VPHM / Shire Viropharma Inc - SEC-arkiveringar, Årsredovisning, Fullmaktsutlåtande

Shire Viropharma Inc
US ˙ NASDAQ
DENNA SYMBOL ÄR INTE LÄNGRE AKTIV

Grundläggande statistik
CIK 946840
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Shire Viropharma Inc
SEC Filings (Chronological Order)
Denna sida innehåller en komplett, kronologisk lista över SEC-arkiveringar, exklusive ägande-arkiveringar som vi tillhandahåller på andra ställen.
February 25, 2014 EX-99.(A)(5)(B)

ViroPharma announces results of tender offer for its 2.00% Convertible Senior Notes Due 2017

Exhibit (a)(5)(B) ViroPharma announces results of tender offer for its 2.00% Convertible Senior Notes Due 2017 Exton, PA, US — February 25, 2014 — ViroPharma Incorporated today announced the results of its tender offer (the “Convertible Notes Tender Offer”) pursuant to which each holder of the 2.00% Convertible Senior Notes Due 2017 (the “Convertible Notes”) had the right (the “Fundamental Change

February 25, 2014 SC TO-I/A

- FORM SC TO-I/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VIROPHARMA INCORPORATED (Name of Filing Person (Issuer)) 2.00% Convertible Senior Notes due 2017 (Title of Class of Securities) 928241AH1 (CUS

February 14, 2014 EX-99.1

AGREEMENT

EXHIBIT 99.1 AGREEMENT In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that this Statement on Schedule 13G relating to the Common Stock of ViroPharma Incorporated is being filed with the Securities and Exchange Commission on behalf of each of them. February 14, 2014 BAKER BROS. ADVISORS LP By: Baker Bros. Advisors (GP) LLC, it

February 14, 2014 SC 13G/A

VPHM / Shire Viropharma Inc / Palo Alto Investors, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4) ViroPharma Incorporated (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

February 14, 2014 SC 13G/A

VPHM / Shire Viropharma Inc / BAKER FELIX - SC 13G/A Passive Investment

SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Under the Securities Exchange Act of 1934 (Amendment No.

February 12, 2014 SC 13G/A

VPHM / Shire Viropharma Inc / VANGUARD GROUP INC Passive Investment

viropharmainc.htm - Generated by SEC Publisher for SEC Filing SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 2 )* Name of issuer: ViroPharma Inc Title of Class of Securities: Common Stock CUSIP Number: 928241108 Date of Event Which Requires Filing of this Statement: December 31, 2013 Check the appropriate box to desi

February 10, 2014 SC 13G/A

VPHM / Shire Viropharma Inc / DIMENSIONAL FUND ADVISORS LP - SCHEDULE 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* VIROPHARMA INC (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 4, 2014 15-12G

- FORM 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number: 000-21699 ViroPharma Incorporated (Exact name of registrant as specified in

January 24, 2014 SC TO-I/A

- FORM SC TO-I/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VIROPHARMA INCORPORATED (Name of Filing Person (Issuer)) 2.00% Convertible Senior Notes due 2017 (Title of Class of Securities) 928241AH1 (CUS

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 EX-3.1

FOURTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION VIROPHARMA INCORPORATED * * *

EX-3.1 2 dp43315ex0301.htm EXHIBIT 3.1 Exhibit 3.1 FOURTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF VIROPHARMA INCORPORATED * * * FIRST: The name of the corporation is ViroPharma Incorporated (the “Corporation”). SECOND: The address of its registered office in the State of Delaware is Corporation Trust Center, 1209 Orange Street, City of Wilmington, County of New Castle, Delaware 19801.

January 24, 2014 8-K

Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Material Modification to Rights of Security Holders, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Triggering Events That Accelerate or Increase a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement, Completion of Acquisition or Disposition of Assets - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 24, 2014 (January 23, 2014) VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorpo

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 SC TO-I

- FORM SC TO-I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VIROPHARMA INCORPORATED (Name of Filing Person (Issuer)) 2.00% Convertible Senior Notes due 2017 (Title of Class of Securities) 928241AH1 (CUSIP Number of Class

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 EX-99.A5

2

Exhibit (a)(5) ViroPharma announces tender offer for its 2.00% Convertible Senior Notes Due 2017 Exton, PA, US—January 24, 2014—ViroPharma, Inc. today announced that, in connection with the completion of the acquisition of ViroPharma by Shire plc (LSE: SHP, NASDAQ: SHPG), it has commenced a tender offer (the “Convertible Notes Tender Offer”) to repurchase, at the option of each holder, any and all

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 SC TO-T/A

- FORM SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 7) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (

January 24, 2014 SC 14D9/A

- SCHEDULE 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 7) VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person Filing Statement) Common Stock, $0.002 par value per share (Title of Class of Securities) 928241108 (CUSI

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 EX-3.2

AMENDED AND RESTATED BYLAWS VIROPHARMA INCORPORATED * * * * * ARTICLE 1

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF VIROPHARMA INCORPORATED * * * * * ARTICLE 1 OFFICES Section 1.01. Registered Office. The registered office of the Corporation shall be in the City of Wilmington, County of New Castle, State of Delaware. Section 1.02. Other Offices. The Corporation may also have offices at such other places both within and without the State of Delaware as the Board of Dire

January 24, 2014 EX-99.A1

FUNDAMENTAL CHANGE REPURCHASE RIGHT NOTICE, NOTICE OF RIGHT TO CONVERT, NOTICE OF ENTRY INTO SUPPLEMENTAL INDENTURE AND OFFER TO REPURCHASE TO HOLDERS OF 2.00% CONVERTIBLE SENIOR NOTES DUE 2017 ISSUED BY VIROPHARMA INCORPORATED CUSIP NUMBER: 928241AH

Exhibit (a)(1) FUNDAMENTAL CHANGE REPURCHASE RIGHT NOTICE, NOTICE OF RIGHT TO CONVERT, NOTICE OF ENTRY INTO SUPPLEMENTAL INDENTURE AND OFFER TO REPURCHASE TO HOLDERS OF 2.

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 24, 2014 EX-99.D.3

SUPPLEMENTAL INDENTURE

EX-99.D.3 2 dp43361exd3.htm EXHIBIT (D)(3) Exhibit (d)(3) SUPPLEMENTAL INDENTURE This Supplemental Indenture (this “Supplemental Indenture”) is dated as of January 24, 2014 between ViroPharma Incorporated, a Delaware corporation (the “Issuer”), and Wilmington Trust Company, a Delaware trust company, as Trustee under the Indenture defined below (the “Trustee”). W I T N E S S E T H WHEREAS, the Issu

January 24, 2014 EX-99.(A)(5)(XVII)

Shire successfully completes tender offer for ViroPharma

EX-99.(A)(5)(XVII) 2 dp43311exa5xvii.htm EXHIBIT (A)(5)(XVII) Exhibit (a)(5)(xvii) Press Release www.shire.com Shire successfully completes tender offer for ViroPharma Dublin, Ireland – January 24, 2014 – Shire plc (LSE: SHP, NASDAQ: SHPG) announces the successful completion of the tender offer for all of the outstanding shares of ViroPharma (NASDAQ: VPHM). The tender offer expired at midnight, Ne

January 24, 2014 S-8 POS

- FORM S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-34129 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-60951 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38248 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-38256 POST-EFF

January 15, 2014 SC 14D9/A

- SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 6) VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person Filing Statement) Common Stock, $0.002 par value per share (Title of Class of Securities) 928241108 (CUSI

January 15, 2014 SC TO-T/A

- SCHEDULE TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 6) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (

January 15, 2014 EX-99.A5XV

Shire waives OFT condition relating to the acquisition of ViroPharma Inc.

EX-99.A5XV 2 dp43155sctota-exa5xv.htm EXHIBIT (A)(5)(XV) Exhibit (a)(5)(xv) Press Release www.shire.com Shire waives OFT condition relating to the acquisition of ViroPharma Inc. Dublin, Ireland – January 15, 2014 – Shire plc (LSE: SHP, NASDAQ: SHPG) announces that it has waived the Office of Fair Trading (OFT) approval condition to the announced tender offer for all of the outstanding shares of Vi

January 15, 2014 EX-99.A5XVI

725 Chesterbrook Blvd.

Exhibit (a)(5)(xvi) 725 Chesterbrook Blvd. Wayne Pennsylvania 19087 United States www.shire.com January 15, 2014 Dear ViroPharma Colleagues, When we first met with you in November following the initial merger announcement we committed to communicating information to you when we had it available. In December, we provided a brief update on how we were progressing through integration planning. Today

January 10, 2014 SC 14D9/A

- SC 14D9/A

SC 14D9/A 1 a13-261005sc14d9a.htm SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 5) VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person Filing Statement) Common Stock, $0.002 par value per share (T

January 10, 2014 EX-99

Shire extends tender offer for ViroPharma

Exhibit (a)(5)(xiv) Press Release www.shire.com Shire extends tender offer for ViroPharma Dublin, Ireland – January 10, 2014 – Shire plc (LSE: SHP, NASDAQ: SHPG) announces that it has extended the expiration of its previously announced tender offer by a wholly owned subsidiary of Shire for all of the outstanding common shares of ViroPharma Incorporated (NASDAQ: VPHM) until midnight, New York City

January 10, 2014 SC TO-T/A

- SCHEDULE TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 5) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (

December 30, 2013 EX-99.(A)(13)

As we continue our efforts to keep you as informed as possible with details about our merger with Shire Pharmaceuticals, we wanted to provide additional clarity and information on a few subjects that have generated many questions recently, namely tre

Exhibit (a)(13) Colleagues, As we continue our efforts to keep you as informed as possible with details about our merger with Shire Pharmaceuticals, we wanted to provide additional clarity and information on a few subjects that have generated many questions recently, namely treatment of equity awards and other matters relating to bonuses and compensation.

December 30, 2013 EX-99.(A)(14)

As we continue our efforts to keep you as informed as possible with details about our merger with Shire Pharmaceuticals, we wanted to provide additional clarity and information on a few subjects that have generated many questions recently, namely tre

Exhibit (a)(14) Colleagues, As we continue our efforts to keep you as informed as possible with details about our merger with Shire Pharmaceuticals, we wanted to provide additional clarity and information on a few subjects that have generated many questions recently, namely treatment of equity awards and other matters relating to bonuses and compensation.

December 30, 2013 SC 14D9/A

- SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 4) VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person Filing Statement) Common Stock, $0.002 par value per share (Title of Class of Securities) 928241108 (CUSI

December 27, 2013 SC 14D9/A

- SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 3) VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person Filing Statement) Common Stock, $0.002 par value per share (Title of Class of Securities) 928241108 (CUSI

December 27, 2013 EX-99

Shire extends tender offer for ViroPharma

Exhibit (a)(5)(xiii) Press Release www.shire.com Shire extends tender offer for ViroPharma Dublin, Ireland – December 27, 2013 – Shire plc (LSE: SHP, NASDAQ: SHPG) announces that it has extended the expiration of its previously announced tender offer by a wholly owned subsidiary of Shire for all of the outstanding common shares of ViroPharma (NASDAQ: VPHM) until midnight, New York City time, on Th

December 27, 2013 SC TO-T/A

- FORM SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 4) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (

December 24, 2013 SC TO-T/A

- FORM SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (

December 16, 2013 SC TO-T/A

- FORM SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (

December 16, 2013 SC 14D9/A

- SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 2) VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person Filing Statement) Common Stock, $0.002 par value per share (Title of Class of Securities) 928241108 (CUSI

December 11, 2013 SC TO-T/A

- SCHEDULE TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (

December 11, 2013 EX-99.(A)(5)(X)

IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE

Exhibit (a)(5)(x) IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE BRIAN COHEN, on Behalf of Himself and All Others Similarly Situated, Plaintiff, v.

December 11, 2013 SC 14D9/A

- SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 1) VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person Filing Statement) Common Stock, $0.002 par value per share (Title of Class of Securities) 928241108 (CUSI

December 11, 2013 EX-99.A.5.XI

Hart-Scott-Rodino Waiting Period Expires for Shire’s Acquisition of ViroPharma

Exhibit (a)(5)(xi) Press Release www.shire.com Hart-Scott-Rodino Waiting Period Expires for Shire’s Acquisition of ViroPharma December 11, 2013 – Shire plc (LSE: SHP, NASDAQ: SHPG) announces that the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 (HSR) relating to its previously announced tender offer by a wholly owned subsidiary of Shire for all outstanding shares o

November 25, 2013 EX-99.(A)(1)(V)

Offer to Purchase for Cash All Outstanding Shares of Common Stock of ViroPharma Incorporated $50.00 Net Per Share Venus Newco, Inc. a wholly owned subsidiary of Shire Pharmaceutical Holdings Ireland Limited

QuickLinks - Click here to rapidly navigate through this document Exhibit (a)(1)(v) Offer to Purchase for Cash All Outstanding Shares of Common Stock of ViroPharma Incorporated at $50.

November 25, 2013 EX-99.(A)(1)(III)

NOTICE OF GUARANTEED DELIVERY to Tender Shares of Common Stock of ViroPharma Incorporated $50.00 Net Per Share Venus Newco, Inc. a wholly owned subsidiary of Shire Pharmaceutical Holdings Ireland Limited

QuickLinks - Click here to rapidly navigate through this document Exhibit (a)(1)(iii) NOTICE OF GUARANTEED DELIVERY to Tender Shares of Common Stock of ViroPharma Incorporated at $50.

November 25, 2013 SC 14D9

- SC 14D9

QuickLinks - Click here to rapidly navigate through this document UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

November 25, 2013 EX-99.(A)(5)(VIII)

EFiled: Nov 20 2013 06:33PM EST Transaction ID 54592103 Case No. 9108- IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE

EX-99.(A)(5)(VIII) 9 a2217491zex-99a5viii.htm EX-99.(A)(5)(VIII) Exhibit (a)(5)(viii) EFiled: Nov 20 2013 06:33PM EST Transaction ID 54592103 Case No. 9108- IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE MARY MANLEY, individually and on behalf of all others similarly situated, Plaintiff, v. VIROPHARMA INCORPORATED, VINCENT J. MILANO, PAUL A. BROOKE, WILLIAM D. CLAYPOOL, MICHAEL R. DOUGHERTY, RO

November 25, 2013 SC TO-T

- SC TO-T

QuickLinks - Click here to rapidly navigate through this document UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

November 25, 2013 EX-99.(D)(2)

[Signature Page Follows]

Exhibit (d)(2) CONFIDENTIAL June 20, 2013 Shire Pharmaceutical Holdings Ireland Limited 5 Riverwalk Citywest Business Campus Dublin 24, Ireland Attn: David Colpman Re: Confidentiality Agreement Ladies and Gentlemen: Shire Pharmaceutical Holdings Ireland Limited, a company incorporated in Ireland (“SPHIL”), has expressed interest in exploring a possible transaction with, acquisition of or business combination (directly or through one or more of its affiliates) with ViroPharma Incorporated, a Delaware corporation (together with its subsidiaries, the “Company”), and/or one of its affiliates (any of the foregoing, a “Transaction”).

November 25, 2013 EX-99.(A)(5)(IX)

IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE

Exhibit (a)(5)(ix) EFiled: Nov 21 2013 06:28PM EST Transaction ID 54597778 Case No.

November 25, 2013 EX-99.(A)(7)

730 Stockton Drive Exton, PA 19341 Phone (610) 458-7300 Fax (610) 458-7380

QuickLinks - Click here to rapidly navigate through this document Exhibit (a)(7) 730 Stockton Drive Exton, PA 19341 Phone (610) 458-7300 Fax (610) 458-7380 November 25, 2013 Dear ViroPharma Stockholders: We are pleased to report that ViroPharma Incorporated (the "Company") has entered into an Agreement and Plan of Merger, dated as of November 11, 2013 (the "Merger Agreement"), with Shire Pharmaceutical Holdings Ireland Limited ("SPHIL"), Venus Newco, Inc.

November 25, 2013 EX-99.(A)(5)(VII)

EFiled: Nov 19 2013 03:17PM EST Transaction ID 54581935 Case No. 9104- IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE EILEEN BRADLEY, On Behalf of herself ) and All Others Similarly Situated, ) ) Plaintiff, ) ) v. ) Civil Action No. ) VIROPHARMA I

Exhibit (a)(5)(vii) EFiled: Nov 19 2013 03:17PM EST Transaction ID 54581935 Case No.

November 25, 2013 EX-99.(A)(1)(I)

Offer to Purchase for Cash All Outstanding Shares of Common Stock of ViroPharma Incorporated $50.00 Net Per Share Venus Newco, Inc. a wholly owned subsidiary of Shire Pharmaceutical Holdings Ireland Limited

Table of Contents Exhibit (a)(1)(i) Offer to Purchase for Cash All Outstanding Shares of Common Stock of ViroPharma Incorporated at $50.

November 25, 2013 EX-99.(A)(1)(VI)

Notice of Offer to Purchase for Cash All Outstanding Shares of Common Stock of ViroPharma Incorporated $50.00 Net Per Share Pursuant to the Offer to Purchase Dated November 25, 2013 Venus Newco, Inc. a wholly owned subsidiary of Shire Pharmaceutical

Exhibit (a)(1)(vi) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below).

November 25, 2013 EX-99.(A)(1)(II)

LETTER OF TRANSMITTAL to Tender Shares of Common Stock of ViroPharma Incorporated $50.00 Net Per Share Venus Newco, Inc. a wholly owned subsidiary of Shire Pharmaceutical Holdings Ireland Limited

QuickLinks - Click here to rapidly navigate through this document Exhibit (a)(1)(ii) LETTER OF TRANSMITTAL to Tender Shares of Common Stock of ViroPharma Incorporated at $50.

November 25, 2013 EX-99.(A)(1)(IV)

Offer to Purchase for Cash All Outstanding Shares of Common Stock of ViroPharma Incorporated $50.00 Net Per Share Venus Newco, Inc. a wholly owned subsidiary of Shire Pharmaceutical Holdings Ireland Limited

EX-99.(A)(1)(IV) 5 a2217491zex-99a1iv.htm EX-99.(A)(1)(IV) QuickLinks - Click here to rapidly navigate through this document Exhibit (a)(1)(iv) Offer to Purchase for Cash All Outstanding Shares of Common Stock of ViroPharma Incorporated at $50.00 Net Per Share by Venus Newco, Inc. a wholly owned subsidiary of Shire Pharmaceutical Holdings Ireland Limited THE OFFER AND WITHDRAWAL RIGHTS EXPIRE AT 6

November 14, 2013 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organiza

November 14, 2013 SC14D9C

- SC14D9C

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person(s) Filing Statement) Common Stock, $0.002 par value per share (Title of Class of Securities) 928241108 (CUSIP Number of Class of Securiti

November 14, 2013 EX-99.1

To:

Exhibit 99.1 730 Stockton Drive Exton, Pennsylvania 19341 ViroPharma Incorporated November 14, 2013 To: Holders of ViroPharma Incorporated 2.00% Convertible Senior Notes due 2017 and Wilmington Trust Company, as the Trustee and Paying Agent under the Indenture Rodney Square North 1100 North Market Street Wilmington, Delaware 19890 Corporate Trust Office Attention: Corporate Client Services (ViroPh

November 12, 2013 EX-2.1

AGREEMENT AND PLAN OF MERGER dated as of November 11, 2013, SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED, VENUS NEWCO, INC., VIROPHARMA INCORPORATED SHIRE PLC (solely for the purposes set forth in Section 10.16)

Exhibit 2.1 EXECUTION COPY AGREEMENT AND PLAN OF MERGER dated as of November 11, 2013, among SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED, VENUS NEWCO, INC., VIROPHARMA INCORPORATED and SHIRE PLC (solely for the purposes set forth in Section 10.16) TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Actions 4 Section 1.3 Directors 6 ARTICLE II THE MERGER Section

November 12, 2013 SC14D9C

- SC14D9C

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 VIROPHARMA INCORPORATED (Name of Subject Company) VIROPHARMA INCORPORATED (Name of Person(s) Filing Statement) Common Stock, $0.002 par value per share (Title of Class of Securities) 928241108 (CUSIP Number of Class of Securiti

November 12, 2013 SC TO-C

- FORM SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (Title of Class of

November 12, 2013 EX-10.1

SHIRE PLC as the Company MORGAN STANLEY BANK INTERNATIONAL LIMITED as mandated lead arranger and bookrunner MORGAN STANLEY BANK INTERNATIONAL LIMITED as Agent

Exhibit 10.1 EXECUTION VERSION SHIRE PLC as the Company MORGAN STANLEY BANK INTERNATIONAL LIMITED as mandated lead arranger and bookrunner with MORGAN STANLEY BANK INTERNATIONAL LIMITED as Agent US$ 2,600,000,000 TERM FACILITIES AGREEMENT DATED 11 NOVEMBER 2013 Slaughter and May One Bunhill Row London EC1Y 8YY (REL/APXK) 516285245 CONTENTS Clause Page 1. Definitions and interpretation 1 2. The Fac

November 12, 2013 EX-99.1

Shire to acquire ViroPharma in strategic move to strengthen rare disease portfolio; will augment already strong growth prospects

Exhibit 99.1 Press Release www.shire.com Shire to acquire ViroPharma in strategic move to strengthen rare disease portfolio; will augment already strong growth prospects Earnings accretive, revenue growth-enhancing acquisition Dublin, Ireland and Exton, PA, US – November 11, 2013 – Shire plc (LSE: SHP, NASDAQ: SHPG) and ViroPharma Incorporated (NASDAQ: VPHM) today announce that their Boards of Dir

November 12, 2013 SC TO-C

- FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2013 (November 11, 2013) SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incor

November 12, 2013 SC TO-C

- FORM SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (Title of Class of

November 12, 2013 SC TO-C

- SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2013 (November 11, 2013) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel

November 12, 2013 SC TO-C

- FORM SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (Title of Class of

November 12, 2013 SC 13G/A

BAKER FELIX - SC 13G/A

SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Under the Securities Exchange Act of 1934 (Amendment No.

November 12, 2013 EX-2.1

AGREEMENT AND PLAN OF MERGER dated as of November 11, 2013, SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED, VENUS NEWCO, INC., VIROPHARMA INCORPORATED SHIRE PLC (solely for the purposes set forth in Section 10.16) TABLE OF CONTENTS

Exhibit 2.1 EXECUTION COPY AGREEMENT AND PLAN OF MERGER dated as of November 11, 2013, among SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED, VENUS NEWCO, INC., VIROPHARMA INCORPORATED and SHIRE PLC (solely for the purposes set forth in Section 10.16) TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Actions 4 Section 1.3 Directors 6 ARTICLE II THE MERGER Section

November 12, 2013 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 11, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organiza

November 12, 2013 SC TO-C

- FORM SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (Title of Class of

November 12, 2013 EX-99.1

Press Release www.shire.com

Exhibit 99.1 Press Release www.shire.com Shire to acquire ViroPharma in strategic move to strengthen rare disease portfolio; will augment already strong growth prospects Earnings accretive, revenue growth-enhancing acquisition Dublin, Ireland and Exton, PA, US — November 11, 2013 — Shire plc (LSE: SHP, NASDAQ: SHPG) and ViroPharma Incorporated (NASDAQ: VPHM) today announce that their Boards of Dir

November 12, 2013 SC TO-C

- FORM SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 VIROPHARMA INCORPORATED (Name of Subject Company (Issuer)) VENUS NEWCO, INC. SHIRE PHARMACEUTICAL HOLDINGS IRELAND LIMITED (Names of Filing Persons (Offeror)) Common Stock, Par Value $0.002 Per Share (Title of Class of

October 31, 2013 EX-99.1

VIROPHARMA Incorporated Reports Third Quarter 2013 Financial Results - Cinryze® (C1 Esterase Inhibitor [Human]) North American Net Sales Guidance Raised to $395 to $405 Million -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody, Jr. Director, Investor Relations Phone (610) 321-6290 Michelle Larkin (media) Manager, PR & Advocacy Phone (610) 304-5842 VIROPHARMA Incorporated Reports Third Quarter 2013 Financial Results - Cinryze® (C1 Esterase Inhibitor [Human]) North American Ne

October 31, 2013 10-Q

Quarterly Report - 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2013 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 0-21699 VIROPHARMA INCORPORATED (Exact Nam

October 31, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 a13-2297628k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): October 31, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of

September 3, 2013 8-K

Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 29, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizati

August 12, 2013 SC 13G/A

BAKER FELIX - SC 13G/A

SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Under the Securities Exchange Act of 1934 (Amendment No.

August 12, 2013 EX-99.1

AGREEMENT

EXHIBIT 99.1 AGREEMENT In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that this Statement on Schedule 13G relating to the Common Stock of ViroPharma Incorporated is being filed with the Securities and Exchange Commission on behalf of each of them. August 12, 2013 BAKER BROS. ADVISORS LP By: Baker Bros. Advisors (GP) LLC, its

August 1, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 1, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE (State or Other Jurisdiction of Incorporation or Organization) 0-021699 (Commiss

August 1, 2013 EX-99.2

VIROPHARMA PROVIDES UPDATE ON PHASE 2 CLINICAL EVALUATION OF SUBCUTANEOUS CINRYZE® (C1 ESTERASE INHIBITOR [human] WITH RECOMBINANT HUMAN HYALURONIDASE (rHuPH20)

Exhibit 99.2 VIROPHARMA INCORPORATED Contacts: Michelle Larkin Manager, PR and Advocacy Phone: 610-321-2886 Robert Doody Director, Investor Relations Phone: 610-321-6288 VIROPHARMA PROVIDES UPDATE ON PHASE 2 CLINICAL EVALUATION OF SUBCUTANEOUS CINRYZE® (C1 ESTERASE INHIBITOR [human] WITH RECOMBINANT HUMAN HYALURONIDASE (rHuPH20) Exton, PA, August 1, 2013 — ViroPharma Incorporated (NASDAQ: VPHM) to

August 1, 2013 EX-10.1

VIROPHARMA INCORPORATED ANNUAL INCENTIVE PLAN

Exhibit 10.1 VIROPHARMA INCORPORATED ANNUAL INCENTIVE PLAN 1. Purpose The purpose of the ViroPharma Incorporated Annual Incentive Plan (the “Plan”) is to enhance the ability of ViroPharma Incorporated (the “Company”) to attract, reward and retain employees, to strengthen employee commitment to the Company’s success and to align employee interests with those of the Company’s stockholders by providi

August 1, 2013 EX-99.1

VIROPHARMA Announces Second Quarter 2013 Financial Results

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody Jr. Director, Investor Relations Phone (610) 321-6290 Michelle Larkin (media) Manager, PR & Advocacy Phone (610) 304-5842 VIROPHARMA Announces Second Quarter 2013 Financial Results EXTON, PA, August 1, 2013 — VIROPHARMA INCORPORATED (Nasdaq: VPHM) toda

August 1, 2013 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2013 o TRANSITION REPORT PURSUANT TO S

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2013 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 0-21699 VIROPHARMA INCORPORATED (Exact Name of

June 27, 2013 EX-99.1

VIROPHARMA PROVIDES UPDATE FROM ONGOING PHASE 2 STUDIES OF MARIBAVIR FOR TREATMENT OF CYTOMEGALOVIRUS (CMV) INFECTIONS

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Michelle Larkin Manager, PR and Advocacy Phone: 610-321-2886 Robert Doody Director, Investor Relations Phone: 610-321-6288 VIROPHARMA PROVIDES UPDATE FROM ONGOING PHASE 2 STUDIES OF MARIBAVIR FOR TREATMENT OF CYTOMEGALOVIRUS (CMV) INFECTIONS Exton, PA, June 27, 2013 — ViroPharma Incorporated (Nasdaq: VPHM) today announced updated data from the two ong

June 27, 2013 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 27, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organization

May 24, 2013 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 23, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE (State or Other Jurisdiction of Incorporation or Organization) 0-021699 (Commissio

May 1, 2013 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2013 o TRANSITION REPORT PURSUANT TO

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2013 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 0-21699 VIROPHARMA INCORPORATED (Exact Name of

May 1, 2013 EX-10.1

AMENDMENT NO. 3 Dated as of March 13, 2013 CREDIT AGREEMENT Dated as of September 9, 2011

Exhibit 10.1 AMENDMENT NO. 3 Dated as of March 13, 2013 to CREDIT AGREEMENT Dated as of September 9, 2011 THIS AMENDMENT NO. 3 (this ?Amendment?) is made as of March 13, 2013 by and among ViroPharma Incorporated, a Delaware corporation (the ?Borrower?), the financial institutions listed on the signature pages hereof and JPMorgan Chase Bank, N.A., as Administrative Agent (the ?Administrative Agent?

May 1, 2013 EX-99.1

VIROPHARMA Announces First Quarter 2013 Financial Results - Quarterly Global Cinryze® (C1 esterase inhibitor [human]) Net Sales Grew by 46 Percent to $99.5 Million -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody Jr. Director, Investor Relations Phone (610) 321-6290 Michelle Larkin (media) Manager, PR & Advocacy Phone (610) 304-5842 VIROPHARMA Announces First Quarter 2013 Financial Results - Quarterly Global Cinryze® (C1 esterase inhibitor [human]) Net Sales Gr

May 1, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 1, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE (State or Other Jurisdiction of Incorporation or Organization) 0-021699 (Commission

April 22, 2013 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 22, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE (State or Other Jurisdiction of Incorporation or Organization) 0-021699 (Commiss

April 22, 2013 EX-99.1

TREATMENT WITH VP20621 (NON-TOXIGENIC Clostridium difficile; NTCD) IN A PHASE 2 STUDY RESULTED IN HIGH RATES OF COLONIZATION AND STATISTICALLY SIGNIFICANT REDUCTIONS IN RECURRENCE OF C. difficile INFECTION

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Michelle M. Larkin (media) Manager, PR & Advocacy Phone (610) 321- 2886 [email protected] Robert A. Doody Jr. (investors) Director, Investor Relations Phone (610) 321-6290 R. Clayton Fletcher Vice President, Business Development Phone (610) 321-6789 TREATMENT WITH VP20621 (NON-TOXIGENIC Clostridium difficile; NTCD) IN A PHASE 2 STUDY RESU

April 19, 2013 DEF 14A

- DEF 14A

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14

March 19, 2013 8-K

Entry into a Material Definitive Agreement - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 13, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizatio

March 5, 2013 8-K

Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 1, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of (Commission File Number) (I.R

February 27, 2013 EX-10.32

VIROPHARMA INCORPORATED 2000 EMPLOYEE STOCK PURCHASE PLAN (As amended and restated effective January 1, 2013)

Exhibit 10.32 VIROPHARMA INCORPORATED 2000 EMPLOYEE STOCK PURCHASE PLAN (As amended and restated effective January 1, 2013) 1. Purpose. The ViroPharma Incorporated 2000 Employee Stock Purchase Plan (the “Plan”) is intended to encourage and facilitate the purchase of Shares of the Common Stock of ViroPharma Incorporated (the “Company”) by employees of a Participating Company, thereby providing empl

February 27, 2013 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

February 27, 2013 EX-99.1

VIROPHARMA Incorporated Reports Fourth Quarter and Full Year 2012 Financial Results - Company Delivers Record Full Year Worldwide Cinryze® (C1 esterase inhibitor [human]) Net Sales of $327 Million -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody Jr. Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (media) Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports Fourth Quarter and Full Year 2012 Financial Results - Company Delivers Record Full Year Wo

February 27, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 27, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organiza

February 27, 2013 EX-10.63

FIRST AMENDMENT TO MANUFACTURING AND DISTRIBUTION AGREEMENT (EUROPE AND ROW)

Exhibit 10.63 Confidential Treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as “***”. A complete version of this exhibit has been filed separately with the Securities and Exchange Commission. FIRST AMENDMENT TO MANUFACTURING AND DISTRIBUTION AGREEMENT (EUROPE AND ROW) ViroPharma

February 27, 2013 EX-21

SUBSIDIARIES OF THE COMPANY

Exhibit 21 SUBSIDIARIES OF THE COMPANY Entity Name of State/Country of Incorporation ViroPharma Biologics, Inc.

February 27, 2013 EX-10.62

DCI Management Group, LLC 1019 Fort Salonga Road, Suite 109, Northport, NY 11768 Phone: 631-757-8401 Fax: 631-757-8364 AMENDMENT No. 4

Exhibit 10.62 Confidential Treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as ?***?. A complete version of this exhibit has been filed separately with the Securities and Exchange Commission. DCI Management Group, LLC 1019 Fort Salonga Road, Suite 109, Northport, NY 11768 Phone:

February 14, 2013 SC 13G/A

Palo Alto Investors LP

SC 13G/A 1 viropharm13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3) ViroPharma Incorporated (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) December 31, 2012 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

February 11, 2013 SC 13G/A

DIMENSIONAL FUND ADVISORS LP - SCHEDULE 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* VIROPHARMA INC (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) December 31, 2012 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 11, 2013 SC 13G/A

VANGUARD GROUP INC

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 1 )* Name of issuer: ViroPharma Inc Title of Class of Securities: Common Stock CUSIP Number: 928241108 Date of Event Which Requires Filing of this Statement: December 31, 2012 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: (X) R

February 1, 2013 SC 13G/A

BAKER BROS. ADVISORS LP - SC 13G/A

SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Under the Securities Exchange Act of 1934 (Amendment No.

January 18, 2013 CORRESP

-

ViroPharma Incorporated 730 Stockton Drive Exton, PA 19341 Tel: (610) 458-7300 Fax: (610) 458-7380 January 18, 2013 VIA EDGAR AND FAX Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, D.

January 9, 2013 EX-99.1

2013 JP Morgan Healthcare Conference ViroPharma Incorporated January 8, 2013

EX-99.1 2 a13-23161ex99d1.htm EX-99.1 Exhibit 99.1 2013 JP Morgan Healthcare Conference ViroPharma Incorporated January 8, 2013 2 This presentation contains certain forward-looking statements, including statements regarding our financial guidance for 2013 and 2015, peak year sales estimates for our commercial products, our projected financial condition, the rate of future growth and the developmen

January 9, 2013 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 8, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizati

January 7, 2013 EX-99.1

VIROPHARMA PROVIDES 2013 OUTLOOK - Provides 2013 Annual Net Sales Guidance of Up to $475 Million -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Will Roberts (Media) Corporate Communications Phone (610) 321-6288 Robert A. Doody Jr. (Investors) Investor Relations Phone (610) 321-6290 VIROPHARMA PROVIDES 2013 OUTLOOK - Provides 2013 Annual Net Sales Guidance of Up to $475 Million - Exton, PA, January 7, 2013 — ViroPharma Incorporated (Nasdaq: VPHM) today announced that Vincent Milano, president

January 7, 2013 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 7, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizati

January 4, 2013 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 3, 2013 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of (Commission File Number) (I

December 14, 2012 CORRESP

-

ViroPharma Incorporated 730 Stockton Drive Exton, PA 19341 Tel: (610) 458-7300 Fax: (610) 458-7380 December 14, 2012 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, D.

December 12, 2012 8-K

Entry into a Material Definitive Agreement - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): December 6, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE (State or Other Jurisdiction of Incorporation or Organization) 0-021699 (Commi

October 25, 2012 EX-10.3

VIROPHARMA INCORPORATED AMENDED AND RESTATED 2005 EQUITY INCENTIVE PLAN

Exhibit 10.3 VIROPHARMA INCORPORATED AMENDED AND RESTATED 2005 EQUITY INCENTIVE PLAN The purposes of the Plan are to: (a) further the growth and success of ViroPharma Incorporated (the “Company”) and its Subsidiaries by enabling selected employees, directors, consultants and advisors of the Company and any Subsidiaries to acquire shares of common stock of the Company, thereby increasing their pers

October 25, 2012 EX-10.2

2012 STRATEGIC SUPPLY AGREEMENT

Exhibit 10.2 Confidential Treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as ?***?. A complete version of this exhibit has been filed separately with the Securities and Exchange Commission. 2012 STRATEGIC SUPPLY AGREEMENT This Strategic Supply Agreement (this ?Agreement?) is en

October 25, 2012 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2012 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 0-21699 VIROPHARMA INCORPORATED (Exact Nam

October 25, 2012 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): October 25, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or

October 25, 2012 EX-99.1

VIROPHARMA Incorporated Reports Third Quarter 2012 Financial Results - Quarter Highlighted by Record U.S. Cinryze® (C1 esterase inhibitor [human]) Net Sales of $83.7M; Company Reiterates Cinryze U.S. Net Sales Guidance -

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody, Jr. Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports Third Quarter 2012 Financial Results - Quarter Highlighted by Record U.S. Cinryze® (C1 esterase inhibit

October 25, 2012 EX-10.1

AMENDED AND RESTATED LEASE FOR COMBINATION EAGLEVIEW CORPORATE CENTER 730 STOCKTON DRIVE LANDLORD: 730 STOCKTON DRIVE ASSOCIATES, L.P. and THE HANKIN GROUP TENANT: VIROPHARMA INCORPORATED TABLE OF CONTENTS Page 1. LEASED SPACE AND PURPOSE 2 2. TERM 2

EX-10.1 2 d414649dex101.htm AMENDED AND RESTATED LEASE Exhibit 10.1 AMENDED AND RESTATED LEASE FOR COMBINATION OFFICE/WAREHOUSE AT EAGLEVIEW CORPORATE CENTER 730 STOCKTON DRIVE LANDLORD: 730 STOCKTON DRIVE ASSOCIATES, L.P. and THE HANKIN GROUP TENANT: VIROPHARMA INCORPORATED TABLE OF CONTENTS Page 1. LEASED SPACE AND PURPOSE 2 2. TERM 2 3. RENT 4 4. ADDITIONAL RENT 8 5. NEGATIVE COVENANTS OF TENAN

October 22, 2012 EX-10.1

VIROPHARMA INCORPORATED AMENDED AND RESTATED 2005 EQUITY INCENTIVE PLAN

Exhibit 10.1 VIROPHARMA INCORPORATED AMENDED AND RESTATED 2005 EQUITY INCENTIVE PLAN The purposes of the Plan are to: (a) further the growth and success of ViroPharma Incorporated (the “Company”) and its Subsidiaries by enabling selected employees, directors, consultants and advisors of the Company and any Subsidiaries to acquire shares of common stock of the Company, thereby increasing their pers

October 22, 2012 S-8

- FORM S-8 - VIROPHARMA INCORPORATED

Form S-8 - Viropharma Incorporated As filed with the Securities and Exchange Commission on October 22, 2012 Registration No.

October 3, 2012 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): October 1, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizati

September 25, 2012 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 24, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organiz

September 21, 2012 EX-99.1

Broadening Horizons

Slide Presentation Exhibit 99.1 Broadening Horizons 2012 ViroPharma Incorporated Investor Day September 21, 2012 Introduction Vincent Milano Chief Executive Officer 2 This presentation contains certain forward-looking statements, including statements regarding our financial guidance for 2012 and beyond, our projected financial condition, the rate of future growth and the development and commercial

September 21, 2012 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 21, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation o

September 21, 2012 EX-99.2

VIROPHARMA AND HALOZYME PROVIDE UPDATE ON CLINICAL DEVELOPMENT OF SUBCUTANEOUS CINRYZE® (C1 ESTERASE INHIBITOR [HUMAN]) WITH RECOMBINANT HUMAN HYALURONIDASE (rHuPH20)

Press Release Exhibit 99.2 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 Shannon Sanders (Media) Manager, PR & Advocacy Phone (610) 321-2886 HALOZYME Contact: Anne Erickson Executive Director, Investor Relations Phone (858) 704-8264 VIROPHARMA AND HALOZYME PROVIDE UPDATE ON CLINICAL DEVELOPMENT OF SUBCUTANEOUS CINRYZE® (C1 ESTERASE IN

August 31, 2012 8-K

Entry into a Material Definitive Agreement - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 29, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or O

August 22, 2012 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 20, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or O

August 9, 2012 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 9, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Or

August 9, 2012 EX-10.1

DCI Management Group, LLC 1019 Fort Salonga Road, Suite 109, Northport, NY 11768 Phone: 631-757-8401 Fax: 631-757-8364 AMENDMENT No. 3

EX-10.1 2 d367104dex101.htm AMENDED AGREEMENT FOR THE PURCHASE AND SALE OF BLOOD PLASMA Exhibit 10.1 DCI Management Group, LLC 1019 Fort Salonga Road, Suite 109, Northport, NY 11768 Phone: 631-757-8401 Fax: 631-757-8364 AMENDMENT No. 3 May 1, 2012 ViroPharma Biologics, Inc. 730 Stockton Drive Exton, PA 19341 Re: Third Amendment to that certain Agreement for the Purchase and Sale of Blood Plasma (t

August 9, 2012 EX-10.6

AMENDMENT NO. 4 TO DISTRIBUTION AND SUPPLY AGREEMENT

Exhibit 10.6 AMENDMENT NO. 4 TO DISTRIBUTION AND SUPPLY AGREEMENT This Amendment No. 4 to Distribution and Supply Agreement (this ?Amendment?) is made as of November 30, 2011, by and among ViroPharma Incorporated, a Delaware corporation (hereinafter referred to as ?Manufacturer?), and Prasco, LLC, an Ohio limited liability company (hereinafter referred to as ?Distributor?). Manufacturer and Distri

August 9, 2012 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2012 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 0-21699 VIROPHARMA INCORPORATED (Exact Name of

August 9, 2012 EX-10.5

AMENDMENT NO. 3 TO DISTRIBUTION AND SUPPLY AGREEMENT

Amendment No. 3 to Distribution and Supply Agreement Exhibit 10.5 AMENDMENT NO. 3 TO DISTRIBUTION AND SUPPLY AGREEMENT This Amendment No. 3 to Distribution and Supply Agreement (this “Amendment”) is made as of November 30, 2010, by and among ViroPharma Incorporated, a Delaware corporation (hereinafter referred to as “Manufacturer”), and Prasco, LLC, an Ohio limited liability company (hereinafter r

August 9, 2012 EX-99.1

VIROPHARMA Incorporated Reports Second Quarter 2012 Financial Results - Increases 2012 U.S. Cinryze® (C1 esterase inhibitor [human]) Net Product Sales Guidance to between $320 and $335 Million -

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody, Jr. Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (media) Associate Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports Second Quarter 2012 Financial Results - Increases 2012 U.S. Cinryze® (C1 es

August 9, 2012 EX-10.2

DISTRIBUTION AND SUPPLY AGREEMENT by and between ViroPharma Incorporated Prasco, LLC dated November 30, 2007

Exhibit 10.2 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION DISTRIBUTION AND SUPPLY AGREEMENT by and between ViroPharma Incorporated and Prasco, LLC dated November 30, 2007 CONFIDENTIAL TREATMENT HAS BEEN REQUE

August 9, 2012 EX-10.4

AMENDMENT NO. 2 TO DISTRIBUTION AND SUPPLY AGREEMENT

Amendment No. 2 to Distribution and Supply Agreement Exhibit 10.4 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION AMENDMENT NO. 2 TO DISTRIBUTION AND SUPPLY AGREEMENT ViroPharma Incorporated, a Delaware corporat

August 9, 2012 EX-10.3

AMENDMENT NO. 1 TO DISTRIBUTION AND SUPPLY AGREEMENT

Amendment No.1 to Distribution and Supply Agreement Exhibit 10.3 AMENDMENT NO. 1 TO DISTRIBUTION AND SUPPLY AGREEMENT This Amendment No. 1 to Distribution and Supply Agreement (this “Amendment”) is made as of June 10, 2008, by and among ViroPharma Incorporated, a Delaware corporation (hereinafter referred to as “Manufacturer”), and Prasco, LLC, an Ohio limited liability company (hereinafter referr

August 6, 2012 8-K

Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 6, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Or

August 6, 2012 EX-99.1

VIROPHARMA RECEIVES FDA APPROVAL OF CINRYZE® (C1 ESTERASE INHIBITOR [HUMAN]) INDUSTRIAL SCALE MANUFACTURING - Financial Results expected to be released on Thursday, August 9th at 7:30 AM ET -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Jr. (Investors) Investor Relations Phone (610) 321-6290 VIROPHARMA RECEIVES FDA APPROVAL OF CINRYZE® (C1 ESTERASE INHIBITOR [HUMAN]) INDUSTRIAL SCALE MANUFACTURING - Financial Results expected to be released on Thursday, August 9th at 7:30 AM ET - EXTON, Pa., August 6, 2012 — ViroPharma Incorporated (Nasdaq: VPHM) today announced the U

August 2, 2012 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A

Form 10-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Mark One) x Annual report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2011 OR ¨ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-21699 VI

August 2, 2012 EX-10.62

DEVELOPMENT AND OPTION AGREEMENT Dated as of December 22, 2011 by and between VIROPHARMA INCORPORATED MERITAGE PHARMA, INC.

Development and Option Agreement Exhibit 10.62 EXECUTION COPY CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION DEVELOPMENT AND OPTION AGREEMENT Dated as of December 22, 2011 by and between VIROPHARMA INCORPORATED

August 1, 2012 8-K

Financial Statements and Exhibits, Other Events

8-K 1 d389870d8k.htm VIROPHARMA INCORPORATED - FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 1, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE (State or Other Jurisdic

August 1, 2012 EX-99.1

ViroPharma Provides Update on Phase 2 Clinical Evaluation of Subcutaneous Cinryze® (C1 esterase inhibitor [human]) with Recombinant Human Hyaluronidase (rHuPH20)

Press Release Exhibit 99.1 ViroPharma Provides Update on Phase 2 Clinical Evaluation of Subcutaneous Cinryze® (C1 esterase inhibitor [human]) with Recombinant Human Hyaluronidase (rHuPH20) Exton, PA, August 1, 2012 — ViroPharma Incorporated (NASDAQ: VPHM) today announced that ViroPharma and Halozyme Therapeutics were notified by the Center for Biologics Evaluation and Research (CBER) division of t

June 22, 2012 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 20, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Org

May 23, 2012 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Submission of Matters to a Vote of Security Holders - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 21, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Orga

May 18, 2012 8-K

Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 18, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Orga

May 9, 2012 DEFA14A

- DEFINITIVE ADDITIONAL MATERIALS

Definitive Additional Materials UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

May 1, 2012 EX-99.1

VIROPHARMA Incorporated Reports First Quarter 2012 Financial

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody, Jr. Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (media) Associate Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports First Quarter 2012 Financial Results EXTON, PA, May 1,

May 1, 2012 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 1, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organ

May 1, 2012 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2012 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 0-21699 VIROPHARMA INCORPORATED (Exact Name of Registrant as Spe

May 1, 2012 EX-10.1

Amendment to the Intermediate Supply Agreement of 1 June 2009

Exhibit 10.1 [*CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ****, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.] Amendment to the Intermediate Supply Agreement of 1 June 2009 This Amendment to the Intermediate Supply Agreement (this “Amendment”), dated as of

April 24, 2012 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 23, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizatio

April 13, 2012 DEF 14A

- DEFINITIVE PROXY STATEMENT

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14

April 13, 2012 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 10, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizatio

April 10, 2012 8-K

Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 9, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE (State or Other Jurisdiction of Incorporation or Organization) 0-021699

April 10, 2012 EX-99.1

VIROPHARMA PROVIDES UPDATE ON STATUS OF CITIZEN PETITION REGARDING BIOEQUIVALENCE AND EXCLUSIVITY FOR VANCOCIN® (VANCOMYCIN HYDROCHLORIDE, USP) CAPSULES

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED Contact: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 VIROPHARMA PROVIDES UPDATE ON STATUS OF CITIZEN PETITION REGARDING BIOEQUIVALENCE AND EXCLUSIVITY FOR VANCOCIN® (VANCOMYCIN HYDROCHLORIDE, USP) CAPSULES Exton, PA, April 10, 2012 — ViroPharma Incorporated (Nasdaq: VPHM) today announced the U.S. Food and Drug Admin

March 2, 2012 8-K

Entry into a Material Definitive Agreement - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 28, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or

February 28, 2012 EX-10.61

Share Purchase Agreement RELATING TO THE SALE AND PURCHASE OF ALL SHARES DuoCort Pharma AB DuoCort AB (as the Seller) Goldcup 6975 AB (as the Buyer)

Exhibit 10.61 Execution Copy [*CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ****, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.] Share Purchase Agreement RELATING TO THE SALE AND PURCHASE OF ALL SHARES IN DuoCort Pharma AB BETWEEN DuoCort AB (as the Seller)

February 28, 2012 EX-10.58

EXCLUSIVE CLINICAL STUDY AND DATA LICENSE AGREEMENT

Exhibit 10.58 [*CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ****, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.] EXCLUSIVE CLINICAL STUDY AND DATA LICENSE AGREEMENT THIS EXCLUSIVE CLINICAL STUDY AND DATA LICENSE AGREEMENT (the ?Agreement?) is made as of Jun

February 28, 2012 EX-21

SUBSIDIARIES OF THE COMPANY Entity Name of State/Country of Incorporation ViroPharma Biologics, Inc. Delaware VCO Incorporated Delaware VPDE Incorporated Delaware VPINT Incorporated Delaware VPMP Incorporated Delaware ViroPharma Limited United Kingdo

Exhibit 21 SUBSIDIARIES OF THE COMPANY Entity Name of State/Country of Incorporation ViroPharma Biologics, Inc.

February 28, 2012 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 28, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or

February 28, 2012 EX-99.1

VIROPHARMA Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results – Company Delivers Record Full Year Product Revenue of $544 Million and Record Full Year Diluted Earnings Per Share of $1.68 –

PRESS RELEASE Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody Jr. Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (media) Associate Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results – Co

February 28, 2012 EX-10.59

AMENDMENT NO. 1 TO EXCLUSIVE CLINICAL STUDY AND DATA LICENSE AGREEMENT BETWEEN GENZYME CORPORATION AND VIROPHARMA

Exhibit 10.59 AMENDMENT NO. 1 TO EXCLUSIVE CLINICAL STUDY AND DATA LICENSE AGREEMENT BETWEEN GENZYME CORPORATION AND VIROPHARMA INCORPORATED This Amendment No. 1 (the ?Amendment?) to the Exclusive Clinical Study and Data License Agreement dated June 12, 2009 (the ?Agreement?) by and between Genzyme Corporation (?Genzyme?) and ViroPharma Incorporated (?ViroPharma?), is effective as of October 22, 2

February 28, 2012 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) x Annual report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2011 OR ? Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-21

February 28, 2012 EX-10.60

AMENDMENT NO. 2 TO EXCLUSIVE CLINICAL STUDY AND DATA LICENSE AGREEMENT BETWEEN GENZYME CORPORATION AND VIROPHARMA

Exhibit 10.60 [*CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ****, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.] AMENDMENT NO. 2 TO EXCLUSIVE CLINICAL STUDY AND DATA LICENSE AGREEMENT BETWEEN GENZYME CORPORATION AND VIROPHARMA INCORPORATED This Amendment No

February 28, 2012 EX-10.62

DEVELOPMENT AND OPTION AGREEMENT Dated as of December 22, 2011 by and between VIROPHARMA INCORPORATED MERITAGE PHARMA, INC.

Exhibit 10.62 EXECUTION COPY [*CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ****, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.] DEVELOPMENT AND OPTION AGREEMENT Dated as of December 22, 2011 by and between VIROPHARMA INCORPORATED and MERITAGE PHARMA, INC. [

February 14, 2012 SC 13G/A

DIMENSIONAL FUND ADVISORS LP - SCHEDULE 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* VIROPHARMA INC (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) December 31, 2011 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 14, 2012 SC 13G/A

BAKER FELIX - FORM SC 13G/A

SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Under the Securities Exchange Act of 1934 (Amendment No.

February 13, 2012 SC 13G/A

Palo Alto Investors LP - VIROPHARMA INCORPORATED - SCH 13G AMENDMENT NO. 2

CUSIP No. 928241108 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2) ViroPharma Incorporated (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) December 31, 2011 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pur

February 10, 2012 SC 13G

VANGUARD GROUP INC

viropharmainc.htm - Generated by SEC Publisher for SEC Filing SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.:0 )* Name of issuer: Viropharma Inc Title of Class of Securities: Common Stock CUSIP Number: 928241108 Date of Event Which Requires Filing of this Statement: December 31, 2011 Check the appropriate box to desig

February 7, 2012 8-K

Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 6, 2012 ViroPharma Incorporated (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or

February 7, 2012 EX-99.1

VIROPHARMA PROVIDES UPDATE ON INDUSTRIAL SCALE SUPPLEMENT FOR CINRYZE® (C1 ESTERASE INHIBITOR [HUMAN])

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Kristina M. Broadbelt (Media) Associate Director, PR & Advocacy Phone (610) 321-2358 Robert A. Doody Jr. (Investors) Assistant Director, Investor Relations Phone (610) 321-6290 VIROPHARMA PROVIDES UPDATE ON INDUSTRIAL SCALE SUPPLEMENT FOR CINRYZE® (C1 ESTERASE INHIBITOR [HUMAN]) EXTON, Pa., February 7, 2012 — ViroPharma Incorporated (Nas

January 6, 2012 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 5, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or O

January 5, 2012 EX-99.1

VIROPHARMA PROVIDES 2012 OUTLOOK - Provides 2012 Annual Net Sales Guidance of Up to $660 Million -

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Kristina M. Broadbelt (Media) PR & Advocacy Phone (610) 321-2358 Robert A. Doody Jr. (Investors) Investor Relations Phone (610) 321-6290 VIROPHARMA PROVIDES 2012 OUTLOOK - Provides 2012 Annual Net Sales Guidance of Up to $660 Million - Exton, PA, January 5, 2012 — ViroPharma Incorporated (Nasdaq: VPHM) today announced that Vincent Milano

January 5, 2012 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 5, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or O

January 4, 2012 EX-99.1

VIROPHARMA ANNOUNCES APPOINTMENT OF JULIE H. MCHUGH TO BOARD OF DIRECTORS

Press Release Exhibit 99.1 Contacts: Investors Robert A. Doody Assistant Director, IR Phone (610) 321-6290 Media Kristina Broadbelt Assistant Director, Global PR & Advocacy Phone (610) 321- 2358 VIROPHARMA ANNOUNCES APPOINTMENT OF JULIE H. MCHUGH TO BOARD OF DIRECTORS Exton, PA, January 3, 2012 — ViroPharma Incorporated (Nasdaq: VPHM) today announced the appointment of Julie H. McHugh to its board

January 4, 2012 EX-99.2

RE: Docket Nos. FDA-2006-P-0007 (formerly 2006P-0124) & FDA-2008-D-0626 Implications of New Vancocin® Labeling for Generic Vancomycin Products

ViroPharma supplement to its citizen petition regarding Vancocin Exhibit 99.2 December 22, 2011 Submitted Electronically Division of Dockets Management (HFA-305) Food and Drug Administration 5630 Fishers Lane, Rm. 1061 Rockville, MD 20852 730 Stockton Drive Exton, PA 19341 Phone (610) 321-6202 Fax (610) 458-7380 RE: Docket Nos. FDA-2006-P-0007 (formerly 2006P-0124) & FDA-2008-D-0626 Implications o

January 4, 2012 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 3, 2012 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or O

December 23, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): December 22, 2011 VIROPHARMA INCO

ViroPharma Incorporated - Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

December 23, 2011 EX-99.1

VIROPHARMA PURCHASES EXCLUSIVE OPTION TO ACQUIRE MERITAGE PHARMA - Option Creates Opportunity to Further Augment Rare Disease Development Pipeline with Novel Orphan Drug for Eosinophilic Esophagitis, a Chronic Inflammatory Disease -

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED contacts: William C. Roberts. Vice President, Corporate Communications Phone (610) 321-6288 Kristina M. Broadbelt (for media) Associate Director, PR & Advocacy Phone (610) 321- 2358 MERITAGE PHARMA contact: Adam K. Simpson Chief Business Officer (858) 436-1634 VIROPHARMA PURCHASES EXCLUSIVE OPTION TO ACQUIRE MERITAGE PHARMA - Option Creates Opport

December 14, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): December 14, 2011 VIROPHARMA INCO

Viropharma Inc-Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

December 14, 2011 EX-99.1

VIROPHARMA ANNOUNCES APPROVAL OF MODERNIZED LABELING FOR VANCOCIN® (VANCOMYCIN HYDROCHLORIDE, USP) CAPSULES – Modernized Label Provides Safety and Efficacy Data Based on Clinical Studies – – Company Provides Citizen Petition and Litigation Updates –

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: William C. Roberts Vice President, Corporate Communications Phone (610) 321-6288 Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 VIROPHARMA ANNOUNCES APPROVAL OF MODERNIZED LABELING FOR VANCOCIN® (VANCOMYCIN HYDROCHLORIDE, USP) CAPSULES – Modernized Label Provides Safety and Efficacy Data Based on Clinical Stu

December 6, 2011 EX-99.1

VIROPHARMA AND HALOZYME THERAPEUTICS ANNOUNCE POSITIVE DATA FROM INITIAL PHASE 2 ASSESSMENT OF SUBCUTANEOUS CINRYZE® (C1 ESTERASE INHIBITOR [HUMAN]) WITH HYALURONIDASE (rHuPH20)

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Kristina M. Broadbelt (for media) Associate Director, PR & Advocacy Phone (610) 321- 2358 Robert A. Doody Jr. Assistant Director, Investor Relations Phone (610) 321-6290 HALOZYME Contact: Kurt Gustafson Chief Financial Officer Phone (858) 704-8272 VIROPHARMA AND HALOZYME THERAPEUTICS ANNOUNCE POSITIVE DATA FROM INITIAL PHASE 2 ASSESSMENT OF SUBCUTANEO

December 6, 2011 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): December 6, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizat

November 15, 2011 8-K

Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 15, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organiza

November 15, 2011 EX-99.1

VIROPHARMA COMPLETES ACQUISITION OF DUOCORT PHARMA AB - Completion Follows European Marketing Authorization and Confirmation of Orphan Drug Designation for Plenadren® (Hydrocortisone, Modified Release Tablet) -

Exhibit 99.1 Robert A. Doody Jr. (VPHM) Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (VPHM?for media) Associate Director, PR & Advocacy Phone (610) 321? 2358 VIROPHARMA COMPLETES ACQUISITION OF DUOCORT PHARMA AB - Completion Follows European Marketing Authorization and Confirmation of Orphan Drug Designation for Plenadren? (Hydrocortisone, Modified Release Tabl

November 7, 2011 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 7, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizat

October 27, 2011 EX-99.1

VIROPHARMA TO ACQUIRE DUOCORT PHARMA AB, ADDING IMPORTANT EUROPEAN ORPHAN DRUG TO COMMERCIAL PIPELINE - Positive CHMP Opinion Adopted for Product To Treat Adrenal Insufficiency, an Orphan Disease with Limited Treatment Options -

Robert A. Doody Jr. (VPHM) Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (VPHM - for media) Associate Director, PR & Advocacy Phone (610) 321-2358 Jacob Kaluski (DuoCort Pharma AB) Chairman of the Board of Directors +46 70 356 56 65 Maria Forss (DuoCort Pharma AB) Chief Executive Officer +46 70 967 00 07 VIROPHARMA TO ACQUIRE DUOCORT PHARMA AB, ADDING IMPORTANT

October 27, 2011 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): October 26, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizat

October 27, 2011 EX-10.1

CREDIT AGREEMENT dated as of September 9, 2011 VIROPHARMA INCORPORATED, as Borrower The Lenders Party Hereto JPMORGAN CHASE BANK, N.A. as Administrative Agent BMO HARRIS FINANCING INC., TD BANK, N.A. and MORGAN STANLEY BANK, N.A. as Co-Syndication Ag

Exhibit 10.1 EXECUTION COPY CREDIT AGREEMENT dated as of September 9, 2011 among VIROPHARMA INCORPORATED, as Borrower The Lenders Party Hereto JPMORGAN CHASE BANK, N.A. as Administrative Agent and BMO HARRIS FINANCING INC., TD BANK, N.A. and MORGAN STANLEY BANK, N.A. as Co-Syndication Agents J.P. MORGAN SECURITIES LLC as Sole Bookrunner and Sole Lead Arranger TABLE OF CONTENTS Page ARTICLE I Defin

October 27, 2011 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

ViroPharma, Inc. - Form 10-Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2011 or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 0-21699 VIROP

October 27, 2011 EX-99.1

VIROPHARMA Incorporated Reports Third Quarter 2011 Financial Results - Quarter Highlighted by Record Net Product Sales, European Launch of Cinryze® (C1 esterase inhibitor [human]) and European Approval of Buccolam® (midazolam, oromucosal solution) -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody Jr. Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (for media) Associate Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports Third Quarter 2011 Financial Results - Quarter Highlighted by Reco

October 27, 2011 EX-10.2

EXCLUSIVE LICENSE AGREEMENT

Exclusive License Agreement Exhibit 10.2 Confidential Treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated “***”. A complete version of this exhibit has been filed separately with the Securities and Exchange Commission. EXCLUSIVE LICENSE AGREEMENT This Exclusive License Agreement (t

October 27, 2011 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): October 27, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizat

September 30, 2011 EX-99.1

VIROPHARMA LICENSES RIGHTS FROM INTELLECT NEUROSCIENCES FOR PRODUCT CANDIDATE FOR FRIEDREICH’S ATAXIA

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Jr. Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (for media) Associate Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA LICENSES RIGHTS FROM INTELLECT NEUROSCIENCES FOR PRODUCT CANDIDATE FOR FRIEDREICH?S ATAXIA Exton, PA, September 30, 2011 ? ViroPharma Incorporated (NASDAQ: VPHM) today anno

September 30, 2011 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 29, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organiz

September 15, 2011 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 14, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organiz

September 15, 2011 EX-99.1

VIROPHARMA ANNOUNCES ADDITIONAL SECURITIES REPURCHASE PROGRAM

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 VIROPHARMA ANNOUNCES ADDITIONAL SECURITIES REPURCHASE PROGRAM Exton, PA, September 15, 2011 ? ViroPharma Incorporated (Nasdaq: VPHM) today announced that the company?s Board of Directors has authorized the use of up to an additional $200 million to repurchase shares of its com

September 13, 2011 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 13, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organiz

September 13, 2011 EX-99.1

VIROPHARMA AND HALOZYME THERAPEUTICS ANNOUNCE INITIATION OF PHASE 2 EVALUATION OF SUBCUTANEOUS DELIVERY OF CINRYZE® (C1 ESTERASE INHIBITOR [HUMAN]) WITH HYALURONIDASE (rHuPH20)

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Kristina M. Broadbelt (for media) Associate Director, PR & Advocacy Phone (610) 321- 2358 Robert A. Doody Jr. Assistant Director, Investor Relations Phone (610) 321-6290 HALOZYME Contact: Kurt Gustafson Chief Financial Officer Phone (858) 704-8272 VIROPHARMA AND HALOZYME THERAPEUTICS ANNOUNCE INITIATION OF PHASE 2 EVALUATION OF SUBCUTANEOUS DELIVERY O

September 9, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 9, 2011 VIROPHARMA INCO

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 9, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or

September 6, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 6, 2011 VIROPHARMA INCO

ViroPharma, Inc. - Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 6, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction

September 6, 2011 EX-99.1

VIROPHARMA’S BUCCOLAM® (MIDAZOLAM, OROMUCOSAL SOLUTION) GRANTED EUROPEAN MARKETING AUTHORIZATION FOR TREATMENT OF ACUTE SEIZURES - Approval Offers Convenient Alternative to Treat Seizures in Children and Adolescents – - First Ever Product Approved th

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (Media) Associate Director, PR & Advocacy Phone (610) 321-2358 VIROPHARMA’S BUCCOLAM® (MIDAZOLAM, OROMUCOSAL SOLUTION) GRANTED EUROPEAN MARKETING AUTHORIZATION FOR TREATMENT OF ACUTE SEIZURES - Approval Offers Convenient Alternative to Treat Seizures in C

July 28, 2011 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): July 28, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organization

July 28, 2011 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2011 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 0-21699 VIROPHARMA INCORPORATED (Exact Name of

July 28, 2011 EX-10.2

SECOND AMENDMENT TO PROJECT AGREEMENT No. 2 VIROPHARMA INCORPORATED NORWICH PHARMACEUTICALS, INC. (Formerly OSG Norwich Pharmaceuticals, Inc.) (Vancocin® HCl capsules) SECOND AMENDMENT TO PROJECT AGREEMENT No. 2

Exhibit 10.2 Confidential Treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as “***”. A complete version of this exhibit has been filed separately with the Securities and Exchange Commission. SECOND AMENDMENT TO PROJECT AGREEMENT No. 2 BETWEEN VIROPHARMA INCORPORATED AND NORWICH

July 28, 2011 EX-10.1

COLLABORATION AND LICENSE AGREEMENT

Exhibit 10.1 Confidential Treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as ?***?. A complete version of this exhibit has been filed separately with the Securities and Exchange Commission. COLLABORATION AND LICENSE AGREEMENT THIS COLLABORATION AND LICENSE AGREEMENT (this ?Agre

July 28, 2011 EX-99.1

VIROPHARMA Incorporated Reports Second Quarter 2011 Financial Results - Quarter Highlighted by Record Net Product Sales and European Approval of Cinryze® (C1 Inhibitor [human]) -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody Jr. Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (for media) Associate Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports Second Quarter 2011 Financial Results - Quarter Highlighted by Rec

June 24, 2011 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 24, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organization

June 24, 2011 EX-99.1

VIROPHARMA ANNOUNCES POSITIVE CHMP OPINION FOR BUCCOLAM® (MIDAZOLAM, OROMUCOSAL SOLUTION) IN THE EUROPEAN UNION

Press Release Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (Media) Associate Director, PR & Advocacy Phone (610) 321-2358 VIROPHARMA ANNOUNCES POSITIVE CHMP OPINION FOR BUCCOLAM® (MIDAZOLAM, OROMUCOSAL SOLUTION) IN THE EUROPEAN UNION Exton, PA, June 24, 2011 — ViroPharma Incorporated (Nasdaq: VPHM)

June 15, 2011 EX-99.1

VIROPHARMA’S CINRYZE® (C1 INHIBITOR [HUMAN]) GRANTED EUROPEAN MARKETING AUTHORIZATION FOR HEREDITARY ANGIOEDEMA (HAE) - First and Only Approved Therapy to Meet HAE Patients’ Multiple Management Needs, Including Routine Prevention, Pre-Procedure Preve

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (Media) Associate Director, PR & Advocacy Phone (610) 321-2358 VIROPHARMA?S CINRYZE? (C1 INHIBITOR [HUMAN]) GRANTED EUROPEAN MARKETING AUTHORIZATION FOR HEREDITARY ANGIOEDEMA (HAE) - First and Only Approved Therapy to Meet HAE Patients? Multiple Managemen

June 15, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 15, 2011 VIROPHARMA INCORPOR

ViroPharma Incorporated - Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

May 31, 2011 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 25, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organization)

May 26, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 26, 2011 VIROPHARMA INCORPORA

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 26, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Orga

May 24, 2011 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 23, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organization)

May 11, 2011 EX-99.1

VIROPHARMA AND HALOZYME ANNOUNCE COLLABORATION FOR COMBINATION OF RECOMBINANT HUMAN HYALURONIDASE ENZYME (rHuPH20) TECHNOLOGY WITH C1 ESTERASE INHIBITOR - Initial Clinical Focus in Hereditary Angioedema on Optimized Subcutaneous Formulation of Cinryz

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (Media) Associate Director, PR & Advocacy Phone (610) 321-2358 VIROPHARMA AND HALOZYME ANNOUNCE COLLABORATION FOR COMBINATION OF RECOMBINANT HUMAN HYALURONIDASE ENZYME (rHuPH20) TECHNOLOGY WITH C1 ESTERASE INHIBITOR - Initial Clinical Focus in Hereditary

May 11, 2011 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 10, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organization)

April 28, 2011 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 28, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizatio

April 28, 2011 EX-99.1

VIROPHARMA Incorporated Reports First Quarter 2011 Financial Results - Company Sets New High in Quarterly Product Revenue; Record Sales of Cinryze® (C1 Esterase Inhibitor [Human]) Reach $57 Million in First Quarter -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody Jr. Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (for media) Associate Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports First Quarter 2011 Financial Results - Company Sets New High in Qu

April 28, 2011 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Form 10-Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 15, 2011 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 15, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE (State or Other Jurisdiction of Incorporation or Organization) 0-021699 (Commiss

April 14, 2011 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14

March 18, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 18, 2011 VIROPHARMA INCORPO

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 18, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Or

March 18, 2011 EX-99.1

VIROPHARMA ANNOUNCES POSITIVE CHMP OPINION FOR CINRYZE® (C1 INHIBITOR [HUMAN]) IN EUROPEAN UNION - Approval Recommended for Three Indications: Routine Prevention, Pre-Procedure Prevention, and Treatment in Patients with Hereditary Angioedema (HAE) -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (Media) Associate Director, PR & Advocacy Phone (610) 321-2358 VIROPHARMA ANNOUNCES POSITIVE CHMP OPINION FOR CINRYZE® (C1 INHIBITOR [HUMAN]) IN EUROPEAN UNION - Approval Recommended for Three Indications: Routine Prevention, Pre-Procedure Prevention, and

March 9, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 9, 2011 VIROPHARMA INCORPOR

Viropharma Incorporated - Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 9, 2011 EX-99.1

VIROPHARMA ANNOUNCES SECURITIES REPURCHASE PROGRAM

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Robert A. Doody Assistant Director, Investor Relations Phone (610) 321-6290 VIROPHARMA ANNOUNCES SECURITIES REPURCHASE PROGRAM Exton, PA, March 9, 2011 ? ViroPharma Incorporated (Nasdaq: VPHM) today announced that the company?s Board of Directors has authorized the use of up to $150 million to repurchase shares of its common stock and/or its 2% Senior

February 24, 2011 EX-10.52

VIROPHARMA INCORPORATED AMENDED AND RESTATED 2005 EQUITY INCENTIVE PLAN RESTRICTED SHARE UNIT SUMMARY OF GRANT

Exhibit 10.52 VIROPHARMA INCORPORATED AMENDED AND RESTATED 2005 EQUITY INCENTIVE PLAN RESTRICTED SHARE UNIT SUMMARY OF GRANT ViroPharma Incorporated, a Delaware corporation (the ?Company?), pursuant to its Amended and Restated 2005 Equity Incentive Plan, as amended (the ?Plan?), hereby grants to the individual listed below (the ?Participant?), this Restricted Share Unit Award representing the numb

February 24, 2011 EX-21

SUBSIDIARIES OF THE COMPANY Entity Name of State/Country of Incorporation ViroPharma Biologics, Inc. Delaware VCO Incorporated Delaware VPDE Incorporated Delaware VPINT, Inc. Delaware ViroPharma Limited United Kingdom ViroPharma SPRL Belgium ViroPhar

Exhibit 21 SUBSIDIARIES OF THE COMPANY Entity Name of State/Country of Incorporation ViroPharma Biologics, Inc. Delaware VCO Incorporated Delaware VPDE Incorporated Delaware VPINT, Inc. Delaware ViroPharma Limited United Kingdom ViroPharma SPRL Belgium ViroPharma SAS France ViroPharma GmbH Germany ViroPharma LLC Switzerland Auralis Limited United Kingdom

February 24, 2011 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 24, 2011 VIROPHARMA INCO

ViroPharma Incorporated - Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

February 24, 2011 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Viropharma Incorporated - Form 10-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

February 24, 2011 EX-99.1

VIROPHARMA Incorporated Reports Fourth Quarter and Full Year 2010 Financial Results - Company Achieves Record Quarter and Full Year Product Revenue; Annual Sales of Cinryze® (C1 Esterase Inhibitor [Human]) Grow to $177 Million -

Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Charles A. Rowland, Jr. Vice President, Chief Financial Officer Phone (610) 321-6223 Robert A. Doody Jr. Assistant Director, Investor Relations Phone (610) 321-6290 Kristina M. Broadbelt (for media) Associate Director, PR & Advocacy Phone (610) 321- 2358 VIROPHARMA Incorporated Reports Fourth Quarter and Full Year 2010 Financial Results - Company Achi

February 24, 2011 EX-10.10

ViroPharma Incorporated Board Compensation Policy

Exhibit 10.10 ViroPharma Incorporated Board Compensation Policy Members of the Board of Directors of ViroPharma Incorporated (the “Board”) that are non-executive officers of ViroPharma Incorporated (the “Company”), and directors that are not affiliated with a person or entity that has been granted a contractual right to appoint a director to the Board (“Eligible Directors”), shall receive compensa

February 24, 2011 EX-10.51

2

Exhibit 10.51 *** INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24b-2 UNDER THE SECURITIES AND EXCHANGE ACT OF 1934, AS AMENDED. ViroPharma Incorporated, 730 Stockton Drive, Exton, PA 19341, USA December 14, 2010 Amended and Restated Bulk Materia

February 24, 2011 EX-10.50

Second Amended and Restated Bulk Material Supply Agreement

Exhibit 10.50 *** INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24b-2 UNDER THE SECURITIES AND EXCHANGE ACT OF 1934, AS AMENDED. Second Amended and Restated Bulk Material Supply Agreement Parties ViroPharma Incorporated, a Delaware corporation, w

February 14, 2011 SC 13G/A

SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Under the Securities Exchange Act of 1934 (Amendment No. 10)* VIROPHARMA INCORPORATED (Name of Issuer) Common Stock, par value $0.002 per share (Title of Class of Securities) (CUSIP

SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Under the Securities Exchange Act of 1934 (Amendment No.

February 11, 2011 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) ViroPharma Incorporated (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) December 31, 2010 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

February 11, 2011 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. _)* VIROPHARMA INC (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) Dec

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* VIROPHARMA INC (Name of Issuer) Common Stock (Title of Class of Securities) 928241108 (CUSIP Number) December 31, 2010 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

January 10, 2011 EX-99.1

VIROPHARMA PROVIDES 2011 OUTLOOK

Press release Exhibit 99.1 VIROPHARMA INCORPORATED Contacts: Kristina M. Broadbelt (Media) Assistant Director, PR & Advocacy Phone (610) 321-2358 Robert A. Doody Jr. (Investors) Assistant Director, Investor Relations Phone (610) 321-6290 VIROPHARMA PROVIDES 2011 OUTLOOK Exton, PA, January 10, 2011 — ViroPharma Incorporated (Nasdaq: VPHM) today announced that Vincent Milano, president and chief exe

January 10, 2011 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 10, 2011 VIROPHARMA INCORPORATED (Exact Name of Registrant as Specified in its Charter) DELAWARE 0-021699 23-2789550 (State or Other Jurisdiction of Incorporation or Organizat

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