 000 | 110 889 000 | 333 000 | ||||
| 2020-01-23 | 2020-01-21 | 4 | Frazier Healthcare VII, L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | D | 1 167 000,0000 | 1 167 000 | 1 361 889 000 | 1 167 000 | ||||
| 2020-01-23 | 2020-01-21 | 4 | Malik Shahzad By Advent Life Science Fund II LP. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 1 495 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | Malik Shahzad By Advent Life Sciences LLP | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 53 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | HUNT RONALD By New Leaf Biopharma Opportunities II, L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 792 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 2 208 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | HEALY JAMES By Sofinnova Venture Partners IX, L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 1 750 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | Ahrens Brenton Karl By Canaan X L.P | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 2 000 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 1 900 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | Heron Patrick J By Frazier Healthcare VII-A, L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 333 000,0000 | |||||||
| 2020-01-23 | 2020-01-21 | 4 | Heron Patrick J By Frazier Healthcare VII, L.P. | ITRM | 6.500% Exchangeable Senior Subordinated Note due 2025 | I | 1 167 000,0000 | |||||||
| 2019-06-17 | 2019-06-13 | 4 | HEALY JAMES | ITRM | Restricted Stock Units | D | −5 703 | 5 703 | ||||||
| 2019-06-17 | 2019-06-13 | 4 | Chin Mark | ITRM | Restricted Stock Units | D | 5 703 | 5 703 | ||||||
| 2019-06-17 | 2019-06-13 | 4 | Heron Patrick J | ITRM | Restricted Stock Units | D | 2 852 | 2 852 | ||||||
| 2019-06-17 | 2019-06-13 | 4 | Heron Patrick J | ITRM | Stock Option (Right to Buy) | D | 6,74 | 9 836 | 9 836 | |||||
| 2019-06-17 | 2019-06-13 | 4 | Malik Shahzad | ITRM | Stock Option (Right to Buy) | D | 6,74 | 19 671 | 19 671 | |||||
| 2019-06-17 | 2019-06-13 | 4 | HUNT RONALD | ITRM | Restricted Stock Units | D | 5 703 | 5 703 | ||||||
| 2019-06-17 | 2019-06-13 | 4 | Ahrens Brenton Karl | ITRM | Stock Option (Right to Buy) | D | 6,74 | 19 671 | 19 671 | |||||
| 2019-06-17 | 2019-06-13 | 4 | Kelly David George | ITRM | Restricted Stock Units | D | 11 406 | 11 406 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Kelly David George | ITRM | Restricted Stock Units | D | −6 154 | 0 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Kelly David George | ITRM | Ordinary Shares | D | 6 154 | 25 702 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Ahrens Brenton Karl | ITRM | Restricted Stock Units | D | −6 154 | 0 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Ahrens Brenton Karl | ITRM | Ordinary Shares | D | 6 154 | 6 154 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Heron Patrick J | ITRM | Restricted Stock Units | D | −6 154 | 0 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Heron Patrick J | ITRM | Ordinary Shares | D | 6 154 | 6 154 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Chin Mark | ITRM | Restricted Stock Units | D | −6 154 | 0 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Chin Mark | ITRM | Ordinary Shares | D | 6 154 | 6 154 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | HEALY JAMES | ITRM | Restricted Stock Units | D | −6 154 | 0 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | HEALY JAMES | ITRM | Ordinary Shares | D | 6 154 | 6 154 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Edick Paul R | ITRM | Restricted Stock Units | D | −6 154 | 0 | ||||||
| 2019-05-29 | 2019-05-24 | 4 | Edick Paul R | ITRM | Ordinary Shares | D | 6 154 | 31 390 | ||||||
| 2019-02-19 | 2019-02-15 | 4 | Dunne Michael W. | ITRM | Stock Option (Right to Buy) | D | 5,80 | 85 000 | 85 000 | |||||
| 2019-02-19 | 2019-02-15 | 4 | Fishman Corey N. | ITRM | Stock Option (Right to Buy) | D | 5,80 | 150 000 | 150 000 | |||||
| 2019-02-19 | 2019-02-15 | 4 | Matthews Judith M. | ITRM | Stock Option (Right to Buy) | D | 5,80 | 30 000 | 30 000 | |||||
| 2018-12-04 | 2018-11-30 | 4 | Kelly David George | ITRM | Ordinary Shares | D | 6,2887 | 10 000 | 63 | 19 548 | ||||
| 2018-11-01 | 2018-10-30 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | Ordinary Shares | I | 6,1000 | 58 000 | 354 | 1 089 903 | ||||
| 2018-09-06 | 2018-09-04 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 10,0000 | 500 | 5 | 147 958 | ||||
| 2018-08-28 | 2018-08-27 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 10,0000 | 500 | 5 | 147 458 | ||||
| 2018-08-28 | 2018-08-24 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 10,0000 | 500 | 5 | 146 958 | ||||
| 2018-08-27 | 2018-08-23 | 4 | Edick Paul R | ITRM | Ordinary Shares | D | 10,4374 | 500 | 5 | 25 236 | ||||
| 2018-08-21 | 2018-08-17 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 8,7328 | 2 000 | 17 | 239 953 | ||||
| 2018-06-01 | 2018-05-30 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | Series B-2 Preferred Shares | I | −248 721 | 0 | ||||||
| 2018-06-01 | 2018-05-30 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | Series B-1 Preferred Shares | I | −445 576 | 0 | ||||||
| 2018-06-01 | 2018-05-30 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | Ordinary Shares | I | 13,0000 | 337 606 | 4 389 | 1 031 903 | ||||
| 2018-06-01 | 2018-05-30 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | Ordinary Shares | I | 248 721 | 694 297 | ||||||
| 2018-06-01 | 2018-05-30 | 4 | Chin Mark By Arix Bioscience Holdings Ltd. | ITRM | Ordinary Shares | I | 445 576 | 445 576 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | Series B-2 Preferred Shares | I | −148 603 | 0 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | Series B-1 Preferred Shares | I | −178 230 | 0 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | Series A Preferred Shares | I | −466 793 | 0 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | HUNT RONALD By New Leaf Biopharma Opportunities II, L.P. | ITRM | Ordinary Shares | I | 13,0000 | 384 615 | 5 000 | 384 615 | ||||
| 2018-05-31 | 2018-05-30 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 13,0000 | 278 062 | 3 615 | 1 071 688 | ||||
| 2018-05-31 | 2018-05-30 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 148 603 | 793 626 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 178 230 | 645 023 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | HUNT RONALD By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 466 793 | 466 793 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | Lathi Vijay K By New Leaf Ventures III, L.P. | ITRM | Series B-2 Preferred Shares | I | −148 603 | 0 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | Lathi Vijay K By New Leaf Ventures III, L.P. | ITRM | Series B-1 Preferred Shares | I | −178 230 | 0 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | Lathi Vijay K By New Leaf Ventures III, L.P. | ITRM | Series A Preferred Shares | I | −466 793 | 0 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | Lathi Vijay K By New Leaf Biopharma Opportunities II, L.P. | ITRM | Ordinary Shares | I | 13,0000 | 384 615 | 5 000 | 384 615 | ||||
| 2018-05-31 | 2018-05-30 | 4 | Lathi Vijay K By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 13,0000 | 278 062 | 3 615 | 1 071 688 | ||||
| 2018-05-31 | 2018-05-30 | 4 | Lathi Vijay K By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 148 603 | 793 626 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | Lathi Vijay K By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 178 230 | 645 023 | ||||||
| 2018-05-31 | 2018-05-30 | 4 | Lathi Vijay K By New Leaf Ventures III, L.P. | ITRM | Ordinary Shares | I | 466 793 | 466 793 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Series B-2 Preferred Shares | D | −229 660 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Series B-1 Preferred Shares | D | −275 446 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Series A Preferred Shares | D | −721 408 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | D | 13,0000 | 500 000 | 6 500 | 1 726 514 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | D | 229 660 | 1 226 514 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | D | 275 446 | 996 854 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | D | 721 408 | 721 408 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Fishman Corey N. | ITRM | Series B-2 Preferred Shares | D | −1 591 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Fishman Corey N. | ITRM | Series B-1 Preferred Shares | D | −4 050 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Fishman Corey N. | ITRM | Series A Preferred Shares | D | −33 259 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 13,0000 | 3 000 | 39 | 237 953 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 1 591 | 234 953 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 4 050 | 233 362 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Fishman Corey N. | ITRM | Ordinary Shares | D | 33 259 | 229 312 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Dunne Michael W. | ITRM | Series B-2 Preferred Shares | D | −2 917 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Dunne Michael W. | ITRM | Series B-1 Preferred Shares | D | −4 050 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Dunne Michael W. | ITRM | Series A Preferred Shares | D | −12 730 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 13,0000 | 2 000 | 26 | 146 458 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 2 917 | 144 458 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 4 050 | 141 541 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Dunne Michael W. | ITRM | Ordinary Shares | D | 12 730 | 137 491 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Matthews Judith M. | ITRM | Series B-2 Preferred Shares | D | −2 466 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Matthews Judith M. | ITRM | Series B-1 Preferred Shares | D | −3 038 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Matthews Judith M. | ITRM | Series A Preferred Shares | D | −10 980 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 13,0000 | 4 000 | 52 | 56 130 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 2 466 | 52 130 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 3 038 | 49 664 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Matthews Judith M. | ITRM | Ordinary Shares | D | 10 980 | 46 626 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII-A, L.P. | ITRM | Series B-2 Preferred Shares | I | −44 940 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII-A, L.P. | ITRM | Series B-1 Preferred Shares | I | −53 899 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII-A, L.P. | ITRM | Series A Preferred Shares | I | −141 166 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII, L.P. | ITRM | Series B-2 Preferred Shares | I | −157 701 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII, L.P. | ITRM | Series B-1 Preferred Shares | I | −189 141 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII, L.P. | ITRM | Series A Preferred Shares | I | −495 370 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII-A, L.P. | ITRM | Ordinary Shares | I | 13,0000 | 101 150 | 1 315 | 341 155 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII-A, L.P. | ITRM | Ordinary Shares | I | 44 940 | 240 005 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII-A, L.P. | ITRM | Ordinary Shares | I | 53 899 | 195 065 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII-A, L.P. | ITRM | Ordinary Shares | I | 141 166 | 141 166 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII, L.P. | ITRM | Ordinary Shares | I | 13,0000 | 354 949 | 4 614 | 1 197 161 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII, L.P. | ITRM | Ordinary Shares | I | 157 701 | 842 212 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII, L.P. | ITRM | Ordinary Shares | I | 189 141 | 684 511 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Heron Patrick J By Frazier Healthcare VII, L.P. | ITRM | Ordinary Shares | I | 495 370 | 495 370 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Kelly David George | ITRM | Series A Preferred Shares | D | −9 548 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Kelly David George | ITRM | Ordinary Shares | D | 9 548 | 9 548 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Edick Paul R | ITRM | Series B-2 Preferred Shares | D | −1 591 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Edick Paul R | ITRM | Series B-1 Preferred Shares | D | −4 050 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Edick Paul R | ITRM | Series A Preferred Shares | D | −15 913 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Edick Paul R | ITRM | Ordinary Shares | D | 1 591 | 24 736 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Edick Paul R | ITRM | Ordinary Shares | D | 4 050 | 23 145 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Edick Paul R | ITRM | Ordinary Shares | D | 15 913 | 19 095 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | CANAAN X L.P. | ITRM | Series B-2 Preferred Shares | D | −229 660 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | CANAAN X L.P. | ITRM | Series B-1 Preferred Shares | D | −275 446 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | CANAAN X L.P. | ITRM | Series A Preferred Shares | D | −721 408 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | CANAAN X L.P. | ITRM | Ordinary Shares | D | 13,0000 | 506 656 | 6 587 | 1 733 170 | ||||
| 2018-05-30 | 2018-05-30 | 4 | CANAAN X L.P. | ITRM | Ordinary Shares | D | 229 660 | 1 226 514 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | CANAAN X L.P. | ITRM | Ordinary Shares | D | 275 446 | 996 854 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | CANAAN X L.P. | ITRM | Ordinary Shares | D | 721 408 | 721 408 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Ahrens Brenton Karl By Canaan X, L.P. | ITRM | Series B-2 Preferred Shares | I | −229 660 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Ahrens Brenton Karl By Canaan X, L.P. | ITRM | Series B-1 Preferred Shares | I | −275 446 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Ahrens Brenton Karl By Canaan X, L.P. | ITRM | Series A Preferred Shares | I | −721 408 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Ahrens Brenton Karl By Canaan X, L.P. | ITRM | Ordinary Shares | I | 13,0000 | 506 656 | 6 587 | 1 733 170 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Ahrens Brenton Karl By Canaan X, L.P. | ITRM | Ordinary Shares | I | 229 660 | 1 226 514 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Ahrens Brenton Karl By Canaan X, L.P. | ITRM | Ordinary Shares | I | 275 446 | 996 854 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Ahrens Brenton Karl By Canaan X, L.P. | ITRM | Ordinary Shares | I | 721 408 | 721 408 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences Fund II LP | ITRM | Series B-2 Preferred Shares | I | −218 338 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences Fund II LP | ITRM | Series B-1 Preferred Shares | I | −391 147 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences LLP | ITRM | Series B-2 Preferred Shares | I | −7 771 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences LLP | ITRM | Series B-1 Preferred Shares | I | −13 921 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences Fund II LP | ITRM | Ordinary Shares | I | 13,0000 | 228 840 | 2 975 | 838 325 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences Fund II LP | ITRM | Ordinary Shares | I | 218 338 | 609 485 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences Fund II LP | ITRM | Ordinary Shares | I | 391 147 | 391 147 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences LLP | ITRM | Ordinary Shares | I | 13,0000 | 8 144 | 106 | 29 836 | ||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences LLP | ITRM | Ordinary Shares | I | 7 771 | 21 692 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | Malik Shahzad By Advent Life Sciences LLP | ITRM | Ordinary Shares | I | 13 921 | 13 921 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | HEALY JAMES By Sofinnova Venture Partners IX, L.P. | ITRM | Series B-2 Preferred Shares | I | −229 660 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | HEALY JAMES By Sofinnova Venture Partners IX, L.P. | ITRM | Series B-1 Preferred Shares | I | −275 446 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | HEALY JAMES By Sofinnova Venture Partners IX, L.P. | ITRM | Series A Preferred Shares | I | −721 408 | 0 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | HEALY JAMES By Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | I | 13,0000 | 500 000 | 6 500 | 1 726 514 | ||||
| 2018-05-30 | 2018-05-30 | 4 | HEALY JAMES By Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | I | 229 660 | 1 226 514 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | HEALY JAMES By Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | I | 275 446 | 996 854 | ||||||
| 2018-05-30 | 2018-05-30 | 4 | HEALY JAMES By Sofinnova Venture Partners IX, L.P. | ITRM | Ordinary Shares | I | 721 408 | 721 408 | ||||||
| 2018-05-29 | 2018-05-24 | 4 | Chin Mark | ITRM | Restricted Stock Units | D | 6 154 | 6 154 | ||||||
| 2018-05-29 | 2018-05-24 | 4 | Edick Paul R | ITRM | Restricted Stock Units | D | 6 154 | 6 154 | ||||||
| 2018-05-29 | 2018-05-24 | 4 | Schaffnit Jeffrey R. | ITRM | Stock Option (Right to Buy) | D | 13,00 | 6 365 | 6 365 | |||||
| 2018-05-29 | 2018-05-24 | 4 | Schaffnit Jeffrey R. | ITRM | Stock Option (Right to Buy) | D | 13,00 | 25 461 | 25 461 | |||||
| 2018-05-29 | 2018-05-24 | 4 | HUNT RONALD | ITRM | Stock Option (Right to Buy) | D | 13,00 | 11 241 | 11 241 | |||||
| 2018-05-29 | 2018-05-24 | 4 | Matthews Judith M. | ITRM | Stock Option (Right to Buy) | D | 13,00 | 23 870 | 23 870 | |||||
| 2018-05-29 | 2018-05-24 | 4 | Fishman Corey N. | ITRM | Stock Option (Right to Buy) | D | 13,00 | 127 307 | 127 307 | |||||
| 2018-05-29 | 2018-05-24 | 4 | Ahrens Brenton Karl | ITRM | Restricted Stock Units | D | 6 154 | 6 154 | ||||||
| 2018-05-29 | 2018-05-24 | 4 | HEALY JAMES | ITRM | Restricted Stock Units | D | 6 154 | 6 154 | ||||||
| 2018-05-29 | 2018-05-24 | 4 | Dunne Michael W. | ITRM | Stock Option (Right to Buy) | D | 13,00 | 79 567 | 79 567 | |||||
| 2018-05-29 | 2018-05-24 | 4 | Malik Shahzad | ITRM | Stock Option (Right to Buy) | D | 13,00 | 11 241 | 11 241 | |||||
| 2018-05-29 | 2018-05-24 | 4 | Kelly David George | ITRM | Restricted Stock Units | D | 6 154 | 6 154 | ||||||
| 2018-05-29 | 2018-05-24 | 4 | Heron Patrick J | ITRM | Restricted Stock Units | D | 6 154 | 6 154 | ||||||
| 2018-05-24 | 3 | Fishman Corey N. | ITRM | Ordinary Shares | D | 392 106 | ||||||||
| 2018-05-24 | 3 | Fishman Corey N. | ITRM | Ordinary Shares | D | 392 106 | ||||||||
| 2018-05-24 | 3 | Fishman Corey N. | ITRM | Ordinary Shares | D | 392 106 | ||||||||
| 2018-05-24 | 3 | Dunne Michael W. | ITRM | Ordinary Shares | D | 249 522 | ||||||||
| 2018-05-24 | 3 | Dunne Michael W. | ITRM | Ordinary Shares | D | 249 522 | ||||||||
| 2018-05-24 | 3 | Dunne Michael W. | ITRM | Ordinary Shares | D | 249 522 | ||||||||
| 2018-05-24 | 3 | Matthews Judith M. | ITRM | Ordinary Shares | D | 71 292 | ||||||||
| 2018-05-24 | 3 | Matthews Judith M. | ITRM | Ordinary Shares | D | 71 292 | ||||||||
| 2018-05-24 | 3 | Matthews Judith M. | ITRM | Ordinary Shares | D | 71 292 | ||||||||
| 2018-05-24 | 3 | Schaffnit Jeffrey R. | ITRM | No securities are beneficially owned. | D | 0 | ||||||||
| 2018-05-24 | 3 | Edick Paul R | ITRM | Ordinary Shares | D | 6 364 | ||||||||
| 2018-05-24 | 3 | Edick Paul R | ITRM | Ordinary Shares | D | 6 364 | ||||||||
| 2018-05-24 | 3 | Edick Paul R | ITRM | Ordinary Shares | D | 6 364 |
P
Köp på öppna marknaden eller privat köp av icke-derivatsäkerhet
S
Köp på öppna marknaden eller privat försäljning av icke-derivatsäkerhet
A
Bevilja, tilldelning eller annat förvärv av värdepapper från företaget (såsom en option)
C
Omvandling av derivat
D
Försäljning eller överföring av värdepapper tillbaka til företaget
F
Betalning av lösenpris eller skatteskuld med del av värdepapper som erhållits från bolaget
G
Överlåtelse av värdepapper från eller till insidern
K
Aktieswappar och liknande säkringsaffärer
M
Utövande eller omvandling av derivatsäkerhet som erhållits från företaget (som en option)
V
En transaktion friviligt rapporterad på schema 4
J
Andra (med en fotnot som beskriver transaktionen)
