DRNA Insider Trading - Dicerna Pharmaceuticals Inc

Insideraktier

14 972 175 shares

Insider Sentiment Score

Insider sentiment score hittar de företag som köps av foretagsinsynspersoner.

Det är resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av insiderackumulation. Poängmodellen använder en kombination av nettoantalet insiders som köpt de föregående 90 dagarna, det totala antalet aktier som köpts i procent av aktiekapitalet och det totala antalet aktier som ägs av insiders. Siffran sträcker sig från 0 till 100, med högre siffror som indikerar en högre nivå av ackumulering för sina kamrater, och 50 är genomsnittet.

Uppdateringsfrekvens: Dagligen

Se Insiders Top Picks, som ger en lista över företag med högsta insiderackumulation.

Se Högst rankade aktier

Office Sentiment Score

Officersentiment Score hittar företag som köps av Corporate Officers.

Per definition Corporate Officers är Corporate Insiders, men till skillnad från vissa av de andra Insiders (10 % aktieägare och styrelseledamöter), arbetar ämbetsmän för företaget dagligen och de använder sina egna pengar när de handlar . (10 % aktieägare och styrelseledamöter är ofta fondförvaltare som förvaltar andras pengar.) Som sådan är insideraffärer som görs av tjänstemän mycket mer betydelsefulla och bör behandlas på lämpligt sätt.

Liksom Insider Sentiment Score är Officer Sentiment Score resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av officersackumulering.

Uppdateringsfrekvens: Dagligen

Se insiderns bästa val, vilket ger en lista över företag med högsta insider sentiment.

Se Högst rankade aktier

Viktiga insidernyckeltal

Denna kort visar hur företaget rankas längs olika insidernyckeltal. Procenttilrankningen visar hur detta företag jämförs med andra företag på USA-marknaden. Högre rankingar indikerar bättre situationer.

Till exempel anses det allmänt att insiderköp är en positiv indikator, så företag med mer insiderköp skulle rankas högre än företag med mindre insiderköp (eller til och med insiderförsäljning).

Nettoantalet insiders som köper (rankning)

N/A

Nettoantalet insiders som köper är den totala mängden insiders som säljer minus det totala antalet insiders som säljer under de senaste 90 dagarna. Percentilrankningen visas här (intervall från 0 till 100%).

Procent av flytande köpta av insiders (ranking)

N/A

Procentandelen av aktier köpta av insiders är det totala antalet aktier som köpts av insiders minus det totala antalet aktier som sålts av insiders under de senaste 90 dagarna, dividerat med det totala antalet aktier och multiplicerat med 100.

Insiderhandelsdiagram

Dicerna Pharmaceuticals Inc insideraffärer visas i följande diagram. Insiders är tjänstemän, styrelseledamöter eller betydande investerare i ett företag. I allmänhet är det i allmänhet olagligt för insiders att göra affärer i sina företag baserat på väsentlig, icke-offentlig information. Detta betyder inte att det är olagligt för dem att göra några affärer i sina egna företag. De måste dock rapportera alla affärer till SEC via ett formulär 4.

Insiderlista och lönsamhetsstatistik

Den här tabellen visar listan över kända insiders och genereras automatiskt från anmälningar som avslöjas till SEC. Förutom namnen, den senaste titeln och direktören, tjänstemannen eller ägarbeteckningen på 10 %, tillhandahåller vi de senaste avslöjade innehaven. Dessutom, när det är möjligt tillhandahåller vi insiderns historiska handelsresultat. Det historiska handelsresultatet är ett vägt genomsnitt av resultatet för faktiska köptransaktioner på den öppna marknaden som insidern gjort. För mer information om hur detta beräknas, titta på detta YouTube-webinarium.

See our leaderboard of most profitable insider traders.

Insider	Genomsnitt vinst (%)	Aktier Ägda	Delad Justerad

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Track Records av insiderköp - Kortsiktig vinstanalys

I denna sektion analyserar vi lönsamheten för varje oplanerat, öppet-marknads insiderköp gjorda i DRNA / Dicerna Pharmaceuticals Inc. Denna analys hjälper till att förstå om insidern konsekvent genererar onormala avkastningar och är värd att följa. Denna analys är för ett år efter varje handel, och resultaten är teoretiska .

Tabellen nedan visar de senaste köpen på öppna marknaden som inte var en del av en automatisk handelsplan.

Handelsdatum	Insider	Rapporterade aktier	Rapporterat pris	Justerade aktier	Justerat pris	Kostnadsbasis	Dagar til Max	Pris vid Max	Maximal vinst ($)	Maximal avkastning (%)
2021-08-10	KOZIN MARC D	3 000	23,6620	3 000	23,6620	70 986	115	38.25	43 764	61,65
2021-08-10	FAMBROUGH DOUGLAS	5 000	22,0960	5 000	22,0960	110 480
2020-09-01	FAMBROUGH DOUGLAS	10 000	18,0597	10 000	18,0597	180 597
2017-12-18	Bain Capital Life Sciences Investors, LLC	285 000	7,0000	285 000	7,0000	1 995 000
2016-11-15	FAMBROUGH DOUGLAS	16 500	3,6300	16 500	3,6300	59 895
2016-11-14	FAMBROUGH DOUGLAS	16 600	3,7800	16 600	3,7800	62 748
2016-05-12	Weissman James B	530	3,2897	530	3,2897	1 744

Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.

DRNA / Dicerna Pharmaceuticals Inc Insider Trades

Track Records av insiderförsäljning - Kortsiktig förlustanalys

Tabellen nedan visar de senaste försäljningarna på öppna marknaden som inte var en del av en automatisk handelsplan.

Handelsdatum	Insider	Rapporterade aktier	Rapporterat pris	Justerade aktier	Justerat pris	Kostnadsbasis	Dagar til Min	Pris vid Min	Maximal förlust undvikits ($)	Maximal förlust undvikits ($)
2021-09-17	Aradhye Shreeram	2 056	21,4700	2 056	21,4700	44 142	19	19.26	−4 543	−10,29
2021-09-17	Zeng Ling	1 334	21,4700	1 334	21,4700	28 641
2021-06-25	Paglia Regina M.	1 000	38,0037	1 000	38,0037	38 004
2021-06-22	Paglia Regina M.	13 555	37,0957	13 555	37,0957	502 832
2021-06-22	Paglia Regina M.	4 880	36,7108	4 880	36,7108	179 149
2021-06-17	Paglia Regina M.	8 664	35,7881	8 664	35,7881	310 068
2021-06-16	Paglia Regina M.	31 464	35,6284	31 464	35,6284	1 121 012
2021-06-16	Paglia Regina M.	100	36,1500	100	36,1500	3 615
2020-12-10	Koppel Adam	1 000 000	23,4000	1 000 000	23,4000	23 400 000

Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.

Transaktionshistorik

Klicka på länkikonen för att se hela transaktionshistoriken. Transaktioner som rapporteras som en del av en automatisk handelsplan 10b5-1 kommer att ha ett X i kolumnen markerad 10b-5.

Fil datum	Handel datum	Schema	Insider	Ticker	Värdepappertitel	Kod	Direkta	Utövningspris	Enhet pris	Enheter ändrad	Värde ändrad (1K)	Kvarvarande Optioner	Kvarvarande Aktier
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		−15 000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		−15 000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		−25 000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		−25 000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	13,08		−25 000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,47		−25 000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−3 333		0
2021-12-29	2021-12-28	4	Koppel Adam See footnotes	DRNA	Common Stock	U - Other	I		38,2500	−3 080 237	−117 819		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Common Stock	U - Other	D		38,2500	−3 333	−127		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		−68 100		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	22,58		−121 300		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,50		−75 000		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	16,30		−111 800		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	11,77		−180 000		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,30		−105 000		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,09		−33 999		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	2,97		−11 879		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−11 325		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−25 950		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Common Stock	U - Other	D		38,2500	−18 100	−692		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		−46 120		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,69		−81 825		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−13 669		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−7 688		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Common Stock	U - Other	D		38,2500	−5 032	−192		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		−15 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,26		−15 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		−15 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	18,73		−15 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		−25 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	16,30		−25 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		−25 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	13,87		−15 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	13,08		−25 000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−3 333		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Common Stock	U - Other	D		38,2500	−16 157	−618		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		−15 000		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		−15 000		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	10,31		−25 000		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		−25 000		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−3 333		0
2021-12-29	2021-12-28	4	KOZIN MARC D By Marc D. Kozin Revocable Trust	DRNA	Common Stock	D - Sale to Issuer	I		38,2500	−5 000	−191		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Common Stock	D - Sale to Issuer	D		38,2500	−6 333	−242		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		−36 900		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	20,79		−95 650		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−6 150		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−20 475		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Common Stock	U - Other	D		38,2500	−7 775	−297		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		−15 000		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		−15 000		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	14,32		−25 000		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−3 333		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Common Stock	U - Other	D		38,2500	−3 333	−127		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		−15 000		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		−15 000		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		−25 000		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	14,76		−25 000		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−3 333		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Common Stock	U - Other	D		38,2500	−3 333	−127		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		−15 000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		−15 000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,26		−25 000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		−25 000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	13,08		−25 000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		−25 000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−3 333		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Common Stock	U - Other	D		38,2500	−3 333	−127		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		−15 000		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		−15 000		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,61		−25 000		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−3 333		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Common Stock	U - Other	D		38,2500	−3 333	−127		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		−247 700		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	22,58		−250 000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,50		−225 000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,09		−225 000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS By Trust	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	I	16,30		−200 000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS By Trust	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	I	16,30		−200 000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	16,30		−71 900		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	11,77		−505 000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,30		−255 000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		−55 055		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		−281 250		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	2,97		−191 330		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−41 250		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−59 850		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	D - Sale to Issuer	D		38,2500	−231 431	−8 852		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		−51 070		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,69		−124 700		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−8 513		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−21 075		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Common Stock	U - Other	D		38,2500	−6 973	−267		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		−68 100		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	22,58		−121 300		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,50		−75 000		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	16,30		−165 050		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	11,77		−180 000		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,30		−105 000		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,09		−85 000		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−11 325		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−25 950		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Common Stock	U - Other	D		38,2500	−2 367	−91		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		−61 500		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	22,58		−76 144		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	15,61		−270 000		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−17 325		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−10 275		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Common Stock	U - Other	D		38,2500	−14 813	−567		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		−15 000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		−21 000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		−33 000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	14,76		−25 000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	14,13		−8 000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Restricted Stock Units	D - Sale to Issuer	D			−3 333		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Common Stock	U - Other	D		38,2500	−4 666	−178		0
2021-12-17	2021-12-15	4	Aradhye Shreeram	DRNA	Restricted Stock Units	M - Exercise	D			−2 837		8 513
2021-12-17	2021-12-15	4	Aradhye Shreeram	DRNA	Common Stock	F - Taxes	D		38,0500	−833	−32		6 973
2021-12-17	2021-12-15	4	Aradhye Shreeram	DRNA	Common Stock	M - Exercise	D			2 837			7 806
2021-12-17	2021-12-15	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	M - Exercise	D			−3 425		10 275
2021-12-17	2021-12-15	4	Ciappenelli Robert D.	DRNA	Common Stock	F - Taxes	D		38,0500	−1 241	−47		14 813
2021-12-17	2021-12-15	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D			3 425			16 054
2021-12-17	2021-12-15	4	Pagan Douglas W.	DRNA	Restricted Stock Units	M - Exercise	D			−2 050		6 150
2021-12-17	2021-12-15	4	Pagan Douglas W.	DRNA	Common Stock	F - Taxes	D		38,0500	−602	−23		7 775
2021-12-17	2021-12-15	4	Pagan Douglas W.	DRNA	Common Stock	M - Exercise	D			2 050			8 377
2021-12-17	2021-12-15	4	Zeng Ling	DRNA	Restricted Stock Units	M - Exercise	D			−2 562		7 688
2021-12-17	2021-12-15	4	Zeng Ling	DRNA	Common Stock	F - Taxes	D		38,0500	−752	−29		5 032
2021-12-17	2021-12-15	4	Zeng Ling	DRNA	Common Stock	M - Exercise	D			2 562			5 784
2021-12-17	2021-12-15	4	Brown Bob D	DRNA	Restricted Stock Units	M - Exercise	D			−3 775		11 325
2021-12-17	2021-12-15	4	Brown Bob D	DRNA	Common Stock	F - Taxes	D		38,0500	−1 675	−64		2 367
2021-12-17	2021-12-15	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D			3 775			4 042
2021-12-17	2021-12-15	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	M - Exercise	D			−13 750		41 250
2021-12-17	2021-12-15	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	F - Taxes	D		38,0500	−5 348	−203		231 431
2021-12-17	2021-12-15	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D			13 750			236 779
2021-12-17	2021-12-15	4	Weissman James B	DRNA	Restricted Stock Units	M - Exercise	D			−3 775		11 325
2021-12-17	2021-12-15	4	Weissman James B	DRNA	Common Stock	F - Taxes	D		38,0500	−1 675	−64		18 100
2021-12-17	2021-12-15	4	Weissman James B	DRNA	Common Stock	M - Exercise	D			3 775			19 775
2021-12-14	2021-12-13	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	22,58		−8 856		76 144
2021-12-14	2021-12-13	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D		22,5800	8 856	200		12 629
2021-12-13	2021-12-10	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−146 195		55 055
2021-12-13	2021-12-10	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−33 670		191 330
2021-12-13	2021-12-10	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		3,4200	146 195	500		223 029
2021-12-13	2021-12-10	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		2,9700	33 670	100		76 834
2021-11-22	2021-11-18	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−24 936		0
2021-11-22	2021-11-18	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		37,9400	−24 936	−946		267
2021-11-22	2021-11-18	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	24 936	85		25 203
2021-09-21	2021-09-17	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0596	−21 250	−448		267
2021-09-17	2021-09-17	4	Zeng Ling	DRNA	Common Stock	S - Sale	D		21,4700	−1 334	−29		3 222
2021-09-17	2021-09-15	4	Zeng Ling	DRNA	Restricted Stock Units	M - Exercise	D			−4 556		13 669
2021-09-17	2021-09-15	4	Zeng Ling	DRNA	Common Stock	M - Exercise	D			4 556			4 556
2021-09-17	2021-09-17	4	Aradhye Shreeram	DRNA	Common Stock	S - Sale	D		21,4700	−2 056	−44		4 969
2021-09-17	2021-09-15	4	Aradhye Shreeram	DRNA	Restricted Stock Units	M - Exercise	D			−7 025		21 075
2021-09-17	2021-09-15	4	Aradhye Shreeram	DRNA	Common Stock	M - Exercise	D			7 025			7 025
2021-08-10	2021-08-10	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		22,0960	5 000	110		43 164
2021-08-10	2021-08-10	4	KOZIN MARC D	DRNA	Common Stock	P - Purchase	D		23,6620	3 000	71		6 333
2021-08-03	2021-08-02	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 312		24 936
2021-08-03	2021-08-02	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		37,3770	−8 312	−311		21 517
2021-08-03	2021-08-02	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 312	28		29 829
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Restricted Stock Units	M - Exercise	D			−1 712		11 988
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Restricted Stock Units	M - Exercise	D			−1 450		7 250
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Common Stock	F - Taxes	D		37,0500	−1 404	−52		2 027
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D			1 712			3 431
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D			1 450			1 719
2021-07-08	2021-07-06	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−30 000		33 999
2021-07-08	2021-07-06	4	Weissman James B	DRNA	Common Stock	S - Sale	D		39,0900	−30 000	−1 173		16 000
2021-07-08	2021-07-06	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		9,0900	30 000	273		46 000
2021-07-06	2021-07-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 312		33 248
2021-07-06	2021-07-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		37,8466	−1 066	−40		21 517
2021-07-06	2021-07-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		37,3029	−7 246	−270		22 583
2021-07-06	2021-07-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 312	28		29 829
2021-06-29	2021-06-25	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	22,58		−1 000		49 221
2021-06-29	2021-06-25	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		38,0037	−1 000	−38		269
2021-06-29	2021-06-25	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		22,5800	1 000	23		1 269
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	24,05		−2 406		55 094
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	22,58		−2 279		50 221
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−13 750		85 000
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		36,7108	−4 880	−179		269
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		37,0957	−13 555	−503		5 149
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		24,0500	2 406	58		18 704
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		22,5800	2 279	51		16 298
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	13 750	178		14 019
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	24,05		−4 000		57 500
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−4 664		98 750
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		35,7881	−8 664	−310		269
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		24,0500	4 000	96		8 933
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4 664	60		4 933
2021-06-17	2021-06-15	4	Pagan Douglas W.	DRNA	Restricted Stock Units	M - Exercise	D			−6 825		20 475
2021-06-17	2021-06-15	4	Pagan Douglas W.	DRNA	Common Stock	F - Taxes	D		35,7400	−2 004	−72		5 760
2021-06-17	2021-06-15	4	Pagan Douglas W.	DRNA	Common Stock	M - Exercise	D			6 825			7 764
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	26,62		−1 564		5 261
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	22,58		−10 000		52 500
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−20 000		103 414
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		36,1500	−100	−4		269
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		35,6284	−31 464	−1 121		369
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		26,6200	1 564	42		31 833
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		22,5800	10 000	226		30 269
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	20 000	259		20 269
2021-06-17	2021-06-15	4	Paglia Regina M.	DRNA	Restricted Stock Units	M - Exercise	D			−381		1 144
2021-06-17	2021-06-15	4	Paglia Regina M.	DRNA	Common Stock	F - Taxes	D		35,7400	−112	−4		269
2021-06-17	2021-06-15	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D			381			381
2021-06-15	2021-06-14	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	15,61		−20 000		270 000
2021-06-15	2021-06-14	4	Ciappenelli Robert D.	DRNA	Common Stock	S - Sale	D		38,0000	−20 000	−760		3 773
2021-06-15	2021-06-14	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D		15,6100	20 000	312		23 773
2021-06-15	2021-06-11	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	15,61		−10 000		290 000
2021-06-15	2021-06-11	4	Ciappenelli Robert D.	DRNA	Common Stock	S - Sale	D		35,0000	−10 000	−350		3 773
2021-06-15	2021-06-11	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D		15,6100	10 000	156		13 773
2021-06-15	2021-06-11	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−10 000		85 000
2021-06-15	2021-06-11	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		34,0000	−10 000	−340		21 517
2021-06-15	2021-06-11	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	10 000	91		31 517
2021-06-08	2021-06-07	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−10 000		95 000
2021-06-08	2021-06-07	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		33,0000	−10 000	−330		21 517
2021-06-08	2021-06-07	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	10 000	91		31 517
2021-06-07	2021-06-03	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15 000		15 000
2021-06-07	2021-06-03	4	HOFFMAN STEPHEN J	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2021-06-07	2021-06-03	4	HOFFMAN STEPHEN J	DRNA	Restricted Stock Units	M - Exercise	D			−3 333		0
2021-06-07	2021-06-03	4	HOFFMAN STEPHEN J	DRNA	Common Stock	M - Exercise	D			3 333			29 071
2021-06-07	2021-06-03	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15 000		15 000
2021-06-07	2021-06-03	4	Freed Martin I	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2021-06-07	2021-06-03	4	Freed Martin I	DRNA	Restricted Stock Units	M - Exercise	D			−3 333		0
2021-06-07	2021-06-03	4	Freed Martin I	DRNA	Common Stock	M - Exercise	D			3 333			3 333
2021-06-07	2021-06-03	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15 000		15 000
2021-06-07	2021-06-03	4	Smith Cynthia	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2021-06-07	2021-06-03	4	Smith Cynthia	DRNA	Restricted Stock Units	M - Exercise	D			−3 333		0
2021-06-07	2021-06-03	4	Smith Cynthia	DRNA	Common Stock	M - Exercise	D			3 333			3 333
2021-06-07	2021-06-03	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15 000		15 000
2021-06-07	2021-06-03	4	KOZIN MARC D	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2021-06-07	2021-06-03	4	KOZIN MARC D	DRNA	Restricted Stock Units	M - Exercise	D			−3 333		0
2021-06-07	2021-06-03	4	KOZIN MARC D	DRNA	Common Stock	M - Exercise	D			3 333			3 333
2021-06-07	2021-06-03	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15 000		15 000
2021-06-07	2021-06-03	4	GRAY PATRICK M.	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2021-06-07	2021-06-03	4	GRAY PATRICK M.	DRNA	Restricted Stock Units	M - Exercise	D			−3 333		0
2021-06-07	2021-06-03	4	GRAY PATRICK M.	DRNA	Common Stock	M - Exercise	D			3 333			3 333
2021-06-07	2021-06-03	4	Protopapas Anna	DRNA	Restricted Stock Units	M - Exercise	D			−3 333		0
2021-06-07	2021-06-03	4	Protopapas Anna	DRNA	Common Stock	M - Exercise	D			3 333			3 333
2021-06-07	2021-06-03	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15 000		15 000
2021-06-07	2021-06-03	4	BUCHI J KEVIN	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2021-06-07	2021-06-03	4	BUCHI J KEVIN	DRNA	Restricted Stock Units	M - Exercise	D			−4 666		0
2021-06-07	2021-06-03	4	BUCHI J KEVIN	DRNA	Common Stock	M - Exercise	D			4 666			4 666
2021-06-07	2021-06-03	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15 000		15 000
2021-06-07	2021-06-03	4	Doberstein Stephen K	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2021-06-07	2021-06-03	4	Doberstein Stephen K	DRNA	Restricted Stock Units	M - Exercise	D			−3 333		0
2021-06-07	2021-06-03	4	Doberstein Stephen K	DRNA	Common Stock	M - Exercise	D			3 333			3 333
2021-06-07	2021-06-03	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15 000		15 000
2021-06-07	2021-06-03	4	Koppel Adam	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2021-06-07	2021-06-03	4	Koppel Adam	DRNA	Restricted Stock Units	M - Exercise	D			−3 333		0
2021-06-07	2021-06-03	4	Koppel Adam	DRNA	Common Stock	M - Exercise	D			3 333			3 333
2021-06-03	2021-06-01	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−4 431		123 414
2021-06-03	2021-06-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		31,9687	−305	−10		0
2021-06-03	2021-06-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		30,8599	−4 126	−127		305
2021-06-03	2021-06-01	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4 431	57		4 431
2021-06-03	2021-06-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 312		41 560
2021-06-03	2021-06-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		32,0165	−342	−11		21 517
2021-06-03	2021-06-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		30,8818	−7 970	−246		21 859
2021-06-03	2021-06-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 312	28		29 829
2021-05-05	2021-05-03	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−4 431		127 845
2021-05-05	2021-05-03	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		31,2485	−475	−15		0
2021-05-05	2021-05-03	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		30,1692	−3 956	−119		475
2021-05-05	2021-05-03	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4 431	57		4 431
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 312		49 872
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		31,6600	−24	−1		21 517
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		31,0103	−1 135	−35		21 541
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		30,1574	−7 153	−216		22 676
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 312	28		29 829
2021-05-03	2021-04-30	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−10 000		105 000
2021-05-03	2021-04-30	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		32,0000	−10 000	−320		21 517
2021-05-03	2021-04-30	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	10 000	91		31 517
2021-05-03	2021-04-29	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−10 000		115 000
2021-05-03	2021-04-29	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		31,0000	−10 000	−310		21 517
2021-05-03	2021-04-29	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	10 000	91		31 517
2021-04-20	2021-04-16	4	Weissman James B	DRNA	Common Stock	S - Sale	D		29,9900	−4 904	−147		16 000
2021-04-05	2021-04-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 312		58 184
2021-04-05	2021-04-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		26,4950	−188	−5		21 517
2021-04-05	2021-04-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,8548	−8 124	−210		21 705
2021-04-05	2021-04-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 312	28		29 829
2021-04-05	2021-03-01	4/A	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 312		66 496
2021-04-05	2021-03-01	4/A	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 312	28		29 829
2021-04-05	2021-02-03	4/A	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−5 246		0
2021-04-05	2021-02-03	4/A	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−3 066		74 808
2021-04-05	2021-02-03	4/A	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	5 246	16		29 829
2021-04-05	2021-02-03	4/A	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	3 066	10		24 583
2021-04-05	2021-01-25	4/A	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−16 630		5 246
2021-04-05	2021-01-25	4/A	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	16 630	49		43 147
2021-04-05	2021-04-01	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−4 431		132 276
2021-04-05	2021-04-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		25,8551	−4 431	−115		0
2021-04-05	2021-04-01	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4 431	57		4 431
2021-03-02	2021-03-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−8 312		91 746
2021-03-02	2021-03-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		29,4889	−783	−23		21 517
2021-03-02	2021-03-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		28,9031	−7 529	−218		22 300
2021-03-02	2021-03-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	8 312	76		29 829
2021-03-02	2021-03-01	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−4 431		136 707
2021-03-02	2021-03-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		29,4699	−356	−10		0
2021-03-02	2021-03-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		28,9197	−4 075	−118		356
2021-03-02	2021-03-01	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4 431	57		4 431
2021-02-08	2021-02-05	4	Weissman James B	DRNA	Common Stock	S - Sale	D		26,9900	−7 156	−193		20 904
2021-02-04	2021-02-03	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−8 312		100 058
2021-02-04	2021-02-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,0000	−8 312	−208		21 517
2021-02-04	2021-02-03	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	8 312	76		29 829
2021-02-04	2021-02-02	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−4 431		141 138
2021-02-04	2021-02-02	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		24,0000	−4 431	−106		0
2021-02-04	2021-02-02	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4 431	57		4 431
2021-01-27	2021-01-25	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−16 630		108 370
2021-01-27	2021-01-25	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,0000	−21 630	−541		21 517
2021-01-27	2021-01-25	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	16 630	151		43 147
2021-01-27	2021-01-25	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−4 431		145 569
2021-01-27	2021-01-25	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		25,0000	−6 326	−158		0
2021-01-27	2021-01-25	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4 431	57		6 326
2021-01-13	2021-01-12	4	Weissman James B	DRNA	Common Stock	S - Sale	D		24,0820	−5 808	−140		28 060
2021-01-13	2021-01-12	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		24,0732	−5 808	−140		26 517
2021-01-12	2021-01-12	4	Aradhye Shreeram	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		51 070		51 070
2021-01-12	2021-01-12	4	Aradhye Shreeram	DRNA	Restricted Stock Units	A - Award	D			11 350		11 350
2021-01-12	2021-01-12	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		68 100		68 100
2021-01-12	2021-01-12	4	Weissman James B	DRNA	Restricted Stock Units	A - Award	D			15 100		15 100
2021-01-12	2021-01-11	4	Weissman James B	DRNA	Common Stock	S - Sale	D		23,9900	−3 800	−91		33 868
2021-01-12	2021-01-08	4	Weissman James B	DRNA	Restricted Stock Units	M - Exercise	D			−8 650		25 950
2021-01-12	2021-01-08	4	Weissman James B	DRNA	Common Stock	F - Taxes	D		23,2900	−2 842	−66		37 668
2021-01-12	2021-01-08	4	Weissman James B	DRNA	Common Stock	M - Exercise	D			8 650			40 510
2021-01-12	2021-01-12	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		247 700		247 700
2021-01-12	2021-01-12	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	A - Award	D			55 000		55 000
2021-01-12	2021-01-08	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	M - Exercise	D			−19 950		59 850
2021-01-12	2021-01-08	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	F - Taxes	D		23,2900	−6 159	−143		37 030
2021-01-12	2021-01-08	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D			19 950			43 189
2021-01-12	2021-01-12	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		68 100		68 100
2021-01-12	2021-01-12	4	Brown Bob D	DRNA	Restricted Stock Units	A - Award	D			15 100		15 100
2021-01-12	2021-01-08	4	Brown Bob D	DRNA	Restricted Stock Units	M - Exercise	D			−8 650		25 950
2021-01-12	2021-01-08	4	Brown Bob D	DRNA	Common Stock	F - Taxes	D		23,2900	−2 842	−66		32 325
2021-01-12	2021-01-08	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D			8 650			35 167
2021-01-12	2021-01-12	4	Zeng Ling	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		46 120		46 120
2021-01-12	2021-01-12	4	Zeng Ling	DRNA	Restricted Stock Units	A - Award	D			10 250		10 250
2021-01-12	2021-01-12	4	Pagan Douglas W.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		36 900		36 900
2021-01-12	2021-01-12	4	Pagan Douglas W.	DRNA	Restricted Stock Units	A - Award	D			8 200		8 200
2021-01-12	2021-01-12	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		61 500		61 500
2021-01-12	2021-01-12	4	Paglia Regina M.	DRNA	Restricted Stock Units	A - Award	D			13 700		13 700
2021-01-12	2021-01-08	4	Paglia Regina M.	DRNA	Restricted Stock Units	M - Exercise	D			−2 900		8 700
2021-01-12	2021-01-08	4	Paglia Regina M.	DRNA	Common Stock	F - Taxes	D		23,2900	−1 005	−23		1 895
2021-01-12	2021-01-08	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D			2 900			2 900
2021-01-12	2021-01-12	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		61 500		61 500
2021-01-12	2021-01-12	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	A - Award	D			13 700		13 700
2021-01-12	2021-01-08	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	M - Exercise	D			−5 775		17 325
2021-01-12	2021-01-08	4	Ciappenelli Robert D.	DRNA	Common Stock	F - Taxes	D		23,2900	−2 002	−47		3 773
2021-01-12	2021-01-08	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D			5 775			5 775
2020-12-14	2020-12-10	4	Koppel Adam See footnotes	DRNA	Common Stock	S - Sale	I		23,4000	−1 000 000	−23 400		3 080 237
2020-12-03	2020-12-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		0
2020-12-03	2020-12-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,1931	−8 185	−206		26 517
2020-12-03	2020-12-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		34 702
2020-12-03	2020-12-01	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−4 360		0
2020-12-03	2020-12-01	4	Weissman James B	DRNA	Common Stock	S - Sale	D		25,2071	−4 360	−110		31 860
2020-12-03	2020-12-01	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	4 360	15		36 220
2020-11-06	2020-11-04	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		−30 000		150 000
2020-11-06	2020-11-04	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		23,2500	−15 000	−349		0
2020-11-06	2020-11-04	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		22,2500	−15 000	−334		15 000
2020-11-06	2020-11-04	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	30 000	388		30 000
2020-11-03	2020-11-02	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		8 185
2020-11-03	2020-11-02	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0300	−8 185	−172		26 517
2020-11-03	2020-11-02	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		34 702
2020-11-03	2020-11-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−4 360		4 360
2020-11-03	2020-11-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,9480	−4 360	−91		31 860
2020-11-03	2020-11-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	4 360	15		36 220
2020-10-22	2020-10-20	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−10 000		11 879
2020-10-22	2020-10-20	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	10 000	30		31 860
2020-10-20	2020-10-16	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−16 370		16 370
2020-10-20	2020-10-16	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0000	−16 370	−344		26 517
2020-10-20	2020-10-16	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	16 370	56		42 887
2020-10-19	2020-10-15	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 720		8 720
2020-10-19	2020-10-15	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,2000	−8 720	−176		21 860
2020-10-19	2020-10-15	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	8 720	30		30 580
2020-10-02	2020-10-01	4	Aradhye Shreeram	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,69		124 700		124 700
2020-10-02	2020-10-01	4	Aradhye Shreeram	DRNA	Restricted Stock Units	A - Award	D			28 100		28 100
2020-10-02	2020-10-01	4	Zeng Ling	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,69		81 825		81 825
2020-10-02	2020-10-01	4	Zeng Ling	DRNA	Restricted Stock Units	A - Award	D			18 225		18 225
2020-09-18	2020-09-16	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−21 250		77 874
2020-09-18	2020-09-16	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	21 250	73		26 517
2020-09-16	2020-09-14	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−267		0
2020-09-16	2020-09-14	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	267	1		5 267
2020-09-04	2020-07-01	4/A	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−4 360		25 980
2020-09-04	2020-07-01	4/A	Weissman James B	DRNA	Common Stock	S - Sale	D		26,8678	−1 307	−35		21 860
2020-09-04	2020-07-01	4/A	Weissman James B	DRNA	Common Stock	S - Sale	D		26,3881	−3 053	−81		23 167
2020-09-04	2020-07-01	4/A	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4 360	13		26 220
2020-09-01	2020-09-01	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		18,0597	10 000	181		22 300
2020-08-05	2020-08-03	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		32 740
2020-08-05	2020-08-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		22,7999	−2 521	−57		5 000
2020-08-05	2020-08-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		22,3355	−5 664	−127		7 521
2020-08-05	2020-08-03	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		13 185
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−259		17 440
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−4 101		21 879
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Common Stock	S - Sale	D		22,7993	−1 432	−33		21 860
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Common Stock	S - Sale	D		22,3120	−2 928	−65		23 292
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	259	1		26 220
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4 101	12		25 961
2020-07-06	2020-07-01	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−4 360		25 980
2020-07-06	2020-07-01	4	Weissman James B	DRNA	Common Stock	S - Sale	D		26,8678	−1 307	−35		21 860
2020-07-06	2020-07-01	4	Weissman James B	DRNA	Common Stock	S - Sale	D		26,3881	−3 053	−81		23 167
2020-07-06	2020-07-01	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4 360	13		26 220
2020-07-06	2020-07-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		40 925
2020-07-06	2020-07-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		26,8533	−2 371	−64		5 000
2020-07-06	2020-07-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		26,3604	−5 814	−153		7 371
2020-07-06	2020-07-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		13 185
2020-07-02	2020-07-01	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	26,62		6 825		6 825
2020-07-02	2020-07-01	4	Paglia Regina M.	DRNA	Restricted Stock Units	A - Award	D			1 525		1 525
2020-06-23	2020-06-19	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−9 670		21 876
2020-06-23	2020-06-19	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,0000	−9 670	−242		5 000
2020-06-23	2020-06-19	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	9 670	29		14 670
2020-06-16	2020-06-15	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15 000		15 000
2020-06-16	2020-06-15	4	HOFFMAN STEPHEN J	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2020-06-16	2020-06-15	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15 000		15 000
2020-06-16	2020-06-15	4	Koppel Adam	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2020-06-16	2020-06-15	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15 000		15 000
2020-06-16	2020-06-15	4	GRAY PATRICK M.	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2020-06-16	2020-06-15	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15 000		15 000
2020-06-16	2020-06-15	4	Doberstein Stephen K	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2020-06-16	2020-06-15	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		21 000		21 000
2020-06-16	2020-06-15	4	BUCHI J KEVIN	DRNA	Restricted Stock Units	A - Award	D			4 666		4 666
2020-06-16	2020-06-15	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15 000		15 000
2020-06-16	2020-06-15	4	Smith Cynthia	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2020-06-16	2020-06-15	4	Protopapas Anna	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15 000		15 000
2020-06-16	2020-06-15	4	Protopapas Anna	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2020-06-16	2020-06-15	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15 000		15 000
2020-06-16	2020-06-15	4	KOZIN MARC D	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2020-06-16	2020-06-15	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15 000		15 000
2020-06-16	2020-06-15	4	Freed Martin I	DRNA	Restricted Stock Units	A - Award	D			3 333		3 333
2020-06-02	2020-06-01	4	Pagan Douglas W.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	20,79		95 650		95 650
2020-06-02	2020-06-01	4	Pagan Douglas W.	DRNA	Restricted Stock Units	A - Award	D			27 300		27 300
2020-06-02	2020-06-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		49 110
2020-06-02	2020-06-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0091	−8 185	−172		5 000
2020-06-02	2020-06-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		13 185
2020-06-02	2020-06-01	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−4 360		30 340
2020-06-02	2020-06-01	4	Weissman James B	DRNA	Common Stock	S - Sale	D		21,0567	−4 360	−92		21 860
2020-06-02	2020-06-01	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4 360	13		26 220
2020-05-12	2020-05-11	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−13 281		31 546
2020-05-12	2020-05-11	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		24,0000	−13 281	−319		5 000
2020-05-12	2020-05-11	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	13 281	39		18 281
2020-05-07	2020-05-05	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		57 295
2020-05-07	2020-05-05	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0000	−8 185	−172		5 000
2020-05-07	2020-05-05	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		13 185
2020-05-06	2020-05-04	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		4 360		34 700
2020-05-06	2020-05-04	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,2000	−4 360	−88		21 860
2020-05-06	2020-05-04	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4 360	13		26 220
2020-04-22	2020-04-20	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		−25 624		186 375
2020-04-22	2020-04-20	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		22,9500	−25 624	−588		19 421
2020-04-22	2020-04-20	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	25 624	140		45 045
2020-04-21	2020-04-20	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−13 281		44 827
2020-04-21	2020-04-20	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		23,0000	−13 281	−305		5 000
2020-04-21	2020-04-20	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	13 281	39		18 281
2020-04-21	2020-04-17	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		65 480
2020-04-21	2020-04-17	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,1800	−8 185	−173		5 000
2020-04-21	2020-04-17	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		13 185
2020-04-14	2020-04-13	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−4 360		39 060
2020-04-14	2020-04-13	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,2000	−4 360	−88		21 860
2020-04-14	2020-04-13	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4 360	13		26 220
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−12 968		14 063
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		−7 501		211 999
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		19,9500	−20 469	−408		19 421
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		2,9700	12 968	39		39 890
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	7 501	41		26 922
2020-03-16	2020-03-12	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	A - Award	D	15,61		25 000		25 000
2020-03-03	2020-03-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−4 360		43 420
2020-03-03	2020-03-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,6087	−4 360	−90		21 860
2020-03-03	2020-03-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4 360	13		26 220
2020-03-03	2020-03-02	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		73 665
2020-03-03	2020-03-02	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0000	−8 185	−172		5 000
2020-03-03	2020-03-02	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		13 185
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−2 535		99 124
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−5 650		81 850
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0000	−8 185	−172		5 000
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	2 535	9		13 185
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	5 650	19		10 650
2020-02-04	2020-02-03	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−4 360		47 780
2020-02-04	2020-02-03	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,2000	−4 360	−88		21 860
2020-02-04	2020-02-03	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4 360	13		26 220
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−20 469		27 031
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−27 500		47 500
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		21,2628	−20 469	−435		19 421
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		21,2704	−27 500	−585		39 890
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		2,9700	20 469	61		67 390
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		2,9700	27 500	82		46 921
2020-01-10	2020-01-08	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		85 000		85 000
2020-01-10	2020-01-08	4	GREEN JOHN B	DRNA	Restricted Stock Units	A - Award	D			23 100		23 100
2020-01-10	2020-01-08	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		85 000		85 000
2020-01-10	2020-01-08	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	A - Award	D			23 100		23 100
2020-01-10	2020-01-08	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		121 300		121 300
2020-01-10	2020-01-08	4	Weissman James B	DRNA	Restricted Stock Units	A - Award	D			34 600		34 600
2020-01-10	2020-01-08	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		85 000		85 000
2020-01-10	2020-01-08	4	ROSSKAMP RALF	DRNA	Restricted Stock Units	A - Award	D			23 100		23 100
2020-01-10	2020-01-08	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		121 300		121 300
2020-01-10	2020-01-08	4	Brown Bob D	DRNA	Restricted Stock Units	A - Award	D			34 600		34 600
2020-01-10	2020-01-08	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		250 000		250 000
2020-01-10	2020-01-08	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	A - Award	D			79 800		79 800
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−2 860		52 140
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−1 500		0
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		21,8753	−4 360	−95		21 860
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	2 860	8		26 220
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	1 500	5		23 360
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−11 941		58 108
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−5 000		101 659
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		22,0000	−11 941	−263		5 000
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	11 941	35		16 941
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	5 000	17		5 000
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−4 951		70 049
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−8 185		106 659
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		22,0051	−1 340	−29		0
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,8445	−21 466	−469		1 340
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	4 951	15		22 806
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8 185	28		17 855
2019-12-27	2019-12-26	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,91		−20 000		230 000
2019-12-27	2019-12-26	4	ROSSKAMP RALF	DRNA	Common Stock	S - Sale	D		22,6882	−20 000	−454		3 564
2019-12-27	2019-12-26	4	ROSSKAMP RALF	DRNA	Common Stock	M - Exercise	D		2,9100	20 000	58		23 564
2019-12-19	2019-12-18	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−80 000		201 250
2019-12-19	2019-12-18	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	S - Sale	D		27,0735	−1 431	−39		12 300
2019-12-19	2019-12-18	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	S - Sale	D		25,8479	−78 569	−2 031		13 731
2019-12-19	2019-12-18	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		3,4200	80 000	274		92 300
2019-12-19	2019-12-17	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	S - Sale	D		26,9443	−2 305	−62		12 300
2019-12-19	2019-12-17	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	S - Sale	D		26,1344	−56 716	−1 482		14 605
2019-12-19	2019-12-18	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		−11 001		63 999
2019-12-19	2019-12-18	4	Weissman James B	DRNA	Common Stock	F - Taxes	D		26,0100	−3 845	−100		21 860
2019-12-19	2019-12-18	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		9,0900	11 001	100		25 705
2019-12-11	2019-12-11	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		−8 000		219 500
2019-12-11	2019-12-11	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	8 000	44		18 698
2019-12-06	2019-12-04	4	Koppel Adam See footnotes	DRNA	Common Stock	S - Sale	I		24,6800	−1 500 000	−37 020		4 080 237
2019-12-03	2019-12-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		−20 000		55 000
2019-12-03	2019-12-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		26,0000	−20 000	−520		14 704
2019-12-03	2019-12-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	20 000	59		34 704
2019-12-02	2019-12-02	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		24,9835	−137 176	−3 427		0
2019-12-02	2019-11-29	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		24,2154	−138 000	−3 342		137 176
2019-12-02	2019-11-27	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		24,0433	−368 700	−8 865		275 176
2019-11-27	2019-11-25	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		−12 500		227 500
2019-11-27	2019-11-25	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		24,9500	−12 500	−312		10 698
2019-11-27	2019-11-25	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	12 500	68		23 198
2019-11-26	2019-11-26	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		23,5855	−239 700	−5 653		643 876
2019-11-26	2019-11-25	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		24,0578	−361 200	−8 690		883 576
2019-11-26	2019-11-22	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		22,5164	−197 700	−4 451		1 244 776
2019-11-21	2019-11-19	4	Bain Capital Life Sciences Investors, LLC See Footnotes	DRNA	Common Stock	S - Sale	I		22,0300	−1 750 000	−38 552		5 580 237
2019-11-21	2019-11-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		22,9782	−351 505	−8 077		1 442 476
2019-11-21	2019-11-20	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		22,9332	−265 505	−6 089		1 793 981
2019-11-21	2019-11-19	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		23,9217	−397 183	−9 501		2 059 486
2019-11-20	2019-11-18	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		−12 500		240 000
2019-11-20	2019-11-18	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		21,0500	−12 500	−263		10 698
2019-11-20	2019-11-18	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	12 500	68		23 198
2019-11-20	2019-11-19	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−20 000		0
2019-11-20	2019-11-19	4	Weissman James B	DRNA	Common Stock	S - Sale	D		24,0000	−20 000	−480		14 704
2019-11-20	2019-11-19	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	20 000	68		34 704
2019-11-20	2019-11-18	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−20 000		20 000
2019-11-20	2019-11-18	4	Weissman James B	DRNA	Common Stock	S - Sale	D		22,0000	−20 000	−440		14 704
2019-11-20	2019-11-18	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	20 000	68		34 704
2019-11-15	2019-11-14	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		20,0000	−3 562	−71		10 698
2019-11-15	2019-11-14	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−20 000		40 000
2019-11-15	2019-11-14	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,0000	−20 000	−400		14 704
2019-11-15	2019-11-14	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	20 000	68		34 704
2019-11-01	2019-10-31	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−15 000		17 699
2019-11-01	2019-10-31	4	Weissman James B	DRNA	Common Stock	S - Sale	D		18,0000	−15 000	−270		14 704
2019-11-01	2019-10-31	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	15 000	51		29 704
2019-11-01	2019-10-31	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		−12 500		252 500
2019-11-01	2019-10-31	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		18,0000	−12 500	−225		14 260
2019-11-01	2019-10-31	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	12 500	68		26 760
2019-10-18	2019-10-18	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−4 104		60 000
2019-10-18	2019-10-18	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−800		0
2019-10-18	2019-10-18	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	4 104	14		14 704
2019-10-18	2019-10-18	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	800	3		10 600
2019-09-19	2019-09-17	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	A - Award	D	14,32		25 000		25 000
2019-08-23	2019-08-23	4	Weissman James B	DRNA	Common Stock	S - Sale	D		13,0676	−14 680	−192		9 800
2019-07-01	2019-07-01	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	15,61		300 000		300 000
2019-06-21	2019-06-20	4	Smith Cynthia	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25 000		25 000
2019-06-21	2019-06-20	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25 000		25 000
2019-06-21	2019-06-20	4	Freed Martin I	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25 000		25 000
2019-06-21	2019-06-20	4	BUCHI J KEVIN	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		33 000		33 000
2019-06-21	2019-06-20	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25 000		25 000
2019-06-21	2019-06-20	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25 000		25 000
2019-06-21	2019-06-20	4	Protopapas Anna	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25 000		25 000
2019-06-21	2019-06-20	4	Koppel Adam	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25 000		25 000
2019-06-21	2019-06-20	4	KOZIN MARC D	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25 000		25 000
2019-05-31	2019-05-29	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Common Stock	S - Sale	I		12,5000	−1 600 000	−20 000		7 330 237
2019-04-04	2019-04-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−15 000		32 699
2019-04-04	2019-04-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		15,0000	−15 000	−225		24 480
2019-04-04	2019-04-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	15 000	51		39 480
2019-03-29	2019-03-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	A - Award	D	14,13		8 000		8 000
2019-01-25	2019-01-23	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	A - Award	D	10,31		25 000		25 000
2019-01-25	2019-01-23	4	Protopapas Anna	DRNA	Director Stock Option (Right to Buy)	A - Award	D	10,31		25 000		25 000
2019-01-25		3	KOZIN MARC D By Marc D. Kozin Revocable Trust	DRNA	Common Stock		I						10 000
2019-01-25		3	KOZIN MARC D By Marc D. Kozin Revocable Trust	DRNA	Common Stock		I						10 000
2019-01-25		3	KOZIN MARC D By Marc D. Kozin Revocable Trust	DRNA	Common Stock		I						10 000
2019-01-04	2019-01-02	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		180 000		180 000
2019-01-04	2019-01-02	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		505 000		505 000
2019-01-04	2019-01-02	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		180 000		180 000
2019-01-04	2019-01-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		180 000		180 000
2019-01-04	2019-01-02	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		180 000		180 000
2018-11-09	2018-11-08	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		14,8599	−107 920	−1 604		2 456 669
2018-11-09	2018-11-07	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		14,7402	−250 000	−3 685		2 564 589
2018-11-06	2018-11-06	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,8434	−263 300	−3 645		2 814 589
2018-11-06	2018-11-05	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		12,8880	−71 400	−920		3 077 889
2018-11-06	2018-11-02	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,4926	−175 700	−2 371		3 149 289
2018-11-06	2018-11-06	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		14,1600	−11	−0		19 150
2018-11-06	2018-11-06	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		14,1600	−1 489	−21		2 586 535
2018-11-06	2018-11-06	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,1800	−761	−10		19 161
2018-11-06	2018-11-06	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,1800	−102 067	−1 345		2 588 024
2018-11-06	2018-11-05	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		12,9800	−295	−4		19 922
2018-11-06	2018-11-05	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		12,9800	−39 606	−514		2 690 091
2018-11-06	2018-11-02	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,4700	−1 412	−19		20 217
2018-11-06	2018-11-02	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,4700	−189 359	−2 551		2 729 697
2018-11-05	2018-11-01	4/A	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,3700	−1 408	−19		21 629
2018-11-05	2018-11-01	4/A	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,3700	−188 867	−2 525		2 919 056
2018-11-05	2018-10-31	4/A	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,6000	−959	−13		23 037
2018-11-05	2018-10-31	4/A	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,6000	−128 670	−1 750		3 107 923
2018-11-05	2018-10-30	4/A	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		14,3100	−678	−10		23 996
2018-11-05	2018-10-30	4/A	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		14,3100	−90 918	−1 301		3 236 593
2018-11-05	2018-10-30	4/A	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,6800	−1 136	−16		24 674
2018-11-05	2018-10-30	4/A	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,6800	−152 364	−2 084		3 327 511
2018-11-01	2018-11-01	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,3757	−180 100	−2 409		3 324 989
2018-11-01	2018-10-31	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,4619	−178 400	−2 402		3 505 089
2018-11-01	2018-10-30	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,8603	−250 000	−3 465		3 683 489
2018-11-01	2018-11-01	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,3700	−1 408	−19		21 629
2018-11-01	2018-11-01	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,3700	−188 167	−2 516		2 919 056
2018-11-01	2018-10-31	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,6000	−959	−13		23 037
2018-11-01	2018-10-31	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,6000	−128 670	−1 750		3 107 923
2018-11-01	2018-10-30	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		14,3100	−678	−10		23 996
2018-11-01	2018-10-30	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		14,3100	−90 918	−1 301		3 236 593
2018-11-01	2018-10-30	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,6800	−1 136	−16		24 674
2018-11-01	2018-10-30	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,6800	−152 364	−2 084		3 327 511
2018-09-06	2018-09-05	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−2 301		47 699
2018-09-06	2018-09-05	4	Weissman James B	DRNA	Common Stock	S - Sale	D		17,5000	−2 301	−40		24 480
2018-09-06	2018-09-05	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	2 301	8		26 781
2018-08-20	2018-08-17	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−14 680		64 104
2018-08-20	2018-08-17	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	14 680	50		24 480
2018-08-17	2018-08-15	4	LANGER DENNIS	DRNA	Common Stock	S - Sale	D		16,0000	−14 531	−232		29 064
2018-08-17	2018-08-15	4	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Common Stock	S - Sale	I		16,0000	−23 810	−381		47 978
2018-08-15	2018-08-13	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	A - Award	D	14,76		25 000		25 000
2018-08-15	2018-08-13	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	A - Award	D	14,76		25 000		25 000
2018-06-26	2018-06-21	4	Wise Bart W	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	13,08		25 000		25 000
2018-06-26		3	Wise Bart W	DRNA	Common Stock		D						11 294
2018-06-26		3	Wise Bart W	DRNA	Common Stock		D						11 294
2018-06-26		3	Wise Bart W	DRNA	Common Stock		D						11 294
2018-06-25	2018-06-21	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	A - Award	D	13,08		25 000		25 000
2018-06-25	2018-06-21	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		25 000		25 000
2018-06-25	2018-06-21	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		25 000		25 000
2018-06-25	2018-06-21	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		25 000		25 000
2018-06-25	2018-06-21	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		33 000		33 000
2018-06-25	2018-06-21	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	13,08		25 000		25 000
2018-06-25	2018-06-21	4	Koppel Adam	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		25 000		25 000
2018-06-11	2018-06-07	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Warrant to Purchase Common Stock	M - Exercise	I	7,00		−156		0
2018-06-11	2018-06-07	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Warrant to Purchase Common Stock	M - Exercise	I	7,00		−21 041		0
2018-06-11	2018-06-07	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	F - Taxes	I		14,4500	−76	−1		25 810
2018-06-11	2018-06-07	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	F - Taxes	I		14,4500	−10 195	−147		3 479 875
2018-06-11	2018-06-07	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	M - Exercise	I		7,0000	156	1		25 886
2018-06-11	2018-06-07	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	M - Exercise	I		7,0000	21 041	147		3 490 070
2018-05-11	2018-05-09	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		15,0000	−9 669	−145		9 670
2018-05-11	2018-05-09	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−10 000		50 000
2018-05-11	2018-05-09	4	Weissman James B	DRNA	Common Stock	S - Sale	D		15,0000	−10 000	−150		9 800
2018-05-11	2018-05-09	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	10 000	34		19 800
2018-04-24	2018-04-20	4	Weissman James B	DRNA	Common Stock	S - Sale	D		13,0000	−8 965	−117		9 800
2018-03-27	2018-03-23	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,0511	−55 300	−611		3 933 489
2018-03-21	2018-03-19	4	Weissman James B	DRNA	Common Stock	S - Sale	D		13,0000	−1 035	−13		18 765
2018-03-21	2018-03-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,1727	−36 224	−405		3 988 789
2018-03-21	2018-03-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,1400	−49 000	−546		4 025 013
2018-03-21	2018-03-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,0718	−31 145	−345		4 074 013
2018-03-21	2018-03-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,2399	−64 600	−726		4 105 158
2018-03-21	2018-03-20	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,1648	−67 985	−759		4 169 758
2018-03-21	2018-03-20	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,1555	−55 200	−616		4 237 743
2018-03-21	2018-03-20	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,0000	−50 000	−550		4 292 943
2018-03-21	2018-03-19	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		12,4550	−34 700	−432		4 342 943
2018-03-21	2018-03-19	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		12,6308	−84 670	−1 069		4 377 643
2018-01-30	2018-01-26	4	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Stock Option (Right to Buy)	M - Exercise	I	3,42		−360		0
2018-01-30	2018-01-26	4	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Common Stock	M - Exercise	I		3,4200	360	1		71 788
2018-01-19	2018-01-18	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,2271	−59 700	−551		4 462 313
2018-01-19	2018-01-17	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,3254	−220 900	−2 060		4 522 013
2018-01-08	2018-01-04	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		105 000		105 000
2018-01-08	2018-01-04	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		255 000		255 000
2018-01-08	2018-01-04	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		105 000		105 000
2018-01-08	2018-01-04	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		105 000		105 000
2018-01-08	2018-01-04	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		57 750		57 750
2018-01-08	2018-01-05	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,1461	−18 100	−166		4 742 913
2018-01-08	2018-01-04	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,1978	−77 400	−712		4 761 013
2018-01-03	2018-01-03	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,2533	−59 100	−547		4 838 413
2018-01-03	2018-01-02	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,4655	−68 000	−644		4 897 513
2018-01-03	2017-12-29	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,1288	−23 100	−211		4 965 513
2018-01-03	2017-12-29	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,1026	−85 400	−777		4 988 613
2017-12-20	2017-12-18	4	RA CAPITAL MANAGEMENT, LLC See Note	DRNA	Redeemable Convertible Preferred Stock	M - Exercise	I		3,1900	−76 500	−244	0
2017-12-20	2017-12-18	4	RA CAPITAL MANAGEMENT, LLC See Note	DRNA	Common Stock	M - Exercise	I			2 645 442			5 074 013
2017-12-20	2017-12-18	4	Kolchinsky Peter See Note	DRNA	Redeemable Convertible Preferred Stock	M - Exercise	I		3,1900	−76 500	−244	0
2017-12-20	2017-12-18	4	Kolchinsky Peter See Note	DRNA	Common Stock	M - Exercise	I			2 645 442			5 074 013
2017-12-20	2017-12-18	4	Domain Partners VIII, L.P.	DRNA	Redeemable Convertible Preferred Stock	C - Conversion	D	3,19		−49 632		0
2017-12-20	2017-12-18	4	Domain Partners VIII, L.P.	DRNA	Common Stock	A - Award	D			37 890			3 469 029
2017-12-20	2017-12-18	4	Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	D		3,1900	1 678 432	5 354		3 431 139
2017-12-20	2017-12-18	4	DP VIII Associates, L.P.	DRNA	Redeemable Convertible Preferred Stock	C - Conversion	D	3,19		−368		0
2017-12-20	2017-12-18	4	DP VIII Associates, L.P.	DRNA	Common Stock	A - Award	D			282			25 730
2017-12-20	2017-12-18	4	DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	D		3,1900	12 444	40		25 448
2017-12-19	2017-12-18	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Redeemable Convertible Preferred Stock	M - Exercise	I		3,1900	−250 000	−798	0
2017-12-19	2017-12-18	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Common Stock	A - Award	I			190 849			8 930 237
2017-12-19	2017-12-18	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Common Stock	M - Exercise	I			8 454 388			8 739 388
2017-12-19	2017-12-18	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Common Stock	P - Purchase	I		7,0000	285 000	1 995		285 000
2017-07-24	2017-07-18	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25 000		25 000
2017-07-20	2017-07-18	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25 000		25 000
2017-07-20	2017-07-18	4	PEACOCK BRUCE	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25 000		25 000
2017-07-20	2017-07-18	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25 000		25 000
2017-07-20	2017-07-18	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	A - Award	D	3,42		25 000		25 000
2017-07-20	2017-07-18	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		33 000		33 000
2017-07-20	2017-07-18	4	Koppel Adam	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25 000		25 000
2017-07-20	2017-07-18	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	3,42		25 000		25 000
2017-06-16	2017-06-15	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	2,91		250 000		250 000
2017-04-13	2017-04-11	4	Koppel Adam	DRNA	Employee Stock Option (Right to buy)	A - Award	D	3,47		25 000		25 000
2017-04-13	2017-04-11	4	RA CAPITAL MANAGEMENT, LLC See Note 1	DRNA	Redeemable Convertible Preferred Stock	J - Other	I	3,19	100,0000	76 500	7 650	76 500
2017-04-12	2017-04-11	4	DP VIII Associates, L.P.	DRNA	Redeemable Convertible Preferred Stock	P - Purchase	D	3,19	100,0000	368	37	368
2017-04-12	2017-04-11	4	Domain Partners VIII, L.P.	DRNA	Redeemable Convertible Preferred Stock	P - Purchase	D	3,19	100,0000	49 632	4 963	49 632
2017-01-05	2017-01-03	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	2,97		75 000		75 000
2017-01-05	2017-01-03	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	2,97		225 000		225 000
2017-01-05	2017-01-03	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy	A - Award	D	2,97		75 000		75 000
2017-01-05	2017-01-03	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	2,97		75 000		75 000
2016-11-17	2016-11-16	4	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Common Stock	S - Sale	I		3,5200	−23 766	−84		71 428
2016-11-16	2016-11-15	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		3,6300	16 500	60		55 579
2016-11-16	2016-11-14	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		3,7800	16 600	63		39 079
2016-06-16	2016-06-14	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	3,26		15 000		15 000
2016-06-15	2016-06-14	4	PEACOCK BRUCE	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		15 000		15 000
2016-06-15	2016-06-14	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		15 000		15 000
2016-06-15	2016-06-14	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		15 000		15 000
2016-06-15	2016-06-14	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		20 000		20 000
2016-06-15	2016-06-14	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		15 000		15 000
2016-06-15	2016-06-14	4	Freed Martin I	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	3,26		25 000		25 000
2016-05-16	2016-05-12	4	Weissman James B	DRNA	Common Stock	P - Purchase	D		3,2899	4 170	14		19 800
2016-05-16	2016-05-12	4	Weissman James B	DRNA	Common Stock	P - Purchase	D		3,2897	530	2		15 630
2016-05-16	2016-05-12	4	Weissman James B	DRNA	Common Stock	P - Purchase	D		3,2399	300	1		15 100
2016-04-18	2016-04-14	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	5,45		265 000		265 000
2016-02-05	2016-02-03	4	LANGER DENNIS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−34 722		6 945
2016-02-05	2016-02-03	4	LANGER DENNIS	DRNA	Common Stock	M - Exercise	D		3,4200	34 722	119		43 595
2016-01-12	2016-01-08	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		225 000		225 000
2016-01-12	2016-01-08	4	Ashburn Theodore	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		−75 000		75 000
2016-01-12	2016-01-08	4	Bhargava Pankaj	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		75 000		75 000
2016-01-12	2016-01-08	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		75 000		75 000
2016-01-12	2016-01-08	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		125 000		125 000
2015-06-29	2015-06-25	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	13,87		15 000		15 000
2015-06-29	2015-06-25	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		15 000		15 000
2015-06-29	2015-06-25	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		15 000		15 000
2015-06-26	2015-06-25	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		15 000		15 000
2015-06-26	2015-06-25	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		20 000		20 000
2015-06-26	2015-06-25	4	PEACOCK BRUCE	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		15 000		15 000
2015-02-24	2015-02-20	4	Skyline Venture Partners V LP	DRNA	Common Stock	S - Sale	I		26,0200	−37 532	−977		1 719 671
2015-01-13	2015-01-09	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		75 000		75 000
2015-01-13	2015-01-09	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		225 000		225 000
2015-01-13	2015-01-09	4	Ashburn Theodore	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		3 333		3 333
2015-01-13	2015-01-09	4	Dentzer James E	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		75 000		75 000
2015-01-13	2015-01-09	4	Bhargava Pankaj	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		56 250		56 250
2015-01-13	2015-01-09	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		75 000		75 000
2014-12-19	2014-12-17	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−1 450		0
2014-12-19	2014-12-17	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		−1 050		0
2014-12-19	2014-12-17	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		3,4200	2 500	9		19 800
2014-12-16	2014-12-15	4	Ashburn Theodore	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	13,08		115 000		115 000
2014-12-16	2014-12-15	4	Ashburn Theodore	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	13,08		115 000		115 000
2014-12-16		3	Ashburn Theodore	DRNA	No securities are beneficially owned		D						0
2014-12-11	2014-12-09	4	PEACOCK BRUCE	DRNA	Director Stock Option (right to buy)	A - Award	D	11,04		25 000		25 000
2014-11-25	2014-11-25	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,5000	−55 035	−633		800 794
2014-11-25	2014-11-25	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,5000	−48 027	−552		698 822
2014-11-25	2014-11-25	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,5000	−18 903	−217		275 046
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,5400	−3 785	−44		855 829
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,5400	−3 303	−38		746 849
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,5500	−14 199	−164		293 949
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,5500	−41 339	−477		859 614
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,5500	−36 074	−417		750 152
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,5400	−1 300	−15		308 148
2014-11-25	2014-11-21	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,0000	−45 124	−496		900 953
2014-11-25	2014-11-21	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,0000	−39 377	−433		786 226
2014-11-25	2014-11-21	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,0000	−15 499	−170		309 448
2014-11-10	2014-11-07	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		9,3300	−30 100	−281		0
2014-11-10	2014-11-07	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		9,2700	−3 500	−32		30 100
2014-11-10	2014-11-07	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		9,0000	−180 564	−1 625		33 600
2014-10-15	2014-10-15	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		10,0100	−51 449	−515		214 164
2014-10-15	2014-10-14	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,0200	−14 464	−159		946 077
2014-10-15	2014-10-14	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,0200	−12 622	−139		825 603
2014-10-15	2014-10-14	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,0200	−4 061	−45		265 613
2014-10-15	2014-10-14	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,0200	−4 968	−55		324 947
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		12,0020	−246	−3		960 541
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		12,0020	−215	−3		838 225
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		12,0020	−69	−1		269 674
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		12,0020	−84	−1		330
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		12,1350	−11 855	−144		960 787
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		12,1350	−10 345	−126		838 440
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		12,1350	−3 328	−40		269 743
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		12,1350	−4 072	−49		329 999
2014-06-24	2014-06-18	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		15 000		15 000
2014-06-23	2014-06-18	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		15 000		15 000
2014-06-23	2014-06-18	4	Miles Vincent J	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		15 000		15 000
2014-06-20	2014-06-18	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	18,73		15 000		15 000
2014-06-20	2014-06-18	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		20 000		20 000
2014-06-20	2014-06-18	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		15 000		15 000
2014-05-08	2014-04-16	4/A	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	16,30		25 000		25 000
2014-04-30	2014-04-16	4/A	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	16,30		25 000		25 000
2014-04-21	2014-02-04	4/A	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Series C Preferred	C - Conversion	I			−71 428		0
2014-04-21	2014-02-04	4/A	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Series B Preferred	C - Conversion	I			−8 586		0
2014-04-21	2014-02-04	4/A	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Series A Preferred	C - Conversion	I			−15 000		0
2014-04-21	2014-02-04	4/A	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Common Stock	C - Conversion	I			95 014			95 194
2014-04-21	2014-04-16	4	RA CAPITAL MANAGEMENT, LLC See Footnotes	DRNA	Director Stock Option (right to buy)	A - Award	I	16,30		25 000		25 000
2014-04-18	2014-04-16	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	16,30		25 000		25 000
2014-04-18	2014-04-16	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	16,30		25 000		25 000
2014-04-18	2014-04-16	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	16,30		25 000		25 000
2014-04-18	2014-04-16	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		471 900		471 900
2014-04-18	2014-04-16	4	Miles Vincent J See footnotes	DRNA	Director Stock Option (right to buy	A - Award	I	16,30		25 000		25 000
2014-04-18	2014-04-16	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	16,30		30 000		30 000
2014-04-18	2014-04-16	4	Dentzer James E	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		108 750		108 750
2014-04-18	2014-04-16	4	Brown Bob D	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		165 050		165 050
2014-04-18	2014-04-16	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		111 800		111 800
2014-04-18	2014-04-16	4	Bhargava Pankaj	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		264 808		264 808
2014-04-11	2014-03-18	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		38,6200	−14 937	−577		1 550 862
2014-04-11	2014-03-18	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		37,7500	−250 000	−9 438		1 565 799
2014-04-11	2014-03-17	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		36,5000	−9 301	−339		1 815 799
2014-04-11	2014-03-14	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		35,5000	−200 000	−7 100		1 825 100
2014-04-11	2014-03-14	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		35,3300	−50 400	−1 781		2 025 100
2014-04-11	2014-03-12	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		37,7700	−1 500	−57		2 075 500
2014-04-11	2014-03-11	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		38,3700	−2 900	−111		2 077 000
2014-04-11	2014-03-11	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		38,0000	−257 100	−9 770		2 079 900
2014-04-03		3	Bhargava Pankaj	DRNA	No securities are beneficially owned		D						0
2014-02-20	2014-01-29	4/A	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series C Preferred	C - Conversion	I			−71 428		0
2014-02-20	2014-01-29	4/A	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series B Preferred	C - Conversion	I			−8 586		0
2014-02-20	2014-01-29	4/A	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series A Preferred	C - Conversion	I			−10 000		0
2014-02-20	2014-01-29	4/A	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Common Stock	C - Conversion	I			90 014			90 014
2014-02-20	2014-01-27	4/A	LANGER DENNIS	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−540		0
2014-02-20	2014-01-27	4/A	LANGER DENNIS	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−8 333		41 667
2014-02-20	2014-01-27	4/A	LANGER DENNIS	DRNA	Common Stock	M - Exercise	D		3,4200	8 873	30		8 873
2014-02-20	2013-09-24	4/A	LANGER DENNIS	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		50 000		50 000
2014-02-20	2014-01-29	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		15,0000	5 000	75		17 300
2014-02-20	2013-11-11	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−4 350		1 450
2014-02-20	2013-11-11	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−4 950		1 050
2014-02-20	2013-11-11	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		3,4200	9 300	32		12 300
2014-02-20	2013-09-24	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		281 250		281 250
2014-02-20	2013-09-24	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		281 250		281 250
2014-02-20	2014-01-29	4	MADDEN DAVID	DRNA	Common Stock	P - Purchase	D		15,0000	7 500	112		120 011
2014-02-20	2014-01-24	4	MADDEN DAVID	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−110 000		0
2014-02-20	2014-01-24	4	MADDEN DAVID	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−1 311		0
2014-02-20	2014-01-24	4	MADDEN DAVID	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−1 200		0
2014-02-20	2014-01-24	4	MADDEN DAVID	DRNA	Common Stock	M - Exercise	D		3,4200	112 511	385		112 511
2014-02-20	2013-09-24	4	MADDEN DAVID	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		110 000		110 000
2014-02-20	2014-01-29	4	Weissman James B	DRNA	Common Stock	P - Purchase	D		15,0000	1 000	15		13 116
2014-02-20	2014-01-27	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−67		800
2014-02-20	2014-01-27	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−11 216		78 784
2014-02-20	2014-01-27	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,2400	11 283	37		12 116
2014-02-20	2013-11-11	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−100		1 500
2014-02-20	2013-11-11	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		−733		867
2014-02-20	2013-11-05	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	833	3		833
2014-02-20	2013-09-24	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		90 000		90 000
2014-02-20	2013-09-24	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		60 000		60 000
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock Warrant (right to buy)	C - Conversion	I	7,00		21 697		21 697
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Series C Preferred Stock Warrants	C - Conversion	I	7,00		−21 697		0
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock Warrant	C - Conversion	I	250,00		755		755
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Series C Preferred Stock	C - Conversion	I			−1 043 429		0
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Series B Preferred Stock	C - Conversion	I			−179 322		0
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Series A Preferred Stock	C - Conversion	I			−312 000		0
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock	P - Purchase	I		15,0000	200 000	3 000		1 734 751
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock	C - Conversion	I			1 043 429			1 534 751
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock	C - Conversion	I			179 322			491 322
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock	C - Conversion	I			312 000			312 000
2014-02-05	2014-02-04	4	RA CAPITAL MANAGEMENT, LLC	DRNA	Series C Preferred Stock, par value $0.0001	C - Conversion	D			−1 428 571		0
2014-02-05	2014-02-04	4	RA CAPITAL MANAGEMENT, LLC See Footnotes	DRNA	Common Stock, par value $0.0001 per share	P - Purchase	I		15,0000	1 000 000	15 000		2 428 571
2014-02-05	2014-02-04	4	RA CAPITAL MANAGEMENT, LLC See Footnotes	DRNA	Common Stock, par value $0.0001 per share	C - Conversion	I			1 428 571			1 428 571
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock Warrant (right to buy)	C - Conversion	I	7,00		21 697		21 697
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Series C Preferred Stock Warrants	C - Conversion	I	7,00		−21 697		0
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock Warrant	C - Conversion	I	250,00		755		755
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Series C Preferred Stock	C - Conversion	I			−1 043 429		0
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Series B Preferred Stock	C - Conversion	I			−179 322		0
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Series A Preferred Stock	C - Conversion	I			−312 000		0
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock	P - Purchase	I		15,0000	200 000	3 000		1 734 751
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock	C - Conversion	I			1 043 429			1 534 751
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock	C - Conversion	I			179 322			491 322
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock	C - Conversion	I			312 000			312 000
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−156		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−9 469		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−3 535		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21 041		21 041
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−21 041		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−1 276 243		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−476 464		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13 004			13 004
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1 752 707			1 752 707
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−156		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−9 469		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−3 535		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21 041		21 041
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−21 041		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−1 276 243		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−476 464		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13 004			13 004
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1 752 707			1 752 707
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−156		0
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−9 469		0
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−3 535		0
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21 041		21 041
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−21 041		0
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−1 276 243		0
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−476 464		0
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13 004			13 004
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1 752 707			1 752 707
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−156		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−9 469		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−3 535		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21 041		21 041
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−21 041		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−1 276 243		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−476 464		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13 004			13 004
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1 752 707			1 752 707
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−156		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−9 469		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−3 535		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21 041		21 041
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−21 041		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−1 276 243		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−476 464		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13 004			13 004
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1 752 707			1 752 707
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−156		0
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−9 469		0
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−3 535		0
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21 041		21 041
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		−21 041		0
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−1 276 243		0
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			−476 464		0
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13 004			13 004
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1 752 707			1 752 707
2014-02-04	2014-02-04	4	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series C Preferred	C - Conversion	I			−71 428		0
2014-02-04	2014-02-04	4	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series B Preferred	C - Conversion	I			−8 586		0
2014-02-04	2014-02-04	4	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series A Preferred	C - Conversion	I			−10 000		0
2014-02-04	2014-02-04	4	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Common Stock	C - Conversion	I			90 014			90 194
2014-02-04		3	Brookside Capital Trading Fund, L.P.	DRNA	Common Stock		I						2 337 000
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	D	7,00		156		156
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	D	7,00		−156		0
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	D			−9 469		0
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	D			−3 535		0
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	D			13 004			13 004
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	D	7,00		21 041		21 041
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	D	7,00		−21 041		0
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	D			−1 276 243		0
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	D			−476 464		0
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	D			1 752 707			1 752 707
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−572 142		0
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−499 285		0
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−161 071		0
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			−196 071		0
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	P - Purchase	I		15,0000	400 500	6 008		972 642
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	P - Purchase	I		15,0000	349 500	5 242		848 785
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	P - Purchase	I		15,0000	112 000	1 680		273 071
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	P - Purchase	I		15,0000	138 000	2 070		334 071
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	C - Conversion	I			572 142			972 642
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	C - Conversion	I			499 285			848 785
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	C - Conversion	I			161 071			273 071
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	C - Conversion	I			196 071			334 071
2014-01-29		3	FAMBROUGH DOUGLAS	DRNA	Common Stock		D						12 300
2014-01-29		3	MADDEN DAVID	DRNA	Common Stock		D						112 511
2014-01-29		3	LANGER DENNIS	DRNA	Common Stock		D						8 873
2014-01-29		3	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Common Stock		I						180
2014-01-29		3	Miles Vincent J	DRNA	No securities are beneficially owned		D						0
2014-01-29		3	Brown Bob D	DRNA	Common Stock		D						19 339
2014-01-29		3	Weissman James B	DRNA	Common Stock		D						12 116

Köp på öppna marknaden eller privat köp av icke-derivatsäkerhet

Köp på öppna marknaden eller privat försäljning av icke-derivatsäkerhet

Bevilja, tilldelning eller annat förvärv av värdepapper från företaget (såsom en option)

Omvandling av derivat

Försäljning eller överföring av värdepapper tillbaka til företaget

Betalning av lösenpris eller skatteskuld med del av värdepapper som erhållits från bolaget

Överlåtelse av värdepapper från eller till insidern

Aktieswappar och liknande säkringsaffärer

Utövande eller omvandling av derivatsäkerhet som erhållits från företaget (som en option)

En transaktion friviligt rapporterad på schema 4

Andra (med en fotnot som beskriver transaktionen)

DRNA / Dicerna Pharmaceuticals Inc - Insider Trading and Ownership Report - SEC Form 3, 4, 5