Karyopharm Therapeutics Inc.
US ˙ NasdaqGS ˙ US48576U1060

SecurityKPTI / Karyopharm Therapeutics Inc.
InsiderMichael Mano
This page shows the track record and history of Mano Michael insider trades in Karyopharm Therapeutics Inc.. The SEC defines Insiders as officers, directors, or significant investors (greater than 10% ownership) in a company. It is illegal for insiders to make trades in their companies based on material, non-public information ("MNPI"). This does not mean it is illegal for them to make any trades in their own companies. However, they must report all trades to the SEC via a Form 4.
Insider Purchases - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made by Michael Mano in KPTI / Karyopharm Therapeutics Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

KPTI / Karyopharm Therapeutics Inc. Insider Trades
Insider Sales - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made by Michael Mano in KPTI / Karyopharm Therapeutics Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
2025-09-15 234 6.4300 234 6.4300 1,505 4 5.4100 -238 -15.83
2025-03-04 2,793 6.2900 2,793 6.2900 17,568
2024-09-04 3,971 0.7218 265 10.8270 2,866
2024-03-01 3,576 1.2000 238 18.0000 4,291
2024-02-29 16,973 1.1700 1,132 17.5500 19,858
2023-09-01 3,888 1.3313 259 19.9695 5,176
2023-03-01 6,878 3.0292 459 45.4380 20,835

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

KPTI / Karyopharm Therapeutics Inc. Insider Trades
Insider Transaction History
File
Date
Trade
Date
Form Insider Ticker Security Title Code 10b5-1 Direct Exercise
Price
Unit
Price
Units
Changed
Value
Changed (1K)
Remaining
Options
Remaining
Shares
2025-09-16 2025-09-15 4 Mano Michael KPTI Common Stock S - Sale D 6.4300 -234 -2 21,425
2025-09-16 2025-09-12 4 Mano Michael KPTI Common Stock A - Award D 612 21,659
2025-03-06 2025-03-04 4 Mano Michael KPTI Common Stock S - Sale D 6.2900 -2,793 -18 21,047
2025-03-04 2025-02-28 4 Mano Michael KPTI Common Stock A - Award D 2,250 23,840
2025-03-04 2025-02-28 4 Mano Michael KPTI Common Stock A - Award D 3,333 21,590
2024-09-05 2024-09-04 4 Mano Michael KPTI Common Stock S - Sale D 0.7218 -3,971 -3 273,881
2024-03-04 2024-03-01 4 Mano Michael KPTI Common S - Sale D 1.2000 -3,576 -4 277,852
2024-03-04 2024-02-29 4 Mano Michael KPTI Common S - Sale D 1.1700 -16,973 -20 281,428
2024-02-29 2024-02-28 4 Mano Michael KPTI Common Stock A - Award D 147,000 298,401
2024-01-25 2024-01-24 4 Mano Michael KPTI Common Stock A - Award D 9,167 151,401
2023-09-05 2023-09-01 4 Mano Michael KPTI Common Stock S - Sale D 1.3313 -3,888 -5 142,234
2023-03-02 2023-03-01 4 Mano Michael KPTI Common Stock S - Sale D 3.0292 -6,878 -21 146,122
2023-03-02 2023-02-28 4 Mano Michael KPTI Common Stock A - Award D 70,000 153,000
2022-09-01 2022-08-31 4 Mano Michael KPTI Common Stock A - Award D 20,000 83,000
2022-03-02 2022-02-28 4 Mano Michael KPTI Stock Option (right to buy) A - Award D 10.33 81,000 81,000
2022-03-02 2022-02-28 4 Mano Michael KPTI Common Stock A - Award D 63,000 63,000
P
Köp på öppna marknaden eller privat köp av icke-derivatsäkerhet
S
Köp på öppna marknaden eller privat försäljning av icke-derivatsäkerhet
A
Bevilja, tilldelning eller annat förvärv av värdepapper från företaget (såsom en option)
C
Omvandling av derivat
D
Försäljning eller överföring av värdepapper tillbaka til företaget
F
Betalning av lösenpris eller skatteskuld med del av värdepapper som erhållits från bolaget
G
Överlåtelse av värdepapper från eller till insidern
K
Aktieswappar och liknande säkringsaffärer
M
Utövande eller omvandling av derivatsäkerhet som erhållits från företaget (som en option)
V
En transaktion friviligt rapporterad på schema 4
J
Andra (med en fotnot som beskriver transaktionen)