RBSH / Rebus Holdings, Inc. - SEC-arkiveringar, Årsredovisning, Fullmaktsutlåtande

Rebus Holdings, Inc.
US ˙ OTCPK

Grundläggande statistik
CIK 1421204
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Rebus Holdings, Inc.
SEC Filings (Chronological Order)
Denna sida innehåller en komplett, kronologisk lista över SEC-arkiveringar, exklusive ägande-arkiveringar som vi tillhandahåller på andra ställen.
August 21, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2023 ☐ TRANSITION REPORT PU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2023 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 REBUS HOLDINGS, INC. (Exact name of registra

August 14, 2023 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 000-55331 CUSIP NUMBER NOTIFICATION OF LATE FILING 75619J 103 (Check one): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-SAR ☐ Form N-CSR For Period Ended: June 30, 2023 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transi

May 15, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2023 ☐ TRANSITION REPORT P

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2023 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 REBUS HOLDINGS, INC. (Exact name of registr

March 31, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 000-55331 REBUS HOLDING

November 21, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2022 ☐ TRANSITION REPO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2022 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 REBUS HOLDINGS, INC. (Exact name of reg

November 16, 2022 8-K

Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 16, 2022 (November 9, 2022) Rebus Holdings, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 000-55331 20-0438951 (State or other jurisdiction of i

November 14, 2022 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25

NT 10-Q 1 rebusholdingsnt10q.htm NT 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC File Number 000-55331 NOTIFICATION OF LATE FILING (Check One): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-SAR ☐ Form N-CSR For Period Ended: September 30, 2022 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report

October 13, 2022 EX-16.1

Letter to SEC from Liggett & Webb P.A. dated October 13, 2022

Exhibit 16.1 October 13, 2022 Securities and Exchange Commission 100 F Street N.E. Washington, D.C. 20549 RE: Rebus Holdings, Inc. File Ref No: 000-55331 We have read the statements of Rebus Holdings, Inc., pertaining to our firm included under Item 4.01 of Form 8-K dated October 10, 2022 and agree with such statements as they pertain to our firm. We have read Item 4.01, captioned ?Changes in Comp

October 13, 2022 8-K

Changes in Registrant's Certifying Accountant, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 13, 2022 (October 10, 2022) Rebus Holdings, Inc. (Exact name of registrant as specified in Charter) 000-55331 Delaware 0001421204 20-0438951 (State or other jurisdiction of in

August 12, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2022 ☐ TRANSITION REPORT PU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2022 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 REBUS HOLDINGS, INC. (Exact name of registra

May 13, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2022 ☐ TRANSITION REPORT P

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2022 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 REBUS HOLDINGS, INC. (Exact name of registr

March 31, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ☐ TRANSITION REPORT PURSUA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 000-55331 REBUS HOLDING

March 31, 2022 EX-21.01

List of Subsidiaries of Registrant

Exhibit 21.01 List of Subsidiaries of Rebus Holdings, Inc. ? Inspyr Therapeutics, Inc., ? Ridgeway Therapeutics, Inc. (CA Corporation), and ? Lewis and Clark Pharmaceuticals, Inc.

December 9, 2021 424B3

5,806,864 Shares Common Stock

Rule 424(b)(3) Registration No. 333-255618 PROSPECTUS 5,806,864 Shares Common Stock This prospectus relates to the resale of 5,806,864 shares of our common stock, by the selling stockholder(s) identified in the selling stockholders tables beginning on page 18 of this prospectus (?Selling Stockholder(s)?). We will not receive any proceeds from the sale of these shares by the Selling Stockholders. T

December 8, 2021 CORRESP

REBUS HOLDINGS, INC.

CORRESP 1 filename1.htm REBUS HOLDINGS, INC. December 8, 2021 Tim Buchmiller Staff Attorney Office of Life Sciences Division of Corporation Finance United States Securities and Exchange Commission Washington, DC 20549 RE: Rebus Holdings, Inc. Registration Statement on Form S-1 Filed December 3, 2021 File No. 333-255618 Dear Mr. Buchmiller: Pursuant to Rule 461 under the Securities Act of 1933, as

December 3, 2021 EX-23.01

Consent of Independent Registered Certified Public Accountant

Exhibit 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the use in this Pre-effective Amendment No.1 to Form S-1 Registration Statement of our report dated March 31, 2021, except for footnote 3 “Reverse Stock Split,”, footnote 9 “Reverse Stock Split” and footnote 15 “Reverse Stock Split,” as to which the date is December 3, 2021, relating to the December 3

December 3, 2021 EX-21.01

List of Subsidiaries of Registrant

Exhibit 21.01 List of Subsidiaries of Rebus Holdings, Inc. ? Lewis and Clark Pharmaceuticals, Inc. ? Inspyr Therapeutics, Inc.

December 3, 2021 EX-5.01

Consent of Silvestre Law Group, P.C. (contained in opinion filed as Exhibit 5.01 to this Registration Statement

Exhibit 5.01 SILVESTRE LAW GROUP, P.C. 2629 Townsgate Road #215 Westlake Village, CA 91361 (818) 597-7552 Fax (805) 553-9783 December 3, 2021 Rebus Holdings, Inc. 2629 Townsgate Road #215 Westlake Village, CA 91361 Ladies and Gentlemen: We have acted as counsel to Rebus Holdings, Inc., a Delaware corporation (the “Company”) in connection with the Pre-effective Amendment No. 1 to the Registration S

December 3, 2021 S-1/A

As filed with the Securities and Exchange Commission on December 3, 2021

As filed with the Securities and Exchange Commission on December 3, 2021 Registration No.

November 12, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2021 ☐ TRANSITION REPO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2021 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 REBUS HOLDINGS, INC. (Exact name of reg

November 12, 2021 EX-3.16(II)

Rebus Holdings Bylaws dated November 11, 2021

EX-3.16(II) 2 rebusholdingsex3-16ii.htm EXHIBIT 3.16(II) Exhibit 3.16(ii) AMENDED AND RESTATED BYLAWS OF REBUS HOLDINGS, INC. (Amended and Restated on November 11, 2021) BYLAWS OF REBUS HOLDINGS, INC. ARTICLE I CORPORATE OFFICES 1.1 REGISTERED OFFICE. The registered office of Rebus Holdings, Inc. shall be fixed in the corporation’s certificate of incorporation, as the same may be amended and/or re

October 12, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 12, 2021 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 000-55331 20-0438951 (State or other jurisdiction of incorporation or

October 12, 2021 8-K/A

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 12, 2021 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 000-55331 20-0438951 (State or other jurisdiction

October 12, 2021 EX-99.01

INSPYR THERAPEUTICS Inspyr Therapeutics Announces New Holding Company Structure and Reverse Stock Split

Exhibit 99.01 INSPYR THERAPEUTICS Inspyr Therapeutics Announces New Holding Company Structure and Reverse Stock Split WESTLAKE VILLAGE, CA, October 12, 2021 (GLOBE NEWSWIRE) ? Inspyr Therapeutics, Inc. (?Inspyr?) is announcing (i) a 1-for-75 reverse stock split of its common stock and (ii) a holding company restructuring whereby Rebus Holdings, Inc. (?Rebus?), a newly created entity will serve as

October 5, 2021 EX-3.03(II)

Amended and Restated Bylaws of Inspyr Therapeutics, Inc.

EX-3.03(II) 5 inspyrtherapex3-03ii.htm EXHIBIT 3.03(II) Exhibit 3.03(ii) AMENDED AND RESTATED BYLAWS OF INSPYR THERAPEUTICS, INC. (October 5, 2021) ARTICLE I. NAME OF CORPORATION The name of the corporation is Inspyr Therapeutics, Inc. ARTICLE II. OFFICES SECTION 1. The principal office of the corporation shall be fixed in the corporation’s certificate of incorporation, as the same may be amended

October 5, 2021 EX-3.02(I)

Certificate of Merger between Inspyr Therapeutics, Inc. and Rebus Sub, Inc.

Exhibit 3.02(i) CERTIFICATE OF MERGER OF REBUS SUB, INC., WITH AND INTO INSPYR THERAPEUTICS, INC. Pursuant to Section 251 of the General Corporation Law of the State of Delaware (?DGCL?), the undersigned corporation hereby certifies that: FIRST: The name and state of incorporation of each of the constituent corporations to the merger are as follows: Name State of Incorporation Inspyr Therapeutics,

October 5, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 4, 2021 (September 28, 2021) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 000-55331 20-0438951 (State or other jurisdiction of incorpo

October 5, 2021 EX-3.01(I)

Amended and Restated Certificate of Incorporation of Inspyr Therapeutics, Inc. effecting 1-for-75 Reverse Stock Split

Exhibit 3.01(i) AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF INSPYR THERAPEUTICS, INC. a Delaware Corporation The undersigned does hereby certify on behalf of Inspyr Therapeutics, Inc. (the ?Corporation?), a corporation organized and existing under the Delaware General Corporation Law, as follows: FIRST: That the undersigned is the duly elected and acting Chief Executive Officer of the Cor

October 5, 2021 EX-2.1

Form of agreement and Plan of Merger among Inspyr Therapeutics, Inc., Rebus Holdings, Inc., and Rebus Sub, Inc. dated September 28, 2021.

Exhibit 2.01 AGREEMENT AND PLAN OF MERGER AGREEMENT AND PLAN OF MERGER (this ?Agreement?), dated as of September 28, 2021, by and among Inspyr Therapeutics, Inc., a Delaware corporation (the ?Company?), Rebus Holdings, Inc., a Delaware corporation and a direct wholly owned subsidiary of the Company (?Rebus?), and Rebus Sub, Inc., a Delaware corporation and a direct wholly owned subsidiary of Rebus

September 3, 2021 DEF 14C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ? Preliminary Information Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(2)) ? Definitive Information Statement Inspyr Therapeutics, Inc. (Name of R

August 25, 2021 PRE 14C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ☒ Preliminary Information Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(2)) ☐ Definitive Information Statement Inspyr Therapeutics, Inc. (Name of R

August 16, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2021 ☐ TRANSITION REPORT PU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2021 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of reg

June 21, 2021 EX-10.01

Form of Convertible Debenture for June 2021 Private Placement

Exhibit 10.01 NEITHER THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGI

June 21, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 21, 2021 (June 16, 2021) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation

May 17, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2021 ☐ TRANSITION REPORT P

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2021 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of re

April 29, 2021 S-1

Registration Statement - S-1

As filed with the Securities and Exchange Commission on April 29, 2021 Registration No.

April 29, 2021 EX-23.01

Consent of Independent Registered Certified Public Accountant

Exhibit 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the use in this Form S-1 Registration Statement of our report dated March 31, 2021, relating to the December 31, 2020 and 2019 consolidated financial statements of Inspyr Therapeutics, Inc., which appear in this Registration Statement and related Prospectus. Our report includes an explanatory paragrap

April 29, 2021 EX-5.01

Consent of Silvestre Law Group, P.C. (contained in opinion filed as Exhibit 5.01 to this Registration Statement

Exhibit 5.01 SILVESTRE LAW GROUP, P.C. 2629 Townsgate Road #215 Westlake Village, CA 91361 (818) 597-7552 Fax (805) 553-9783 April 29, 2021 Inspyr Therapeutics, Inc. 2629 Townsgate Road #215 Westlake Village, CA 91361 Ladies and Gentlemen: We have acted as counsel to Inspyr Therapeutics, Inc., a Delaware corporation (the “Company”) in connection with the Registration Statement on Form S-1 (the “Re

April 1, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 1, 2021 (March 31, 2021) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporatio

April 1, 2021 EX-99.01

INSPYR THERAPEUTICS Inspyr Therapeutics Reports Financial Results and Business Update For Full Year 2020

Exhibit 99.01 INSPYR THERAPEUTICS Inspyr Therapeutics Reports Financial Results and Business Update For Full Year 2020 ? Implements new corporate strategy to focus on precision therapeutics for the treatment of cancer ? Strengthens pipeline by acquiring a proprietary portfolio of novel adenosine immuno-modulator compounds ? Lead asset, RT-AR001, pre-IND filing is on track for the first half of 202

March 31, 2021 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 ☐ TRANSITION REPORT PURSUA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 000-55331 INSPYR THERAP

January 12, 2021 EX-99.01

INSPYR THERAPEUTICS Inspyr Therapeutics Secures $500,000 to Support the Development of its Adenosine Pipeline

Exhibit 99.01 INSPYR THERAPEUTICS Inspyr Therapeutics Secures $500,000 to Support the Development of its Adenosine Pipeline ● Proceeds support the development of lead asset, RT-AR001, an adenosine receptor antagonist ● Funds were secured from an existing institutional investor Westlake Village, CA, January 12, 2021 – Inspyr Therapeutics, Inc. (OTC: NSPX), a pharmaceutical company focused on the re

January 12, 2021 EX-10.01

Form of Convertible Debenture for January 2021 Private Placement

Exhibit 10.01 NEITHER THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGI

January 12, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Unregistered Sales of Equity Securities, Other Events, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 12, 2021 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organizat

November 27, 2020 EX-3.01(I)

Amended and Restated Certificate of Incorporation

EX-3.01(I) 2 inspyrtherapeuticsex3-01i.htm EXHIBIT 3.01(I) Exhibit 3.01(i) AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF INSPYR THERAPEUTICS, INC. ARTICLE I The name of this Corporation is Inspyr Therapeutics, Inc. (this “Corporation”). ARTICLE II The address of the registered office of the corporation in the State of Delaware is 850 New Burton Road, Suite 201, Dover, Delaware, county of Ke

November 27, 2020 EX-10.01

Conversion Price Adjustment Agreement

Exhibit 10.01 CONVERSION PRICE ADJUSTMENT AGREEMENT This conversion price adjustment agreement (“Agreement”) dated as of November 25, 2020 is by and among Sabby Healthcare Master Fund, Ltd., Sabby Volatility Warrant Master Fund, Ltd. (collectively, “Sabby”) and Inspyr Therapeutics, Inc., a Delaware corporation (the “Company”). Any terms not specifically defined herein shall have the definition asc

November 27, 2020 8-K

Entry into a Material Definitive Agreement, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

8-K 1 inspyrtherapeutics8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 27, 2020 (November 25, 2020) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (S

November 20, 2020 10-Q

Quarterly Report - QUARTERLY REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2020 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of

November 16, 2020 NT 10-Q

- NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC File Number 000-55331 NOTIFICATION OF LATE FILING (Check One): ? Form 10-K ? Form 20-F ? Form 11-K ? Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR For Period Ended: September 30, 2020 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Report on Form

November 4, 2020 DEF 14C

- DEFINITIVE INFORMATION STATEMENT

DEF 14C 1 ea129314-def14cinspyrtherap.htm DEFINITIVE INFORMATION STATEMENT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ☐ Preliminary Information Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(

November 2, 2020 CORRESP

-

SILVESTRE LAW GROUP, P.C. 2629 Townsgate Road, Suite 215 Westlake Village, CA 91361 (818) 597-7552 Fax (805) 553-9783 November 2, 2020 Division of Corporation Finance Office of Life Sciences United States Securities and Exchange Commission Washington, DC 20549 RE: Inspyr Therapeutics, Inc. Preliminary Information Statement on Schedule 14C Filed October 16, 2020 File No. 000-55331 Dear Ladies and G

November 2, 2020 PRER14C

- AMENDMENT NO. 1 TO PRELIMINARY INFORMATION STATEMENT

PRER14C 1 ea129247-prer14cinspyrther.htm AMENDMENT NO. 1 TO PRELIMINARY INFORMATION STATEMENT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ☒ Preliminary Information Statement ☐ Confidential, for Use of the Commission O

October 29, 2020 EX-10.01

Form of Debenture for October 2020 Private Placement

Exhibit 10.01 NEITHER THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGI

October 29, 2020 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant - CURRENT REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 29, 2020 (October 23, 2020) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorpo

October 16, 2020 PRE 14C

- PRELIMINARY INFORMATION STATEMENT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ☒ Preliminary Information Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(2)) ☐ Definitive Information Statement Inspyr Therapeutics, Inc. (Name of R

October 15, 2020 PRE 14A

- PRELIMINARY INFORMATION STATEMENT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ☒ Preliminary Information Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(2)) ☐ Definitive Information Statement Inspyr Therapeutics, Inc. (Name of R

October 8, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Unregistered Sales of Equity Securities, Changes in Control of Registrant, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Other Events - CURRENT REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 8, 2020 (October 5, 2020) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorpora

October 8, 2020 EX-10.01

Termination of Licensing Agreement with Ridgeway Therapeutics, Inc. dated October 5, 2020

Exhibit 10.01 October 5, 2020 Inspyr Therapeutics, Inc. 2629 Townsgate Road #215 Westlake Village, CA 91361 (818) 597-7552 [email protected] Ridgeway Therapeutics, Inc. [Address] [Address] [Email] Dear Colin Hislop, Inspyr Therapeutics, Inc. (“Inspyr”) is providing this letter agreement (“Letter Agreement”) to Ridgeway Therapeutics, Inc. (“Ridgeway”) in connection with the License Agreem

October 8, 2020 EX-99.01

Inspyr Therapeutics acquires a novel immuno-onoclogy precision targeting platform for the treatment of cancer Preclinical data demonstrated delayed tumor growth, reduces metastases and anti-tumor immune response

EX-99.01 4 ea127966ex99-01inspyrtherap.htm PRESS RELEASE DATED OCTOBER 8, 2020 Exhibit 99.01 Inspyr Therapeutics acquires a novel immuno-onoclogy precision targeting platform for the treatment of cancer Preclinical data demonstrated delayed tumor growth, reduces metastases and anti-tumor immune response Westlake Village, CA (October 8, 2020) – Inspyr Therapeutics, Inc. (OTC/PINK: NSPX), announces

October 8, 2020 EX-3.01(I)

Certificate of Designation of Preferences, Rights and Limitations of Series F 0% Convertible Preferred Stock

Exhibit 3.01(i) INSPYR THERAPEUTICS, inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES F 0% CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151(g) OF THE Delaware GENERAL CORPORATION LAW The undersigned, Michael Cain does hereby certify that: 1. He is the President of Inspyr Therapeutics, Inc., a Delaware corporation (the “Corporation”). 2. The Corporation is authori

August 14, 2020 10-Q

Quarterly Report - QUARTERLY REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2020 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of regi

July 6, 2020 10-Q

Quarterly Report - QUARTERLY REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2020 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of reg

July 2, 2020 NT 10-Q

- NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC File Number 000-55331 NOTIFICATION OF LATE FILING (Check One): ¨ Form 10-K ¨ Form 20-F ¨ Form 11-K x Form 10-Q ¨ Form 10-D ¨ Form N-SAR ¨ Form N-CSR For Period Ended: March 31, 2020 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Transition Report on Form 10-

June 29, 2020 8-K

Financial Statements and Exhibits, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year

8-K 1 ea123552-8kinspyrtherape.htm CURRENT REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 29, 2020 (June 26, 2020) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-043

June 29, 2020 EX-3.01I

Amended and Restated Certificate of Incorporation, effective June 26, 2020

Exhibit 3.01(i) AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF INSPYR THERAPEUTICS, INC. a Delaware Corporation The undersigned does hereby certify on behalf of Inspyr Therapeutics, Inc. (the “Corporation”), a corporation organized and existing under the Delaware General Corporation Law, as follows: FIRST: That the undersigned is the duly elected and acting Chief Executive Officer of the Cor

May 27, 2020 DEF 14C

- DEFINITIVE INFORMATION STATEMENT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ☐ Preliminary Information Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(2)) ☒ Definitive Information Statement Inspyr Therapeutics, Inc. (Name of R

May 15, 2020 PRE 14C

- PRELIMINARY INFORMATION STATEMENT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ☒ Preliminary Information Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(2)) ☐ Definitive Information Statement Inspyr Therapeutics, Inc. (Name of R

May 14, 2020 10-K

Annual Report - ANNUAL REPORT

10-K 1 f10k2019inspyrthera.htm ANNUAL REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . C

May 14, 2020 EX-10.25

Form of Securities Purchase Agreement for May 2020 Preferred Stock Offering

Exhibit 10.25 May 2, 2020 Inspyr Therapeutics, Inc. 31200 Via Colinas #200 Westlake Village, CA 91362 Re: Inspyr Therapeutics, Inc. - Subscription for Shares of Series E Preferred Stock Ladies and Gentlemen: The undersigned hereby acknowledges and agrees to the following: 1. The undersigned hereby subscribes for shares totaling an aggregate consideration of $5,000 of Series E Convertible Preferred

May 14, 2020 EX-3.10.I

Certificate of Designation of Preferences, Rights and Limitations of Series E 0% Convertible Preferred Stock

Exhibit 3.10(i) INSPYR THERAPEUTICS, inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES E 0% CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151(g) OF THE Delaware GENERAL CORPORATION LAW The undersigned, Michael Cain does hereby certify that: 1. He is the President of Inspyr Therapeutics, Inc., a Delaware corporation (the “Corporation”). 2. The Corporation is authori

May 14, 2020 EX-4.36

Form of Series E Preferred Stock Certificate

EX-4.36 3 f10k2019ex4-36inspyr.htm FORM OF SERIES E PREFERRED STOCK CERTIFICATE Exhibit 4.36 SE-001 Series E 0% Convertible Preferred [*] Shares Inspyr Therapeutics, Inc. A Delaware Corporation THIS CERTIFIES THAT [*] is the record holder of ([*]) shares of the Series E 0% Convertible Preferred Stock of Inspyr Therapeutics, Inc. transferable only on the register of said company, in person or by du

May 14, 2020 EX-23.01

Consent of Liggett & Webb, P.A.

Exhibit 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFICATED PUBLIC ACCOUNTANTS We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (SEC File No. 333-192553) of Inspyr Therapeutics, Inc. of our report which includes an explanatory paragraph expressing substantial doubt regarding the Company’s ability to continue as a going concern dated May 14, 2020, relat

May 13, 2020 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 13, 2020 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organization)

March 30, 2020 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 30, 2020 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organizatio

March 6, 2020 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

8-K 1 ea119382-8kinspyrtherape.htm CURRENT REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 6, 2020 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or o

March 6, 2020 EX-10.01

Form of Debenture for March 2020 Private Placement

Exhibit 10.01 NEITHER THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGI

December 20, 2019 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q - Quarterly Report - QUARTERLY REPORT

10-Q 1 f10q0919inspyrtherapeutics.htm QUARTERLY REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Num

September 30, 2019 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 30, 2019 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 000-55331 20-0438951 (State or other jurisdiction of incorporation or organiza

September 30, 2019 EX-3.01

Amended and Restated Certificate of Incorporation, effective September 30, 2019

EX-3.01 2 f8k093019ex3-01iinspyrthera.htm EXHIBIT 3.01I Exhibit 3.01(i) AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF INSPYR THERAPEUTICS, INC. a Delaware Corporation The undersigned does hereby certify on behalf of Inspyr Therapeutics, Inc. (the “Corporation”), a corporation organized and existing under the Delaware General Corporation Law, as follows: FIRST: That the undersigned is the du

September 13, 2019 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q - Quarterly Report - QUARTERLY REPORT

10-Q 1 f10q0619inspyrtherapeutics.htm QUARTERLY REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number:

September 11, 2019 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q - Quarterly Report - QUARTERLY REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of re

August 6, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K 1 f8k071519inspyrtherap.htm CURRENT REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 6, 2019 (July 15, 2019) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-04389

August 6, 2019 10-K

NSPX / Inspyr Therapeutics, Inc. 10-K - Annual Report - ANNUAL REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2018 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 000-55331 INSPYR THERAP

August 6, 2019 EX-23.01

Consent of Liggett & Webb, P.A.

Exhibit 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (SEC File No. 333-192553) of Inspyr Therapeutics, Inc. of our report which includes an explanatory paragraph expressing substantial doubt regarding the Company’s ability to continue as a going concern dated August 6, 2019, relati

June 14, 2019 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q - Quarterly Report - QUARTERLY REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2018 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of

May 22, 2019 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q - Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2018 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of reg

May 22, 2019 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q - Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2018 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of regi

April 26, 2019 EX-99.03

Nominating and Governance Committee Charter

Exhibit 99.03 INSPYR THERAPEUTICS NOMINATING AND CORPORATE GOVERNANCE COMMITTEE CHARTER Purpose The purpose of the Nominating and Corporate Governance Committee (the “Committee”) is to: ● Assist the Board by identifying individuals qualified to become Board members, consistent with criteria approved by the Board ● Recommend for the Board’s approval the slate of nominees to be proposed by the Board

April 26, 2019 EX-99.02

Leadership Development and Compensation Committee Charter

Exhibit 99.02 INSPYR THERAPEUTICS LEADERSHIP DEVELOPMENT AND COMPENSATION COMMITTEE CHARTER Purpose The basic purpose of the Leadership Development and Compensation Committee is to oversee Inspyr Therapeutics’s executive officer compensation programs. The Committee will provide this oversight through a process that supports Inspyr Therapeutics’s business objectives and incorporates sound corporate

April 26, 2019 EX-99.01

Audit Committee Charter

Exhibit 99.01 INSPYR THERAPEUTICS AUDIT COMMITTEE CHARTER Purpose The purpose of the Audit Committee is to: ● oversee Inspyr Therapeutics’s accounting and financial reporting processes, Inspyr Therapeutics’s internal systems of control and audits of Inspyr Therapeutics’s financial statements. ● oversee Inspyr Therapeutics’s relationship with its independent auditors, including appointing or changi

April 26, 2019 EX-23.01

Consent of Liggett & Webb, P.A.

Exhibit 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the incorporation by reference in on Registration Statement on Form S-8 (SEC File No. 333-192553) of Inspyr Therapeutics, Inc. of our report which includes an explanatory paragraph expressing substantial doubt regarding the Company’s ability to continue as a going concern dated April 26, 2019, relatin

April 26, 2019 EX-14.01

Code of Ethics

Exhibit 14.01 Code of Ethics and Conduct Last Revised: August 1, 2016 This Code of Ethics and Conduct (the “Code”) applies to all directors, officers, and employees of Inspyr Therapeutics, Inc. (the “Company”) and is designed to deter wrongdoing and promote the following: ● Honest and ethical conduct; ● Full, fair, accurate, timely, and understandable disclosure in reports and documents that are f

April 26, 2019 EX-21.01

List of Subsidiaries of Registrant

Exhibit 21.01 List of Subsidiaries of Inspyr Therapeutics, Inc. ● Lewis and Clark Pharmaceuticals, Inc.

April 26, 2019 10-K

Form of Securities Purchase Agreement for January 2019 Preferred Stock Offering

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2017 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 000-55331 INSPYR THERAP

April 26, 2019 EX-4.45

Form of Series D Preferred Stock Certificate

EX-4.45 3 s117409ex4-45.htm EXHIBIT 4.45 Exhibit 4.45 SD-001 Series D 0% Convertible Preferred [*] Shares Inspyr Therapeutics, Inc. A Delaware Corporation THIS CERTIFIES THAT [*] is the record holder of ([*]) shares of the Series D 0% Convertible Preferred Stock of Inspyr Therapeutics, Inc. transferable only on the register of said company, in person or by duly authorized attorney, upon surrender

April 26, 2019 EX-3.08(I)

Certificate of Designation of Preferences, Rights and Limitations of Series D 0% Convertible Preferred Stock

EX-3.08(I) 2 s117409ex3-08i.htm EXHIBIT 3.08(I) Exhibit 3.08(i) INSPYR THERAPEUTICS, inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES D 0% CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151(g) OF THE Delaware GENERAL CORPORATION LAW The undersigned, Christopher Lowe does hereby certify that: 1. He is the President of Inspyr Therapeutics, Inc., a Delaware corporatio

April 26, 2019 EX-10.23

Form of Securities Purchase Agreement for January 2019 Preferred Stock Offering

EX-10.23 4 s117409ex10-23.htm EXHIBIT 10.23 Exhibit 10.23 December [*], 2018 Inspyr Therapeutics, Inc. 31200 Via Colinas #200 Westlake Village, CA 91362 Re: Inspyr Therapeutics, Inc. - Subscription for Shares of Series D Preferred Stock Ladies and Gentlemen: The undersigned hereby acknowledges and agrees to the following: 1. The undersigned hereby subscribes for shares totaling an aggregate consid

April 2, 2019 NT 10-K

NSPX / Inspyr Therapeutics, Inc. NT 10-K

NT 10-K 1 s117225nt10k.htm NT 10-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC File Number 000-55331 NOTIFICATION OF LATE FILING (Check One): ☒ Form 10-K ☐ Form 20-F ☐ Form 11-K ☐ Form 10-Q ☐ Form 10-D ☐ Form N-SAR ☐ Form N-CSR For Period Ended: December 31, 2018 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on For

January 22, 2019 DEF 14C

NSPX / Inspyr Therapeutics, Inc. DEF 14C

DEF 14C 1 s115457def14c.htm DEF 14C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ¨ Preliminary Information Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(2)) x Definitive Information Statement

January 10, 2019 PRE 14C

NSPX / Inspyr Therapeutics, Inc. PRE 14C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14C INFORMATION Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934 Check the appropriate box: ☒ Preliminary Information Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14c-5(d)(2)) ☐ Definitive Information Statement Inspyr Therapeutics, Inc. (Name of R

July 3, 2018 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 3, 2018 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organization)

July 3, 2018 EX-10.02

Form of Debenture for July 2018 Private Placement

Exhibit 10.02 NEITHER THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGI

July 3, 2018 EX-10.01

Form of Securities Purchase Agreement for July 2018 Private Placement

Exhibit 10.01 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of July , 2018, between Inspyr Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject to the terms and condition

February 15, 2018 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K 1 s1090808k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 14, 2018 (February 9, 2018) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or othe

December 21, 2017 EX-99.01

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 99.01 REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM To the Shareholders of Lewis and Clark Pharmaceuticals, Inc. We have audited the accompanying balance sheets of Lewis and Clark Pharmaceuticals, Inc. (the “Company”) as of December 31, 2016 and 2015, and the related statements of operations, deficiency in stockholder’s equity, and cash flows for the years ended December 31, 2016

December 21, 2017 EX-99.03

Inspyr Therapeutics, Inc. NOTES TO PRO FORMA UNAUDITED FINANCIAL STATEMENTS

Exhibit 99.03 Inspyr Therapeutics, Inc. NOTES TO PRO FORMA UNAUDITED FINANCIAL STATEMENTS Unaudited Pro Forma Condensed Financial Information. The Pro forma Unaudited Financial Statements have been prepared in order to present condensed consolidated financial position and results of operations of Inspyr Therapeutics, Inc. and Lewis and Clark Pharmaceuticals, Inc. as if the acquisition had occurred

December 21, 2017 8-K/A

Financial Statements and Exhibits

8-K/A 1 s1084318ka.htm 8-K/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December [*], 2017 (July 31, 2017) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or

December 21, 2017 EX-99.02

LEWIS AND CLARK PHARMACEUTICALS, INC. CONDENSED BALANCE SHEETS

EX-99.02 3 s108431ex99-02.htm EXHIBIT 99.02 Exhibit 99.02 LEWIS AND CLARK PHARMACEUTICALS, INC. CONDENSED BALANCE SHEETS June 30, 2017 December 31, 2016 (Unaudited) Assets Current assets: Cash $ 5,694 $ 320,946 Prepaid expenses 2,693 2,693 Total current assets 8,387 323,639 Property and equipment, net of accumulated depreciation of $15,902 and $13,517, respectively 12,461 14,846 Total assets $ 20,

November 20, 2017 10-Q

NSPX / Inspyr Therapeutics, Inc. FORM 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2017 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of

November 14, 2017 NT 10-Q

NSPX / Inspyr Therapeutics, Inc. NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC File Number 000-55331 NOTIFICATION OF LATE FILING (Check One): ? Form 10-K ? Form 20-F ? Form 11-K x Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR For Period Ended: September 30, 2017 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Report on Form

November 3, 2017 EX-4.01

2017 Equity Compensation Plan adopted 11/1/17

Exhibit 4.01 INSPYR THERAPEUTICS, INC. 2017 EQUITY COMPENSATION PLAN Adopted on November 1, 2017 1. Purposes of the Plan. The purposes of this Plan are: ? to attract and retain the best available personnel for positions of substantial responsibility, ? to provide additional incentive to Employees, Directors and Consultants, and ? to promote the success of the Company?s business. The Plan permits t

November 3, 2017 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 3, 2017 (November 1, 2017) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 000-55331 20-0438951 (State or other jurisdiction of incorpor

September 15, 2017 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 15, 2017 (September 12, 2017) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of inc

September 12, 2017 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 12, 2017 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organiz

September 12, 2017 EX-10.01

Form of Securities Purchase Agreement for September 2017 Private Placement

EX-10.01 2 s107467ex10-01.htm EXHIBIT 10.1 Exhibit 10.01 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of September 12, 2017, between Inspyr Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchas

September 12, 2017 EX-10.02

Form of Senior Convertible Debenture due 9/12/17 issued pursuant to Securities Purchase Agreement

EX-10.02 3 s107467ex10-02.htm EXHIBIT 10.02 Exhibit 10.02 EXHIBIT A NEITHER THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT B

September 12, 2017 EX-99.01

Inspyr Therapeutics Announces Private Placement of Senior Convertible Debentures

EX-99.01 5 s107467ex99-01.htm EXHIBIT 99.01 Exhibit 99.01 Inspyr Therapeutics Announces Private Placement of Senior Convertible Debentures WESTLAKE VILLAGE, Calif., September 12, 2017— Inspyr Therapeutics (OTCQB: NSPX), a clinical-stage biotechnology company developing a novel prodrug therapeutic for the treatment of cancer, announced today that the company has entered into definitive agreements w

September 12, 2017 EX-10.03

Form of Registration Rights Agreement entered into 9/12/17

EX-10.03 4 s107467ex10-03.htm EXHIBIT 10.03 Exhibit 10.03 EXHIBIT B REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this “Agreement”) is made and entered into as of September 12, 2017, between Inspyr Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the several purchasers signatory hereto (each such purchaser, a “Purchaser” and, collectively, the “Purchasers

September 12, 2017 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 12, 2017 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organiz

September 12, 2017 EX-10.01

Form of Exchange Agreement for September 2017 Private Placement

EX-10.01 2 s107465ex10-01.htm EXHIBIT 10.01 Exhibit 10.01 EXCHANGE AGREEMENT EXCHANGE AGREEMENT (the “Agreement”) is made as of the 12th day of September 2017, by and between Inspyr Therapeutics, Inc., a Delaware corporation (the “Company”), and the holders which are signatories on the signature page hereto (the “Holder(s)”). WHEREAS, pursuant to that certain Securities Purchase Agreement, by and

September 12, 2017 EX-10.02

Form of Senior Convertible Debenture due 9/12/18 issued pursuant to Exchange Agreement

Exhibit 10.02 EXHIBIT A NEITHER THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFE

August 14, 2017 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q (Quarterly Report)

10-Q 1 s10709310q.htm 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2017 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTIC

August 3, 2017 EX-10.2

Form of Share Escrow Agreement pursuant to Lewis & Clark Share Exchange Transaction

Exhibit 10.2 SHARE ESCROW AGREEMENT This SHARE ESCROW AGREEMENT (this ?Agreement?) dated as of this day of July 2017 by and among INSPYR THERAPEUTICS, INC., a Delaware corporation (the ?Company?), having an address at 31200 Via Colinas #200, Westlake Village, CA 91362, ROBERT D. THOMPSON, LARRY E. RODMAN, JOHN MONTGOMERY AND GRETCHEN MONTGOMERY, each individuals (the ?Principals?), each having add

August 3, 2017 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 3, 2017 (July 31, 2017) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporatio

August 3, 2017 EX-10.1

Form of Share Exchange Agreement between Inspyr Therapeutics and Lewis & Clark Pharmaceuticals

Exhibit 10.1 Share Exchange Agreement This Share Exchange Agreement, dated as of July [*], 2017, is made by and among INSPYR THERAPEUTICS, INC., a Delaware corporation (the ?Acquiror Company?), LEWIS AND CLARK PHARMACEUTICALS, INC., a Virginia corporation (the ?Company?), each of the Persons listed on Schedule I hereto that comprise all of the shareholders of the Company, and each of which is a si

May 15, 2017 10-Q

Inspyr Therapeutics 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2017 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name of reg

April 24, 2017 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

8-K 1 s1059478k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 24, 2017 (April 18, 2017) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jur

April 17, 2017 10-K

Inspyr Therapeutics 10-K (Annual Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2016 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 000-55331 INSPYR THERAP

April 17, 2017 EX-23.01

CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS

Exhibit 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the incorporation by reference in on Registration Statement on Form S-8 (SEC File No. 333-192553) of Inspyr Therapeutics, Inc. of our report which includes an explanatory paragraph expressing substantial doubt regarding the Company’s ability to continue as a going concern dated April 17, 2017, relatin

March 31, 2017 NT 10-K

Inspyr Therapeutics NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC File Number 000-55331 NOTIFICATION OF LATE FILING (Check One): x Form 10-K ? Form 20-F ? Form 11-K ? Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR For Period Ended: December 31, 2016 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Report on Form

March 23, 2017 424B3

6,800,014 Shares Common Stock

424B3 1 v462529424b3.htm 424B3 SUPPLEMENT No. 1 DATED March 23, 2017 (To Prospectus dated February 1, 2017) Rule 424(b)(3) Registration No. 333-215561 6,800,014 Shares Common Stock This prospectus supplement (“Supplement”) modifies, supersedes and supplements information contained in, and should be read in conjunction with, that certain prospectus, dated February 1, 2017 (“Prospectus”), of Inspyr

March 20, 2017 EX-3.01

Certificate of Designation of Preferences, Rights and Limitations of Series C 0% Convertible Preferred Stock

EX-3.01 2 v462102ex3-01.htm EXHIBIT 3.01 Exhibit 3.01 Inspyr Therapeutics, Inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES C CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE Delaware GENERAL CORPORATION LAW The undersigned, Christopher Lowe does hereby certify that: 1. He is the President and Secretary of Inspyr Therapeutics, Inc., a Delaware corporation

March 20, 2017 EX-10.01

Form of Securities Purchase Agreement for March 2017 – April 2017 Private Placement

Exhibit 10.01 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of March 14, 2017, between Inspyr Therapeutics, Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively, the ?Purchasers?). WHEREAS, subject to the terms and condit

March 20, 2017 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 20, 2017 (March 14, 2017) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of (Commission

March 20, 2017 EX-4.01

Form of Series C Preferred Stock Certificate

Exhibit 4.01 SC-[*] Series C 0% Convertible Preferred [*] Shares Inspyr Therapeutics, Inc. A Delaware Corporation THIS CERTIFIES THAT [Name] is the record holder of [*] ([*]) shares of the Series C 0% Convertible Preferred Stock of Inspyr Therapeutics, Inc. transferable only on the register of said company, in person or by duly authorized attorney, upon surrender of this certificate properly endor

March 20, 2017 EX-10.02

Form of Series M, N and O warrants for March 2017 – April 2017 Private Placement

Exhibit 10.02 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGIS

March 3, 2017 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

8-K 1 v4611108-k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 3, 2017 (February 28, 2017) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 000-55331 20-0438951 (State or ot

March 3, 2017 EX-10.01

Form of Separation Agreement with Russell Richerson dated February 28, 2017

Exhibit 10.01 SEPARATION AGREEMENT This Separation Agreement ("Agreement") is made by and between Inspyr Therapeutics, Inc. (the "Company"), and Russell Richerson ("Employee"). WHEREAS, on September 2, 2009 the Company and Employee entered into an employment agreement (which together with all prior amendment thereto shall be the ?Employment Agreement); WHEREAS, on September 2, 2009 the Company and

February 1, 2017 424B3

10,072,736 shares of Common Stock issuable upon the exercise of outstanding warrants 28,958,440 shares of Common Stock being sold by Selling Shareholders

424B3 1 v458073424b3.htm FORM 424(B)(3) SUPPLEMENT No. 2 DATED February 1, 2017 (To Prospectus dated August 3, 2016) Rule 424(b)(3) Registration No. 333-208918 10,072,736 shares of Common Stock issuable upon the exercise of outstanding warrants And 28,958,440 shares of Common Stock being sold by Selling Shareholders This prospectus supplement (“Supplement”) modifies, supersedes and supplements inf

February 1, 2017 424B3

6,800,014 Shares Common Stock

424B3 1 v457846424b3.htm 424B3 PROSPECTUS Rule 424(b)(3) Registration No. 333-215561 6,800,014 Shares Common Stock This prospectus relates to the resale of 6,800,014 shares of our common stock, by the selling stockholders identified in the selling stockholders tables beginning on page 16 of this prospectus (“Selling Stockholders”). We will not receive any proceeds from the sale of these shares by

January 30, 2017 CORRESP

Inspyr Therapeutics ESP

CORRESP 1 filename1.htm INSPYR THERAPEUTICS, INC. January 30, 2017 Suzanne Hayes Assistant Director Office of Healthcare and Insurance Division of Corporation Finance United States Securities and Exchange Commission Washington, DC 20549 RE: Inspyr Therapeutics, Inc. Registration Statement on Form S-1 Filed January 13, 2017 File No. 333-215561 Dear Ms. Hayes: We have been advised by your staff tele

January 27, 2017 CORRESP

Inspyr Therapeutics ESP

CORRESP 1 filename1.htm INSPYR THERAPEUTICS, INC. January 27, 2017 Suzanne Hayes Assistant Director Office of Healthcare and Insurance Division of Corporation Finance United States Securities and Exchange Commission Washington, DC 20549 RE: Inspyr Therapeutics, Inc. Registration Statement on Form S-1 Filed January 13, 2017 File No. 333-215561 Dear Ms. Hayes: We are submitting this letter in respon

January 13, 2017 EX-4.41

Form of Common Stock Purchase Warrant issued to 3rd party pursuant to Mr. Lowe’s Employment Agreement

Exhibit 4.41 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGIST

January 13, 2017 S-1

Registration Statement - S-1

As filed with the Securities and Exchange Commission on January 13, 2017 Registration No.

January 13, 2017 EX-5.01

SILVESTRE LAW GROUP, P.C. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 (818) 597-7552 Fax (805) 553-9783

Exhibit 5.01 SILVESTRE LAW GROUP, P.C. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 (818) 597-7552 Fax (805) 553-9783 January 13, 2017 Inspyr Therapeutics, Inc. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 Ladies and Gentlemen: We have acted as counsel to Inspyr Therapeutics, Inc., a Delaware corporation (the ? Company ?) in connection with the Registration Statement on Form

January 13, 2017 EX-23.01

CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS

Exhibit 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the use in this Form S-1 Registration Statement of our report dated March 30, 2016 (January 13, 2017 as to the effects of the reverse stock-split described in Note 14), relating to the financial statements of Inspyr Therapeutics, Inc. (fka GenSpera, Inc.), which appear in this Registration Statement a

December 12, 2016 EX-10.02

Form of Registration Rights Agreement for December 2016 Private Placement

Exhibit 10.02 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this ?Agreement?) is made and entered into as of December 9, 2016, between Inspyr Therapeutics, Inc., a Delaware corporation (the ?Company?), and each of the several purchasers signatory hereto (each such purchaser, a ?Purchaser? and, collectively, the ?Purchasers?). This Agreement is made pursuant to the Securities Pu

December 12, 2016 EX-99.01

Inspyr Announces Private Placement of $1.0 Million

EX-99.01 7 v454787ex99-01.htm EXHIBIT 99.01 Exhibit 99.01 Inspyr Announces Private Placement of $1.0 Million WESTLAKE VILLAGE, CA, December 12, 2016 Inspyr Therapeutics (OTCQB:NSPX) (“Inspyr” or the “Company”), a biotech company developing novel prodrug therapeutics for the treatment of cancer, today announced that it has entered into definitive securities purchase agreements with institutional an

December 12, 2016 EX-4.01

Form of Series B Preferred Stock Certificate

Exhibit 4.01 SB-[*] Series B 0% Convertible Preferred [*] Shares Inspyr Therapeutics, Inc. A Delaware Corporation THIS CERTIFIES THAT [Name] is the record holder of [*] ([*]) shares of the Series B 0% Convertible Preferred Stock of Inspyr Therapeutics, Inc. transferable only on the register of said company, in person or by duly authorized attorney, upon surrender of this certificate properly endor

December 12, 2016 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

8-K 1 v4547878k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 12, 2016 (December 9, 2016) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or

December 12, 2016 EX-10.03

Form of Series J, K and L Warrants for December 2016 Private Placement

EX-10.03 6 v454787ex10-03.htm EXHIBIT 10.3 Exhibit 10.03 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR

December 12, 2016 EX-3.01

Certificate of Designation of Preferences, Rights and Limitations of Series B 0% Convertible Preferred Stock

EX-3.01 2 v454787ex3-01.htm EXHIBIT 3.01 Exhibit 3.01 EXHIBIT A Inspyr Therapeutics, Inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES B CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE Delaware GENERAL CORPORATION LAW The undersigned, Christopher Lowe does hereby certify that: 1. He is the President and Secretary of Inspyr Therapeutics, Inc., a Delaware co

December 12, 2016 EX-10.01

Form of Securities Purchase Agreement for December 2016 Private Placement

EX-10.01 4 v454787ex10-01.htm EXHIBIT 10.01 Exhibit 10.01 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of December 9, 2016, between Inspyr Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchase

November 18, 2016 10-Q

Inspyr Therapeutics 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark one) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2016 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 INSPYR THERAPEUTICS, INC. (Exact name o

November 14, 2016 NT 10-Q

Inspyr Therapeutics NT 10-Q

NT 10-Q 1 v452902nt10q.htm NT 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 000-55331 NOTIFICATION OF LATE FILING CUSIPNUMBER 45782A 205 (Check one): ¨ Form 10-K ¨ Form 20-F ¨ Form 11-K x Form 10-Q ¨ Form 10-D ¨ Form N-SAR ¨ Form N-CSR For Period Ended: September 30, 2016 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨

November 10, 2016 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 10, 2016 (November 4, 2016) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 000-55331 20-0438951 (State or other jurisdiction of incorpo

November 10, 2016 EX-3.01(I)

Amended and Restated Certificate of Incorporation dated October 21, 2016

Exhibit 3.01(i) AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF INSPYR THERAPEUTICS, INC. a Delaware Corporation The undersigned does hereby certify on behalf of Inspyr Therapeutics, Inc. (the ?Corporation?), a corporation organized and existing under the Delaware General Corporation Law, as follows: FIRST: That the undersigned is the duly elected and acting Chief Executive Officer of the Cor

October 20, 2016 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K 1 v4508698k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 20, 2016 Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction

October 20, 2016 EX-99.01

Inspyr Broadens Intellectual Property Portfolio with New Patent Issued on Methods for Producing Cancer Compounds

Exhibit 99.01 Inspyr Broadens Intellectual Property Portfolio with New Patent Issued on Methods for Producing Cancer Compounds WESTLAKE VILLAGE, CA (October 20, 2016) ? Inspyr Therapeutics, Inc. (OTCQB:NSPX), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, announced that the United States Patent and Trademark Office (USPTO) recently issued patent 9,446,141 B2

October 14, 2016 EX-99.01

Inspyr Therapeutics Appoints Claire Thom, Pharm.D. to Board of Directors

Exhibit 99.01 Inspyr Therapeutics Appoints Claire Thom, Pharm.D. to Board of Directors WESTLAKE VILLAGE, CA (October 12, 2016) ? Inspyr Therapeutics, Inc. (OTCQB:NSPX), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, announced today the appointment of Claire Thom, Pharm.D. to its Board of Directors. ?Claire has broad experience in the global oncology industry,

October 14, 2016 EX-99.02

Inspyr Therapeutics Appoints Richard Buller, M.D., Ph.D. to Board of Directors

Exhibit 99.02 Inspyr Therapeutics Appoints Richard Buller, M.D., Ph.D. to Board of Directors WESTLAKE VILLAGE, CA (October 13, 2016) ? Inspyr Therapeutics, Inc. (OTCQB:NSPX), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, announced today the appointment of Richard Buller, M.D., Ph.D. to its Board of Directors. ?We are excited to have Rich join the Board as hi

October 14, 2016 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

8-K 1 v4505298k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 14, 2016 (October 12, 2016) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or

October 11, 2016 424B3

10,072,736 shares of Common Stock issuable upon the exercise of outstanding warrants 28,958,440 shares of Common Stock being sold by Selling Shareholders

SUPPLEMENT No. 1 DATED October 11, 2016 (To Prospectus dated August 3, 2016) Rule 424(b)(3) Registration No. 333-208918 10,072,736 shares of Common Stock issuable upon the exercise of outstanding warrants And 28,958,440 shares of Common Stock being sold by Selling Shareholders This prospectus supplement (?Supplement?) modifies, supersedes and supplements information contained in, and should be rea

September 12, 2016 EX-10.01

Form of Indemnification Agreement with Directors and Officers

Exhibit 10.01 INDEMNIFICATION AGREEMENT This Indemnification Agreement ("Agreement") is entered into as of the [*] day of [*], 20[*] by and between Inspyr Therapeutics, Inc. a Delaware corporation (the ?Company?), and [*] ("Indemnitee"). RECITALS A. The Company and Indemnitee recognize the continued difficulty in obtaining liability insurance for the Company's directors and officers, the significa

September 12, 2016 8-K

Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 12, 2016 (September 9, 2016) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of inco

August 18, 2016 EX-24

LIMITED POWER OF ATTORNEY

Exhibit 24 LIMITED POWER OF ATTORNEY The undersigned does hereby make, constitute and appoint Silvestre Law Group, P.

August 17, 2016 EX-24

LIMITED POWER OF ATTORNEY

Exhibit 24 LIMITED POWER OF ATTORNEY The undersigned does hereby make, constitute and appoint Silvestre Law Group, P.

August 15, 2016 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q - Quarterly Report - FORM 10-Q

10-Q 1 v44589410q.htm FORM 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2016 Or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 Inspyr Therap

August 15, 2016 10-Q

NSPX / Inspyr Therapeutics, Inc. 10-Q - Quarterly Report - FORM 10-Q

10-Q 1 v44589410q.htm FORM 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2016 Or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 Inspyr Therap

August 10, 2016 EX-99.1

Inspyr Therapeutics Appoints Ronald Shazer, M.D., as Senior Vice President and Chief Medical Officer

EX-99.1 4 v446564ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 Inspyr Therapeutics Appoints Ronald Shazer, M.D., as Senior Vice President and Chief Medical Officer SAN ANTONIO (August 8, 2016) – Inspyr Therapeutics, Inc. (OTCQB: NSPX), a clinical-stage biotechnology company developing novel prodrug therapeutics for the treatment of cancer, announces the appointment of Ronald Shazer, M.D. as Senior Vice Pre

August 10, 2016 EX-10.2

Form of Proprietary Information, Inventions and Competition Agreement

Exhibit 10.2 INSPYR THERAPEUTICS, INC. (FKA GENSPERA, INC.) CONFIDENTIAL INFORMATION AND INVENTION ASSIGNMENT AGREEMENT Employee Name: Ronald Shazer, MD Effective Date: August 8, 2016 As a condition of my becoming employed (or my employment being continued) by Inspyr Therapeutics, Inc. (fka GenSpera, Inc.), a Delaware corporation, or any of its current or future subsidiaries, affiliates, successor

August 10, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

8-K 1 v4465648k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 10, 2016 (August 8, 2016) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or oth

August 10, 2016 EX-10.1

Form of Proprietary Information, Inventions and Competition Agreement

Exhibit 10.1 EMPLOYMENT AGREEMENT This Employment Agreement (this ?Agreement?) is made and entered into as of this 8th day of August 2016, by and between Inspyr Therapeutics, Inc. (fka GenSpera, Inc.), a Delaware corporation (the ?Company?), and Ronald L. Shazer, M.D. (the ?Employee?). WITNESSETH: WHEREAS, the Company desires to employ Employee as its Senior Vice President and Chief Medical Office

August 10, 2016 EX-10.1

Form of Proprietary Information, Inventions and Competition Agreement

Exhibit 10.1 EMPLOYMENT AGREEMENT This Employment Agreement (this ?Agreement?) is made and entered into as of this 8th day of August 2016, by and between Inspyr Therapeutics, Inc. (fka GenSpera, Inc.), a Delaware corporation (the ?Company?), and Ronald L. Shazer, M.D. (the ?Employee?). WITNESSETH: WHEREAS, the Company desires to employ Employee as its Senior Vice President and Chief Medical Office

August 10, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

8-K 1 v4465648k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 10, 2016 (August 8, 2016) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or oth

August 10, 2016 EX-10.2

Form of Proprietary Information, Inventions and Competition Agreement

Exhibit 10.2 INSPYR THERAPEUTICS, INC. (FKA GENSPERA, INC.) CONFIDENTIAL INFORMATION AND INVENTION ASSIGNMENT AGREEMENT Employee Name: Ronald Shazer, MD Effective Date: August 8, 2016 As a condition of my becoming employed (or my employment being continued) by Inspyr Therapeutics, Inc. (fka GenSpera, Inc.), a Delaware corporation, or any of its current or future subsidiaries, affiliates, successor

August 10, 2016 EX-99.1

Inspyr Therapeutics Appoints Ronald Shazer, M.D., as Senior Vice President and Chief Medical Officer

EX-99.1 4 v446564ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 Inspyr Therapeutics Appoints Ronald Shazer, M.D., as Senior Vice President and Chief Medical Officer SAN ANTONIO (August 8, 2016) – Inspyr Therapeutics, Inc. (OTCQB: NSPX), a clinical-stage biotechnology company developing novel prodrug therapeutics for the treatment of cancer, announces the appointment of Ronald Shazer, M.D. as Senior Vice Pre

August 5, 2016 EX-10.01

Christopher Lowe employment Agreement

Exhibit 10.01 EMPLOYMENT AGREEMENT This Employment Agreement (this ?Agreement?) is made and entered into as of this 2nd day of August 2016, by and between GenSpera, Inc., a Delaware corporation (the ?Company?), and Christopher Lowe (the ?Employee?). WITNESSETH : WHEREAS, the Company desires to employ Employee as its Chief Executive Officer and Employee desires to accept such employment; and WHEREA

August 5, 2016 EX-10.02

INSPYR THERAPEUTICS, INC. (FKA GENSPERA, INC.) CONFIDENTIAL INFORMATION AND INVENTION ASSIGNMENT AGREEMENT Employee Name: Christopher Lowe Effective Date: August 2, 2016

Exhibit 10.02 INSPYR THERAPEUTICS, INC. (FKA GENSPERA, INC.) CONFIDENTIAL INFORMATION AND INVENTION ASSIGNMENT AGREEMENT Employee Name: Christopher Lowe Effective Date: August 2, 2016 As a condition of my becoming employed (or my employment being continued) by Inspyr Therapeutics, Inc. (fka GenSpera, Inc.), a Delaware corporation, or any of its current or future subsidiaries, affiliates, successor

August 5, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 5, 2016 (August 2, 2016) Inspyr Therapeutics, Inc. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporati

August 5, 2016 EX-99.01

Inspyr Therapeutics Appoints Christopher Lowe Chief Executive Officer and Director

Exhibit 99.01 Inspyr Therapeutics Appoints Christopher Lowe Chief Executive Officer and Director SAN ANTONIO (August 4, 2016) ? Inspyr Therapeutics, Inc. (OTCQB: NSPX), a clinical-stage biotechnology company developing novel prodrug therapeutics for the treatment of cancer, announces that Christopher Lowe has been appointed President and Chief Executive Officer, and as a member of the Company?s Bo

August 3, 2016 424B3

10,072,736 shares of Common Stock issuable upon the exercise of outstanding warrants 28,958,440 shares of Common Stock being sold by Selling Shareholders

424B3 1 v445951424b3.htm 424B3 PROSPECTUS Rule 424(b)(3) Registration No. 333-208918 10,072,736 shares of Common Stock issuable upon the exercise of outstanding warrants And 28,958,440 shares of Common Stock being sold by Selling Shareholders This prospectus covers the sale and issuance of up to 10,072,736 shares of our common stock (“Shares”) to holder of our outstanding warrants (“Investor Warra

August 2, 2016 EX-3.01

Amendment to the Amended and Restated Certificate of Incorporation, effective August 1, 2016

Exhibit 3.01

August 2, 2016 EX-99.01

GenSpera Announces Name Change to Inspyr Therapeutics

Exhibit 99.01 GenSpera Announces Name Change to Inspyr Therapeutics SAN ANTONIO (August 1, 2016) ? GenSpera, Inc. (OTC/QB: GNSZ), a clinical-stage biotechnology company developing a novel prodrug therapeutic for the treatment of cancer, announces that it will change its corporate name to Inspyr Therapeutics, Inc. and will begin trading on the OTCQB under the ticker symbol NSPX effective August 2,

August 2, 2016 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 2, 2016 (August 1, 2016) Inspyr Therapeutics, Inc (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporatio

July 20, 2016 EX-4.01

Form of Inducement Award non-Qualified Stock Option Grant

Exhibit 4.01 GENSPERA, INC. INDUCEMENT AWARD STOCK OPTION PLAN SECTION 1. GENERAL PURPOSE OF THE PLAN; DEFINITIONS The name of the plan is the GenSpera, Inc. Inducement Award Stock Option Plan (the ?Plan?). The purpose of the Plan is to provide non-qualified stock options to individuals who were not previously employees or non-employee directors of GenSpera, Inc. (the ?Company?) (or following such

July 20, 2016 EX-4.02

Form of Inducement Award non-Qualified Stock Option Grant

Exhibit 4.02 GENSPERA. INC. NON-QUALIFIED STOCK OPTION AGREEMENT Name of Optionee: [*] No. of Option Shares: [*] Option Exercise Price per Share: [*] Grant Date: [*] Expiration Date: [*] GenSpera, Inc., (the “Company”) hereby grants to the Optionee named above a non-qualified option (the “Stock Option”) to purchase on or prior to the Expiration Date specified above, subject to the restrictions con

July 20, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

8-K 1 v4445238k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 20, 2016 (July 15, 2016) GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of

July 19, 2016 EX-5.01

SILVESTRE LAW GROUP, P.C. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 (818) 597-7552 Fax (805) 553-9783

Exhibit 5.01 SILVESTRE LAW GROUP, P.C. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 (818) 597-7552 Fax (805) 553-9783 July 19, 2016 GenSpera, Inc. 2511 N. Loop 1604 W, Suite 204 San Antonio, TX 78258 Ladies and Gentlemen: We have acted as counsel to GenSpera, Inc., a Delaware corporation (the ?Company?) in connection with the Post-Effective Amendment No. 1 to the Registration Statement

July 19, 2016 EX-23.01

CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS

EXHIBIT 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the use in this Post-Effective Amendment No. 1 to the Form S-1 Registration Statement of our report dated March 30, 2016, relating to the financial statements of GenSpera, Inc., which appear in this Registration Statement and related Prospectus. Our report includes an explanatory paragraph expressing

July 19, 2016 POS AM

- POS AM

As filed with the Securities and Exchange Commission on July 19, 2016 Registration No.

May 13, 2016 10-Q

GenSpera FORM 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2016 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 GENSPERA, INC. (Exact name of registrant as

May 12, 2016 EX-7.01

EMPLOYMENT AGREEMENT

Exhibit 7.01 EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”), dated as of September 2, 2009 (the “Effective Date”), is made by and between GenSpera, Inc., a Delaware corporation (the “Company”), and Craig Dionne (“Executive”). This Agreement is intended to confirm the understanding and set forth the agreement between the Company and Executive with respect to Executive’s employment

May 12, 2016 SC 13D

NSPX / Inspyr Therapeutics, Inc. / DIONNE CRAIG A - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934* GenSpera, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 37251Q118 (CUSIP Number) Craig A. Dionne, Ph.D. 14439 NW Military Highway, Suite 108, #202 San Antonio, TX 78231 (210) 204-6194 (Name, Address and Telephone Number of Person Authorized to Receive

March 30, 2016 EX-23.01

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 23.01 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (SEC File No. 333-192553) of GenSpera, Inc. of our report which includes an explanatory paragraph as to the Company’s ability to continue as a going concern dated March 30, 2016 relating to our audit of the financial statements which a

March 30, 2016 10-K

GenSpera 10-K (Annual Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2015 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .. Commission File Number 000-55331 GENSPERA, IN

March 22, 2016 EX-99.01

GenSpera Announces Management Changes

Exhibit 99.01 GenSpera Announces Management Changes SAN ANTONIO (March 22, 2016) ? GenSpera, Inc. (OTC/QB: GNSZ), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, announces that Craig A. Dionne, Ph.D., has resigned as GenSpera?s Chairman of the Board and as a Director, and has submitted a notice of termination as GenSpera?s CEO and CFO, all effective immediatel

March 22, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 22, 2016 (March 16, 2016) GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 000-55331 20-0438951 (State or other jurisdiction of incorporation or organi

March 11, 2016 EX-99.01

GenSpera Engages FLG Partners LLC and Partner Chris Lowe for Strategic Business Advisory Services

Exhibit 99.01 GenSpera Engages FLG Partners LLC and Partner Chris Lowe for Strategic Business Advisory Services SAN ANTONIO (March 11, 2016) ? GenSpera, Inc. (OTC/QB: GNSZ), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, announces that the Company?s board of directors has engaged FLG Partners, LLC and its partner Chris Lowe to provide strategic advice to furt

March 11, 2016 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 11, 2016 GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organization) (Commiss

February 16, 2016 SC 13G/A

NSPX / Inspyr Therapeutics, Inc. / DIONNE CRAIG A - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 1)* GenSpera, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 37251Q118 (CUSIP Number) 12/31/2015 (Date of Event Which Requir

January 29, 2016 424B3

32,839,529 Shares Common Stock

PROSPECTUS Filed Pursuant to Rule 424(b)(3) Registration No. 333-208918 32,839,529 Shares Common Stock This prospectus relates to the resale of 32,839,529 shares of our common stock, by the selling stockholders identified in the selling stockholders tables beginning on page 19 of this prospectus (?Selling Stockholders?). We will not receive any proceeds from the sale of these shares by the Selling

January 28, 2016 CORRESP

Inspyr Therapeutics ESP

GENSPERA, INC. January 28, 2016 Suzanne Hayes Assistant Director Office of Healthcare and Insurance Division of Corporation Finance United States Securities and Exchange Commission Washington, DC 20549 RE: GenSpera, Inc. Amendment No. 1 to Registration Statement on Form S-1 Filed January 22, 2016 File No. 333-208918 Dear Ms. Hayes: We have been advised by your staff telephonically that there are n

January 22, 2016 EX-5.01

SILVESTRE LAW GROUP, P.C. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 (818) 597-7552 Fax (805) 553-9783

Exhibit 5.01 SILVESTRE LAW GROUP, P.C. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 (818) 597-7552 Fax (805) 553-9783 January 22, 2016 GenSpera, Inc. 2511 N. Loop 1604 W, Suite 204 San Antonio, TX 78258 Ladies and Gentlemen: We have acted as counsel to GenSpera, Inc., a Delaware corporation (the ? Company ?) in connection with the Amendment No.1 to the Registration Statement on Form S-1

January 22, 2016 EX-23.01

CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS

EXHIBIT 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the use in this Amendment No.1 to the Form S-1 Registration Statement of our report dated March 20, 2015, relating to the financial statements of GenSpera, Inc., which appear in this Registration Statement and related Prospectus. Our report includes an explanatory paragraph expressing substantial doub

January 22, 2016 S-1/A

- S-1/A

S-1/A 1 v429220s1a.htm S-1/A As filed with the Securities and Exchange Commission on January 22, 2016 Registration No. 333-208918 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENSPERA, INC. (Exact name of registrant as specified in its charter) Delaware 2834 20-0438951 (State or jurisdict

January 22, 2016 CORRESP

-

GENSPERA, INC. January 22, 2016 Suzanne Hayes Assistant Director Office of Healthcare and Insurance Division of Corporation Finance United States Securities and Exchange Commission Washington, DC 20549 RE: GenSpera, Inc. Registration Statement on Form S-1 Filed January 8, 2016 File No. 333-208918 Dear Ms. Hayes: We are submitting this letter in response to your comments of January 19, 2016 with re

January 11, 2016 EX-99.01

1 Investor Presentation January 2016 OTC/QB : GNSZ www.GenSpera.com Craig A. Dionne, PhD President & CEO

Exhibit 99.01 1 Investor Presentation January 2016 OTC/QB : GNSZ www.GenSpera.com Craig A. Dionne, PhD President & CEO 2 Forward - Looking Statements Any statements that are not historical facts are forward - looking statements that involve risks and uncertainties that could cause actual results to differ materially from those in the forward - looking statements, which may include, but are not lim

January 11, 2016 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 11, 2016 GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organization) (Commi

January 11, 2016 EX-99.02

1 Corporate Presentation January 2016 OTC QB : GNSZ www.GenSpera.com Craig A. Dionne, PhD President & CEO

Exhibit 99.02 1 Corporate Presentation January 2016 OTC QB : GNSZ www.GenSpera.com Craig A. Dionne, PhD President & CEO 2 Safe Harbor Statement Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995: Any statements that are not historical facts are forward - looking statements that involve risks and uncertainties that could cause actual results to differ materially from t

January 8, 2016 EX-23.01

CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS

EXHIBIT 23.01 CONSENT OF INDEPENDENT REGISTERED CERTIFIED PUBLIC ACCOUNTANTS We hereby consent to the use in this Form S-1 Registration Statement of our report dated March 20, 2015, relating to the financial statements of GenSpera, Inc., which appear in this Registration Statement and related Prospectus. Our report includes an explanatory paragraph expressing substantial doubt regarding the Compan

January 8, 2016 EX-5.01

SILVESTRE LAW GROUP, P.C. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 (818) 597-7552 Fax (805) 553-9783

Exhibit 5.01 SILVESTRE LAW GROUP, P.C. 31200 Via Colinas, Suite 200 Westlake Village, CA 91362 (818) 597-7552 Fax (805) 553-9783 January 8, 2016 GenSpera, Inc. 2511 N. Loop 1604 W, Suite 204 San Antonio, TX 78258 Ladies and Gentlemen: We have acted as counsel to GenSpera, Inc., a Delaware corporation (the ? Company ?) in connection with the Registration Statement on Form S-1 (the ? Registration St

January 8, 2016 S-1

As filed with the Securities and Exchange Commission on January 8, 2016

S-1 1 v425134s1.htm S-1 As filed with the Securities and Exchange Commission on January 8, 2016 Registration No. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENSPERA, INC. (Exact name of registrant as specified in its charter) Delaware 2834 20-0438951 (State or jurisdiction of incorporation or organization

January 8, 2016 EX-3.02

GENSPERA, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS SERIES A 0% CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151(G) OF THE DELAWARE GENERAL CORPORATION LAW

Exhibit 3.02 GENSPERA, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES A 0% CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151(G) OF THE DELAWARE GENERAL CORPORATION LAW The undersigned, Craig Dionne, PhD and Russell Richerson, PhD, do hereby certify that: 1. They are the President and Secretary, respectively, of GenSpera, Inc., a Delaware corporation (the “Corpor

January 6, 2016 8-K

Financial Statements and Exhibits, Other Events

8-K 1 v4284438k.htm CURRENT REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 6, 2016 GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of inc

January 6, 2016 EX-99.01

GenSpera Issues Letter to Stockholders

EX-99.01 2 v428443ex99-01.htm EXHIBIT 99.01 Exhibit 99.01 GenSpera Issues Letter to Stockholders SAN ANTONIO (January 6, 2016) – GenSpera, Inc. (OTC/QB: GNSZ), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, announces that President and CEO Craig A. Dionne, Ph.D., has issued the following letter to stockholders. To My Fellow Stockholders: During 2015 GenSpera

December 23, 2015 EX-10.05

Form of Series H and I Common Stock Purchase Warrants for December 2015 Private Placement

EX-10.05 8 v427710ex10-05.htm EXHIBIT 10.05 Exhibit 10.05 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED O

December 23, 2015 EX-10.02

Form of Series M, N and O warrants for March 2017 – April 2017 Private Placement

Exhibit 10.02 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this ?Agreement?) is made and entered into as of December 23, 2015, between GenSpera, Inc., a Delaware corporation (the ?Company?), and each of the several purchasers signatory hereto (each such purchaser, a ?Purchaser? and, collectively, the ?Purchasers?). This Agreement is made pursuant to the Securities Purchase Agr

December 23, 2015 EX-4.01

Form of Series A Preferred Stock Certificate

Exhibit 4.01 SA-[*] Series A Convertible Preferred [*] Shares GenSpera, Inc. A Delaware Corporation THIS CERTIFIES THAT [Name] is the record holder of [*] ([*]) shares of the Series A 0% Convertible Preferred Stock of GenSpera, Inc. transferable only on the register of said company, in person or by duly authorized attorney, upon surrender of this certificate properly endorsed or assigned. This cer

December 23, 2015 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 23, 2015 GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organization) (Commission File No

December 23, 2015 424B3

Common Shares

SUPPLEMENT No. 1 DATED DECEMBER 23, 2015 (To Prospectus dated August 19, 2015) Rule 424(b)(3) Registration No. 333-206242 18,555,308 Common Shares This prospectus supplement (“Supplement”) modifies and supplements information contained in, and should be read in conjunction with, that certain prospectus, dated August 19, 2015 (“Prospectus”), of GenSpera, Inc. (”Company). The Prospectus relates to t

December 23, 2015 EX-10.03

Form of Series F and Series G Common Stock Purchase Warrants for December 2015 Private Placement

Exhibit 10.03 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGIS

December 23, 2015 EX-10.01

Form of Securities Purchase Agreement for March 2017 – April 2017 Private Placement

Exhibit 10.01 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of December 23, 2015, between GenSpera, Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively, the ?Purchasers?). WHEREAS, subject to the terms and conditions set

December 23, 2015 EX-99.01

GenSpera Announces Private Placement of $2.5 Million

Exhibit 99.01 December 23, 2015 GenSpera Announces Private Placement of $2.5 Million SAN ANTONIO, December 23, 2015? GenSpera, Inc. (OTCQB: GNSZ) (?GenSpera? or the ?Company?), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, today announced that it has entered into definitive agreements with institutional investors, led by a healthcare-dedicated fund, for the

December 23, 2015 EX-3.01

Certificate of Designation of Preferences, Rights and Limitations of Series A 0% Convertible Preferred Stock

EX-3.01 2 v427710ex3-01.htm EXHIBIT 3.01 Exhibit 3.01 genspera, inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES A 0% CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151(g) OF THE Delaware GENERAL CORPORATION LAW The undersigned, Craig Dionne, PhD and Russell Richerson, PhD, do hereby certify that: 1. They are the President and Secretary, respectively, of GenSpera,

December 23, 2015 EX-10.04

Form of Amendment Agreement from December 2015 Private Placement

Exhibit 10.04 WARRANT AMENDMENT AGREEMENT This Warrant Amendment Agreement (this ?Agreement?), dated as of December 23, 2015, is by and between GenSpera, Inc., a Delaware corporation (the ?Company?) and the undersigned holders (the ?Holders?) with respect to (i) those certain Series D Common Stock Purchase Warrants (the ?Series D Warrants?) issued by the Company, which Series D Warrant is exercisa

December 8, 2015 EX-99.01

GenSpera to Present at ICV Manhattan Investor Conference

Exhibit 99.01 GenSpera to Present at ICV Manhattan Investor Conference SAN ANTONIO, December 8, 2015 ? GenSpera, Inc. (OTC/QB: GNSZ), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, announces that President and CEO Craig A. Dionne, Ph.D., will present a corporate overview at ICV Manhattan Investor Conference today, Tuesday, December 8, 2015, at 10:15 a.m. East

December 8, 2015 8-K

Financial Statements and Exhibits, Other Events

8-K 1 v4264658k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 8, 2015 GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorpor

December 8, 2015 EX-99.02

1 ICV Conference December 8 - 9, 2015 OTC/QB : GNSZ www.GenSpera.com Craig A. Dionne, PhD President & CEO

Exhibit 99.02 1 ICV Conference December 8 - 9, 2015 OTC/QB : GNSZ www.GenSpera.com Craig A. Dionne, PhD President & CEO 2 Forward - Looking Statements Any statements that are not historical facts are forward - looking statements that involve risks and uncertainties that could cause actual results to differ materially from those in the forward - looking statements, which may include, but are not li

November 23, 2015 EX-99.02

EX-99.02

Exhibit 99.02 ? Two stage, single-arm, open label single-institution phase II clinical trial of G-202 in recurrent or progressive glioblastoma ? Accrual goal of 34 efficacy-evaluable patients, defined as those that receive two cycles of drug followed by disease assessment ? Up to 3 prior recurrences allowed ? Primary endpoint: 6 month PFS ? Secondary endpoints include safety, efficacy, effects of

November 23, 2015 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 23, 2015 (November 20, 2015) GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or

November 23, 2015 EX-99.01

Mipsagargin Demonstrates Clinical Benefit in Subset of Glioblastoma Patients GenSpera’s Interim Phase II Glioblastoma Data Showcased at Society for Neuro-Oncology Annual Meeting

Exhibit 99.01 Mipsagargin Demonstrates Clinical Benefit in Subset of Glioblastoma Patients GenSpera?s Interim Phase II Glioblastoma Data Showcased at Society for Neuro-Oncology Annual Meeting SAN ANTONIO, November 20, 2015 ? GenSpera Inc. (OTCQB: GNSZ), a biotech company developing a novel prodrug therapeutic for the treatment of cancer, today announced results from the Phase II study investigatin

November 17, 2015 8-K

Submission of Matters to a Vote of Security Holders

8-K 1 v4250348k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 17, 2015 (November 13, 2015) GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jur

November 13, 2015 EX-99.01

GenSpera Provides Update on Clinical Development Programs Upcoming Poster Presentation on Phase II Mipsagargin for the Treatment of Glioblastoma

Exhibit 99.01 GenSpera Provides Update on Clinical Development Programs Upcoming Poster Presentation on Phase II Mipsagargin for the Treatment of Glioblastoma SAN ANTONIO (November 13, 2015) ? GenSpera, Inc. (OTC/QB: GNSZ), a biotech company developing a novel prodrug therapeutics for the treatment of cancer, is providing an update on its clinical development programs and corporate developments. T

November 13, 2015 8-K

Financial Statements and Exhibits, Other Events

8-K 1 v4247078k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 13, 2015 GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorpo

November 13, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q

10-Q 1 v42381610q.htm FORM 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C.20549 FORM 10-Q (Mark one) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2015 Or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-55331 GENSPERA

October 29, 2015 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 29, 2015 GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organization) (Commi

October 29, 2015 EX-99.01

World-renowned Neuro-oncologist Santosh Kesari, MD, PhD joins GenSpera’s Scientific Advisory Board

EX-99.01 2 v423232ex99-01.htm EXHIBIT 99.01 Exhibit 99.01 World-renowned Neuro-oncologist Santosh Kesari, MD, PhD joins GenSpera’s Scientific Advisory Board SAN ANTONIO (October 29, 2015) – GenSpera, Inc. (OTC/QB: GNSZ), a San Antonio-based biotech company that develops innovative prodrug therapeutics for the treatment of cancer, announces that Santosh Kesari, MD, PhD, a board-certified neurologis

October 22, 2015 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 22, 2015 (October 21, 2015) GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or o

October 22, 2015 EX-99.01

1 BIO Investor Forum October 21, 2015 OTC/QB : GNSZ www.GenSpera.com Craig A. Dionne, PhD President & CEO

Exhibit 99.01 1 BIO Investor Forum October 21, 2015 OTC/QB : GNSZ www.GenSpera.com Craig A. Dionne, PhD President & CEO 2 Forward - Looking Statements Any statements that are not historical facts are forward - looking statements that involve risks and uncertainties that could cause actual results to differ materially from those in the forward - looking statements, which may include, but are not li

October 6, 2015 DEF 14A

Inspyr Therapeutics DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (RULE 14a-101) SCHEDULE 14A INFORMATION Proxy statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy statement o Confidential, for Use of the Commission Only (as permitted by Ru

September 25, 2015 PRE 14A

Inspyr Therapeutics PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (RULE 14a-101) SCHEDULE 14A INFORMATION Proxy statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: x Preliminary Proxy statement ? Confidential, for Use of the Commission Only (as permitted by Ru

September 9, 2015 EX-99.02

GenSpera Announces Encouraging Interim Phase II Data for Glioblastoma, Showcases Positive Future for Mipsagargin Across Multiple Types of Solid Tumors First-in Class Agent is Well Tolerated in Brain Cancer Patients – Trials to be Expanded

Exhibit 99.02 IMMEDIATE RELEASE Media Relations: PCG Advisory Sean Leous +1-646-863-8998 [email protected] Investors Relations: PCG Advisory Adam Holdsworth +1-646-862-4607 [email protected] GenSpera Announces Encouraging Interim Phase II Data for Glioblastoma, Showcases Positive Future for Mipsagargin Across Multiple Types of Solid Tumors First-in Class Agent is Well Tolerated in Brain C

September 9, 2015 EX-99.01

1 Rodman and Renshaw Presentation September 9, 2015 OTC QB : GNSZ Craig A. Dionne, PhD President & CEO

Exhibit 99.01 1 Rodman and Renshaw Presentation September 9, 2015 OTC QB : GNSZ Craig A. Dionne, PhD President & CEO 2 Safe Harbor Statement Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995: Any statements that are not historical facts are forward - looking statements that involve risks and uncertainties that could cause actual results to differ materially from thos

September 9, 2015 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 9, 2015 GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or organization) (Comm

September 4, 2015 8-K

Inspyr Therapeutics FORM 8-K (Current Report/Significant Event)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 4, 2015 (September 2, 2015) GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or

August 19, 2015 424B3

18,555,308 Shares Common Stock

Filed Pursuant to Rule 424b3 Registration No. 333-206242 PROSPECTUS 18,555,308 Shares Common Stock This prospectus relates to the resale of 18,555,308 shares of our common stock, by the selling stockholders identified in the selling stockholders tables beginning on page 13 of this prospectus (?Selling Stockholders?). We will not receive any proceeds from the sale of these shares by the Selling Sto

August 18, 2015 CORRESP

Inspyr Therapeutics ESP

CORRESP 1 filename1.htm GENSPERA, INC. August 18, 2015 Jeffrey P. Riedler Assistant Director Division of Corporate Finance United States Securities and Exchange Commission Washington, DC 20549 RE: GenSpera, Inc. Registration Statement on Form S-1 Filed August 8, 2017 File No. 333-206242 Dear Mr. Riedler: We are in receipt of your letter dated August 17, 2015 advising us that the above referenced r

August 14, 2015 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 14, 2015 (August 12, 2015) GENSPERA, INC. (Exact name of registrant as specified in Charter) Delaware 0001421204 20-0438951 (State or other jurisdiction of incorporation or org

August 14, 2015 EX-99.01

EX-99.01

EX-99.01 2 v418319ex99-01.htm EXHIBIT 99.01 Exhibit 99.01

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