| Utestående aktier | 168,712,220 shares |
| Insideraktier | 47 784 968 shares |
| Insynsägande | 28,32 % |
| Totalt antal insynspersoner | 51 |
Insider Sentiment Score
Insider sentiment score hittar de företag som köps av foretagsinsynspersoner.
Det är resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av insiderackumulation. Poängmodellen använder en kombination av nettoantalet insiders som köpt de föregående 90 dagarna, det totala antalet aktier som köpts i procent av aktiekapitalet och det totala antalet aktier som ägs av insiders. Siffran sträcker sig från 0 till 100, med högre siffror som indikerar en högre nivå av ackumulering för sina kamrater, och 50 är genomsnittet.
Uppdateringsfrekvens: Dagligen
Se Insiders Top Picks, som ger en lista över företag med högsta insiderackumulation.
Office Sentiment Score
Officersentiment Score hittar företag som köps av Corporate Officers.
Per definition Corporate Officers är Corporate Insiders, men till skillnad från vissa av de andra Insiders (10 % aktieägare och styrelseledamöter), arbetar ämbetsmän för företaget dagligen och de använder sina egna pengar när de handlar . (10 % aktieägare och styrelseledamöter är ofta fondförvaltare som förvaltar andras pengar.) Som sådan är insideraffärer som görs av tjänstemän mycket mer betydelsefulla och bör behandlas på lämpligt sätt.
Liksom Insider Sentiment Score är Officer Sentiment Score resultatet av en sofistikerad, kvantitativ multifaktormodell som identifierar företag med de högsta nivåerna av officersackumulering.
Uppdateringsfrekvens: Dagligen
Se insiderns bästa val, vilket ger en lista över företag med högsta insider sentiment.
Viktiga insidernyckeltal
Denna kort visar hur företaget rankas längs olika insidernyckeltal. Procenttilrankningen visar hur detta företag jämförs med andra företag på USA-marknaden. Högre rankingar indikerar bättre situationer.
Till exempel anses det allmänt att insiderköp är en positiv indikator, så företag med mer insiderköp skulle rankas högre än företag med mindre insiderköp (eller til och med insiderförsäljning).
Procent av flytande köpta av insiders (ranking)
-0.020 %( )
10159 out of 11237Procentandelen av aktier köpta av insiders är det totala antalet aktier som köpts av insiders minus det totala antalet aktier som sålts av insiders under de senaste 90 dagarna, dividerat med det totala antalet aktier och multiplicerat med 100.
Insiderhandelsdiagram
ACADIA Pharmaceuticals Inc. insideraffärer visas i följande diagram. Insiders är tjänstemän, styrelseledamöter eller betydande investerare i ett företag. I allmänhet är det i allmänhet olagligt för insiders att göra affärer i sina företag baserat på väsentlig, icke-offentlig information. Detta betyder inte att det är olagligt för dem att göra några affärer i sina egna företag. De måste dock rapportera alla affärer till SEC via ett formulär 4.
Insiderlista och lönsamhetsstatistik
Den här tabellen visar listan över kända insiders och genereras automatiskt från anmälningar som avslöjas till SEC. Förutom namnen, den senaste titeln och direktören, tjänstemannen eller ägarbeteckningen på 10 %, tillhandahåller vi de senaste avslöjade innehaven. Dessutom, när det är möjligt tillhandahåller vi insiderns historiska handelsresultat. Det historiska handelsresultatet är ett vägt genomsnitt av resultatet för faktiska köptransaktioner på den öppna marknaden som insidern gjort. För mer information om hur detta beräknas, titta på detta YouTube-webinarium.
See our leaderboard of most profitable insider traders.
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
|
14159, L.p.
Director, 10% Owner -
[D]
|
71 647 | 71 647 | |
|
667, L.p.
Director, 10% Owner -
[D]
|
38 452 877 | 39 365 965 | |
| Thomas H Aasen EXEC VP, CFO AND CBO - [O] | 0 | 0 | |
|
Baker Bros. Advisors Lp
Director, 10% Owner -
[D]
|
39 365 965 | 39 365 965 | |
|
Felix Baker
10% Owner -
|
38 452 877 | 39 365 965 | |
|
Julian Baker
10% Owner -
|
38 452 877 | 39 365 965 | |
|
Jeffrey T Barnes
10% Owner -
|
236 500 | 3 160 238 | |
| Michael T Borer Director - [D] | 0 | 0 | |
| Glenn Baity EVP AND GC - [O] | 83 734 | 83 734 | |
|
Baker Bros. Advisors (GP) LLC
Director, 10% Owner -
[D]
|
38 452 877 | 39 365 965 | |
|
Baker Brothers Life Sciences LP
Director, 10% Owner -
[D]
|
38 452 877 | 39 365 965 | |
| Stephen R Biggar | 0 | ||
| Gordon M Binder | 6 500 | ||
| Laura Brege Director - [D] | 15 095 | 15 095 | |
|
Mark Carthy
10% Owner -
|
236 500 | 3 160 238 | |
| Stephen Davis CEO, Director - [D] [O] | 186 555 | 186 555 | |
| James M Daly Director - [D] | 34 041 | 34 041 |
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
|
Jonathan Fleming
10% Owner -
|
236 500 | 3 160 238 | |
| Garofalo Elizabeth A. Director - [D] | 25 382 | 25 382 | |
| Carl L Gordon Director - [D] | 774 006 | 774 006 | |
| Mary Ann Gray Director - [D] | 149 476 | 149 476 | |
| Edmund Harrigan Director - [D] | 35 041 | 35 041 | |
| Uli Hacksell CEO, Director - [D] [O] | 115 549 | 115 549 | |
| Leslie L Iversen Director - [D] | 36 127 | 36 127 | |
| Lester J Ph D Kaplan Director - [D] | 17 000 | 17 000 | |
| Kim Austin D. EVP,General Counsel, Secretary - [O] | 46 901 | 46 901 | |
| James Kihara PRINCIPAL ACCOUNTING OFFICER - [O] | 20 395 | 20 395 | |
|
Michael Lytton
10% Owner -
|
236 500 | 3 160 238 | |
|
Mrna Fund Ii Lp
10% Owner -
|
236 500 | ||
| Eric Alejandro Miller Controller & PAO - [O] | 270 | 270 | |
| Roger Mills EVP, DEVELOPMENT AND CMO - [O] | 18 550 | 18 550 | |
| Terrence O Moore EVP, CHIEF COMMERCIAL OFFICER - [O] | 1 671 | 1 671 | |
|
Nomura International Plc
10% Owner -
|
2 199 010 | 2 199 010 | |
| Adora Ndu Director - [D] | 24 801 | 24 801 |
| Insider | Genomsnitt vinst (%) | Aktier Ägda |
Delad Justerad |
|---|---|---|---|
|
Nomura Phase4 Ventures GP LTD
10% Owner -
|
2 199 010 | 2 199 010 | |
|
Nomura Phase4 Ventures LP
10% Owner -
|
2 199 010 | 2 199 010 | |
|
Phase4 Ventures LTD Nomura
10% Owner -
|
2 199 010 | 2 199 010 | |
|
Obp Management Iv Lp
10% Owner -
|
236 500 | 3 160 238 | |
|
Oxford Bioscience Partners Iv Lp
10% Owner -
|
3 160 238 | 3 160 238 | |
| Torsten Rasmussen Director - [D] | 8 500 | 8 500 | |
| Elena Ridloff EVP and CFO - [O] | 10 553 | 10 553 | |
| Daniel B Soland Director - [D] | 44 041 | 44 041 | |
| Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER - [O] | 40 130 | 40 130 | |
| Stankovic Srdjan R. President - [O] | 61 234 | 61 234 | |
| Brendan Teehan EVP, COO, HEAD OF COMMERCIAL - [O] | 62 105 | 62 105 | |
| Bo-Ragnar Tolf | 21 000 | ||
|
Alan G Walton
Director, 10% Owner -
[D]
|
8 833 | 3 160 238 | |
| William McDowall Wells Director - [D] | 0 | 0 | |
| Yang Michael J. EVP and CCO - [O] | 8 059 | 8 059 | |
| Young Todd S. | 4 688 | ||
| Osch Martien van Director - [D] | 1 168 892 | 1 168 892 |
Report errors via our new Insider Auditing Tool
Track Records av insiderköp - Kortsiktig vinstanalys
I denna sektion analyserar vi lönsamheten för varje oplanerat, öppet-marknads insiderköp gjorda i ACAD / ACADIA Pharmaceuticals Inc.. Denna analys hjälper till att förstå om insidern konsekvent genererar onormala avkastningar och är värd att följa. Denna analys är för ett år efter varje handel, och resultaten är teoretiska .
Tabellen nedan visar de senaste köpen på öppna marknaden som inte var en del av en automatisk handelsplan.
Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.
Track Records av insiderförsäljning - Kortsiktig förlustanalys
I denna sektion analyserar vi lönsamheten för varje oplanerat, öppet-marknads insiderköp gjorda i ACAD / ACADIA Pharmaceuticals Inc.. Denna analys hjälper till att förstå om insidern konsekvent genererar onormala avkastningar och är värd att följa. Denna analys är för ett år efter varje handel, och resultaten är teoretiska .
Tabellen nedan visar de senaste försäljningarna på öppna marknaden som inte var en del av en automatisk handelsplan.
Justeringar av aktierär de justerade aktierna efter justerat pris. Justeringar av aktierär de justerade aktierna efter uppdelning.
Transaktionshistorik
Klicka på länkikonen för att se hela transaktionshistoriken. Transaktioner som rapporteras som en del av en automatisk handelsplan 10b5-1 kommer att ha ett X i kolumnen markerad 10b-5.
| Fil datum |
Handel datum |
Schema | Insider | Ticker | Värdepappertitel | Kod | Direkta | Utövningspris | Enhet pris |
Enheter ändrad |
Värde ändrad (1K) |
Kvarvarande Optioner |
Kvarvarande Aktier |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-09-03 | 2025-09-02 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | 25,9753 | −1 600 | −42 | 25 382 | ||||
| 2025-08-19 | 2025-08-18 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 25,1829 | −22 000 | −554 | 40 130 | ||||
| 2025-06-05 | 2025-06-04 | 4 | Brege Laura | ACAD | Common Stock | D | 21,7800 | −14 446 | −315 | 15 095 | ||||
| 2025-06-02 | 2025-05-29 | 4 | Brege Laura | ACAD | Common Stock | D | 9 387 | 29 541 | ||||||
| 2025-06-02 | 2025-05-29 | 4 | Daly James M | ACAD | Common Stock | D | 9 387 | 34 041 | ||||||
| 2025-06-02 | 2025-05-29 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | 9 387 | 26 982 | ||||||
| 2025-06-02 | 2025-05-29 | 4 | Ndu Adora | ACAD | Common Stock | D | 9 387 | 24 801 | ||||||
| 2025-06-02 | 2025-05-29 | 4 | HARRIGAN EDMUND | ACAD | Common Stock | D | 9 387 | 35 041 | ||||||
| 2025-06-02 | 2025-05-29 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 9 387 | 44 041 | ||||||
| 2025-06-02 | 2025-05-29 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 16 214 | 39 365 965 | ||||||
| 2025-06-02 | 2025-05-29 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 16 214 | 39 365 965 | ||||||
| 2025-05-19 | 2025-05-16 | 4 | Kihara James | ACAD | Common Stock | D | 20,0000 | −2 000 | −40 | 20 395 | ||||
| 2025-05-19 | 2025-05-16 | 4 | Kihara James | ACAD | Common Stock | D | 25,0000 | −2 000 | −50 | 22 395 | ||||
| 2025-05-19 | 2025-05-16 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 25,0000 | −2 000 | −50 | 62 130 | ||||
| 2025-05-02 | 2025-05-02 | 4 | Kihara James | ACAD | Common Stock | D | 14,6000 | −1 327 | −19 | 23 526 | ||||
| 2025-05-02 | 2025-05-01 | 4 | Kihara James | ACAD | Common Stock | D | 2 596 | 24 853 | ||||||
| 2025-05-02 | 2025-05-02 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 14,6000 | −3 498 | −51 | 62 773 | ||||
| 2025-05-02 | 2025-05-01 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 6 815 | 66 271 | ||||||
| 2025-04-08 | 2025-04-08 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 14,8200 | −2 708 | −40 | 59 456 | ||||
| 2025-04-08 | 2025-04-05 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 5 275 | 62 164 | ||||||
| 2025-04-08 | 2025-04-08 | 4 | Kihara James | ACAD | Common Stock | D | 14,8200 | −1 028 | −15 | 22 257 | ||||
| 2025-04-08 | 2025-04-05 | 4 | Kihara James | ACAD | Common Stock | D | 2 010 | 23 285 | ||||||
| 2025-03-26 | 2025-03-26 | 4 | Kihara James | ACAD | Common Stock | D | 17,0500 | −1 095 | −19 | 21 275 | ||||
| 2025-03-26 | 2025-03-25 | 4 | Kihara James | ACAD | Common Stock | D | 2 142 | 22 370 | ||||||
| 2025-03-26 | 2025-03-26 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 17,0500 | −3 171 | −54 | 56 889 | ||||
| 2025-03-26 | 2025-03-25 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 6 178 | 60 060 | ||||||
| 2025-03-06 | 2025-03-05 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | 18,2300 | −4 919 | −90 | 17 595 | ||||
| 2025-02-25 | 2025-02-24 | 4 | Kihara James | ACAD | Common Stock | D | 19,9600 | −475 | −9 | 20 228 | ||||
| 2025-02-25 | 2025-02-23 | 4 | Kihara James | ACAD | Common Stock | D | 840 | 20 703 | ||||||
| 2025-02-25 | 2025-02-24 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 19,9600 | −773 | −15 | 53 882 | ||||
| 2025-02-25 | 2025-02-23 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 1 353 | 54 655 | ||||||
| 2024-11-19 | 2024-11-19 | 4 | Teehan Brendan | ACAD | Common Stock | D | 16,8100 | −10 329 | −174 | 62 105 | ||||
| 2024-11-19 | 2024-11-17 | 4 | Teehan Brendan | ACAD | Common Stock | D | 9 913 | 72 434 | ||||||
| 2024-11-19 | 2024-11-17 | 4 | Teehan Brendan | ACAD | Common Stock | D | 9 913 | 72 434 | ||||||
| 2024-11-19 | 2024-11-19 | 4 | Kihara James | ACAD | Common Stock | D | 16,8100 | −4 073 | −68 | 19 863 | ||||
| 2024-11-19 | 2024-11-17 | 4 | Kihara James | ACAD | Common Stock | D | 3 965 | 23 936 | ||||||
| 2024-11-19 | 2024-11-17 | 4 | Kihara James | ACAD | Common Stock | D | 3 965 | 23 936 | ||||||
| 2024-11-19 | 2024-11-19 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 16,8100 | −10 259 | −172 | 53 302 | ||||
| 2024-11-19 | 2024-11-17 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 9 913 | 63 561 | ||||||
| 2024-11-19 | 2024-11-17 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 9 913 | 63 561 | ||||||
| 2024-10-15 | 2024-10-12 | 4 | Ndu Adora | ACAD | Common Stock | D | 4 381 | 15 414 | ||||||
| 2024-08-20 | 2024-08-19 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 15,2800 | −9 733 | −149 | 43 735 | ||||
| 2024-08-20 | 2024-08-16 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 13 629 | 53 468 | ||||||
| 2024-08-20 | 2024-08-16 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 5 275 | 39 839 | ||||||
| 2024-08-20 | 2024-08-19 | 4 | Teehan Brendan | ACAD | Common Stock | D | 15,2800 | −9 534 | −146 | 52 177 | ||||
| 2024-08-20 | 2024-08-16 | 4 | Teehan Brendan | ACAD | Common Stock | D | 13 629 | 61 711 | ||||||
| 2024-08-20 | 2024-08-16 | 4 | Teehan Brendan | ACAD | Common Stock | D | 5 024 | 48 082 | ||||||
| 2024-08-20 | 2024-08-19 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 15,2800 | −31 747 | −485 | 186 555 | ||||
| 2024-08-20 | 2024-08-16 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 44 782 | 218 302 | ||||||
| 2024-08-20 | 2024-08-16 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 17 333 | 173 520 | ||||||
| 2024-06-11 | 2024-06-10 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 14,7900 | −975 | −14 | 34 564 | ||||
| 2024-06-11 | 2024-06-08 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 1 893 | 35 539 | ||||||
| 2024-05-31 | 2024-05-29 | 4 | Brege Laura | ACAD | Common Stock | D | 6 652 | 20 154 | ||||||
| 2024-05-31 | 2024-05-29 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 6 652 | 34 654 | ||||||
| 2024-05-31 | 2024-05-29 | 4 | HARRIGAN EDMUND | ACAD | Common Stock | D | 6 652 | 25 654 | ||||||
| 2024-05-31 | 2024-05-29 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | 6 652 | 22 514 | ||||||
| 2024-05-31 | 2024-05-29 | 4 | Daly James M | ACAD | Common Stock | D | 6 652 | 24 654 | ||||||
| 2024-05-31 | 2024-05-29 | 4 | Ndu Adora | ACAD | Common Stock | D | 6 652 | 11 033 | ||||||
| 2024-05-31 | 2024-05-29 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 18 774 | 39 349 751 | ||||||
| 2024-05-31 | 2024-05-29 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 18 774 | 39 349 751 | ||||||
| 2024-05-03 | 2024-05-02 | 4 | Kihara James | ACAD | Common Stock | D | 16,9400 | −1 326 | −22 | 14 370 | ||||
| 2024-05-03 | 2024-05-01 | 4 | Kihara James | ACAD | Common Stock | D | 2 596 | 15 696 | ||||||
| 2024-05-03 | 2024-05-02 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 16,9400 | −11 427 | −194 | 155 231 | ||||
| 2024-05-03 | 2024-05-01 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 22 391 | 166 658 | ||||||
| 2024-05-03 | 2024-05-02 | 4 | Teehan Brendan | ACAD | Common Stock | D | 16,9400 | −3 477 | −59 | 42 133 | ||||
| 2024-05-03 | 2024-05-01 | 4 | Teehan Brendan | ACAD | Common Stock | D | 6 814 | 45 610 | ||||||
| 2024-05-03 | 2024-05-02 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 16,9400 | −3 503 | −59 | 32 053 | ||||
| 2024-05-03 | 2024-05-01 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 6 814 | 35 556 | ||||||
| 2024-04-09 | 2024-04-08 | 4 | Kihara James | ACAD | Common Stock | D | 17,8700 | −762 | −14 | 13 100 | ||||
| 2024-04-09 | 2024-04-08 | 4 | Kihara James | ACAD | Common Stock | D | 17,8700 | −1 028 | −18 | 13 862 | ||||
| 2024-04-09 | 2024-04-07 | 4 | Kihara James | ACAD | Common Stock | D | 1 489 | 14 890 | ||||||
| 2024-04-09 | 2024-04-05 | 4 | Kihara James | ACAD | Common Stock | D | 2 010 | 13 401 | ||||||
| 2024-04-09 | 2024-04-08 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 17,8700 | −2 716 | −49 | 28 742 | ||||
| 2024-04-09 | 2024-04-05 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 5 275 | 31 458 | ||||||
| 2024-04-09 | 2024-04-08 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 17,8700 | −17 716 | −317 | 144 267 | ||||
| 2024-04-09 | 2024-04-08 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 17,8700 | −8 858 | −158 | 161 983 | ||||
| 2024-04-09 | 2024-04-05 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 34 666 | 170 841 | ||||||
| 2024-04-09 | 2024-04-05 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 17 333 | 136 175 | ||||||
| 2024-04-09 | 2024-04-08 | 4 | Teehan Brendan | ACAD | Common Stock | D | 17,8700 | −2 568 | −46 | 38 796 | ||||
| 2024-04-09 | 2024-04-05 | 4 | Teehan Brendan | ACAD | Common Stock | D | 5 024 | 41 364 | ||||||
| 2024-03-27 | 2024-03-27 | 4 | Teehan Brendan | ACAD | Common Stock | D | 17,9000 | −5 140 | −92 | 36 340 | ||||
| 2024-03-27 | 2024-03-25 | 4 | Teehan Brendan | ACAD | Common Stock | D | 10 048 | 41 480 | ||||||
| 2024-03-27 | 2024-03-27 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 17,9000 | −17 714 | −317 | 118 842 | ||||
| 2024-03-27 | 2024-03-25 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 34 666 | 136 556 | ||||||
| 2024-03-27 | 2024-03-27 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 17,9000 | −5 434 | −97 | 26 183 | ||||
| 2024-03-27 | 2024-03-25 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 10 550 | 31 617 | ||||||
| 2024-02-27 | 2024-02-26 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 24,6700 | −772 | −19 | 21 067 | ||||
| 2024-02-27 | 2024-02-23 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 1 353 | 21 839 | ||||||
| 2024-02-27 | 2024-02-26 | 4 | Teehan Brendan | ACAD | Common Stock | D | 24,6700 | −624 | −15 | 31 432 | ||||
| 2024-02-27 | 2024-02-23 | 4 | Teehan Brendan | ACAD | Common Stock | D | 1 107 | 32 056 | ||||||
| 2024-02-27 | 2024-02-26 | 4 | Kihara James | ACAD | Common Stock | D | 24,6700 | −474 | −12 | 11 391 | ||||
| 2024-02-27 | 2024-02-23 | 4 | Kihara James | ACAD | Common Stock | D | 840 | 11 865 | ||||||
| 2024-02-27 | 2024-02-26 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 24,6700 | −5 577 | −138 | 101 890 | ||||
| 2024-02-27 | 2024-02-23 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 10 946 | 107 467 | ||||||
| 2024-01-09 | 2024-01-08 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 29,9600 | −590 | −18 | 46 901 | ||||
| 2024-01-09 | 2024-01-06 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 1 634 | 47 491 | ||||||
| 2024-01-09 | 2024-01-08 | 4 | Teehan Brendan | ACAD | Common Stock | D | 29,9600 | −731 | −22 | 30 949 | ||||
| 2024-01-09 | 2024-01-06 | 4 | Teehan Brendan | ACAD | Common Stock | D | 1 287 | 31 680 | ||||||
| 2024-01-09 | 2024-01-08 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 29,9600 | −3 732 | −112 | 96 521 | ||||
| 2024-01-09 | 2024-01-06 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 9 528 | 100 253 | ||||||
| 2023-12-15 | 2023-12-15 | 4 | Kihara James | ACAD | Common Stock | D | 28,3000 | −2 000 | −57 | 11 025 | ||||
| 2023-11-28 | 2023-11-24 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | −2 918 | 15 862 | ||||||
| 2023-11-21 | 2023-11-20 | 4 | Kihara James | ACAD | Common Stock | D | 22,6400 | −1 985 | −45 | 13 025 | ||||
| 2023-11-21 | 2023-11-17 | 4 | Kihara James | ACAD | Common Stock | D | 1 982 | 15 010 | ||||||
| 2023-11-21 | 2023-11-17 | 4 | Kihara James | ACAD | Common Stock | D | 1 982 | 15 010 | ||||||
| 2023-11-21 | 2023-11-20 | 4 | Teehan Brendan | ACAD | Common Stock | D | 22,6400 | −4 960 | −112 | 30 393 | ||||
| 2023-11-21 | 2023-11-17 | 4 | Teehan Brendan | ACAD | Common Stock | D | 4 956 | 35 353 | ||||||
| 2023-11-21 | 2023-11-17 | 4 | Teehan Brendan | ACAD | Common Stock | D | 4 956 | 35 353 | ||||||
| 2023-11-21 | 2023-11-20 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 22,6400 | −5 108 | −116 | 20 486 | ||||
| 2023-11-21 | 2023-11-17 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 4 956 | 25 594 | ||||||
| 2023-11-21 | 2023-11-17 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 4 956 | 25 594 | ||||||
| 2023-10-16 | 2023-10-12 | 4 | Ndu Adora | ACAD | Common Stock | D | 4 381 | 4 381 | ||||||
| 2023-10-06 | 2023-10-06 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 21,9600 | −51 563 | −1 132 | 89 131 | ||||
| 2023-10-06 | 2023-10-05 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 103 999 | 140 694 | ||||||
| 2023-10-06 | 2023-10-06 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 21,9600 | −16 369 | −359 | 45 857 | ||||
| 2023-10-06 | 2023-10-05 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 36 174 | 62 226 | ||||||
| 2023-09-19 | 2023-09-15 | 4 | Kihara James | ACAD | Common Stock | D | 25,8800 | −2 000 | −52 | 10 778 | ||||
| 2023-08-23 | 2023-08-21 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 28,9970 | −10 000 | −290 | 15 682 | ||||
| 2023-07-18 | 2023-07-14 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 30,0435 | −100 000 | −3 004 | 36 695 | ||||
| 2023-07-18 | 2023-07-14 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 20,7700 | 100 000 | 2 077 | 136 695 | ||||
| 2023-07-13 | 2023-07-12 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 25,0517 | −55 104 | −1 380 | 36 695 | ||||
| 2023-07-13 | 2023-07-11 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 25,0000 | −16 498 | −412 | 91 799 | ||||
| 2023-06-16 | 2023-06-15 | 4 | Kihara James | ACAD | Common Stock | D | 24,1500 | −2 000 | −48 | 9 144 | ||||
| 2023-06-14 | 2023-06-12 | 4 | Brege Laura | ACAD | Common Stock | D | 24,8680 | −4 500 | −112 | 13 502 | ||||
| 2023-06-12 | 2023-06-08 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 25,0200 | −974 | −24 | 22 824 | ||||
| 2023-06-12 | 2023-06-08 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 1 893 | 23 798 | ||||||
| 2023-06-05 | 2023-06-01 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 8 552 | 28 002 | ||||||
| 2023-06-05 | 2022-06-07 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 6 391 | 19 450 | ||||||
| 2023-06-05 | 2021-06-22 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 3 059 | 13 059 | ||||||
| 2023-06-05 | 2023-06-01 | 4 | Brege Laura | ACAD | Common Stock | D | 8 552 | 18 002 | ||||||
| 2023-06-05 | 2022-06-07 | 4 | Brege Laura | ACAD | Common Stock | D | 6 391 | 9 450 | ||||||
| 2023-06-05 | 2021-06-22 | 4 | Brege Laura | ACAD | Common Stock | D | 3 059 | 3 059 | ||||||
| 2023-06-05 | 2023-06-01 | 4 | HARRIGAN EDMUND | ACAD | Common Stock | D | 8 552 | 19 002 | ||||||
| 2023-06-05 | 2022-06-07 | 4 | HARRIGAN EDMUND | ACAD | Common Stock | D | 6 391 | 10 450 | ||||||
| 2023-06-05 | 2021-06-22 | 4 | HARRIGAN EDMUND | ACAD | Common Stock | D | 3 059 | 4 059 | ||||||
| 2023-06-05 | 2023-06-01 | 4 | Daly James M | ACAD | Common Stock | D | 8 552 | 18 002 | ||||||
| 2023-06-05 | 2022-06-07 | 4 | Daly James M | ACAD | Common Stock | D | 6 391 | 9 450 | ||||||
| 2023-06-05 | 2021-06-22 | 4 | Daly James M | ACAD | Common Stock | D | 3 059 | 3 059 | ||||||
| 2023-06-05 | 2023-06-01 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | 8 552 | 18 780 | ||||||
| 2023-06-05 | 2022-09-29 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | 1 919 | 10 228 | ||||||
| 2023-06-05 | 2022-06-07 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | 6 391 | 8 309 | ||||||
| 2023-06-05 | 2023-06-01 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 13 304 | 39 330 977 | ||||||
| 2023-06-05 | 2023-06-01 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 13 304 | 39 330 977 | ||||||
| 2023-05-24 | 2023-05-24 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,6500 | 259 109 | 6 646 | 39 317 673 | ||||
| 2023-05-24 | 2023-05-24 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,6500 | 24 113 | 618 | 3 610 443 | ||||
| 2023-05-24 | 2023-05-24 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,5138 | 28 878 | 737 | 39 058 564 | ||||
| 2023-05-24 | 2023-05-24 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,5138 | 2 688 | 69 | 3 586 330 | ||||
| 2023-05-24 | 2023-05-24 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,2723 | 218 171 | 5 514 | 39 029 686 | ||||
| 2023-05-24 | 2023-05-24 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,2723 | 20 304 | 513 | 3 583 642 | ||||
| 2023-05-24 | 2023-05-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,5400 | 74 582 | 1 905 | 38 811 515 | ||||
| 2023-05-24 | 2023-05-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,5400 | 6 941 | 177 | 3 563 338 | ||||
| 2023-05-24 | 2023-05-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,3302 | 116 672 | 2 955 | 38 736 933 | ||||
| 2023-05-24 | 2023-05-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,3302 | 10 858 | 275 | 3 556 397 | ||||
| 2023-05-24 | 2023-05-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 17,0100 | 12 500 | 213 | 38 620 261 | ||||
| 2023-05-24 | 2023-05-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 17,0100 | 12 500 | 213 | 38 620 261 | ||||
| 2023-05-24 | 2023-05-22 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 24,8000 | 40 632 | 1 008 | 38 607 761 | ||||
| 2023-05-24 | 2023-05-22 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 24,8000 | 3 781 | 94 | 3 533 039 | ||||
| 2023-05-24 | 2023-05-22 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 24,4604 | 82 148 | 2 009 | 38 567 129 | ||||
| 2023-05-24 | 2023-05-22 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 24,4604 | 7 645 | 187 | 3 529 258 | ||||
| 2023-05-19 | 2023-05-17 | 4 | Kihara James | ACAD | Common Stock | D | 22,5000 | −5 947 | −134 | 11 144 | ||||
| 2023-05-19 | 2023-05-17 | 4 | Kihara James | ACAD | Common Stock | D | 5 947 | 17 091 | ||||||
| 2023-05-19 | 2023-05-17 | 4 | Kihara James | ACAD | Common Stock | D | 5 947 | 17 091 | ||||||
| 2023-05-19 | 2023-05-17 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 22,5000 | −15 310 | −344 | 21 905 | ||||
| 2023-05-19 | 2023-05-17 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 14 869 | 37 215 | ||||||
| 2023-05-19 | 2023-05-17 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 14 869 | 37 215 | ||||||
| 2023-05-19 | 2023-05-17 | 4 | Teehan Brendan | ACAD | Common Stock | D | 22,5000 | −14 869 | −335 | 24 356 | ||||
| 2023-05-19 | 2023-05-17 | 4 | Teehan Brendan | ACAD | Common Stock | D | 14 869 | 39 225 | ||||||
| 2023-05-19 | 2023-05-17 | 4 | Teehan Brendan | ACAD | Common Stock | D | 14 869 | 39 225 | ||||||
| 2023-05-02 | 2023-05-01 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 21,1800 | −917 | −19 | 25 513 | ||||
| 2023-05-02 | 2023-04-29 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 3 005 | 26 430 | ||||||
| 2023-05-02 | 2023-05-01 | 4 | Teehan Brendan | ACAD | Common Stock | D | 21,1800 | −548 | −12 | 9 487 | ||||
| 2023-05-02 | 2023-04-29 | 4 | Teehan Brendan | ACAD | Common Stock | D | 1 567 | 10 035 | ||||||
| 2023-05-02 | 2023-05-01 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 21,1800 | −7 806 | −165 | 108 297 | ||||
| 2023-05-02 | 2023-04-29 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 15 625 | 116 103 | ||||||
| 2023-04-11 | 2023-04-10 | 4 | Kihara James | ACAD | Common Stock | D | 18,1400 | −523 | −9 | 5 197 | ||||
| 2023-04-11 | 2023-04-07 | 4 | Kihara James | ACAD | Common Stock | D | 1 489 | 5 720 | ||||||
| 2023-04-07 | 2023-04-06 | 4 | Teehan Brendan | ACAD | Common Stock | D | 18,1600 | −1 751 | −32 | 8 468 | ||||
| 2023-04-07 | 2023-04-05 | 4 | Teehan Brendan | ACAD | Common Stock | D | 5 024 | 10 219 | ||||||
| 2023-04-07 | 2023-04-06 | 4 | Kihara James | ACAD | Common Stock | D | 18,1600 | −701 | −13 | 4 231 | ||||
| 2023-04-07 | 2023-04-05 | 4 | Kihara James | ACAD | Common Stock | D | 2 009 | 4 932 | ||||||
| 2023-04-07 | 2023-04-06 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 18,1600 | −1 916 | −35 | 7 477 | ||||
| 2023-04-07 | 2023-04-05 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 5 275 | 9 393 | ||||||
| 2023-04-07 | 2023-04-06 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 18,1600 | −8 582 | −156 | 100 478 | ||||
| 2023-04-07 | 2023-04-05 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 17 333 | 109 060 | ||||||
| 2023-04-07 | 2023-04-06 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 18,1600 | −1 456 | −26 | 23 425 | ||||
| 2023-04-07 | 2023-04-05 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 4 773 | 24 881 | ||||||
| 2023-02-27 | 2023-02-24 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 18,7800 | −3 851 | −72 | 91 727 | ||||
| 2023-02-27 | 2023-02-23 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 10 945 | 95 578 | ||||||
| 2023-02-27 | 2023-02-24 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 18,7800 | −577 | −11 | 4 118 | ||||
| 2023-02-27 | 2023-02-23 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 1 353 | 4 695 | ||||||
| 2023-02-27 | 2023-02-24 | 4 | Teehan Brendan | ACAD | Common Stock | D | 18,7800 | −461 | −9 | 5 195 | ||||
| 2023-02-27 | 2023-02-23 | 4 | Teehan Brendan | ACAD | Common Stock | D | 1 107 | 5 656 | ||||||
| 2023-02-27 | 2023-02-24 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 18,7800 | −803 | −15 | 20 108 | ||||
| 2023-02-27 | 2023-02-23 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 2 214 | 20 911 | ||||||
| 2023-02-27 | 2023-02-24 | 4 | Kihara James | ACAD | Common Stock | D | 18,7800 | −350 | −7 | 2 923 | ||||
| 2023-02-27 | 2023-02-23 | 4 | Kihara James | ACAD | Common Stock | D | 840 | 3 273 | ||||||
| 2023-01-17 | 2023-01-12 | 4 | Brege Laura | ACAD | Common Stock | D | 18,2500 | −12 500 | −228 | 0 | ||||
| 2023-01-17 | 2023-01-12 | 4 | Brege Laura | ACAD | Common Stock | D | 17,0100 | 12 500 | 213 | 12 500 | ||||
| 2023-01-17 | 2023-01-12 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 5,2200 | 15 000 | 78 | 38 484 981 | ||||
| 2023-01-17 | 2023-01-12 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 5,2200 | 15 000 | 78 | 38 484 981 | ||||
| 2023-01-10 | 2023-01-09 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 17,1303 | −3 904 | −67 | 84 633 | ||||
| 2023-01-10 | 2023-01-06 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 9 528 | 88 537 | ||||||
| 2023-01-10 | 2023-01-09 | 4 | Teehan Brendan | ACAD | Common Stock | D | 17,1303 | −532 | −9 | 4 549 | ||||
| 2023-01-10 | 2023-01-06 | 4 | Teehan Brendan | ACAD | Common Stock | D | 1 286 | 5 081 | ||||||
| 2023-01-10 | 2023-01-09 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 17,1303 | −589 | −10 | 18 697 | ||||
| 2023-01-10 | 2023-01-06 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 1 633 | 19 286 | ||||||
| 2022-11-22 | 2022-11-21 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 15,0700 | −1 847 | −28 | 61 234 | ||||
| 2022-11-22 | 2022-11-19 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 6 250 | 63 081 | ||||||
| 2022-10-18 | 2022-10-15 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 15,8100 | −1 326 | −21 | 56 831 | ||||
| 2022-10-18 | 2022-10-15 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 2 969 | 58 157 | ||||||
| 2022-10-18 | 2022-10-15 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 15,8100 | −2 804 | −44 | 79 009 | ||||
| 2022-10-18 | 2022-10-15 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 5 938 | 81 813 | ||||||
| 2022-06-10 | 2022-06-09 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 17,9095 | −653 | −12 | 3 342 | ||||
| 2022-06-10 | 2022-06-08 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 1 893 | 3 995 | ||||||
| 2022-06-09 | 2022-06-07 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 17 104 | 38 469 981 | ||||||
| 2022-06-09 | 2022-06-07 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 17 104 | 38 469 981 | ||||||
| 2022-05-03 | 2022-05-02 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 18,1819 | −5 483 | −100 | 75 875 | ||||
| 2022-05-03 | 2022-04-29 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | −15 625 | 15 625 | ||||||
| 2022-05-03 | 2022-04-29 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 15 625 | 81 358 | ||||||
| 2022-05-03 | 2022-05-02 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 18,1818 | −2 865 | −52 | 55 188 | ||||
| 2022-05-03 | 2022-04-29 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −9 616 | 9 616 | ||||||
| 2022-05-03 | 2022-04-29 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 9 616 | 58 053 | ||||||
| 2022-05-03 | 2022-05-02 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 18,1820 | −894 | −16 | 16 742 | ||||
| 2022-05-03 | 2022-04-29 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | −3 005 | 3 005 | ||||||
| 2022-05-03 | 2022-04-29 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 3 005 | 17 636 | ||||||
| 2022-05-03 | 2022-05-02 | 4 | Teehan Brendan | ACAD | Common Stock | D | 18,1820 | −552 | −10 | 3 437 | ||||
| 2022-05-03 | 2022-04-29 | 4 | Teehan Brendan | ACAD | Restricted Stock Units | D | −1 567 | 1 567 | ||||||
| 2022-05-03 | 2022-04-29 | 4 | Teehan Brendan | ACAD | Common Stock | D | 1 567 | 3 989 | ||||||
| 2022-04-11 | 2022-04-08 | 4 | Kihara James | ACAD | Common Stock | D | 27,0500 | −1 025 | −28 | 2 433 | ||||
| 2022-04-11 | 2022-04-07 | 4 | Kihara James | ACAD | Restricted Stock Units | D | −2 977 | 2 978 | ||||||
| 2022-04-11 | 2022-04-07 | 4 | Kihara James | ACAD | Common Stock | D | 2 977 | 3 458 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | Kihara James | ACAD | Restricted Stock Units | D | 8 039 | 8 039 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | Kihara James | ACAD | Stock Options (Right to Buy) | D | 25,75 | 13 793 | 13 793 | |||||
| 2022-04-07 | 2022-04-05 | 4 | Teehan Brendan | ACAD | Restricted Stock Units | D | 20 096 | 20 096 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | Teehan Brendan | ACAD | Stock Options (Right to Buy) | D | 25,75 | 68 966 | 68 966 | |||||
| 2022-04-07 | 2022-04-05 | 4 | Schneyer Mark C. | ACAD | Restricted Stock Units | D | 21 101 | 21 101 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | Schneyer Mark C. | ACAD | Stock Options (Right to Buy) | D | 25,75 | 72 414 | 72 414 | |||||
| 2022-04-07 | 2022-04-05 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | 96 463 | 96 463 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | 19 092 | 19 092 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | KIM AUSTIN D. | ACAD | Stock Options (Right to Buy) | D | 25,75 | 65 517 | 65 517 | |||||
| 2022-04-07 | 2022-04-05 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | 144 695 | 144 695 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | 36 174 | 36 174 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | Stankovic Srdjan R. | ACAD | Stock Options (Right to Buy) | D | 25,75 | 124 138 | 124 138 | |||||
| 2022-04-07 | 2022-04-05 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | 277 331 | 277 331 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | 69 333 | 69 333 | ||||||
| 2022-04-07 | 2022-04-05 | 4 | DAVIS STEPHEN | ACAD | Stock Options (Right to Buy) | D | 25,75 | 237 931 | 237 931 | |||||
| 2022-02-25 | 2022-02-23 | 4 | Schneyer Mark C. | ACAD | Restricted Stock Units | D | 1 352 | 4 059 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 23,8000 | −553 | −13 | 2 102 | ||||
| 2022-02-25 | 2022-02-23 | 4 | Schneyer Mark C. | ACAD | Common Stock | D | 1 352 | 2 655 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | 2 213 | 6 642 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 23,8000 | −782 | −19 | 14 631 | ||||
| 2022-02-25 | 2022-02-23 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 2 213 | 15 413 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | Teehan Brendan | ACAD | Restricted Stock Units | D | 1 106 | 3 321 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | Teehan Brendan | ACAD | Common Stock | D | 23,8000 | −472 | −11 | 2 422 | ||||
| 2022-02-25 | 2022-02-23 | 4 | Teehan Brendan | ACAD | Common Stock | D | 1 106 | 2 894 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | 10 945 | 32 837 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 23,8000 | −3 928 | −93 | 65 733 | ||||
| 2022-02-25 | 2022-02-23 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 10 945 | 69 661 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | Kihara James | ACAD | Restricted Stock Units | D | 840 | 2 520 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | Kihara James | ACAD | Common Stock | D | 23,8000 | −359 | −9 | 481 | ||||
| 2022-02-25 | 2022-02-23 | 4 | Kihara James | ACAD | Common Stock | D | 840 | 840 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | 4 919 | 14 758 | ||||||
| 2022-02-25 | 2022-02-23 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 23,8000 | −1 501 | −36 | 48 437 | ||||
| 2022-02-25 | 2022-02-23 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 4 919 | 49 938 | ||||||
| 2022-01-10 | 2022-01-06 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | −9 527 | 19 056 | ||||||
| 2022-01-10 | 2022-01-06 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 23,0500 | −3 718 | −86 | 58 716 | ||||
| 2022-01-10 | 2022-01-06 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 9 527 | 62 434 | ||||||
| 2022-01-10 | 2022-01-06 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | −1 633 | 3 267 | ||||||
| 2022-01-10 | 2022-01-06 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 23,0500 | −574 | −13 | 13 200 | ||||
| 2022-01-10 | 2022-01-06 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 1 633 | 13 774 | ||||||
| 2022-01-10 | 2022-01-06 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −5 444 | 10 889 | ||||||
| 2022-01-10 | 2022-01-06 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 23,0500 | −1 937 | −45 | 45 019 | ||||
| 2022-01-10 | 2022-01-06 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 5 444 | 46 956 | ||||||
| 2022-01-10 | 2022-01-06 | 4 | Teehan Brendan | ACAD | Restricted Stock Units | D | −1 286 | 2 573 | ||||||
| 2022-01-10 | 2022-01-06 | 4 | Teehan Brendan | ACAD | Common Stock | D | 23,0500 | −538 | −12 | 1 788 | ||||
| 2022-01-10 | 2022-01-06 | 4 | Teehan Brendan | ACAD | Common Stock | D | 1 286 | 2 326 | ||||||
| 2021-12-20 | 3 | Schneyer Mark C. | ACAD | Common Stock | D | 1 303 | ||||||||
| 2021-11-23 | 2021-11-22 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 19,0100 | −2 803 | −53 | 41 512 | ||||
| 2021-11-23 | 2021-11-19 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −6 250 | 6 250 | ||||||
| 2021-11-23 | 2021-11-19 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 6 250 | 44 315 | ||||||
| 2021-11-19 | 2021-11-17 | 4 | Kihara James | ACAD | Restricted Stock Units | D | 15 860 | 15 860 | ||||||
| 2021-11-19 | 2021-11-17 | 4 | Kihara James | ACAD | Restricted Stock Units | D | 15 860 | 15 860 | ||||||
| 2021-11-19 | 2021-11-17 | 4 | Teehan Brendan | ACAD | Restricted Stock Units | D | 39 651 | 39 651 | ||||||
| 2021-11-19 | 2021-11-17 | 4 | Teehan Brendan | ACAD | Restricted Stock Units | D | 39 651 | 39 651 | ||||||
| 2021-11-05 | 3 | Teehan Brendan | ACAD | Common Stock | D | 807 | ||||||||
| 2021-10-19 | 2021-10-18 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 17,4100 | −1 338 | −23 | 38 065 | ||||
| 2021-10-19 | 2021-10-15 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −2 969 | 2 969 | ||||||
| 2021-10-19 | 2021-10-15 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 2 969 | 39 403 | ||||||
| 2021-10-19 | 2021-10-18 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 17,4100 | −2 963 | −52 | 52 906 | ||||
| 2021-10-19 | 2021-10-15 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | −5 938 | 5 938 | ||||||
| 2021-10-19 | 2021-10-15 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 5 938 | 55 869 | ||||||
| 2021-10-01 | 2021-09-29 | 4 | GAROFALO ELIZABETH A. | ACAD | Restricted Stock Units | D | 1 918 | 1 919 | ||||||
| 2021-10-01 | 2021-09-29 | 4 | GAROFALO ELIZABETH A. | ACAD | Common Stock | D | 1 918 | 1 918 | ||||||
| 2021-06-24 | 2021-06-22 | 4 | SOLAND DANIEL B | ACAD | Restricted Stock Units | D | 6 391 | 6 391 | ||||||
| 2021-06-24 | 2021-06-22 | 4 | SOLAND DANIEL B | ACAD | Director Stock Options (Right to Buy) | D | 24,88 | 11 637 | 11 637 | |||||
| 2021-06-24 | 2021-06-22 | 4 | GAROFALO ELIZABETH A. | ACAD | Restricted Stock Units | D | 6 391 | 6 391 | ||||||
| 2021-06-24 | 2021-06-22 | 4 | GAROFALO ELIZABETH A. | ACAD | Director Stock Options (Right to Buy) | D | 24,88 | 11 637 | 11 637 | |||||
| 2021-06-24 | 2021-06-22 | 4 | HARRIGAN EDMUND | ACAD | Restricted Stock Units | D | 6 391 | 6 391 | ||||||
| 2021-06-24 | 2021-06-22 | 4 | HARRIGAN EDMUND | ACAD | Director Stock Options (Right to Buy) | D | 24,88 | 11 637 | 11 637 | |||||
| 2021-06-24 | 2021-06-22 | 4 | Daly James M | ACAD | Restricted Stock Units | D | 6 391 | 6 391 | ||||||
| 2021-06-24 | 2021-06-22 | 4 | Daly James M | ACAD | Director Stock Options (Right to Buy) | D | 24,88 | 11 637 | 11 637 | |||||
| 2021-06-24 | 2021-06-22 | 4 | Brege Laura | ACAD | Restricted Stock Units | D | 6 391 | 6 391 | ||||||
| 2021-06-24 | 2021-06-22 | 4 | Brege Laura | ACAD | Director Stock Options (Right to Buy) | D | 24,88 | 11 637 | 11 637 | |||||
| 2021-06-24 | 2021-06-22 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Non-Qualified Stock Options (right to buy) | I | 24,88 | 23 274 | 23 274 | |||||
| 2021-06-24 | 2021-06-22 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 12 782 | 38 452 877 | ||||||
| 2021-06-24 | 2021-06-22 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 12 782 | 38 452 877 | ||||||
| 2021-04-30 | 2021-04-30 | 4 | Ridloff Elena | ACAD | Common Stock | D | 20,3300 | −1 032 | −21 | 10 553 | ||||
| 2021-04-30 | 2021-04-29 | 4 | Ridloff Elena | ACAD | Restricted Stock Units | D | −3 245 | 6 491 | ||||||
| 2021-04-30 | 2021-04-29 | 4 | Ridloff Elena | ACAD | Common Stock | D | 3 245 | 11 585 | ||||||
| 2021-04-30 | 2021-04-30 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 20,3300 | −1 054 | −21 | 11 371 | ||||
| 2021-04-30 | 2021-04-29 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | −3 005 | 6 010 | ||||||
| 2021-04-30 | 2021-04-29 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 3 005 | 12 425 | ||||||
| 2021-04-30 | 2021-04-30 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 20,3300 | −7 850 | −160 | 49 312 | ||||
| 2021-04-30 | 2021-04-29 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | −15 625 | 31 250 | ||||||
| 2021-04-30 | 2021-04-29 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 15 625 | 57 162 | ||||||
| 2021-04-30 | 2021-04-30 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 20,3300 | −4 230 | −86 | 36 434 | ||||
| 2021-04-30 | 2021-04-29 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −9 615 | 19 232 | ||||||
| 2021-04-30 | 2021-04-29 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 9 615 | 40 664 | ||||||
| 2021-02-25 | 2021-02-23 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | 19 677 | 19 677 | ||||||
| 2021-02-25 | 2021-02-23 | 4 | Stankovic Srdjan R. | ACAD | Stock Options (Right to Buy) | D | 49,74 | 72 463 | 72 463 | |||||
| 2021-02-25 | 2021-02-23 | 4 | Kihara James | ACAD | Restricted Stock Units | D | 3 360 | 3 360 | ||||||
| 2021-02-25 | 2021-02-23 | 4 | Kihara James | ACAD | Stock Options (Right to Buy) | D | 49,74 | 6 187 | 6 187 | |||||
| 2021-02-25 | 2021-02-23 | 4 | Ridloff Elena | ACAD | Restricted Stock Units | D | 9 839 | 9 839 | ||||||
| 2021-02-25 | 2021-02-23 | 4 | Ridloff Elena | ACAD | Stock Options (Right to Buy) | D | 49,74 | 36 231 | 36 231 | |||||
| 2021-02-25 | 2021-02-23 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | 8 855 | 8 855 | ||||||
| 2021-02-25 | 2021-02-23 | 4 | KIM AUSTIN D. | ACAD | Stock Options (Right to Buy) | D | 49,74 | 32 608 | 32 608 | |||||
| 2021-02-25 | 2021-02-23 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | 43 782 | 43 782 | ||||||
| 2021-02-25 | 2021-02-23 | 4 | DAVIS STEPHEN | ACAD | Stock Options (Right to Buy) | D | 49,74 | 161 230 | 161 230 | |||||
| 2021-02-08 | 2021-02-04 | 4 | DAVIS STEPHEN | ACAD | Employee Stock Options (Right to Buy) | D | 21,28 | 23 750 | 23 750 | |||||
| 2021-02-08 | 2021-02-04 | 4 | DAVIS STEPHEN | ACAD | Employee Stock Options (Right to Buy) | D | 29,59 | 40 625 | 40 625 | |||||
| 2021-02-08 | 2021-02-04 | 4 | DAVIS STEPHEN | ACAD | Employee Stock Options (Right to Buy) | D | 35,80 | 40 625 | 40 625 | |||||
| 2021-02-08 | 2021-02-04 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 50,6100 | −14 195 | −718 | 28 900 | ||||
| 2021-02-08 | 2021-02-04 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 31 250 | 43 059 | ||||||
| 2021-02-08 | 2021-02-04 | 4 | Ridloff Elena | ACAD | Common Stock | D | 50,6100 | −2 051 | −104 | 8 340 | ||||
| 2021-02-08 | 2021-02-04 | 4 | Ridloff Elena | ACAD | Common Stock | D | 6 490 | 10 391 | ||||||
| 2021-02-08 | 2021-02-04 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 21,28 | 11 875 | 11 875 | |||||
| 2021-02-08 | 2021-02-04 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 35,80 | 21 875 | 21 875 | |||||
| 2021-02-08 | 2021-02-04 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 29,59 | 15 625 | 15 625 | |||||
| 2021-02-08 | 2021-02-04 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 50,6100 | −8 429 | −427 | 31 049 | ||||
| 2021-02-08 | 2021-02-04 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 19 231 | 39 478 | ||||||
| 2021-02-08 | 2021-02-04 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 50,6100 | −2 107 | −107 | 9 911 | ||||
| 2021-02-08 | 2021-02-04 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 6 009 | 12 018 | ||||||
| 2021-01-14 | 2021-01-12 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (Right to Buy) | D | 18,12 | −700 | 89 562 | |||||
| 2021-01-14 | 2021-01-12 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 55,0100 | −700 | −39 | 20 247 | ||||
| 2021-01-14 | 2021-01-12 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 18,1200 | 700 | 13 | 20 947 | ||||
| 2021-01-08 | 2021-01-06 | 4 | YANG MICHAEL J. | ACAD | Restricted Stock Units | D | −2 722 | 8 167 | ||||||
| 2021-01-08 | 2021-01-06 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 53,3400 | −1 120 | −60 | 8 059 | ||||
| 2021-01-08 | 2021-01-06 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 2 722 | 9 179 | ||||||
| 2021-01-08 | 2021-01-06 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | −1 633 | 4 900 | ||||||
| 2021-01-08 | 2021-01-06 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 53,3400 | −678 | −36 | 5 518 | ||||
| 2021-01-08 | 2021-01-06 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 1 633 | 6 196 | ||||||
| 2021-01-08 | 2021-01-06 | 4 | Ridloff Elena | ACAD | Restricted Stock Units | D | −1 016 | 9 873 | ||||||
| 2021-01-08 | 2021-01-06 | 4 | Ridloff Elena | ACAD | Common Stock | D | 53,3400 | −1 016 | −54 | 3 901 | ||||
| 2021-01-08 | 2021-01-06 | 4 | Ridloff Elena | ACAD | Common Stock | D | 2 722 | 4 917 | ||||||
| 2021-01-08 | 2021-01-06 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | −9 527 | 28 583 | ||||||
| 2021-01-08 | 2021-01-06 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 53,3400 | −3 484 | −186 | 24 482 | ||||
| 2021-01-08 | 2021-01-06 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 9 527 | 27 966 | ||||||
| 2021-01-08 | 2021-01-08 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (Right to Buy) | D | 18,12 | −3 488 | 90 262 | |||||
| 2021-01-08 | 2021-01-08 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (Right to Buy) | D | 21,28 | −12 864 | 22 761 | |||||
| 2021-01-08 | 2021-01-08 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (Right to Buy) | D | 35,80 | −13 381 | 56 250 | |||||
| 2021-01-08 | 2021-01-08 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 55,2192 | −29 733 | −1 642 | 20 247 | ||||
| 2021-01-08 | 2021-01-08 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 18,1200 | 3 488 | 63 | 49 980 | ||||
| 2021-01-08 | 2021-01-08 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 21,2800 | 12 864 | 274 | 46 492 | ||||
| 2021-01-08 | 2021-01-08 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 35,8000 | 13 381 | 479 | 33 628 | ||||
| 2021-01-08 | 2021-01-07 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 55,1159 | −61 619 | −3 396 | 20 247 | ||||
| 2021-01-08 | 2021-01-07 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 35,8000 | 61 619 | 2 206 | 81 866 | ||||
| 2021-01-08 | 2021-01-06 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (Right to Buy) | D | 35,80 | −61 619 | 69 631 | |||||
| 2021-01-08 | 2021-01-06 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −5 444 | 16 333 | ||||||
| 2021-01-08 | 2021-01-06 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 53,3400 | −1 725 | −92 | 20 247 | ||||
| 2021-01-08 | 2021-01-06 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 5 444 | 21 972 | ||||||
| 2020-11-20 | 2020-11-20 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 53,5000 | −2 728 | −146 | 16 528 | ||||
| 2020-11-20 | 2020-11-19 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −6 250 | 12 500 | ||||||
| 2020-11-20 | 2020-11-19 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 6 250 | 19 256 | ||||||
| 2020-10-29 | 2020-10-27 | 4 | KIM AUSTIN D. | ACAD | Stock Option (Right to Buy) | D | 17,58 | −8 750 | 113 750 | |||||
| 2020-10-29 | 2020-10-27 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 45,1013 | −8 750 | −395 | 3 851 | ||||
| 2020-10-29 | 2020-10-27 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 17,5800 | 8 750 | 154 | 12 601 | ||||
| 2020-10-19 | 2020-10-16 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 42,5600 | −1 247 | −53 | 6 457 | ||||
| 2020-10-19 | 2020-10-15 | 4 | YANG MICHAEL J. | ACAD | Restricted Stock Units | D | −2 500 | 5 000 | ||||||
| 2020-10-19 | 2020-10-15 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 2 500 | 7 704 | ||||||
| 2020-10-19 | 2020-10-16 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 42,5600 | −1 297 | −55 | 13 006 | ||||
| 2020-10-19 | 2020-10-15 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −2 969 | 5 938 | ||||||
| 2020-10-19 | 2020-10-15 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 2 969 | 14 303 | ||||||
| 2020-10-19 | 2020-10-16 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 42,5600 | −2 960 | −126 | 14 786 | ||||
| 2020-10-19 | 2020-10-15 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | −5 937 | 11 876 | ||||||
| 2020-10-19 | 2020-10-15 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 5 937 | 17 746 | ||||||
| 2020-10-01 | 2020-09-29 | 4 | GAROFALO ELIZABETH A. | ACAD | Restricted Stock Units | D | 3 837 | 3 837 | ||||||
| 2020-10-01 | 2020-09-29 | 4 | GAROFALO ELIZABETH A. | ACAD | Stock Option (Right to Buy) | D | 40,41 | 6 865 | 6 865 | |||||
| 2020-07-09 | 2020-07-07 | 4 | YANG MICHAEL J. | ACAD | Stock Option (Right to Buy) | D | 25,12 | −14 750 | 44 292 | |||||
| 2020-07-09 | 2020-07-07 | 4 | YANG MICHAEL J. | ACAD | Stock Option (Right to Buy) | D | 21,28 | −5 000 | 25 000 | |||||
| 2020-07-09 | 2020-07-07 | 4 | YANG MICHAEL J. | ACAD | Stock Option (Right to Buy) | D | 19,98 | −7 500 | 570 000 | |||||
| 2020-07-09 | 2020-07-07 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 56,5382 | −11 100 | −628 | 5 204 | ||||
| 2020-07-09 | 2020-07-07 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 56,0503 | −16 150 | −905 | 16 304 | ||||
| 2020-07-09 | 2020-07-07 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 25,1200 | 14 750 | 371 | 32 454 | ||||
| 2020-07-09 | 2020-07-07 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 21,2800 | 5 000 | 106 | 17 704 | ||||
| 2020-07-09 | 2020-07-07 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 19,9800 | 7 500 | 150 | 12 704 | ||||
| 2020-06-25 | 2020-06-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Non-Qualified Stock Options (right to buy) | I | 52,73 | 11 158 | 11 158 | |||||
| 2020-06-25 | 2020-06-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 6 118 | 38 440 095 | ||||||
| 2020-06-25 | 2020-06-23 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 6 118 | 38 440 095 | ||||||
| 2020-06-25 | 2020-06-23 | 4 | Brege Laura | ACAD | Restricted Stock Units | D | 3 059 | 3 059 | ||||||
| 2020-06-25 | 2020-06-23 | 4 | Brege Laura | ACAD | Director Stock Options (Right to Buy) | D | 52,73 | 5 579 | 5 579 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Daly James M | ACAD | Restricted Stock Units | D | 3 059 | 3 059 | ||||||
| 2020-06-25 | 2020-06-23 | 4 | Daly James M | ACAD | Director Stock Options (Right to Buy) | D | 52,73 | 5 579 | 5 579 | |||||
| 2020-06-25 | 2020-06-23 | 4 | HARRIGAN EDMUND | ACAD | Restricted Stock Units | D | 3 059 | 3 059 | ||||||
| 2020-06-25 | 2020-06-23 | 4 | HARRIGAN EDMUND | ACAD | Director Stock Options (Right to Buy) | D | 52,73 | 5 579 | 5 579 | |||||
| 2020-06-25 | 2020-06-23 | 4 | SOLAND DANIEL B | ACAD | Restricted Stock Units | D | 3 059 | 3 059 | ||||||
| 2020-06-25 | 2020-06-23 | 4 | SOLAND DANIEL B | ACAD | Director Stock Options (Right to Buy) | D | 52,73 | 5 579 | 5 579 | |||||
| 2020-06-19 | 2020-06-19 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 18,12 | −16 452 | 93 750 | |||||
| 2020-06-19 | 2020-06-19 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 50,1164 | −16 452 | −825 | 11 334 | ||||
| 2020-06-19 | 2020-06-19 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 18,1200 | 16 452 | 298 | 27 786 | ||||
| 2020-06-19 | 2020-06-18 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 18,12 | −39 798 | 110 202 | |||||
| 2020-06-19 | 2020-06-18 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 19,98 | −17 494 | 34 112 | |||||
| 2020-06-19 | 2020-06-18 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 19,65 | −8 551 | 0 | |||||
| 2020-06-19 | 2020-06-18 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 50,0088 | −65 843 | −3 293 | 11 334 | ||||
| 2020-06-19 | 2020-06-18 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 18,1200 | 39 798 | 721 | 77 177 | ||||
| 2020-06-19 | 2020-06-18 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 19,9800 | 17 494 | 350 | 37 379 | ||||
| 2020-06-19 | 2020-06-18 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 19,6500 | 8 551 | 168 | 19 885 | ||||
| 2020-05-15 | 2020-05-14 | 4 | DAVIS STEPHEN | ACAD | Stock Option (Right to Buy) | D | 19,65 | −88 542 | 100 000 | |||||
| 2020-05-15 | 2020-05-14 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 45,0148 | −4 321 | −195 | 11 809 | ||||
| 2020-05-15 | 2020-05-14 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 45,6489 | −84 221 | −3 845 | 16 130 | ||||
| 2020-05-15 | 2020-05-14 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 19,6500 | 88 542 | 1 740 | 100 351 | ||||
| 2020-05-15 | 2020-05-13 | 4 | DAVIS STEPHEN | ACAD | Stock Option (Right to Buy) | D | 19,65 | −111 458 | 188 542 | |||||
| 2020-05-15 | 2020-05-13 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 45,1173 | −8 197 | −370 | 11 809 | ||||
| 2020-05-15 | 2020-05-13 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 45,7133 | −63 392 | −2 898 | 20 006 | ||||
| 2020-05-15 | 2020-05-13 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 46,4302 | −20 756 | −964 | 83 398 | ||||
| 2020-05-15 | 2020-05-13 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 48,5981 | −5 205 | −253 | 104 154 | ||||
| 2020-05-15 | 2020-05-13 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 48,9822 | −13 908 | −681 | 109 359 | ||||
| 2020-05-15 | 2020-05-13 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 19,6500 | 111 458 | 2 190 | 123 267 | ||||
| 2020-05-13 | 2020-05-11 | 4 | Daly James M | ACAD | Stock Option (Right to Buy) | D | 27,25 | −15 000 | 0 | |||||
| 2020-05-13 | 2020-05-11 | 4 | Daly James M | ACAD | Stock Option (Right to Buy) | D | 25,24 | −11 250 | 11 250 | |||||
| 2020-05-13 | 2020-05-11 | 4 | Daly James M | ACAD | Common Stock | D | 51,1306 | −26 250 | −1 342 | 0 | ||||
| 2020-05-13 | 2020-05-11 | 4 | Daly James M | ACAD | Common Stock | D | 27,2500 | 15 000 | 409 | 26 250 | ||||
| 2020-05-13 | 2020-05-11 | 4 | Daly James M | ACAD | Common Stock | D | 25,2400 | 11 250 | 284 | 11 250 | ||||
| 2020-05-01 | 2020-04-30 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 49,2100 | −4 308 | −212 | 11 334 | ||||
| 2020-05-01 | 2020-04-29 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −9 615 | 28 847 | ||||||
| 2020-05-01 | 2020-04-29 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 9 615 | 15 642 | ||||||
| 2020-05-01 | 2020-04-30 | 4 | Ridloff Elena | ACAD | Common Stock | D | 49,2200 | −1 050 | −52 | 2 195 | ||||
| 2020-05-01 | 2020-04-29 | 4 | Ridloff Elena | ACAD | Restricted Stock Units | D | −3 245 | 9 736 | ||||||
| 2020-05-01 | 2020-04-29 | 4 | Ridloff Elena | ACAD | Stock Option (Right to Buy) | D | 25,12 | −10 000 | 35 547 | |||||
| 2020-05-01 | 2020-04-29 | 4 | Ridloff Elena | ACAD | Common Stock | D | 3 245 | 3 245 | ||||||
| 2020-05-01 | 2020-04-29 | 4 | Ridloff Elena | ACAD | Common Stock | D | 50,7353 | −10 000 | −507 | 0 | ||||
| 2020-05-01 | 2020-04-29 | 4 | Ridloff Elena | ACAD | Common Stock | D | 25,1200 | 10 000 | 251 | 10 000 | ||||
| 2020-05-01 | 2020-04-30 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 49,2100 | −6 770 | −333 | 11 809 | ||||
| 2020-05-01 | 2020-04-29 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | −15 625 | 46 875 | ||||||
| 2020-05-01 | 2020-04-29 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 15 625 | 18 579 | ||||||
| 2020-05-01 | 2020-04-30 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 49,2100 | −1 501 | −74 | 5 204 | ||||
| 2020-05-01 | 2020-04-29 | 4 | YANG MICHAEL J. | ACAD | Restricted Stock Units | D | −4 206 | 12 621 | ||||||
| 2020-05-01 | 2020-04-29 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 4 206 | 6 705 | ||||||
| 2020-05-01 | 2020-04-30 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 49,2200 | −1 072 | −53 | 2 441 | ||||
| 2020-05-01 | 2020-04-29 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | −3 004 | 9 015 | ||||||
| 2020-05-01 | 2020-04-29 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 3 004 | 3 513 | ||||||
| 2020-04-24 | 2020-04-23 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 21,28 | −11 875 | 35 625 | |||||
| 2020-04-24 | 2020-04-23 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 19,65 | −7 074 | 8 551 | |||||
| 2020-04-24 | 2020-04-23 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 50,0675 | −18 949 | −949 | 6 027 | ||||
| 2020-04-24 | 2020-04-23 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 21,2800 | 11 875 | 253 | 24 976 | ||||
| 2020-04-24 | 2020-04-23 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 19,6500 | 7 074 | 139 | 13 101 | ||||
| 2020-04-22 | 2020-04-22 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 19,98 | −19 644 | 51 606 | |||||
| 2020-04-22 | 2020-04-22 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 19,65 | −34 375 | 15 625 | |||||
| 2020-04-22 | 2020-04-22 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 50,0177 | −54 019 | −2 702 | 6 027 | ||||
| 2020-04-22 | 2020-04-22 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 19,9800 | 19 644 | 392 | 60 046 | ||||
| 2020-04-22 | 2020-04-22 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 19,6500 | 34 375 | 675 | 40 402 | ||||
| 2020-04-22 | 2020-04-20 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Option (Right to Buy) | D | 19,65 | −100 000 | 50 000 | |||||
| 2020-04-22 | 2020-04-20 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 50,1545 | −100 000 | −5 015 | 6 027 | ||||
| 2020-04-22 | 2020-04-20 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 19,6500 | 100 000 | 1 965 | 106 027 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 34,4665 | 42 473 | 1 464 | 38 433 977 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 34,4665 | 3 837 | 132 | 3 470 609 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 33,6321 | 33 464 | 1 125 | 38 391 504 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 33,6321 | 3 023 | 102 | 3 466 772 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 32,8498 | 2 201 | 72 | 38 358 040 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 32,8498 | 199 | 7 | 3 463 749 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 32,6072 | 46 225 | 1 507 | 38 355 839 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 32,6072 | 4 175 | 136 | 3 463 550 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,9350 | 275 | 9 | 38 309 614 | ||||
| 2020-03-18 | 2020-03-18 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,9350 | 25 | 1 | 3 459 375 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 33,8624 | 93 006 | 3 149 | 38 309 339 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 33,8624 | 8 402 | 285 | 3 459 350 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 32,3194 | 24 223 | 783 | 38 216 333 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 32,3194 | 2 188 | 71 | 3 450 948 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 32,1908 | 29 624 | 954 | 38 192 110 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 32,1908 | 2 676 | 86 | 3 448 760 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,8300 | 7 612 | 242 | 38 162 486 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,8300 | 688 | 22 | 3 446 084 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,7356 | 43 212 | 1 371 | 38 154 874 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,7356 | 3 903 | 124 | 3 445 396 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 30,9955 | 3 913 | 121 | 38 111 662 | ||||
| 2020-03-18 | 2020-03-17 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 30,9955 | 353 | 11 | 3 441 493 | ||||
| 2020-03-18 | 2020-03-16 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,5136 | 631 281 | 19 894 | 38 107 749 | ||||
| 2020-03-18 | 2020-03-16 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,5136 | 57 022 | 1 797 | 3 441 140 | ||||
| 2020-03-18 | 2020-03-16 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,1853 | 5 503 | 172 | 37 476 468 | ||||
| 2020-03-18 | 2020-03-16 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 31,1853 | 497 | 15 | 3 384 118 | ||||
| 2020-01-08 | 2020-01-06 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | 38 110 | 38 110 | ||||||
| 2020-01-08 | 2020-01-06 | 4 | DAVIS STEPHEN | ACAD | Stock Options (Right to Buy) | D | 42,81 | 138 304 | 138 304 | |||||
| 2020-01-08 | 2020-01-06 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | 21 777 | 21 777 | ||||||
| 2020-01-08 | 2020-01-06 | 4 | Stankovic Srdjan R. | ACAD | Stock Options (Right to Buy) | D | 42,81 | 79 031 | 79 031 | |||||
| 2020-01-08 | 2020-01-06 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | 6 533 | 6 533 | ||||||
| 2020-01-08 | 2020-01-06 | 4 | KIM AUSTIN D. | ACAD | Stock Options (Right to Buy) | D | 42,81 | 23 709 | 23 709 | |||||
| 2020-01-08 | 2020-01-06 | 4 | Ridloff Elena | ACAD | Restricted Stock Units | D | 10 889 | 10 889 | ||||||
| 2020-01-08 | 2020-01-06 | 4 | Ridloff Elena | ACAD | Stock Options (Right to Buy) | D | 42,81 | 39 516 | 39 516 | |||||
| 2020-01-08 | 2020-01-06 | 4 | YANG MICHAEL J. | ACAD | Restricted Stock Units | D | 10 889 | 10 889 | ||||||
| 2020-01-08 | 2020-01-06 | 4 | YANG MICHAEL J. | ACAD | Stock Options (Right to Buy) | D | 42,81 | 39 516 | 39 516 | |||||
| 2020-01-08 | 2020-01-07 | 4 | Brege Laura | ACAD | Stock Option (Right to Buy) | D | 1,75 | −10 000 | 0 | |||||
| 2020-01-08 | 2020-01-07 | 4 | Brege Laura | ACAD | Common Stock | D | 42,1900 | −10 000 | −422 | 0 | ||||
| 2020-01-08 | 2020-01-07 | 4 | Brege Laura | ACAD | Common Stock | D | 1,7500 | 10 000 | 18 | 10 000 | ||||
| 2019-12-13 | 2019-12-11 | 4 | KIM AUSTIN D. | ACAD | Stock Option (Right to Buy) | D | 17,58 | −17 500 | 122 500 | |||||
| 2019-12-13 | 2019-12-11 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 45,0615 | −17 500 | −789 | 509 | ||||
| 2019-12-13 | 2019-12-11 | 4 | KIM AUSTIN D. | ACAD | Common Stock | D | 17,5800 | 17 500 | 308 | 18 009 | ||||
| 2019-12-13 | 2019-12-12 | 4 | YANG MICHAEL J. | ACAD | Stock Option (Right to Buy) | D | 35,86 | −72 979 | 312 500 | |||||
| 2019-12-13 | 2019-12-12 | 4 | YANG MICHAEL J. | ACAD | Stock Option (Right to Buy) | D | 21,28 | −10 000 | 30 000 | |||||
| 2019-12-13 | 2019-12-12 | 4 | YANG MICHAEL J. | ACAD | Stock Option (Right to Buy) | D | 19,98 | −22 500 | 577 500 | |||||
| 2019-12-13 | 2019-12-12 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 43,7350 | −5 032 | −220 | 2 499 | ||||
| 2019-12-13 | 2019-12-12 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 44,4930 | −100 447 | −4 469 | 7 531 | ||||
| 2019-12-13 | 2019-12-12 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 35,8600 | 72 979 | 2 617 | 107 978 | ||||
| 2019-12-13 | 2019-12-12 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 21,2800 | 10 000 | 213 | 34 999 | ||||
| 2019-12-13 | 2019-12-12 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 19,9800 | 22 500 | 450 | 24 999 | ||||
| 2019-12-11 | 2019-12-09 | 4 | Ridloff Elena | ACAD | Stock Option (Right to Buy) | D | 15,81 | −36 000 | 64 000 | |||||
| 2019-12-11 | 2019-12-09 | 4 | Ridloff Elena | ACAD | Common Stock | D | 49,0940 | −19 478 | −956 | 0 | ||||
| 2019-12-11 | 2019-12-09 | 4 | Ridloff Elena | ACAD | Common Stock | D | 49,8080 | −5 502 | −274 | 19 478 | ||||
| 2019-12-11 | 2019-12-09 | 4 | Ridloff Elena | ACAD | Common Stock | D | 50,5950 | −11 020 | −558 | 24 980 | ||||
| 2019-12-11 | 2019-12-09 | 4 | Ridloff Elena | ACAD | Common Stock | D | 15,8100 | 36 000 | 569 | 36 000 | ||||
| 2019-12-11 | 2019-12-09 | 4 | YANG MICHAEL J. | ACAD | Stock Option (Right to Buy) | D | 35,86 | −14 521 | 385 479 | |||||
| 2019-12-11 | 2019-12-09 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 50,0531 | −3 502 | −175 | 1 623 | ||||
| 2019-12-11 | 2019-12-09 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 50,5950 | −11 019 | −558 | 5 125 | ||||
| 2019-12-11 | 2019-12-09 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 35,8600 | 14 521 | 521 | 16 144 | ||||
| 2019-12-06 | 2019-12-05 | 4 | DAVIS STEPHEN | ACAD | Stock Option (Right to Buy) | D | 19,65 | −150 000 | 300 000 | |||||
| 2019-12-06 | 2019-12-05 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 51,3200 | −28 256 | −1 450 | 2 954 | ||||
| 2019-12-06 | 2019-12-05 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 52,0900 | −40 159 | −2 092 | 31 210 | ||||
| 2019-12-06 | 2019-12-05 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 52,8200 | −81 585 | −4 309 | 71 369 | ||||
| 2019-12-06 | 2019-12-05 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 19,6500 | 150 000 | 2 948 | 152 954 | ||||
| 2019-11-21 | 2019-11-19 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −6 250 | 18 750 | ||||||
| 2019-11-21 | 2019-11-19 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 46,4100 | −2 160 | −100 | 6 027 | ||||
| 2019-11-21 | 2019-11-19 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 6 250 | 8 187 | ||||||
| 2019-10-17 | 2019-10-15 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | −5 937 | 17 813 | ||||||
| 2019-10-17 | 2019-10-15 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 39,6500 | −2 983 | −118 | 2 954 | ||||
| 2019-10-17 | 2019-10-15 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 5 937 | 5 937 | ||||||
| 2019-10-17 | 2019-10-15 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | −2 968 | 8 907 | ||||||
| 2019-10-17 | 2019-10-15 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 39,6500 | −1 031 | −41 | 1 937 | ||||
| 2019-10-17 | 2019-10-15 | 4 | Stankovic Srdjan R. | ACAD | Common Stock | D | 2 968 | 2 968 | ||||||
| 2019-10-17 | 2019-10-15 | 4 | YANG MICHAEL J. | ACAD | Restricted Stock Units | D | −2 500 | 7 500 | ||||||
| 2019-10-17 | 2019-10-15 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 39,6500 | −877 | −35 | 1 623 | ||||
| 2019-10-17 | 2019-10-15 | 4 | YANG MICHAEL J. | ACAD | Common Stock | D | 2 500 | 2 500 | ||||||
| 2019-10-17 | 2019-10-15 | 4 | Miller Eric Alejandro | ACAD | Restricted Stock Units | D | −417 | 1 254 | ||||||
| 2019-10-17 | 2019-10-15 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 39,6500 | −147 | −6 | 270 | ||||
| 2019-10-17 | 2019-10-15 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 417 | 417 | ||||||
| 2019-10-11 | 2019-10-10 | 4 | DAVIS STEPHEN | ACAD | Stock Option (Right to Buy) | D | 19,65 | −120 208 | 450 000 | |||||
| 2019-10-11 | 2019-10-10 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 40,1890 | −120 208 | −4 831 | 0 | ||||
| 2019-10-11 | 2019-10-10 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 19,6500 | 120 208 | 2 362 | 120 208 | ||||
| 2019-10-11 | 2019-10-09 | 4 | DAVIS STEPHEN | ACAD | Stock Option (Right to Buy) | D | 19,65 | −29 792 | 570 208 | |||||
| 2019-10-11 | 2019-10-09 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 40,0010 | −29 792 | −1 192 | 0 | ||||
| 2019-10-11 | 2019-10-09 | 4 | DAVIS STEPHEN | ACAD | Common Stock | D | 19,6500 | 29 792 | 585 | 29 792 | ||||
| 2019-09-20 | 2019-09-20 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 40,0000 | 1 494 025 | 59 761 | 37 470 965 | ||||
| 2019-09-20 | 2019-09-20 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 40,0000 | 68 475 | 2 739 | 3 383 621 | ||||
| 2019-09-11 | 2019-09-11 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 41,1800 | −4 645 | −191 | 0 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Stock Option (Right to Buy) | D | 16,50 | −1 972 | 3 598 | |||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Stock Option (Right to Buy) | D | 35,80 | −4 593 | 4 594 | |||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Stock Option (Right to Buy) | D | 36,54 | −4 439 | 2 911 | |||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Stock Option (Right to Buy) | D | 29,24 | −6 063 | 552 | |||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Stock Option (Right to Buy) | D | 32,28 | −3 900 | 0 | |||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Stock Option (Right to Buy) | D | 20,65 | −7 500 | 0 | |||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 39,4900 | −28 467 | −1 124 | 4 645 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 16,5000 | 1 972 | 33 | 33 112 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 35,8000 | 4 593 | 164 | 31 140 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 36,5400 | 4 439 | 162 | 26 547 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 29,2400 | 6 063 | 177 | 22 108 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 32,2800 | 3 900 | 126 | 16 045 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Miller Eric Alejandro | ACAD | Common Stock | D | 20,6500 | 7 500 | 155 | 12 145 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Daly James M | ACAD | Stock Option (Right to Buy) | D | 17,52 | −30 000 | 0 | |||||
| 2019-09-11 | 2019-09-09 | 4 | Daly James M | ACAD | Common Stock | D | 38,3900 | −400 | −15 | 0 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Daly James M | ACAD | Common Stock | D | 37,7873 | −29 600 | −1 119 | 400 | ||||
| 2019-09-11 | 2019-09-09 | 4 | Daly James M | ACAD | Common Stock | D | 17,5200 | 30 000 | 526 | 30 000 | ||||
| 2019-06-28 | 2019-06-26 | 4 | HARRIGAN EDMUND | ACAD | Stock Option (Right to Buy) | D | 25,24 | −22 500 | 22 500 | |||||
| 2019-06-28 | 2019-06-26 | 4 | Daly James M | ACAD | Stock Option (Right to Buy) | D | 25,24 | −22 500 | 22 500 | |||||
| 2019-06-28 | 2019-06-26 | 4 | SOLAND DANIEL B | ACAD | Stock Option (Right to Buy) | D | 25,24 | −22 500 | 22 500 | |||||
| 2019-06-28 | 2019-06-26 | 4 | Brege Laura | ACAD | Stock Option (Right to Buy) | D | 25,24 | −15 000 | 15 000 | |||||
| 2019-06-28 | 2019-06-26 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Non-Qualified Stock Option (right to buy) | I | 25,24 | 30 000 | 30 000 | |||||
| 2019-06-07 | 2019-06-06 | 4 | BAKER BROS. ADVISORS LP | ACAD | Common Stock | D | 31 229 | 102 876 | ||||||
| 2019-06-07 | 2019-06-06 | 4 | BAKER BROS. ADVISORS LP | ACAD | Common Stock | D | 31 229 | 102 876 | ||||||
| 2019-06-07 | 2019-06-06 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | −421 756 | 3 315 146 | ||||||
| 2019-05-01 | 2019-04-29 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | 62 500 | 62 500 | ||||||
| 2019-05-01 | 2019-04-29 | 4 | DAVIS STEPHEN | ACAD | Stock Options (Right to Buy) | D | 25,12 | 219 298 | 219 298 | |||||
| 2019-05-01 | 2019-04-29 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | 38 462 | 38 462 | ||||||
| 2019-05-01 | 2019-04-29 | 4 | Stankovic Srdjan R. | ACAD | Stock Options (Right to Buy) | D | 25,12 | 134 953 | 134 953 | |||||
| 2019-05-01 | 2019-04-29 | 4 | KIM AUSTIN D. | ACAD | Restricted Stock Units | D | 12 019 | 12 019 | ||||||
| 2019-05-01 | 2019-04-29 | 4 | KIM AUSTIN D. | ACAD | Stock Options (Right to Buy) | D | 25,12 | 42 173 | 42 173 | |||||
| 2019-05-01 | 2019-04-29 | 4 | Ridloff Elena | ACAD | Restricted Stock Units | D | 12 981 | 12 981 | ||||||
| 2019-05-01 | 2019-04-29 | 4 | Ridloff Elena | ACAD | Stock Options (Right to Buy) | D | 25,12 | 45 547 | 45 547 | |||||
| 2019-05-01 | 2019-04-29 | 4 | YANG MICHAEL J. | ACAD | Restricted Stock Units | D | 16 827 | 16 827 | ||||||
| 2019-05-01 | 2019-04-29 | 4 | YANG MICHAEL J. | ACAD | Stock Options (Right to Buy) | D | 25,12 | 59 042 | 59 042 | |||||
| 2019-05-01 | 2019-04-29 | 4 | Miller Eric Alejandro | ACAD | Restricted Stock Units | D | 3 442 | 3 442 | ||||||
| 2019-05-01 | 2019-04-29 | 4 | Miller Eric Alejandro | ACAD | Stock Options (Right to Buy) | D | 25,12 | 6 039 | 6 039 | |||||
| 2019-04-02 | 2019-04-01 | 4 | Ridloff Elena | ACAD | Restricted Stock Units | D | 40 000 | 40 000 | ||||||
| 2019-01-11 | 2019-01-09 | 4 | Brege Laura | ACAD | Stock Option (Right to Buy) | D | 2,16 | −10 000 | 0 | |||||
| 2019-01-11 | 2019-01-09 | 4 | Brege Laura | ACAD | Common Stock | D | 20,0041 | −10 000 | −200 | 0 | ||||
| 2019-01-11 | 2019-01-09 | 4 | Brege Laura | ACAD | Common Stock | D | 2,1600 | 10 000 | 22 | 10 000 | ||||
| 2018-12-04 | 2018-11-30 | 4 | BAKER BROS. ADVISORS LP | ACAD | Common Stock Warrant (right to buy) | D | 0,01 | 1 569 | 1 569 | |||||
| 2018-12-04 | 2018-11-30 | 4 | BAKER BROS. ADVISORS LP | ACAD | Common Stock Warrant (right to buy) | D | 0,01 | 1 569 | 1 569 | |||||
| 2018-12-04 | 2018-11-30 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock Warrant (right to buy) | I | 0,01 | −10 731 | 0 | |||||
| 2018-12-04 | 2018-11-30 | 4 | BAKER BROS. ADVISORS LP | ACAD | Common Stock | D | 71 647 | 71 647 | ||||||
| 2018-12-04 | 2018-11-30 | 4 | BAKER BROS. ADVISORS LP | ACAD | Common Stock | D | 71 647 | 71 647 | ||||||
| 2018-12-04 | 2018-11-30 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | −489 977 | 0 | ||||||
| 2018-12-04 | 2018-11-30 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 17,0000 | 11 178 823 | 190 040 | 35 976 940 | ||||
| 2018-12-04 | 2018-11-30 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 17,0000 | 585 882 | 9 960 | 3 736 902 | ||||
| 2018-11-20 | 2018-11-19 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | 25 000 | 25 000 | ||||||
| 2018-11-20 | 2018-11-19 | 4 | Stankovic Srdjan R. | ACAD | Employee Stock Options (Right to Buy) | D | 18,12 | 150 000 | 150 000 | |||||
| 2018-11-09 | 3 | Miller Eric Alejandro | ACAD | Common Stock | D | 6 424 | ||||||||
| 2018-11-09 | 3 | Miller Eric Alejandro | ACAD | Common Stock | D | 6 424 | ||||||||
| 2018-11-09 | 3 | Miller Eric Alejandro | ACAD | Common Stock | D | 6 424 | ||||||||
| 2018-10-24 | 2018-10-15 | 4 | DAVIS STEPHEN | ACAD | Restricted Stock Units | D | 23 750 | 23 750 | ||||||
| 2018-10-24 | 2018-10-15 | 4 | DAVIS STEPHEN | ACAD | Stock Option(right to buy) | D | 21,28 | 95 000 | 95 000 | |||||
| 2018-10-24 | 2018-10-15 | 4 | Stankovic Srdjan R. | ACAD | Restricted Stock Units | D | 11 875 | 11 875 | ||||||
| 2018-10-24 | 2018-10-15 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (right to buy) | D | 21,28 | 47 500 | 47 500 | |||||
| 2018-10-24 | 2018-10-15 | 4 | YANG MICHAEL J. | ACAD | Restricted Stock Units | D | 10 000 | 10 000 | ||||||
| 2018-10-24 | 2018-10-15 | 4 | YANG MICHAEL J. | ACAD | Stock Option (right to buy) | D | 21,28 | 40 000 | 40 000 | |||||
| 2018-10-24 | 2018-10-15 | 4 | YOUNG TODD S. | ACAD | Restricted Stock Units | D | 4 688 | 4 688 | ||||||
| 2018-10-24 | 2018-10-15 | 4 | YOUNG TODD S. | ACAD | Stock Option (right to buy) | D | 21,28 | 18 750 | 18 750 | |||||
| 2018-09-24 | 2018-09-20 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 19,0924 | 131 007 | 2 501 | 24 798 117 | ||||
| 2018-09-24 | 2018-09-20 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 19,0924 | 14 555 | 278 | 3 151 020 | ||||
| 2018-09-24 | 2018-09-20 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 19,0110 | 38 207 | 726 | 24 667 110 | ||||
| 2018-09-24 | 2018-09-20 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 19,0110 | 4 245 | 81 | 3 136 465 | ||||
| 2018-09-24 | 2018-09-20 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 18,6366 | 920 495 | 17 155 | 24 628 903 | ||||
| 2018-09-24 | 2018-09-20 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 18,6366 | 102 267 | 1 906 | 3 132 220 | ||||
| 2018-07-20 | 2018-07-18 | 4 | KIM AUSTIN D. | ACAD | Stock Option (right to buy) | D | 17,58 | 140 000 | 140 000 | |||||
| 2018-06-08 | 2018-06-06 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 17,52 | 15 000 | 15 000 | |||||
| 2018-06-08 | 2018-06-06 | 4 | Daly James M | ACAD | Stock Option (right to buy) | D | 17,52 | 15 000 | 15 000 | |||||
| 2018-06-08 | 2018-06-06 | 4 | Daly James M | ACAD | Stock Option (right to buy) | D | 17,52 | 15 000 | 15 000 | |||||
| 2018-06-08 | 2018-06-06 | 4 | HARRIGAN EDMUND | ACAD | Stock Option (right to buy) | D | 17,52 | 15 000 | 15 000 | |||||
| 2018-06-08 | 2018-06-06 | 4 | HARRIGAN EDMUND | ACAD | Stock Option (right to buy) | D | 17,52 | 15 000 | 15 000 | |||||
| 2018-06-08 | 2018-06-06 | 4 | SOLAND DANIEL B | ACAD | Stock Option (right to buy) | D | 17,52 | 15 000 | 15 000 | |||||
| 2018-06-08 | 2018-06-06 | 4 | SOLAND DANIEL B | ACAD | Stock Option (right to buy) | D | 17,52 | 15 000 | 15 000 | |||||
| 2018-06-08 | 2018-06-06 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Non-Qualified Stock Option (right to buy) | I | 17,52 | 30 000 | 30 000 | |||||
| 2018-04-20 | 2018-04-18 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 19,98 | 28 125 | 28 125 | |||||
| 2018-04-20 | 2018-04-18 | 4 | DAVIS STEPHEN | ACAD | Stock Option (right to buy) | D | 19,98 | 135 000 | 135 000 | |||||
| 2018-04-20 | 2018-04-18 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (right to buy) | D | 19,98 | 71 250 | 71 250 | |||||
| 2018-04-20 | 2018-04-18 | 4 | YANG MICHAEL J. | ACAD | Stock Option (right to buy) | D | 19,98 | 60 000 | 60 000 | |||||
| 2018-04-20 | 2018-04-18 | 4 | YOUNG TODD S. | ACAD | Stock Option (right to buy) | D | 19,98 | 28 125 | 28 125 | |||||
| 2018-03-02 | 2018-03-02 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 22,5200 | 3 000 | 68 | 10 000 | ||||
| 2018-03-02 | 2018-03-01 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 24,5200 | 2 000 | 49 | 7 000 | ||||
| 2018-03-02 | 2018-03-01 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 24,0900 | 3 000 | 72 | 5 000 | ||||
| 2018-03-02 | 2018-03-01 | 4 | SOLAND DANIEL B | ACAD | Common Stock | D | 23,0200 | 2 000 | 46 | 2 000 | ||||
| 2018-01-31 | 2018-01-29 | 4 | Baity Glenn | ACAD | Common Stock | D | 32,3884 | −36 558 | −1 184 | 83 734 | ||||
| 2018-01-11 | 2018-01-10 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 2,18 | −50 179 | 0 | |||||
| 2018-01-11 | 2018-01-10 | 4 | Baity Glenn | ACAD | Common Stock | D | 2,1800 | 50 179 | 109 | 120 292 | ||||
| 2018-01-04 | 2018-01-02 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 8,49 | −10 000 | 0 | |||||
| 2018-01-04 | 2018-01-02 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 8,06 | −15 000 | 0 | |||||
| 2018-01-04 | 2018-01-02 | 4 | Brege Laura | ACAD | Common Stock | D | 30,0617 | −25 000 | −752 | 0 | ||||
| 2018-01-04 | 2018-01-02 | 4 | Brege Laura | ACAD | Common Stock | D | 8,4900 | 10 000 | 85 | 25 000 | ||||
| 2018-01-04 | 2018-01-02 | 4 | Brege Laura | ACAD | Common Stock | D | 8,0600 | 15 000 | 121 | 15 000 | ||||
| 2018-01-04 | 2018-01-02 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 2,18 | −74 321 | 0 | |||||
| 2018-01-04 | 2018-01-02 | 4 | Baity Glenn | ACAD | Common Stock | D | 30,1414 | −74 321 | −2 240 | 70 113 | ||||
| 2018-01-04 | 2018-01-02 | 4 | Baity Glenn | ACAD | Common Stock | D | 2,1800 | 74 321 | 162 | 144 434 | ||||
| 2017-11-29 | 2017-11-27 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock Warrant (right to buy) | I | 1,38 | −39 378 | 0 | |||||
| 2017-11-29 | 2017-11-27 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 28,0000 | −1 941 | −54 | 489 977 | ||||
| 2017-11-29 | 2017-11-27 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 1,3800 | 39 378 | 54 | 491 918 | ||||
| 2017-10-16 | 2017-10-13 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock Warrant (right to buy) | I | 1,38 | −1 426 590 | 0 | |||||
| 2017-10-16 | 2017-10-13 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 35,4000 | −55 457 | −1 963 | 23 708 408 | ||||
| 2017-10-16 | 2017-10-13 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 1,3800 | 1 426 590 | 1 969 | 23 763 865 | ||||
| 2017-10-06 | 2017-10-05 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 2,00 | −20 000 | 0 | |||||
| 2017-10-06 | 2017-10-05 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −7 500 | 0 | |||||
| 2017-10-06 | 2017-10-05 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 2,18 | −1 000 | 124 500 | |||||
| 2017-10-06 | 2017-10-05 | 4 | Baity Glenn | ACAD | Common Stock | D | 40,9078 | −37 500 | −1 534 | 69 656 | ||||
| 2017-10-06 | 2017-10-05 | 4 | Baity Glenn | ACAD | Common Stock | D | 2,0000 | 20 000 | 40 | 107 156 | ||||
| 2017-10-06 | 2017-10-05 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 7 500 | 12 | 99 656 | ||||
| 2017-10-06 | 2017-10-05 | 4 | Baity Glenn | ACAD | Common Stock | D | 2,1800 | 1 000 | 2 | 79 656 | ||||
| 2017-10-06 | 2017-10-04 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 2,18 | −4 500 | 125 500 | |||||
| 2017-10-06 | 2017-10-04 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −6 500 | 7 500 | |||||
| 2017-10-06 | 2017-10-04 | 4 | Baity Glenn | ACAD | Common Stock | D | 2,1800 | 4 500 | 10 | 78 656 | ||||
| 2017-10-06 | 2017-10-04 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 6 500 | 11 | 74 156 | ||||
| 2017-09-08 | 2017-09-07 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (right to buy) | D | 35,80 | 131 250 | 131 250 | |||||
| 2017-09-08 | 2017-09-07 | 4 | YANG MICHAEL J. | ACAD | Stock Option (right to buy) | D | 35,80 | 93 750 | 93 750 | |||||
| 2017-09-08 | 2017-09-07 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 35,80 | 46 875 | 46 875 | |||||
| 2017-09-08 | 2017-09-07 | 4 | YOUNG TODD S. | ACAD | Stock Option (right to buy) | D | 35,80 | 56 250 | 56 250 | |||||
| 2017-09-08 | 2017-09-07 | 4 | DAVIS STEPHEN | ACAD | Stock Option (right to buy) | D | 35,80 | 243 750 | 243 750 | |||||
| 2017-09-01 | 2017-08-30 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −16 507 | 14 000 | |||||
| 2017-09-01 | 2017-08-30 | 4 | Baity Glenn | ACAD | Common Stock | D | 34,8706 | −26 507 | −924 | 67 656 | ||||
| 2017-09-01 | 2017-08-30 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 16 507 | 27 | 94 163 | ||||
| 2017-08-11 | 2017-08-09 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −13 400 | 30 507 | |||||
| 2017-08-11 | 2017-08-09 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −922 | 0 | |||||
| 2017-08-11 | 2017-08-09 | 4 | Baity Glenn | ACAD | Common Stock | D | 34,8788 | −14 322 | −500 | 77 656 | ||||
| 2017-08-11 | 2017-08-09 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 13 400 | 22 | 91 978 | ||||
| 2017-08-11 | 2017-08-09 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 922 | 1 | 78 578 | ||||
| 2017-08-08 | 2017-08-04 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −6 500 | 43 907 | |||||
| 2017-08-08 | 2017-08-04 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 6 500 | 11 | 77 656 | ||||
| 2017-07-21 | 2017-07-20 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −28 097 | 28 000 | |||||
| 2017-07-21 | 2017-07-20 | 4 | Baity Glenn | ACAD | Common Stock | D | 30,0000 | −38 097 | −1 143 | 71 156 | ||||
| 2017-07-21 | 2017-07-20 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 28 097 | 46 | 109 253 | ||||
| 2017-07-19 | 2017-07-17 | 4 | SOLAND DANIEL B | ACAD | Stock Option (right to buy) | D | 28,85 | 15 000 | 15 000 | |||||
| 2017-07-19 | 2017-07-17 | 4 | HARRIGAN EDMUND | ACAD | Stock Option (right to buy) | D | 28,85 | 15 000 | 15 000 | |||||
| 2017-07-19 | 2017-07-17 | 4 | Daly James M | ACAD | Stock Option (right to buy) | D | 28,85 | 15 000 | 15 000 | |||||
| 2017-06-26 | 2017-06-22 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −1 903 | 56 097 | |||||
| 2017-06-26 | 2017-06-22 | 4 | Baity Glenn | ACAD | Common Stock | D | 30,0004 | −1 903 | −57 | 81 156 | ||||
| 2017-06-26 | 2017-06-22 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 1 903 | 3 | 83 059 | ||||
| 2017-06-14 | 2017-06-13 | 4 | HARRIGAN EDMUND | ACAD | Stock Option (right to buy) | D | 27,25 | 15 000 | 15 000 | |||||
| 2017-06-14 | 2017-06-13 | 4 | Brege Laura | ACAD | Stock Option (right to buy) | D | 27,25 | 15 000 | 15 000 | |||||
| 2017-06-14 | 2017-06-13 | 4 | Daly James M | ACAD | Stock Option (right to buy) | D | 27,25 | 15 000 | 15 000 | |||||
| 2017-06-14 | 2017-06-13 | 4 | SOLAND DANIEL B | ACAD | Stock Option (right to buy) | D | 27,25 | 15 000 | 15 000 | |||||
| 2017-06-14 | 2017-06-13 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Non-Qualified Stock Option (right to buy) | I | 27,25 | 30 000 | 30 000 | |||||
| 2017-05-17 | 2017-05-15 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −14 093 | 58 000 | |||||
| 2017-05-17 | 2017-05-15 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 14 093 | 23 | 81 156 | ||||
| 2017-03-31 | 2017-03-29 | 4 | YANG MICHAEL J. | ACAD | Stock Option (right to buy) | D | 35,86 | 400 000 | 400 000 | |||||
| 2017-03-10 | 2017-03-08 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 36,54 | 33 750 | 33 750 | |||||
| 2017-03-10 | 2017-03-08 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (right to buy) | D | 36,54 | 93 750 | 93 750 | |||||
| 2017-03-10 | 2017-03-08 | 4 | YOUNG TODD S. | ACAD | Stock Option (right to buy) | D | 36,54 | 37 500 | 37 500 | |||||
| 2017-03-10 | 2017-03-08 | 4 | DAVIS STEPHEN | ACAD | Stock Option (right to buy) | D | 36,54 | 243 750 | 243 750 | |||||
| 2017-03-10 | 2017-03-08 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 36,54 | 46 875 | 46 875 | |||||
| 2017-02-23 | 2017-02-21 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 34,45 | −7 856 | 82 500 | |||||
| 2017-02-23 | 2017-02-21 | 4 | Moore Terrence O | ACAD | Common Stock | D | 39,6500 | −7 856 | −311 | 1 671 | ||||
| 2017-02-23 | 2017-02-21 | 4 | Moore Terrence O | ACAD | Common Stock | D | 34,4500 | 7 856 | 271 | 9 527 | ||||
| 2017-02-16 | 2017-02-14 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,64 | −6 365 | 0 | |||||
| 2017-02-16 | 2017-02-14 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 8,32 | −3 224 | 0 | |||||
| 2017-02-16 | 2017-02-14 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 8,32 | −16 776 | 0 | |||||
| 2017-02-16 | 2017-02-14 | 4 | Baity Glenn | ACAD | Common Stock | D | 39,6555 | −26 365 | −1 046 | 67 063 | ||||
| 2017-02-16 | 2017-02-14 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6400 | 6 365 | 10 | 93 428 | ||||
| 2017-02-16 | 2017-02-14 | 4 | Baity Glenn | ACAD | Common Stock | D | 8,3200 | 20 000 | 166 | 87 063 | ||||
| 2017-02-16 | 2017-02-16 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 34,35 | −29 644 | 90 356 | |||||
| 2017-02-16 | 2017-02-16 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 27,20 | −19 687 | 13 125 | |||||
| 2017-02-16 | 2017-02-16 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 19,61 | −17 421 | 36 102 | |||||
| 2017-02-16 | 2017-02-16 | 4 | Moore Terrence O | ACAD | Common Stock | D | 39,8807 | −66 752 | −2 662 | 1 671 | ||||
| 2017-02-16 | 2017-02-16 | 4 | Moore Terrence O | ACAD | Common Stock | D | 34,4500 | 29 644 | 1 021 | 68 423 | ||||
| 2017-02-16 | 2017-02-16 | 4 | Moore Terrence O | ACAD | Common Stock | D | 27,2000 | 19 687 | 535 | 38 779 | ||||
| 2017-02-16 | 2017-02-16 | 4 | Moore Terrence O | ACAD | Common Stock | D | 19,6100 | 17 421 | 342 | 19 092 | ||||
| 2017-02-16 | 2017-02-15 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 19,61 | −1 700 | 53 523 | |||||
| 2017-02-16 | 2017-02-15 | 4 | Moore Terrence O | ACAD | Common Stock | D | 39,6500 | −1 700 | −67 | 1 671 | ||||
| 2017-02-16 | 2017-02-15 | 4 | Moore Terrence O | ACAD | Common Stock | D | 19,6100 | 1 700 | 33 | 3 371 | ||||
| 2017-02-16 | 2017-02-14 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 19,61 | −74 381 | 55 223 | |||||
| 2017-02-16 | 2017-02-14 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 19,61 | −12 747 | 7 649 | |||||
| 2017-02-16 | 2017-02-14 | 4 | Moore Terrence O | ACAD | Common Stock | D | 39,6863 | −89 088 | −3 536 | 1 671 | ||||
| 2017-02-16 | 2017-02-14 | 4 | Moore Terrence O | ACAD | Common Stock | D | 19,6100 | 87 128 | 1 709 | 90 759 | ||||
| 2017-02-03 | 2017-02-01 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −21 078 | 0 | |||||
| 2017-02-03 | 2017-02-01 | 4 | Baity Glenn | ACAD | Common Stock | D | 35,1497 | −31 078 | −1 092 | 67 063 | ||||
| 2017-02-03 | 2017-02-01 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 21 078 | 33 | 98 141 | ||||
| 2016-12-29 | 2016-12-28 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −5 500 | 72 093 | |||||
| 2016-12-29 | 2016-12-28 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 5 500 | 9 | 77 063 | ||||
| 2016-12-29 | 2016-12-27 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −9 800 | 21 078 | |||||
| 2016-12-29 | 2016-12-27 | 4 | Baity Glenn | ACAD | Common Stock | D | 30,4565 | −9 800 | −298 | 71 563 | ||||
| 2016-12-29 | 2016-12-27 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 9 800 | 15 | 81 363 | ||||
| 2016-12-21 | 2016-12-20 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 30 878 | |||||
| 2016-12-21 | 2016-12-20 | 4 | Baity Glenn | ACAD | Common Stock | D | 30,0001 | −10 000 | −300 | 71 563 | ||||
| 2016-12-21 | 2016-12-20 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 81 563 | ||||
| 2016-12-21 | 2016-12-19 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,64 | −8 635 | 0 | |||||
| 2016-12-21 | 2016-12-19 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6400 | 8 635 | 14 | 71 563 | ||||
| 2016-11-14 | 2016-11-10 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 200 | 40 878 | |||||
| 2016-11-14 | 2016-11-10 | 4 | Baity Glenn | ACAD | Common Stock | D | 30,0674 | −10 200 | −307 | 62 921 | ||||
| 2016-11-14 | 2016-11-10 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 200 | 16 | 73 121 | ||||
| 2016-08-24 | 2016-08-22 | 4 | YOUNG TODD S. | ACAD | Stock Option (right to buy) | D | 34,32 | 200 000 | 200 000 | |||||
| 2016-08-18 | 2016-08-16 | 4 | HARRIGAN EDMUND | ACAD | Common Stock | D | 32,9700 | 1 000 | 33 | 1 000 | ||||
| 2016-08-12 | 2016-08-10 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 33,0000 | 1 169 877 | 38 606 | 22 337 275 | ||||
| 2016-08-12 | 2016-08-10 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 33,0000 | 133 153 | 4 394 | 3 029 953 | ||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 6,78 | −2 625 | 0 | |||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 6,78 | −3 375 | 0 | |||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 6,78 | −645 | 0 | |||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 6,78 | −5 298 | 0 | |||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 35,0022 | −11 943 | −418 | 62 921 | ||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 6,7800 | 2 625 | 18 | 74 864 | ||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 6,7800 | 3 375 | 23 | 72 239 | ||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 6,7800 | 645 | 4 | 68 864 | ||||
| 2016-07-13 | 2016-07-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 6,7800 | 5 298 | 36 | 68 219 | ||||
| 2016-07-13 | 2016-07-11 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 6,78 | −4 057 | 5 298 | |||||
| 2016-07-13 | 2016-07-11 | 4 | Baity Glenn | ACAD | Common Stock | D | 35,0016 | −4 057 | −142 | 62 921 | ||||
| 2016-07-13 | 2016-07-11 | 4 | Baity Glenn | ACAD | Common Stock | D | 6,7800 | 4 057 | 28 | 66 978 | ||||
| 2016-06-13 | 2016-06-10 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Non-Qualified Stock Option (right to buy) | I | 39,60 | 26 500 | 26 500 | |||||
| 2016-06-10 | 2016-06-10 | 4 | HARRIGAN EDMUND | ACAD | Stock Option (right to buy) | D | 39,60 | 12 500 | 12 500 | |||||
| 2016-06-10 | 2016-06-10 | 4 | SOLAND DANIEL B | ACAD | Stock Option (right to buy) | D | 39,60 | 12 500 | 12 500 | |||||
| 2016-06-10 | 2016-06-10 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 39,60 | 12 500 | 12 500 | |||||
| 2016-06-10 | 2016-06-10 | 4 | Daly James M | ACAD | Stock Option (right to buy) | D | 39,60 | 12 500 | 12 500 | |||||
| 2016-06-09 | 2016-06-07 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 9,04 | −10 000 | 0 | |||||
| 2016-06-09 | 2016-06-07 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 9,04 | −6 637 | 0 | |||||
| 2016-06-09 | 2016-06-07 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 9,0400 | 10 000 | 90 | 149 476 | ||||
| 2016-06-09 | 2016-06-07 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 9,0400 | 6 637 | 60 | 139 476 | ||||
| 2016-04-20 | 2016-04-18 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 1,75 | −33 697 | 0 | |||||
| 2016-04-20 | 2016-04-18 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 33,5341 | −33 697 | −1 130 | 36 127 | ||||
| 2016-04-20 | 2016-04-18 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 1,7500 | 33 697 | 59 | 69 824 | ||||
| 2016-04-07 | 2016-04-07 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 1,36 | 1,3600 | −10 000 | −14 | 0 | |||
| 2016-04-07 | 2016-04-07 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 1,36 | 1,3600 | −55 147 | −75 | 0 | |||
| 2016-04-07 | 2016-04-07 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 1,30 | 1,3000 | −57 692 | −75 | 0 | |||
| 2016-04-07 | 2016-04-07 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 1,30 | 1,3000 | −10 000 | −13 | 0 | |||
| 2016-04-07 | 2016-04-07 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 1,3600 | 10 000 | 14 | 132 839 | ||||
| 2016-04-07 | 2016-04-07 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 1,3600 | 55 147 | 75 | 122 839 | ||||
| 2016-04-07 | 2016-04-07 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 1,3000 | 57 692 | 75 | 67 692 | ||||
| 2016-04-07 | 2016-04-07 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 1,3000 | 10 000 | 13 | 10 000 | ||||
| 2016-04-01 | 2016-04-01 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 28,5484 | 262 253 | 7 487 | 21 167 398 | ||||
| 2016-04-01 | 2016-04-01 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 28,5484 | 28 647 | 818 | 2 896 800 | ||||
| 2016-04-01 | 2016-04-01 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 27,8202 | 10 818 | 301 | 20 905 145 | ||||
| 2016-04-01 | 2016-04-01 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 27,8202 | 1 182 | 33 | 2 868 153 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 27,7173 | 318 969 | 8 841 | 20 894 327 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 27,7173 | 34 844 | 966 | 2 866 971 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 27,5588 | 60 587 | 1 670 | 20 575 358 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 27,5588 | 6 618 | 182 | 2 832 127 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 26,5545 | 28 433 | 755 | 20 514 771 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 26,5545 | 3 106 | 82 | 2 825 509 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 26,4944 | 180 122 | 4 772 | 20 486 338 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 26,4944 | 19 676 | 521 | 2 822 403 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 26,2850 | 13 433 | 353 | 20 306 216 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 26,2850 | 1 467 | 39 | 2 802 727 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,6070 | 14 775 | 378 | 20 292 783 | ||||
| 2016-04-01 | 2016-03-31 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,6070 | 1 614 | 41 | 2 801 260 | ||||
| 2016-04-01 | 2016-03-30 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 26,3472 | 16 057 | 423 | 2 799 646 | ||||
| 2016-04-01 | 2016-03-30 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,9750 | 37 882 | 984 | 2 783 589 | ||||
| 2016-04-01 | 2016-03-30 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 25,9247 | 408 607 | 10 593 | 2 745 707 | ||||
| 2016-03-17 | 2016-03-15 | 4 | DAVIS STEPHEN | ACAD | Stock Option (right to buy) | D | 19,65 | 600 000 | 600 000 | |||||
| 2016-03-17 | 2016-03-15 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (right to buy) | D | 19,65 | 150 000 | 150 000 | |||||
| 2016-03-17 | 2016-03-15 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 19,65 | 150 000 | 150 000 | |||||
| 2016-03-17 | 2016-03-15 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 19,65 | 150 000 | 150 000 | |||||
| 2016-03-04 | 2016-03-02 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 15,37 | −7 000 | 0 | |||||
| 2016-03-04 | 2016-03-02 | 4 | Baity Glenn | ACAD | Common Stock | D | 20,7971 | −7 000 | −146 | 62 921 | ||||
| 2016-03-04 | 2016-03-02 | 4 | Baity Glenn | ACAD | Common Stock | D | 15,3700 | 7 000 | 108 | 69 921 | ||||
| 2016-01-11 | 2016-01-07 | 4 | Daly James M | ACAD | Stock Option (right to buy) | D | 28,73 | 15 000 | 15 000 | |||||
| 2016-01-08 | 2016-01-07 | 4/A | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 29,0000 | 1 801 161 | 52 234 | 20 278 008 | ||||
| 2016-01-08 | 2016-01-07 | 4/A | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 29,0000 | 785 045 | 22 766 | 2 337 100 | ||||
| 2016-01-08 | 2016-01-07 | 4 | 14159, L.P. See Footnotes | ACAD | Common Stock | I | 29,0000 | 1 801 161 | 52 234 | 20 278 008 | ||||
| 2016-01-08 | 2016-01-07 | 4 | 14159, L.P. See Footnotes | ACAD | Common Stock | I | 29,0000 | 785 045 | 22 766 | 2 337 100 | ||||
| 2015-12-15 | 2015-12-11 | 4 | BAKER BROS. ADVISORS LP | ACAD | Non-Qualified Stock Option (right to buy) | I | 32,50 | 15 000 | 15 000 | |||||
| 2015-11-30 | 2015-11-25 | 4 | HARRIGAN EDMUND | ACAD | Stock Option (right to buy) | D | 38,28 | 15 000 | 15 000 | |||||
| 2015-11-30 | 2015-11-25 | 4 | Stankovic Srdjan R. | ACAD | Stock Option (right to buy) | D | 38,28 | 250 000 | 250 000 | |||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 1,75 | −4 874 | 33 697 | |||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 9,04 | −9 126 | 0 | |||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 9,04 | −10 000 | 0 | |||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 9,04 | −6 000 | 0 | |||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 36,0109 | −30 000 | −1 080 | 36 127 | ||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 1,7500 | 4 874 | 9 | 66 127 | ||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 9,0400 | 9 126 | 82 | 61 253 | ||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 9,0400 | 10 000 | 90 | 52 127 | ||||
| 2015-11-13 | 2015-11-11 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 9,0400 | 6 000 | 54 | 42 127 | ||||
| 2015-09-03 | 2015-09-01 | 4 | DAVIS STEPHEN | ACAD | Stock Option (right to buy) | D | 35,91 | 225 000 | 225 000 | |||||
| 2015-08-21 | 2015-08-19 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 11,00 | −8 500 | 0 | |||||
| 2015-08-21 | 2015-08-19 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 11,0000 | 8 500 | 94 | 36 127 | ||||
| 2015-08-21 | 2015-08-19 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 11,00 | −8 500 | 0 | |||||
| 2015-08-21 | 2015-08-19 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 11,0000 | 8 500 | 94 | 36 127 | ||||
| 2015-08-13 | 2015-08-11 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 11,00 | −8 500 | 0 | |||||
| 2015-08-13 | 2015-08-11 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 11,0000 | 8 500 | 94 | 17 000 | ||||
| 2015-06-17 | 2015-06-15 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-17 | 2015-06-15 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-17 | 2015-06-15 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-17 | 2015-06-15 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-17 | 2015-06-15 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 39,06 | 14 000 | 14 000 | |||||
| 2015-06-17 | 2015-06-15 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-17 | 2015-06-15 | 4 | SOLAND DANIEL B | ACAD | Stock Option (right to buy) | D | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-17 | 2015-06-15 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-17 | 2015-06-15 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-17 | 2015-06-15 | 4 | BAKER BROS. ADVISORS LP | ACAD | Non-Qualified Stock Option (right to buy) | I | 39,06 | 12 500 | 12 500 | |||||
| 2015-06-03 | 2015-06-01 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 8,85 | −7 627 | 0 | |||||
| 2015-06-03 | 2015-06-01 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 8,85 | −6 500 | 0 | |||||
| 2015-06-03 | 2015-06-01 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 8,8500 | 7 627 | 67 | 27 627 | ||||
| 2015-06-03 | 2015-06-01 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 8,8500 | 6 500 | 58 | 20 000 | ||||
| 2015-03-24 | 2015-03-20 | 4 | DAVIS STEPHEN | ACAD | Stock Option (right to buy) | D | 34,45 | 120 000 | 120 000 | |||||
| 2015-03-24 | 2015-03-20 | 4 | DAVIS STEPHEN | ACAD | Stock Option (right to buy) | D | 34,45 | 100 000 | 100 000 | |||||
| 2015-03-24 | 2015-03-20 | 4 | SOLAND DANIEL B | ACAD | Stock Option (right to buy) | D | 34,45 | |||||||
| 2015-03-24 | 2015-03-20 | 4 | Mills Roger | ACAD | Stock Option (right to buy) | D | 34,45 | 180 000 | 180 000 | |||||
| 2015-03-24 | 2015-03-20 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 34,45 | 120 000 | 120 000 | |||||
| 2015-03-24 | 2015-03-20 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 34,45 | 120 000 | 120 000 | |||||
| 2015-02-19 | 2015-02-17 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 1,36 | −10 000 | 0 | |||||
| 2015-02-19 | 2015-02-17 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 8,49 | −7 067 | 0 | |||||
| 2015-02-19 | 2015-02-17 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 8,49 | −2 780 | 0 | |||||
| 2015-02-19 | 2015-02-17 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 35,0453 | −19 847 | −696 | 8 500 | ||||
| 2015-02-19 | 2015-02-17 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 1,3600 | 10 000 | 14 | 28 347 | ||||
| 2015-02-19 | 2015-02-17 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 8,4900 | 7 067 | 60 | 18 347 | ||||
| 2015-02-19 | 2015-02-17 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 8,4900 | 2 780 | 24 | 11 280 | ||||
| 2015-02-19 | 2015-02-17 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,55 | −30 000 | 313 500 | |||||
| 2015-02-19 | 2015-02-17 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 34,2956 | −30 000 | −1 029 | 115 549 | ||||
| 2015-02-19 | 2015-02-17 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 30 000 | 145 549 | ||||||
| 2015-02-19 | 2015-02-17 | 4 | Hacksell Uli | ACAD | Common Stock | D | −30 000 | 0 | ||||||
| 2015-02-19 | 2015-02-17 | 4 | Hacksell Uli | ACAD | Common Stock | D | 1,5500 | 30 000 | 46 | 30 000 | ||||
| 2015-02-13 | 2015-02-11 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,75 | −10 000 | 0 | |||||
| 2015-02-13 | 2015-02-11 | 4 | Brege Laura | ACAD | Common Stock | D | 33,6349 | −10 000 | −336 | 0 | ||||
| 2015-02-13 | 2015-02-11 | 4 | Brege Laura | ACAD | Common Stock | D | 1,7500 | 10 000 | 18 | 10 000 | ||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 15,02 | −2 996 | 0 | |||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 15,02 | −10 000 | 0 | |||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 9,04 | −10 000 | 0 | |||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 9,04 | −4 977 | 0 | |||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Common Stock | D | 33,0235 | −27 973 | −924 | 0 | ||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Common Stock | D | 15,0200 | 2 996 | 45 | 27 973 | ||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Common Stock | D | 15,0200 | 10 000 | 150 | 24 977 | ||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Common Stock | D | 9,0400 | 4 977 | 45 | 14 977 | ||||
| 2015-01-16 | 2015-01-15 | 4 | BORER MICHAEL T | ACAD | Common Stock | D | 9,0400 | 10 000 | 90 | 10 000 | ||||
| 2015-01-16 | 2015-01-14 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 2,00 | −30 000 | 0 | |||||
| 2015-01-16 | 2015-01-14 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 33,9810 | −30 000 | −1 019 | 115 549 | ||||
| 2015-01-16 | 2015-01-14 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 30 000 | 145 549 | ||||||
| 2015-01-16 | 2015-01-14 | 4 | Hacksell Uli | ACAD | Common Stock | D | −30 000 | 0 | ||||||
| 2015-01-16 | 2015-01-14 | 4 | Hacksell Uli | ACAD | Common Stock | D | 2,0000 | 30 000 | 60 | 30 000 | ||||
| 2015-01-15 | 2015-01-13 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 8,49 | −7 220 | 2 780 | |||||
| 2015-01-15 | 2015-01-13 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 15,02 | −4 685 | 0 | |||||
| 2015-01-15 | 2015-01-13 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 35,0001 | −11 905 | −417 | 8 500 | ||||
| 2015-01-15 | 2015-01-13 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 8,4900 | 7 220 | 61 | 20 405 | ||||
| 2015-01-15 | 2015-01-13 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 15,0200 | 4 685 | 70 | 13 185 | ||||
| 2015-01-15 | 2015-01-13 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 11,00 | −4 250 | 0 | |||||
| 2015-01-15 | 2015-01-13 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 35,0000 | −4 250 | −149 | 0 | ||||
| 2015-01-15 | 2015-01-13 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 11,0000 | 4 250 | 47 | 4 250 | ||||
| 2014-12-17 | 2014-12-15 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 2,00 | −30 000 | 30 000 | |||||
| 2014-12-17 | 2014-12-15 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 30,9972 | −30 000 | −930 | 115 549 | ||||
| 2014-12-17 | 2014-12-15 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 30 000 | 145 549 | ||||||
| 2014-12-17 | 2014-12-15 | 4 | Hacksell Uli | ACAD | Common Stock | D | −30 000 | 0 | ||||||
| 2014-12-17 | 2014-12-15 | 4 | Hacksell Uli | ACAD | Common Stock | D | 2,0000 | 30 000 | 60 | 30 000 | ||||
| 2014-12-17 | 2014-12-15 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 11,00 | −4 250 | 4 250 | |||||
| 2014-12-17 | 2014-12-15 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 8,85 | −6 500 | 0 | |||||
| 2014-12-17 | 2014-12-15 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 7,67 | −1 500 | 0 | |||||
| 2014-12-17 | 2014-12-15 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 31,7400 | −12 250 | −389 | 0 | ||||
| 2014-12-17 | 2014-12-15 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 11,0000 | 4 250 | 47 | 12 250 | ||||
| 2014-12-17 | 2014-12-15 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 8,8500 | 6 500 | 58 | 8 000 | ||||
| 2014-12-17 | 2014-12-15 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 7,6700 | 1 500 | 12 | 1 500 | ||||
| 2014-12-10 | 2014-12-09 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −8 000 | 52 000 | |||||
| 2014-12-10 | 2014-12-09 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 8 000 | 12 | 62 423 | ||||
| 2014-11-26 | 2014-11-26 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 11,00 | −15 000 | 0 | |||||
| 2014-11-26 | 2014-11-26 | 4 | BORER MICHAEL T | ACAD | Common Stock | D | 30,0510 | −15 000 | −451 | 0 | ||||
| 2014-11-26 | 2014-11-26 | 4 | BORER MICHAEL T | ACAD | Common Stock | D | 11,0000 | 15 000 | 165 | 15 000 | ||||
| 2014-11-26 | 2014-11-26 | 4 | Mills Roger | ACAD | Stock Option (right to buy) | D | 1,55 | −25 000 | 139 035 | |||||
| 2014-11-26 | 2014-11-26 | 4 | Mills Roger | ACAD | Common Stock | D | 30,0906 | −25 000 | −752 | 18 550 | ||||
| 2014-11-26 | 2014-11-26 | 4 | Mills Roger | ACAD | Common Stock | D | 25 000 | 43 550 | ||||||
| 2014-11-26 | 2014-11-24 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 2,00 | −30 000 | 60 000 | |||||
| 2014-11-26 | 2014-11-24 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 29,2799 | −30 000 | −878 | 115 549 | ||||
| 2014-11-26 | 2014-11-24 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 30 000 | 145 549 | ||||||
| 2014-11-26 | 2014-11-24 | 4 | Hacksell Uli | ACAD | Common Stock | D | −30 000 | 0 | ||||||
| 2014-11-26 | 2014-11-24 | 4 | Hacksell Uli | ACAD | Common Stock | D | 2,0000 | 30 000 | 60 | 30 000 | ||||
| 2014-11-21 | 2014-11-21 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 1,36 | −5 810 | 9 117 | |||||
| 2014-11-21 | 2014-11-21 | 4 | Wells William McDowall | ACAD | Common Stock | D | 29,0000 | −5 810 | −168 | 0 | ||||
| 2014-11-21 | 2014-11-21 | 4 | Wells William McDowall | ACAD | Common Stock | D | 1,3600 | 5 810 | 8 | 5 810 | ||||
| 2014-10-10 | 2014-10-08 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 2,00 | −30 000 | 90 000 | |||||
| 2014-10-10 | 2014-10-08 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 24,1510 | −30 000 | −725 | 115 549 | ||||
| 2014-10-10 | 2014-10-08 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 30 000 | 145 549 | ||||||
| 2014-10-10 | 2014-10-08 | 4 | Hacksell Uli | ACAD | Common Stock | D | −30 000 | 0 | ||||||
| 2014-10-10 | 2014-10-08 | 4 | Hacksell Uli | ACAD | Common Stock | D | 2,0000 | 30 000 | 60 | 30 000 | ||||
| 2014-09-16 | 2014-09-12 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 1,36 | −9 190 | 14 927 | |||||
| 2014-09-16 | 2014-09-12 | 4 | Wells William McDowall | ACAD | Common Stock | D | 29,1483 | −9 190 | −268 | 0 | ||||
| 2014-09-16 | 2014-09-12 | 4 | Wells William McDowall | ACAD | Common Stock | D | 1,3600 | 9 190 | 12 | 9 190 | ||||
| 2014-09-16 | 2014-09-15 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,75 | −10 000 | 10 000 | |||||
| 2014-09-16 | 2014-09-15 | 4 | Brege Laura | ACAD | Common Stock | D | 28,0669 | −10 000 | −281 | 0 | ||||
| 2014-09-16 | 2014-09-15 | 4 | Brege Laura | ACAD | Common Stock | D | 1,7500 | 10 000 | 18 | 10 000 | ||||
| 2014-09-12 | 2014-09-10 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 2,00 | −30 000 | 120 000 | |||||
| 2014-09-12 | 2014-09-10 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 27,3607 | −30 000 | −821 | 115 549 | ||||
| 2014-09-12 | 2014-09-10 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 30 000 | 145 549 | ||||||
| 2014-09-12 | 2014-09-10 | 4 | Hacksell Uli | ACAD | Common Stock | D | −30 000 | 0 | ||||||
| 2014-09-12 | 2014-09-10 | 4 | Hacksell Uli | ACAD | Common Stock | D | 2,0000 | 30 000 | 60 | 30 000 | ||||
| 2014-09-09 | 2014-09-05 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 26,96 | 25 000 | 25 000 | |||||
| 2014-09-04 | 2014-09-02 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 1,30 | −57 692 | 0 | |||||
| 2014-09-04 | 2014-09-02 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 26,7600 | −57 692 | −1 544 | 8 500 | ||||
| 2014-09-04 | 2014-09-02 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 1,3000 | 57 692 | 75 | 66 192 | ||||
| 2014-09-04 | 2014-09-02 | 4 | Wells William McDowall | ACAD | Stock option (right to buy) | D | 1,36 | −20 000 | 24 117 | |||||
| 2014-09-04 | 2014-09-02 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 1,36 | −10 000 | 0 | |||||
| 2014-09-04 | 2014-09-02 | 4 | Wells William McDowall | ACAD | Common Stock | D | 27,0000 | −15 000 | −405 | 0 | ||||
| 2014-09-04 | 2014-09-02 | 4 | Wells William McDowall | ACAD | Common Stock | D | 26,7600 | −15 000 | −401 | 15 000 | ||||
| 2014-09-04 | 2014-09-02 | 4 | Wells William McDowall | ACAD | Common Stock | D | 1,3600 | 30 000 | 41 | 30 000 | ||||
| 2014-08-15 | 2014-08-15 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 6,86 | −15 000 | 0 | |||||
| 2014-08-15 | 2014-08-15 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 22,8914 | −15 000 | −343 | 115 549 | ||||
| 2014-08-15 | 2014-08-15 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 15 000 | 130 549 | ||||||
| 2014-08-15 | 2014-08-15 | 4 | Hacksell Uli | ACAD | Common Stock | D | −15 000 | 0 | ||||||
| 2014-08-15 | 2014-08-15 | 4 | Hacksell Uli | ACAD | Common Stock | D | 6,8600 | 15 000 | 103 | 15 000 | ||||
| 2014-07-16 | 2014-07-15 | 4 | DAVIS STEPHEN | ACAD | Stock Option (right to buy) | D | 20,77 | 320 000 | 320 000 | |||||
| 2014-07-16 | 2014-07-14 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 6,86 | −20 000 | 15 000 | |||||
| 2014-07-16 | 2014-07-14 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 22,2187 | −20 000 | −444 | 115 549 | ||||
| 2014-07-16 | 2014-07-14 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 20 000 | 135 549 | ||||||
| 2014-07-16 | 2014-07-14 | 4 | Hacksell Uli | ACAD | Common Stock | D | −20 000 | 0 | ||||||
| 2014-07-16 | 2014-07-14 | 4 | Hacksell Uli | ACAD | Common Stock | D | 6,8600 | 20 000 | 137 | 20 000 | ||||
| 2014-06-18 | 2014-06-16 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 6,86 | −20 000 | 35 000 | |||||
| 2014-06-18 | 2014-06-16 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 23,1002 | −20 000 | −462 | 115 549 | ||||
| 2014-06-18 | 2014-06-16 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 20 000 | 135 549 | ||||||
| 2014-06-18 | 2014-06-16 | 4 | Hacksell Uli | ACAD | Common Stock | D | −20 000 | 0 | ||||||
| 2014-06-18 | 2014-06-16 | 4 | Hacksell Uli | ACAD | Common Stock | D | 6,8600 | 20 000 | 137 | 20 000 | ||||
| 2014-06-10 | 2014-06-06 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 21,99 | 12 500 | 12 500 | |||||
| 2014-06-10 | 2014-06-06 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 21,99 | 12 500 | 12 500 | |||||
| 2014-06-10 | 2014-06-06 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 21,99 | 12 500 | 12 500 | |||||
| 2014-06-10 | 2014-06-06 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 21,99 | 14 000 | 14 000 | |||||
| 2014-06-10 | 2014-06-06 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 21,99 | 12 500 | 12 500 | |||||
| 2014-06-10 | 2014-06-06 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 21,99 | 12 500 | 12 500 | |||||
| 2014-06-10 | 2014-06-06 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 21,99 | 12 500 | 12 500 | |||||
| 2014-06-10 | 2014-06-09 | 4 | Wells William McDowall | ACAD | Stock option (right to buy) | D | 1,60 | −15 000 | 0 | |||||
| 2014-06-10 | 2014-06-09 | 4 | Wells William McDowall | ACAD | Common Stock | D | 23,0304 | −15 000 | −345 | 0 | ||||
| 2014-06-10 | 2014-06-09 | 4 | Wells William McDowall | ACAD | Common Stock | D | 1,6000 | 15 000 | 24 | 15 000 | ||||
| 2014-06-10 | 2014-06-06 | 4 | BAKER BROS. ADVISORS LP | ACAD | Non-Qualified Stock Option (right to buy) | I | 21,99 | 12 500 | 12 500 | |||||
| 2014-06-04 | 2014-06-02 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 6,10 | −4 450 | 0 | |||||
| 2014-06-04 | 2014-06-02 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 20,5249 | −4 450 | −91 | 8 500 | ||||
| 2014-06-04 | 2014-06-02 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 6,1000 | 4 450 | 27 | 12 950 | ||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 15,02 | −5 315 | 4 685 | |||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 9,04 | −10 000 | 0 | |||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 11,00 | −8 500 | 0 | |||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 8,85 | −2 542 | 0 | |||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 8,85 | −6 500 | 0 | |||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 20,0333 | −32 857 | −658 | 8 500 | ||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 15,0200 | 5 315 | 80 | 41 357 | ||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 9,0400 | 10 000 | 90 | 36 042 | ||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 11,0000 | 8 500 | 94 | 26 042 | ||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 8,8500 | 2 542 | 22 | 17 542 | ||||
| 2014-05-02 | 2014-05-01 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 8,8500 | 6 500 | 58 | 15 000 | ||||
| 2014-04-17 | 2014-04-15 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 6,95 | −25 000 | 0 | |||||
| 2014-04-17 | 2014-04-15 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 17,7534 | −25 000 | −444 | 115 549 | ||||
| 2014-04-17 | 2014-04-15 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 25 000 | 140 549 | ||||||
| 2014-04-17 | 2014-04-15 | 4 | Hacksell Uli | ACAD | Common Stock | D | −25 000 | 0 | ||||||
| 2014-04-17 | 2014-04-15 | 4 | Hacksell Uli | ACAD | Common Stock | D | 6,9500 | 25 000 | 174 | 25 000 | ||||
| 2014-04-04 | 2014-04-04 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 1,75 | −15 500 | 27 357 | |||||
| 2014-04-04 | 2014-04-04 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 1,75 | −10 000 | 0 | |||||
| 2014-04-04 | 2014-04-04 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 6,10 | −4 500 | 0 | |||||
| 2014-04-04 | 2014-04-04 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 21,9795 | −30 000 | −659 | 8 500 | ||||
| 2014-04-04 | 2014-04-04 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 1,7500 | 15 500 | 27 | 38 500 | ||||
| 2014-04-04 | 2014-04-04 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 1,7500 | 10 000 | 18 | 23 000 | ||||
| 2014-04-04 | 2014-04-04 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 6,1000 | 4 500 | 27 | 13 000 | ||||
| 2014-04-04 | 2014-04-04 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,55 | −7 500 | 82 971 | |||||
| 2014-04-04 | 2014-04-04 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 22,4840 | −15 000 | −337 | 0 | ||||
| 2014-04-04 | 2014-04-04 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 15 000 | 15 000 | ||||||
| 2014-04-04 | 2014-04-04 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −15 000 | 23 848 | ||||||
| 2014-04-04 | 2014-04-04 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5500 | 7 500 | 12 | 38 848 | ||||
| 2014-04-04 | 2014-04-04 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,75 | −14 285 | 20 000 | |||||
| 2014-04-04 | 2014-04-04 | 4 | Brege Laura | ACAD | Common Stock | D | 22,5359 | −14 285 | −322 | 0 | ||||
| 2014-04-04 | 2014-04-04 | 4 | Brege Laura | ACAD | Common Stock | D | 1,7500 | 14 285 | 25 | 14 285 | ||||
| 2014-03-11 | 2014-03-07 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 27,20 | 250 000 | 250 000 | |||||
| 2014-03-11 | 2014-03-07 | 4 | Mills Roger | ACAD | Stock Option (right to buy) | D | 27,20 | 155 000 | 155 000 | |||||
| 2014-03-11 | 2014-03-07 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 27,20 | 35 000 | 35 000 | |||||
| 2014-03-11 | 2014-03-07 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 27,20 | 115 000 | 115 000 | |||||
| 2014-03-07 | 2014-03-05 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 28,5000 | 11 738 | 335 | 452 540 | ||||
| 2014-03-07 | 2014-03-05 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 28,5000 | 475 644 | 13 556 | 18 476 847 | ||||
| 2014-03-07 | 2014-03-05 | 4 | BAKER BROS. ADVISORS LP See Footnotes | ACAD | Common Stock | I | 28,5000 | 38 934 | 1 110 | 1 552 055 | ||||
| 2014-02-28 | 2014-02-26 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 6,17 | −42 000 | 0 | |||||
| 2014-02-28 | 2014-02-26 | 4 | Baity Glenn | ACAD | Common Stock | D | 30,2790 | −42 000 | −1 272 | 47 788 | ||||
| 2014-02-28 | 2014-02-26 | 4 | Baity Glenn | ACAD | Common Stock | D | 6,1700 | 42 000 | 259 | 89 788 | ||||
| 2014-02-20 | 2014-02-18 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 6,95 | −25 000 | 25 000 | |||||
| 2014-02-20 | 2014-02-18 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 24,1411 | −25 000 | −604 | 115 549 | ||||
| 2014-02-20 | 2014-02-18 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 25 000 | 140 549 | ||||||
| 2014-02-20 | 2014-02-18 | 4 | Hacksell Uli | ACAD | Common Stock | D | −25 000 | 0 | ||||||
| 2014-02-20 | 2014-02-18 | 4 | Hacksell Uli | ACAD | Common Stock | D | 6,9500 | 25 000 | 174 | 25 000 | ||||
| 2014-01-17 | 2014-01-15 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 6,95 | −25 000 | 50 000 | |||||
| 2014-01-17 | 2014-01-15 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 24,0115 | −25 000 | −600 | 115 549 | ||||
| 2014-01-17 | 2014-01-15 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 25 000 | 140 549 | ||||||
| 2014-01-17 | 2014-01-15 | 4 | Hacksell Uli | ACAD | Common Stock | D | −25 000 | 0 | ||||||
| 2014-01-17 | 2014-01-15 | 4 | Hacksell Uli | ACAD | Common Stock | D | 6,9500 | 25 000 | 174 | 25 000 | ||||
| 2014-01-17 | 2014-01-15 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,36 | −10 000 | 0 | |||||
| 2014-01-17 | 2014-01-15 | 4 | Brege Laura | ACAD | Common Stock | D | 24,1764 | −10 000 | −242 | 0 | ||||
| 2014-01-17 | 2014-01-15 | 4 | Brege Laura | ACAD | Common Stock | D | 1,3600 | 10 000 | 14 | 10 000 | ||||
| 2014-01-03 | 2014-01-02 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,55 | −22 000 | 90 471 | |||||
| 2014-01-03 | 2014-01-02 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 24,8778 | −30 000 | −746 | 0 | ||||
| 2014-01-03 | 2014-01-02 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 30 000 | 30 000 | ||||||
| 2014-01-03 | 2014-01-02 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −30 000 | 31 348 | ||||||
| 2014-01-03 | 2014-01-02 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5500 | 22 000 | 34 | 61 348 | ||||
| 2014-01-03 | 2014-01-02 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 1,30 | −29 500 | 0 | |||||
| 2014-01-03 | 2014-01-02 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 2,16 | −20 500 | 7 277 | |||||
| 2014-01-03 | 2014-01-02 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 2,16 | −10 000 | 0 | |||||
| 2014-01-03 | 2014-01-02 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 25,0292 | −60 000 | −1 502 | 13 500 | ||||
| 2014-01-03 | 2014-01-02 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 1,3000 | 29 500 | 38 | 73 500 | ||||
| 2014-01-03 | 2014-01-02 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 2,1600 | 20 500 | 44 | 44 000 | ||||
| 2014-01-03 | 2014-01-02 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 2,1600 | 10 000 | 22 | 23 500 | ||||
| 2013-12-18 | 2013-12-17 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,55 | −6 500 | 343 500 | |||||
| 2013-12-18 | 2013-12-17 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 6 500 | 115 549 | ||||||
| 2013-12-18 | 2013-12-17 | 4 | Hacksell Uli | ACAD | Common Stock | D | −6 500 | 0 | ||||||
| 2013-12-18 | 2013-12-17 | 4 | Hacksell Uli | ACAD | Common Stock | D | 1,5500 | 6 500 | 10 | 6 500 | ||||
| 2013-12-16 | 2013-12-12 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 6,95 | −1 000 | 25 000 | |||||
| 2013-12-16 | 2013-12-12 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,55 | −11 000 | 112 471 | |||||
| 2013-12-16 | 2013-12-12 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 6,9500 | 1 000 | 7 | 39 348 | ||||
| 2013-12-16 | 2013-12-12 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5500 | 11 000 | 17 | 38 348 | ||||
| 2013-12-16 | 2013-12-02 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −2 000 | 27 348 | ||||||
| 2013-12-12 | 2013-12-10 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,36 | −44 117 | 0 | |||||
| 2013-12-12 | 2013-12-10 | 4 | Brege Laura | ACAD | Common Stock | D | 23,4130 | −44 117 | −1 033 | 0 | ||||
| 2013-12-12 | 2013-12-10 | 4 | Brege Laura | ACAD | Common Stock | D | 1,3600 | 44 117 | 60 | 44 117 | ||||
| 2013-12-04 | 2013-12-02 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 2,00 | −15 000 | 0 | |||||
| 2013-12-04 | 2013-12-02 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 23,4538 | −15 000 | −352 | 109 049 | ||||
| 2013-12-04 | 2013-12-02 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 15 000 | 124 049 | ||||||
| 2013-12-04 | 2013-12-02 | 4 | Hacksell Uli | ACAD | Common Stock | D | −15 000 | 0 | ||||||
| 2013-12-04 | 2013-12-02 | 4 | Hacksell Uli | ACAD | Common Stock | D | 2,0000 | 15 000 | 30 | 15 000 | ||||
| 2013-11-01 | 2013-11-01 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 2,00 | −15 000 | 15 000 | |||||
| 2013-11-01 | 2013-11-01 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 23,2425 | −15 000 | −349 | 109 049 | ||||
| 2013-11-01 | 2013-11-01 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 15 000 | 124 049 | ||||||
| 2013-11-01 | 2013-11-01 | 4 | Hacksell Uli | ACAD | Common Stock | D | −15 000 | 0 | ||||||
| 2013-11-01 | 2013-11-01 | 4 | Hacksell Uli | ACAD | Common Stock | D | 2,0000 | 15 000 | 30 | 15 000 | ||||
| 2013-11-01 | 2013-11-01 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 1,30 | −37 692 | 0 | |||||
| 2013-11-01 | 2013-11-01 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 23,0031 | −37 692 | −867 | 8 500 | ||||
| 2013-11-01 | 2013-11-01 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 1,3000 | 37 692 | 49 | 46 192 | ||||
| 2013-10-11 | 2013-10-10 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,30 | −10 000 | 0 | |||||
| 2013-10-11 | 2013-10-10 | 4 | Brege Laura | ACAD | Common Stock | D | 21,6256 | −10 000 | −216 | 0 | ||||
| 2013-10-11 | 2013-10-10 | 4 | Brege Laura | ACAD | Common Stock | D | 1,3000 | 10 000 | 13 | 10 000 | ||||
| 2013-10-03 | 2013-10-01 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,55 | −17 500 | 123 471 | |||||
| 2013-10-03 | 2013-10-01 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 6,95 | −5 000 | 26 000 | |||||
| 2013-10-03 | 2013-10-01 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 27,8707 | −30 000 | −836 | 0 | ||||
| 2013-10-03 | 2013-10-01 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 30 000 | 30 000 | ||||||
| 2013-10-03 | 2013-10-01 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −30 000 | 24 085 | ||||||
| 2013-10-03 | 2013-10-01 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5500 | 17 500 | 27 | 54 085 | ||||
| 2013-10-03 | 2013-10-01 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 6,9500 | 5 000 | 35 | 36 585 | ||||
| 2013-09-20 | 2013-09-20 | 4 | Mills Roger | ACAD | Stock Option (right to buy) | D | 1,55 | −35 965 | 164 035 | |||||
| 2013-09-20 | 2013-09-20 | 4 | Mills Roger | ACAD | Common Stock | D | 25,0052 | −35 965 | −899 | 15 775 | ||||
| 2013-09-20 | 2013-09-20 | 4 | Mills Roger | ACAD | Common Stock | D | 35 965 | 51 740 | ||||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 2,16 | −34 722 | 0 | |||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 9,04 | −10 000 | 0 | |||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 2,16 | −10 000 | 0 | |||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 8,85 | −5 084 | 0 | |||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 8,85 | −6 500 | 0 | |||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 6,10 | −50 | 4 450 | |||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 22,9018 | −66 356 | −1 520 | 8 500 | ||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 2,1600 | 34 722 | 75 | 74 856 | ||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 2,1600 | 10 000 | 22 | 40 134 | ||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 9,0400 | 10 000 | 90 | 30 134 | ||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 8,8500 | 5 084 | 45 | 20 134 | ||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 8,8500 | 6 500 | 58 | 15 050 | ||||
| 2013-09-13 | 2013-09-12 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 6,1000 | 50 | 0 | 8 550 | ||||
| 2013-09-13 | 2013-09-12 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 1,30 | −45 500 | 29 500 | |||||
| 2013-09-13 | 2013-09-12 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 1,30 | −10 000 | 0 | |||||
| 2013-09-13 | 2013-09-12 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 6,10 | −4 500 | 0 | |||||
| 2013-09-13 | 2013-09-12 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 22,9245 | −60 000 | −1 375 | 13 500 | ||||
| 2013-09-13 | 2013-09-12 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 1,3000 | 45 500 | 59 | 73 500 | ||||
| 2013-09-13 | 2013-09-12 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 1,3000 | 10 000 | 13 | 28 000 | ||||
| 2013-09-13 | 2013-09-12 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 6,1000 | 4 500 | 27 | 18 000 | ||||
| 2013-09-12 | 2013-09-10 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,30 | −46 153 | 0 | |||||
| 2013-09-12 | 2013-09-10 | 4 | Brege Laura | ACAD | Common Stock | D | 22,7969 | −46 153 | −1 052 | 0 | ||||
| 2013-09-12 | 2013-09-10 | 4 | Brege Laura | ACAD | Common Stock | D | 1,3000 | 46 153 | 60 | 46 153 | ||||
| 2013-09-05 | 2013-09-03 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 1,30 | −20 000 | 37 692 | |||||
| 2013-09-05 | 2013-09-03 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 2,16 | −10 000 | 0 | |||||
| 2013-09-05 | 2013-09-03 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 1,30 | −10 000 | 0 | |||||
| 2013-09-05 | 2013-09-03 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 20,2775 | −40 000 | −811 | 8 500 | ||||
| 2013-09-05 | 2013-09-03 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 1,3000 | 20 000 | 26 | 48 500 | ||||
| 2013-09-05 | 2013-09-03 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 1,3000 | 10 000 | 13 | 28 500 | ||||
| 2013-09-05 | 2013-09-03 | 4 | Rasmussen Torsten | ACAD | Common Stock | I | 2,1600 | 10 000 | 22 | 18 500 | ||||
| 2013-08-28 | 2013-08-26 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 8,49 | −10 000 | 0 | |||||
| 2013-08-28 | 2013-08-26 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 7,67 | −5 000 | 1 500 | |||||
| 2013-08-28 | 2013-08-26 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 20,7129 | −10 000 | −207 | 0 | ||||
| 2013-08-28 | 2013-08-26 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 20,6164 | −5 000 | −103 | 10 000 | ||||
| 2013-08-28 | 2013-08-26 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 8,4900 | 10 000 | 85 | 15 000 | ||||
| 2013-08-28 | 2013-08-26 | 4 | GRAY MARY ANN | ACAD | Common Stock | D | 7,6700 | 5 000 | 38 | 5 000 | ||||
| 2013-08-20 | 2013-08-19 | 4 | Moore Terrence O | ACAD | Stock Option (right to buy) | D | 19,61 | 150 000 | 150 000 | |||||
| 2013-08-15 | 2013-08-13 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,08 | −17 771 | 0 | |||||
| 2013-08-15 | 2013-08-13 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,08 | −35 000 | 0 | |||||
| 2013-08-15 | 2013-08-13 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 20,1448 | −52 771 | −1 063 | 109 049 | ||||
| 2013-08-15 | 2013-08-13 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 52 771 | 161 820 | ||||||
| 2013-08-15 | 2013-08-13 | 4 | Hacksell Uli | ACAD | Common Stock | D | −52 771 | 0 | ||||||
| 2013-08-15 | 2013-08-13 | 4 | Hacksell Uli | ACAD | Common Stock | D | 1,0800 | 17 771 | 19 | 52 771 | ||||
| 2013-08-15 | 2013-08-13 | 4 | Hacksell Uli | ACAD | Common Stock | D | 1,0800 | 35 000 | 38 | 35 000 | ||||
| 2013-08-15 | 2013-08-13 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,55 | −15 000 | 58 708 | |||||
| 2013-08-15 | 2013-08-13 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,55 | −30 000 | 82 263 | |||||
| 2013-08-15 | 2013-08-13 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 20,1530 | −60 000 | −1 209 | 0 | ||||
| 2013-08-15 | 2013-08-13 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 60 000 | 60 000 | ||||||
| 2013-08-15 | 2013-08-13 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −60 000 | 31 585 | ||||||
| 2013-08-15 | 2013-08-13 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5500 | 15 000 | 23 | 91 585 | ||||
| 2013-08-15 | 2013-08-13 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5500 | 30 000 | 46 | 76 585 | ||||
| 2013-06-11 | 2013-06-07 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-11 | 2013-06-07 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-11 | 2013-06-07 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-11 | 2013-06-07 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 17,01 | 14 000 | 14 000 | |||||
| 2013-06-11 | 2013-06-07 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-11 | 2013-06-07 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 17,01 | 300 000 | 300 000 | |||||
| 2013-06-11 | 2013-06-07 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 17,01 | 175 000 | 175 000 | |||||
| 2013-06-11 | 2013-06-07 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-11 | 2013-06-07 | 4 | Mills Roger | ACAD | Stock Option (right to buy) | D | 17,01 | 175 000 | 175 000 | |||||
| 2013-06-11 | 2013-06-07 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-11 | 2013-06-07 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 17,01 | 130 000 | 130 000 | |||||
| 2013-06-11 | 2013-06-07 | 4 | BAKER BROS. ADVISORS LP | ACAD | Non-Qualified Stock Option (right to buy) | I | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-11 | 2013-06-07 | 4 | BAKER BROS. ADVISORS LP | ACAD | Non-Qualified Stock Option (right to buy) | I | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-11 | 2013-06-07 | 4 | BAKER BROS. ADVISORS LP | ACAD | Non-Qualified Stock Option (right to buy) | I | 17,01 | 12 500 | 12 500 | |||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,4641 | 5 437 | 79 | 440 802 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,4641 | 217 986 | 3 153 | 18 001 203 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,4641 | 26 577 | 384 | 1 513 121 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,5502 | 3 790 | 55 | 435 365 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,5502 | 151 980 | 2 211 | 17 783 217 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,5502 | 18 530 | 270 | 1 486 544 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,5838 | 4 312 | 63 | 431 575 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,5838 | 172 893 | 2 521 | 17 631 237 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,5838 | 21 080 | 307 | 1 468 014 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,4565 | 5 437 | 79 | 427 263 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,4565 | 217 986 | 3 151 | 17 458 344 | ||||
| 2013-06-05 | 2013-06-05 | 4 | BAKER FELIX | ACAD | Common Stoc | I | 14,4565 | 26 577 | 384 | 1 446 934 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4159 | 2 775 | 40 | 421 826 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4159 | 111 266 | 1 604 | 17 240 358 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4159 | 13 566 | 196 | 1 420 357 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4525 | 11 552 | 167 | 419 051 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4525 | 463 197 | 6 694 | 17 129 092 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4525 | 56 475 | 816 | 1 406 791 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4977 | 890 | 13 | 407 499 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4977 | 35 702 | 518 | 16 665 895 | ||||
| 2013-06-05 | 2013-06-04 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,4977 | 4 353 | 63 | 1 350 316 | ||||
| 2013-06-05 | 2013-06-03 | 4 | BAKER FELIX | ACAD | Common Stock | I | 13,9990 | 5 189 | 73 | 406 609 | ||||
| 2013-06-05 | 2013-06-03 | 4 | BAKER FELIX | ACAD | Common Stock | I | 13,9990 | 208 063 | 2 913 | 16 630 193 | ||||
| 2013-06-05 | 2013-06-03 | 4 | BAKER FELIX | ACAD | Common Stock | I | 13,9990 | 25 368 | 355 | 1 345 963 | ||||
| 2013-06-05 | 2013-06-03 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,0822 | 11 511 | 162 | 401 420 | ||||
| 2013-06-05 | 2013-06-03 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,0822 | 461 548 | 6 500 | 16 422 130 | ||||
| 2013-06-05 | 2013-06-03 | 4 | BAKER FELIX | ACAD | Common Stock | I | 14,0822 | 56 274 | 792 | 1 320 595 | ||||
| 2013-05-17 | 2013-05-15 | 4 | BAKER FELIX | ACAD | Common Stock | I | 12,5000 | 43 184 | 540 | 389 909 | ||||
| 2013-05-17 | 2013-05-15 | 4 | BAKER FELIX | ACAD | Common Stock | I | 12,5000 | 1 730 970 | 21 637 | 15 960 582 | ||||
| 2013-05-17 | 2013-05-15 | 4 | BAKER FELIX | ACAD | Common Stock | I | 12,5000 | 218 846 | 2 736 | 1 264 321 | ||||
| 2013-05-03 | 2013-05-02 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,08 | −20 449 | 35 000 | |||||
| 2013-05-03 | 2013-05-02 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 12,3427 | −20 449 | −252 | 109 049 | ||||
| 2013-05-03 | 2013-05-02 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 20 449 | 129 498 | ||||||
| 2013-05-03 | 2013-05-02 | 4 | Hacksell Uli | ACAD | Common Stock | D | −20 449 | 0 | ||||||
| 2013-05-03 | 2013-05-02 | 4 | Hacksell Uli | ACAD | Common Stock | D | 1,0800 | 20 449 | 22 | 20 449 | ||||
| 2013-05-03 | 2013-05-01 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,08 | −19 551 | 55 449 | |||||
| 2013-05-03 | 2013-05-01 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 12,7113 | −19 551 | −249 | 109 049 | ||||
| 2013-05-03 | 2013-05-01 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 19 551 | 128 600 | ||||||
| 2013-05-03 | 2013-05-01 | 4 | Hacksell Uli | ACAD | Common Stock | D | −19 551 | 0 | ||||||
| 2013-05-03 | 2013-05-01 | 4 | Hacksell Uli | ACAD | Common Stock | D | 1,0800 | 19 551 | 21 | 19 551 | ||||
| 2013-04-24 | 2013-04-22 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −10 000 | 22 407 | |||||
| 2013-04-24 | 2013-04-22 | 4 | Baity Glenn | ACAD | Common Stock | D | 13,1493 | −10 000 | −131 | 40 000 | ||||
| 2013-04-24 | 2013-04-22 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 10 000 | 16 | 50 000 | ||||
| 2013-04-17 | 2013-04-16 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,08 | −16 729 | 75 000 | |||||
| 2013-04-17 | 2013-04-16 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 12,3168 | −16 729 | −206 | 109 049 | ||||
| 2013-04-17 | 2013-04-16 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 16 729 | 125 778 | ||||||
| 2013-04-17 | 2013-04-16 | 4 | Hacksell Uli | ACAD | Common Stock | D | −16 729 | 0 | ||||||
| 2013-04-17 | 2013-04-16 | 4 | Hacksell Uli | ACAD | Common Stock | D | 1,0800 | 16 729 | 18 | 16 729 | ||||
| 2013-04-17 | 2013-04-17 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 59 078 | |||||
| 2013-04-17 | 2013-04-17 | 4 | Baity Glenn | ACAD | Common Stock | D | 12,2600 | −10 000 | −123 | 40 000 | ||||
| 2013-04-17 | 2013-04-17 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 50 000 | ||||
| 2013-04-17 | 2013-04-16 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 922 | |||||
| 2013-04-17 | 2013-04-16 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 922 | |||||
| 2013-04-17 | 2013-04-16 | 4 | Baity Glenn | ACAD | Common Stock | D | 12,3000 | −20 000 | −246 | 40 000 | ||||
| 2013-04-17 | 2013-04-16 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 60 000 | ||||
| 2013-04-17 | 2013-04-16 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 60 000 | ||||
| 2013-04-17 | 2013-04-15 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 10 922 | |||||
| 2013-04-17 | 2013-04-15 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 10 922 | |||||
| 2013-04-17 | 2013-04-15 | 4 | Baity Glenn | ACAD | Common Stock | D | 12,5000 | −20 000 | −250 | 40 000 | ||||
| 2013-04-17 | 2013-04-15 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 60 000 | ||||
| 2013-04-17 | 2013-04-15 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 60 000 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,55 | −14 029 | 73 708 | |||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 2,00 | −12 500 | 0 | |||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,08 | −7 500 | 0 | |||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 11,0600 | −40 000 | −442 | 0 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 40 000 | 40 000 | ||||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −40 000 | 44 500 | ||||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5500 | 14 029 | 22 | 84 500 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 2,0000 | 12 500 | 25 | 70 471 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,0800 | 7 500 | 8 | 57 971 | ||||
| 2013-04-12 | 2013-04-12 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −10 000 | 32 407 | |||||
| 2013-04-12 | 2013-04-12 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 32 407 | |||||
| 2013-04-12 | 2013-04-12 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 20 922 | |||||
| 2013-04-12 | 2013-04-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 13,0000 | −10 000 | −130 | 40 000 | ||||
| 2013-04-12 | 2013-04-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 10 000 | 16 | 50 000 | ||||
| 2013-04-12 | 2013-04-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 12,7400 | −20 000 | −255 | 40 000 | ||||
| 2013-04-12 | 2013-04-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 60 000 | ||||
| 2013-04-12 | 2013-04-12 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 60 000 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 42 407 | |||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,62 | −10 000 | 42 407 | |||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,55 | −10 000 | 30 922 | |||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Common Stock | D | 13,0000 | −10 000 | −130 | 40 000 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,6200 | 10 000 | 16 | 50 000 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Common Stock | D | 12,0000 | −10 000 | −120 | 40 000 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 50 000 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Common Stock | D | 1,5500 | 10 000 | 16 | 50 000 | ||||
| 2013-04-12 | 2013-04-11 | 4 | Baity Glenn | ACAD | Common Stock | D | 11,0600 | −10 000 | −111 | 40 000 | ||||
| 2013-04-03 | 2013-04-01 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,08 | −40 000 | 91 729 | |||||
| 2013-04-03 | 2013-04-01 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 7,6761 | −40 000 | −307 | 109 049 | ||||
| 2013-04-03 | 2013-04-01 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 40 000 | 149 049 | ||||||
| 2013-04-03 | 2013-04-01 | 4 | Hacksell Uli | ACAD | Common Stock | D | −40 000 | 0 | ||||||
| 2013-04-03 | 2013-04-01 | 4 | Hacksell Uli | ACAD | Common Stock | D | 1,0800 | 40 000 | 43 | 40 000 | ||||
| 2013-04-03 | 2013-04-01 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,08 | −36 490 | 7 500 | |||||
| 2013-04-03 | 2013-04-01 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,08 | −3 510 | 0 | |||||
| 2013-04-03 | 2013-04-01 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 7,6771 | −40 000 | −307 | 0 | ||||
| 2013-04-03 | 2013-04-01 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 40 000 | 40 000 | ||||||
| 2013-04-03 | 2013-04-01 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −40 000 | 50 471 | ||||||
| 2013-04-03 | 2013-04-01 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,0800 | 36 490 | 39 | 90 471 | ||||
| 2013-04-03 | 2013-04-01 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,0800 | 3 510 | 4 | 53 981 | ||||
| 2013-04-03 | 2013-04-01 | 4 | Mills Roger | ACAD | Common Stock | D | 7,6875 | −58 584 | −450 | 14 017 | ||||
| 2013-04-03 | 2013-04-02 | 4 | Baity Glenn | ACAD | Common Stock | D | 8,0000 | −13 163 | −105 | 40 000 | ||||
| 2013-02-22 | 2013-02-21 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 1,08 | −4 500 | 0 | |||||
| 2013-02-22 | 2013-02-21 | 4 | Iversen Leslie L | ACAD | Common Stock | D | 4 500 | 13 500 | ||||||
| 2013-01-23 | 3 | Baker Brothers Life Sciences LP | ACAD | Common Stock | D | 14 229 612 | ||||||||
| 2013-01-23 | 3 | 14159, L.P. | ACAD | Common Stock | D | 346 725 | ||||||||
| 2013-01-23 | 3 | 667, L.P. | ACAD | Common Stock | D | 1 045 475 | ||||||||
| 2013-01-23 | 2013-01-18 | 4 | BAKER FELIX | ACAD | Stock Options (right to buy) | I | 5,22 | 15 000 | 15 000 | |||||
| 2013-01-18 | 2013-01-18 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,08 | −7 500 | 0 | |||||
| 2013-01-18 | 2013-01-18 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 7 500 | 109 049 | ||||||
| 2013-01-18 | 2013-01-18 | 4 | Hacksell Uli | ACAD | Common Stock | D | −7 500 | 0 | ||||||
| 2013-01-18 | 2013-01-18 | 4 | Hacksell Uli | ACAD | Common Stock | D | 7 500 | 7 500 | ||||||
| 2013-01-18 | 2013-01-17 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,08 | −12 000 | 43 990 | |||||
| 2013-01-18 | 2013-01-17 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,0800 | 12 000 | 13 | 50 471 | ||||
| 2013-01-15 | 2013-01-14 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 1,08 | −4 500 | 0 | |||||
| 2013-01-15 | 2013-01-14 | 4 | KAPLAN LESTER J PH D | ACAD | Common Stock | D | 1,0800 | 4 500 | 5 | 8 500 | ||||
| 2013-01-10 | 2013-01-10 | 4 | Rasmussen Torsten See footnote (1) | ACAD | Stock option (right to buy) | I | 1,08 | −4 500 | 0 | |||||
| 2013-01-10 | 2013-01-10 | 4 | Rasmussen Torsten | ACAD | Common stock | I | 1,0800 | 4 500 | 5 | 8 500 | ||||
| 2012-12-21 | 3 | BAKER JULIAN See Footnotes | ACAD | Common Stock | I | 14 229 612 | ||||||||
| 2012-12-21 | 3 | BAKER JULIAN See Footnotes | ACAD | Common Stock | I | 1 045 475 | ||||||||
| 2012-12-21 | 3 | BAKER JULIAN See Footnotes | ACAD | Common Stock | I | 346 725 | ||||||||
| 2012-11-29 | 2012-11-28 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,08 | −5 000 | 3 510 | |||||
| 2012-11-29 | 2012-11-28 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 5,2499 | −9 100 | −48 | 0 | ||||
| 2012-11-29 | 2012-11-28 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 5 000 | 9 100 | ||||||
| 2012-11-29 | 2012-11-28 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −5 000 | 28 471 | ||||||
| 2012-11-29 | 2012-11-28 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,0800 | 5 000 | 5 | 33 471 | ||||
| 2012-11-29 | 2012-11-27 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 6,2414 | −30 900 | −193 | 4 100 | ||||
| 2012-11-29 | 2012-11-27 | 4 | Aasen Thomas H By Family Trust | ACAD | Common Stock | I | 33 631 | 35 000 | ||||||
| 2012-11-29 | 2012-11-27 | 4 | Aasen Thomas H | ACAD | Common Stock | D | −33 631 | 28 471 | ||||||
| 2012-11-29 | 2012-11-28 | 4 | Baity Glenn | ACAD | Common Stock | D | 5,2526 | −4 396 | −23 | 43 163 | ||||
| 2012-11-29 | 2012-11-27 | 4 | Baity Glenn | ACAD | Common Stock | D | 6,2788 | −16 206 | −102 | 47 559 | ||||
| 2012-09-11 | 2012-09-07 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,50 | −7 500 | 20 000 | |||||
| 2012-09-11 | 2012-09-07 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5000 | 7 500 | 11 | 62 102 | ||||
| 2012-08-22 | 2012-08-22 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,50 | −23 333 | 0 | |||||
| 2012-08-22 | 2012-08-22 | 4 | Hacksell Uli By Family Trust | ACAD | Common Stock | I | 23 333 | 101 549 | ||||||
| 2012-08-22 | 2012-08-22 | 4 | Hacksell Uli | ACAD | Common Stock | D | −23 333 | 0 | ||||||
| 2012-08-22 | 2012-08-22 | 4 | Hacksell Uli | ACAD | Common Stock | D | 23 333 | 23 333 | ||||||
| 2012-08-06 | 2012-08-03 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,50 | −5 000 | 27 500 | |||||
| 2012-08-06 | 2012-08-03 | 4 | Aasen Thomas H | ACAD | Common Stock | D | 1,5000 | 5 000 | 8 | 54 602 | ||||
| 2012-06-11 | 2012-06-08 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 1,36 | 55 147 | 55 147 | |||||
| 2012-06-11 | 2012-06-08 | 4 | KAPLAN LESTER J PH D | ACAD | Stock option (right to buy) | D | 1,36 | 10 000 | 10 000 | |||||
| 2012-06-11 | 2012-06-08 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 1,36 | 22 058 | 22 058 | |||||
| 2012-06-11 | 2012-06-08 | 4 | BORER MICHAEL T | ACAD | Stock Option (right to buy) | D | 1,36 | 10 000 | 10 000 | |||||
| 2012-06-11 | 2012-06-08 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 1,36 | 55 147 | 55 147 | |||||
| 2012-06-11 | 2012-06-08 | 4 | GRAY MARY ANN | ACAD | Stock option (right to buy) | D | 1,36 | 10 000 | 10 000 | |||||
| 2012-06-11 | 2012-06-08 | 4 | Rasmussen Torsten | ACAD | Stock option (right to buy) | I | 1,36 | 10 000 | 10 000 | |||||
| 2012-06-11 | 2012-06-08 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 1,36 | 93 750 | 93 750 | |||||
| 2012-06-11 | 2012-06-08 | 4 | Iversen Leslie L | ACAD | Stock option (right to buy) | D | 1,36 | 10 000 | 10 000 | |||||
| 2012-06-11 | 2012-06-08 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,36 | 44 117 | 44 117 | |||||
| 2012-06-11 | 2012-06-08 | 4 | Brege Laura | ACAD | Stock option (right to buy) | D | 1,36 | 10 000 | 10 000 | |||||
| 2012-06-11 | 2012-06-08 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 1,36 | 44 117 | 44 117 | |||||
| 2012-06-11 | 2012-06-08 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 1,36 | 10 000 | 10 000 | |||||
| 2012-03-26 | 2012-03-23 | 4/A | Baity Glenn | ACAD | Stock Option (right to buy) | D | 2,18 | 130 000 | 130 000 | |||||
| 2012-03-26 | 2012-03-23 | 4/A | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 2,18 | 175 000 | 175 000 | |||||
| 2012-03-26 | 2012-03-23 | 4/A | Mills Roger | ACAD | Stock Option (right to buy) | D | 2,18 | 175 000 | 175 000 | |||||
| 2012-03-26 | 2012-03-23 | 4/A | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 2,18 | 300 000 | 300 000 | |||||
| 2012-03-26 | 2012-03-23 | 4 | Hacksell Uli | ACAD | Stock Option (right to buy) | D | 1,18 | 300 000 | 300 000 | |||||
| 2012-03-26 | 2012-03-23 | 4 | Aasen Thomas H | ACAD | Stock Option (right to buy) | D | 1,18 | 175 000 | 175 000 | |||||
| 2012-03-26 | 2012-03-23 | 4 | Mills Roger | ACAD | Stock Option (right to buy) | D | 1,18 | 175 000 | 175 000 | |||||
| 2012-03-26 | 2012-03-23 | 4 | Baity Glenn | ACAD | Stock Option (right to buy) | D | 1,18 | 130 000 | 130 000 | |||||
| 2012-01-31 | 2012-01-27 | 4 | Wells William McDowall | ACAD | Stock Option (right to buy) | D | 1,60 | 15 000 | 15 000 | |||||
| 2010-03-16 | 3 | Baity Glenn | ACAD | Common Stock | D | 30 203 | ||||||||
| 2008-06-17 | 2008-06-13 | 4 | WALTON ALAN G | ACAD | Stock Option (Right to Buy) | D | 8,49 | 8 833 | 8 833 | |||||
| 2008-06-17 | 2008-06-13 | 4 | WALTON ALAN G | ACAD | Stock Option (Right to Buy) | D | 8,49 | 10 000 | 10 000 | |||||
| 2008-03-11 | 2008-03-07 | 4 | Hacksell Uli | ACAD | Srock option (right to buy) | D | 8,32 | 60 000 | 60 000 | |||||
| 2008-03-11 | 2008-03-07 | 4 | Aasen Thomas H | ACAD | Stock option (right to buy) | D | 8,32 | 26 000 | 26 000 | |||||
| 2008-03-11 | 2008-03-07 | 4 | Tolf Bo-Ragnar | ACAD | Stock option (right to buy) | D | 8,32 | 21 000 | 21 000 | |||||
| 2007-06-19 | 2007-06-15 | 4 | WALTON ALAN G | ACAD | Stock Option (Right to Buy) | D | 15,02 | 3 994 | 3 994 | |||||
| 2007-06-19 | 2007-06-15 | 4 | WALTON ALAN G | ACAD | Stock Option (Right to Buy) | D | 15,02 | 10 000 | 10 000 | |||||
| 2006-06-15 | 2006-06-13 | 4 | WALTON ALAN G | ACAD | Stock Option (Right to Buy) | D | 9,04 | 16 637 | 16 637 | |||||
| 2005-09-13 | 2005-09-09 | 4 | WALTON ALAN G | ACAD | Stock Option (Right to Buy) | D | 11,00 | 8 500 | 8 500 | |||||
| 2005-08-26 | 3 | Nomura Phase4 Ventures LP Notes | ACAD | Common Stock, par value $0.0001 per share ("Common Stock") | I | 2 199 010 | ||||||||
| 2005-08-02 | 2005-07-29 | 4 | OXFORD BIOSCIENCE PARTNERS IV LP | ACAD | Common Stock Warrant (right to buy) | D | 8,15 | 3,0900 | 89 900 | 278 | 236 500 | |||
| 2005-06-14 | 2005-06-10 | 4 | Binder Gordon M | ACAD | Stock Option (Right to Buy) | D | 8,85 | 6 500 | 6 500 | |||||
| 2005-06-14 | 2005-06-10 | 4 | KAPLAN LESTER J PH D | ACAD | Stock Option (Right to Buy) | D | 8,85 | 5 084 | 5 084 | |||||
| 2005-06-14 | 2005-06-10 | 4 | KAPLAN LESTER J PH D | ACAD | Stock Option (Right to Buy) | D | 8,85 | 6 500 | 6 500 | |||||
| 2005-06-14 | 2005-06-10 | 4 | Rasmussen Torsten Please see footnote. | ACAD | Stock Option (Right to Buy) | I | 8,85 | 2 542 | 2 542 | |||||
| 2005-06-14 | 2005-06-10 | 4 | Rasmussen Torsten Please see footnote. | ACAD | Stock Option (Right to Buy) | I | 8,85 | 6 500 | 6 500 | |||||
| 2005-06-14 | 2005-06-09 | 4 | Iversen Leslie L | ACAD | Stock Option (Right to Buy) | D | 8,85 | 7 627 | 7 627 | |||||
| 2005-06-14 | 2005-06-09 | 4 | Iversen Leslie L | ACAD | Stock Option (Right to Buy) | D | 8,85 | 6 500 | 6 500 | |||||
| 2005-06-14 | 2005-06-10 | 4 | WALTON ALAN G | ACAD | Stock Option (Right to Buy) | D | 8,85 | 5 084 | 5 084 | |||||
| 2005-06-14 | 2005-06-10 | 4 | WALTON ALAN G | ACAD | Stock Option (Right to Buy) | D | 8,85 | 6 500 | 6 500 | |||||
| 2005-04-22 | 2005-04-20 | 4 | GORDON CARL L | ACAD | Common Stock Warrant (Right to Buy) | I | 8,15 | 0,0313 | 89 900 | 3 | 89 900 | |||
| 2005-04-22 | 2005-04-20 | 4 | GORDON CARL L | ACAD | Common Stock | I | 6,7900 | 359 603 | 2 442 | 774 006 | ||||
| 2005-04-22 | 2005-04-20 | 4 | van Osch Martien | ACAD | Common Stock Warrant (Right to Buy) | I | 8,15 | 0,0313 | 91 625 | 3 | 91 625 | |||
| 2005-04-22 | 2005-04-20 | 4 | van Osch Martien | ACAD | Common Stock | I | 6,7900 | 366 501 | 2 489 | 1 168 892 | ||||
| 2005-04-21 | 2005-04-20 | 4 | OXFORD BIOSCIENCE PARTNERS IV LP | ACAD | Common Stock Warrant (right to buy) | D | 8,15 | 146 600 | 146 600 | |||||
| 2005-04-21 | 2005-04-20 | 4 | OXFORD BIOSCIENCE PARTNERS IV LP | ACAD | Common Stock | D | 6,8213 | 586 402 | 4 000 | 3 160 238 |
P
Köp på öppna marknaden eller privat köp av icke-derivatsäkerhet
S
Köp på öppna marknaden eller privat försäljning av icke-derivatsäkerhet
A
Bevilja, tilldelning eller annat förvärv av värdepapper från företaget (såsom en option)
C
Omvandling av derivat
D
Försäljning eller överföring av värdepapper tillbaka til företaget
F
Betalning av lösenpris eller skatteskuld med del av värdepapper som erhållits från bolaget
G
Överlåtelse av värdepapper från eller till insidern
K
Aktieswappar och liknande säkringsaffärer
M
Utövande eller omvandling av derivatsäkerhet som erhållits från företaget (som en option)
V
En transaktion friviligt rapporterad på schema 4
J
Andra (med en fotnot som beskriver transaktionen)
