Market Value1,998,933,000
Total Holdings294
File Date2016-05-13
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
(USD x1000)
Current Value
(USD x1000)
Change
(Percent)
TTOO / T2 Biosystems, Inc.
NWBO / Northwest Biotherapeutics, Inc.
NWBO / Northwest Biotherapeutics, Inc. Put
ADVM / Adverum Biotechnologies, Inc.
ADVM / Adverum Biotechnologies, Inc. Call
ARLZ / Aralez Pharmaceuticals Inc.
NLTX / Neoleukin Therapeutics, Inc.
INSM / Insmed Incorporated
INSM / Insmed Incorporated Call
INSM / Insmed Incorporated Put
ZSAN / Zosano Pharma Corp
CSLT / Castlight Health Inc - Class B
EIGR / Eiger BioPharmaceuticals, Inc.
RENNOVA HEALTH EQUITY WARRANTS / *W (759757115)
WINT / Windtree Therapeutics, Inc.
EXEL / Exelixis, Inc. Call
EXEL / Exelixis, Inc. Put
MTEM / Molecular Templates, Inc. Call
AEZS / COSCIENS Biopharma Inc.
ALQA / Alliqua, Inc.
CLSN / Imunon Inc
FOMX / Foamix Pharmaceuticals Ltd.
ESRX / Express Scripts Holding Co.
RLYP / Relypsa, Inc. Put
QRHC / Quest Resource Holding Corporation
RGLS / Regulus Therapeutics Inc. Call
DERM / Journey Medical Corporation
ESRX / Express Scripts Holding Co. Put
COLL / Collegium Pharmaceutical, Inc.
CMRX / Chimerix, Inc.
NVRO / Nevro Corp. Put
SESN / Sesen Bio Inc.
ABUS / Arbutus Biopharma Corporation
TRIL / Trillium Therapeutics Inc
UTHR / United Therapeutics Corporation Call
UTHR / United Therapeutics Corporation
UTHR / United Therapeutics Corporation Put
BDSI / Biodelivery Sciences International
BDSI / Biodelivery Sciences International Call
BCLI / Brainstorm Cell Therapeutics Inc. Call
HTWR / Heartware International Inc. Put
BCLI / Brainstorm Cell Therapeutics Inc.
VASC / Vascular Solutions, Inc.
THMO / ThermoGenesis Holdings, Inc.
ADMS / Adamas Pharmaceuticals Inc
RLYP / Relypsa, Inc.
US0153511094 / Alexion Pharmaceuticals, Inc.
US0153511094 / Alexion Pharmaceuticals, Inc. Put
LUMO / Lumos Pharma, Inc.
LUMO / Lumos Pharma, Inc. Call
LUMO / Lumos Pharma, Inc. Put
SGMO / Sangamo Therapeutics, Inc. Call
CASC / Cascadian Therapeutics, Inc.
TROV / TrovaGene, Inc.
OPK / OPKO Health, Inc. Put
TROV / TrovaGene, Inc. Call
XLRN / Acceleron Pharma Inc
RPTP / Raptor Pharmaceutical Corp. Call
IDRA / Idera Pharmaceuticals, Inc. Call
607355906 / China Mobile Ltd. Call
SIOX / Sio Gene Therapies Inc.
ENDP / Endo International plc Call
ENDP / Endo International plc
HALO / Halozyme Therapeutics, Inc.
HALO / Halozyme Therapeutics, Inc. Call
HALO / Halozyme Therapeutics, Inc. Put
BMRN / BioMarin Pharmaceutical Inc. Call
BMRN / BioMarin Pharmaceutical Inc. Put
INO / Inovio Pharmaceuticals, Inc.
ANTH / Anthera Pharmaceuticals, Inc. Call
MDGN.WS / Medgenics, Inc., Warrant
VTVT / vTv Therapeutics Inc.
REEMF / Rare Element Resources Ltd.
EW / Edwards Lifesciences Corporation
VYNT / Vyant Bio, Inc.
CLDX / Celldex Therapeutics, Inc. Call
CLDX / Celldex Therapeutics, Inc. Put
FOLD / Amicus Therapeutics, Inc. Call
FOLD / Amicus Therapeutics, Inc. Put
ONCE / Spark Therapeutics, Inc. Call
/ Zephyr Energy PLC
MDCO / Medicines Company Call
ITCI / Intra-Cellular Therapies, Inc. Put
RMTI / Rockwell Medical, Inc.
ONCS / OncoSec Medical Inc
CLVS / Clovis Oncology Inc Put
CLVS / Clovis Oncology Inc Call
CNAT / Conatus Pharmaceuticals Inc.
032420101 / Anacor Pharmaceuticals, Inc. Call
032420101 / Anacor Pharmaceuticals, Inc. Put
91911K102 / Bausch Health Companies Call
LLY / Eli Lilly and Company Put
ALKS / Alkermes plc Put
ACAD / ACADIA Pharmaceuticals Inc.
MBLY / Mobileye Global Inc.
MBLY / Mobileye Global Inc. Call
MBLY / Mobileye Global Inc. Put
AVDL / Avadel Pharmaceuticals plc Put
ITCI / Intra-Cellular Therapies, Inc.
ITCI / Intra-Cellular Therapies, Inc. Call
MBOT / Microbot Medical Inc.
AAPL / Apple Inc. Put
SCON / Superconductor Technologies Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Put
PRSNW / Perseon Corporation Warrants
THC / Tenet Healthcare Corporation Call
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
MTEM / Molecular Templates, Inc.
GWP / GW Pharmaceuticals plc
BIIB / Biogen Inc. Call
BIIB / Biogen Inc. Put
US29266S3040 / Endologix, Inc.
ABUS / Arbutus Biopharma Corporation Call
ADHD / Alcobra Ltd. Call
06740C519 / Barclays Bank iPath S&P 500 VIX Mid-Term Futures ETN due 1/30/2019
HTWR / Heartware International Inc.
ARCT / Arcturus Therapeutics Holdings Inc.
AKRX / Akorn, Inc. Call
PVCT / Provectus Biopharmaceuticals, Inc.
NTRA / Natera, Inc.
MNOV / MediciNova, Inc.
CYNA / Cynapsus Therapeutics Inc.
PSDV / pSivida Corp.
ALQA / Alliqua, Inc. Call
CYTX / Cytori Therapeutics, Inc.
ELDN / Eledon Pharmaceuticals, Inc.
AKRX / Akorn, Inc. Put
09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018
PHG / Koninklijke Philips N.V. - Depositary Receipt (Common Stock) Call
FLDM / Standard BioTools Inc Call
PGNX / Progenics Pharmaceuticals, Inc. Put
US60877T1007 / Momenta Pharmaceuticals, Inc.
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
HZNP / Horizon Therapeutics Plc Call
ZLTQ / ZELTIQ Aesthetics, Inc. Call
SENS / Senseonics Holdings, Inc.
/ Immunomedics, Inc.
ZGNX / Zogenix Inc Call
CBMX / CombiMatrix Corp.
MLNT / Melinta Therapeutics, Inc.
KITE / Kite Pharma, Inc. Call
JUNO / Juno Therapeutics, Inc. Call
US00C4U1L353 / Mylan N.V. Call
PCRX / Pacira BioSciences, Inc. Call
LJPC / La Jolla Pharmaceutical Co.
IOVA / Iovance Biotherapeutics, Inc.
ARLZ / Aralez Pharmaceuticals Inc. Call
VASC / Vascular Solutions, Inc. Put
FLDM / Standard BioTools Inc
FWP / Forward Pharma A/S - ADR
032420101 / Anacor Pharmaceuticals, Inc.
NXTM / NxStage Medical, Inc. Put
IOVA / Iovance Biotherapeutics, Inc. Call
06740C519 / Barclays Bank iPath S&P 500 VIX Mid-Term Futures ETN due 1/30/2019 Call
NSPH / Nanosphere, Inc.
ACERW / Acer Therapeutics Inc. Warrant
584688AC9 / Medicines Company 1.375% Bond due 2017-06-01
AKRX / Akorn, Inc.
49803V115 / Kitov Pharamceuticals Holdings Ltd.
POZN / Pozen, Inc.
ARQL / ArQule, Inc.
BNTCW / Benitec Biopharma Ltd
CEMP / Cempra, Inc. Call
CEMP / Cempra, Inc. Put
RGLS / Regulus Therapeutics Inc. Put
US00484MAA45 / Acorda Therapeutics, Inc. Bond 1.750% 6/1
KITE / Kite Pharma, Inc.
0PP / Portola Pharmaceuticals Inc Call
KITE / Kite Pharma, Inc. Put
PSDV / pSivida Corp. Put
OASM / Oasmia Pharmaceutical AB
NUVA / Nuvasive Inc
CSBR / Champions Oncology, Inc.
SPDR S&P BIOTECH ETF / S&P Put (78464A950)
ZGNX / Zogenix Inc
AERI / Aerie Pharmaceuticals Inc Call
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
76028H209 / Repros Therapeutics, Inc. Call
RGLS / Regulus Therapeutics Inc.
NONOF / Novo Nordisk A/S Call
QURE / uniQure N.V. Call
DERM / Journey Medical Corporation Put
NDRM / NeuroDerm Ltd. Put
FOLD / Amicus Therapeutics, Inc.
ATRS / Antares Pharma Inc
TTHI / Transition Therapeutics Inc.
NUROW / NeuroMetrix, Inc. Warrants
PGNX / Progenics Pharmaceuticals, Inc. Call
/ Ceres, Inc.
KERX / Keryx Biopharmaceuticals, Inc. Put
ALPN / Alpine Immune Sciences, Inc.
ACER / Acer Therapeutics Inc
CLRBW / Cellectar Biosciences, Inc. Warrants expiring 8/20/2019
RGNX / REGENXBIO Inc.
WGBS / WaferGen Bio-Systems, Inc.
RLYP / Relypsa, Inc. Call
SPNC / Spectranetics Corp. (The) Call
ATRS / Antares Pharma Inc Call
US00C4U1L353 / Mylan N.V. Put
BDSI / Biodelivery Sciences International Put
HZNP / Horizon Therapeutics Plc Put
OCAT / Ocata Therapeutics, Inc. Put
ANTH / Anthera Pharmaceuticals, Inc.
PGNX / Progenics Pharmaceuticals, Inc.
QURE / uniQure N.V.
OCRX / Ocera Therapeutics, Inc.
ADMS / Adamas Pharmaceuticals Inc Call
APEN / Apollo Endosurgery Inc
BLUE / bluebird bio, Inc. Call
451731103 / Ignyta, Inc.
MGNX / MacroGenics, Inc. Call
OCUP / Opus Genetics, Inc.
KDNY / Chinook Therapeutics Inc Call
PRTK / Paratek Pharmaceuticals Inc. Call
PRTK / Paratek Pharmaceuticals Inc.
REGN / Regeneron Pharmaceuticals, Inc.
REGN / Regeneron Pharmaceuticals, Inc. Call
REGN / Regeneron Pharmaceuticals, Inc. Put
BNTC / Benitec Biopharma Inc.
IMUX / Immunic, Inc. Call
ABEO / Abeona Therapeutics Inc.
RDUS / Radius Recycling, Inc.
ACAD / ACADIA Pharmaceuticals Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
RDUS / Radius Recycling, Inc. Call
BLCM / Bellicum Pharmaceuticals, Inc. Put
RMTI / Rockwell Medical, Inc. Put
OTLC / Oncotelic Therapeutics, Inc.
09074D103 / Biotie Therapies Corp.
NVAX / Novavax, Inc. Put
OCUL / Ocular Therapeutix, Inc. Call
OCUL / Ocular Therapeutix, Inc.
QURE / uniQure N.V. Put
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Call
ASRT / Assertio Holdings, Inc.
ASRT / Assertio Holdings, Inc. Call
ASRT / Assertio Holdings, Inc. Put
LCI / Lannett Co., Inc. Call
/ GW Pharmaceuticals Plc. Put
/ GW Pharmaceuticals Plc. Call
AVDL / Avadel Pharmaceuticals plc
FGEN / FibroGen, Inc.
PRTA / Prothena Corporation plc
SRPT / Sarepta Therapeutics, Inc.
GALT / Galectin Therapeutics Inc.
PATI / Patriot Transportation Holding, Inc.
TMBR / Timber Pharmaceuticals Inc
CAPR / Capricor Therapeutics, Inc.
ICPT / Intercept Pharmaceuticals Inc Put
RIBT / RiceBran Technologies
SRPT / Sarepta Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Put
NHWK / NightHawk Biosciences, Inc.
TXMD / TherapeuticsMD, Inc. Put
US0153511094 / Alexion Pharmaceuticals, Inc. Call
CYCC / Bio Green Med Solution, Inc.
MSTX / Tidal Trust II - Defiance Daily Target 2X Long MSTR ETF
VRTX / Vertex Pharmaceuticals Incorporated
OEF / iShares Trust - iShares S&P 100 ETF Put
TBRA / Tobira Therapeutics, Inc.
IONS / Ionis Pharmaceuticals, Inc. Put
XOMA / XOMA Royalty Corporation Call
IPCI / Intellipharmaceutics International Inc. Put
IONS / Ionis Pharmaceuticals, Inc.
TPST / Tempest Therapeutics, Inc. Call
MCRB / Seres Therapeutics, Inc.
MCRB / Seres Therapeutics, Inc. Call
ASXC / Asensus Surgical, Inc. Call
ASXC / Asensus Surgical, Inc. Put
ABBV / AbbVie Inc. Put
CELG / Celgene Corp. Call
LRMR / Larimar Therapeutics, Inc. Call
HCMC / Healthier Choices Management Corp.
BCRX / BioCryst Pharmaceuticals, Inc.
GNCA / Genocea Biosciences Inc
HCMC / Healthier Choices Management Corp.
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock)
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Call
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Put
MGNX / MacroGenics, Inc. Put
PIRS / Pieris Pharmaceuticals, Inc.
POAI / Predictive Oncology Inc.
TVTX / Travere Therapeutics, Inc. Put
IMUC / EOM Pharmaceuticals Holdings, Inc.
ENDP / Endo International plc Put
TXMD / TherapeuticsMD, Inc.
TXMD / TherapeuticsMD, Inc. Call
CDTX / Cidara Therapeutics, Inc.
LNKD / LinkedIn Corp. Call
ARIA / ARIAD Pharmaceuticals, Inc. Call
VRTX / Vertex Pharmaceuticals Incorporated Call
VRTX / Vertex Pharmaceuticals Incorporated Put
AKBA / Akebia Therapeutics, Inc. Call
MEIP / MEI Pharma, Inc.
0PP / Portola Pharmaceuticals Inc Put
0PP / Portola Pharmaceuticals Inc
ARDX / Ardelyx, Inc.
INO / Inovio Pharmaceuticals, Inc. Call
CYTK / Cytokinetics, Incorporated Call
AMGN / Amgen Inc.
AMGN / Amgen Inc. Put
NVAX / Novavax, Inc. Call
BCRX / BioCryst Pharmaceuticals, Inc. Put
INFI / Infinity Pharmaceuticals Inc. Call
GBT / Global Blood Therapeutics Inc.
ASXC / Asensus Surgical, Inc.
BLCM / Bellicum Pharmaceuticals, Inc.
BLCM / Bellicum Pharmaceuticals, Inc. Call
OTIC / Otonomy Inc
JNJ / Johnson & Johnson Call
JNJ / Johnson & Johnson Put
TNXP / Tonix Pharmaceuticals Holding Corp.
GILD / Gilead Sciences, Inc. Call
DBVT / DBV Technologies S.A. - Depositary Receipt (Common Stock)
HCA / HCA Healthcare, Inc. Call
ACUR / Acura Pharmaceuticals, Inc.
IONS / Ionis Pharmaceuticals, Inc. Call
EW / Edwards Lifesciences Corporation Call
EW / Edwards Lifesciences Corporation Put
PGEN / Precigen, Inc.
PGEN / Precigen, Inc. Call
PGEN / Precigen, Inc. Put
BIIB / Biogen Inc.
EGRX / Eagle Pharmaceuticals, Inc.
EGRX / Eagle Pharmaceuticals, Inc. Call
EGRX / Eagle Pharmaceuticals, Inc. Put
OCGN / Ocugen, Inc.
CLVS / Clovis Oncology Inc
ABBV / AbbVie Inc.
ABBV / AbbVie Inc. Call
PSTI / Pluristem Therapeutics Inc
GBT / Global Blood Therapeutics Inc. Call
FLXN / Horizon Funds - Horizon Flexible Income ETF
NVIV / InVivo Therapeutics Holdings Corp.
NVIV / InVivo Therapeutics Holdings Corp. Call
GILD / Gilead Sciences, Inc. Put
IL0011177958 / Intec Pharma Ltd
CRDC / Cardica, Inc.
CTIC / CTI BioPharma Corp
CTIC / CTI BioPharma Corp Call
MRTX / Mirati Therapeutics, Inc.
ADXS / Ayala Pharmaceuticals, Inc. Call
ADXS / Ayala Pharmaceuticals, Inc. Put
OPK / OPKO Health, Inc.
OPK / OPKO Health, Inc. Call
KPRX / Kiora Pharmaceuticals, Inc.
TNXP / Tonix Pharmaceuticals Holding Corp. Call
PRSN / Perseon Corporation
RNVA / Rennova Health, Inc.
PRQR / ProQR Therapeutics N.V.
PEGY / Pineapple Energy Inc. Call
AAPL / Apple Inc. Call
OMER / Omeros Corporation
OMER / Omeros Corporation Call
LXRX / Lexicon Pharmaceuticals, Inc.
LXRX / Lexicon Pharmaceuticals, Inc. Call
TVTX / Travere Therapeutics, Inc. Call
TVTX / Travere Therapeutics, Inc.
ALDX / Aldeyra Therapeutics, Inc.
NSPR / InspireMD, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc.
BLUE / bluebird bio, Inc. Put
BLUE / bluebird bio, Inc.
RVNC / Revance Therapeutics, Inc. Call
SLNO / Soleno Therapeutics, Inc.
TENX / Tenax Therapeutics, Inc.
HRTX / Heron Therapeutics, Inc. Call
SGMO / Sangamo Therapeutics, Inc.
MNKD / MannKind Corporation
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
RCKT / Rocket Pharmaceuticals, Inc.
NVRO / Nevro Corp. Call
BPMC / Blueprint Medicines Corporation
BPMC / Blueprint Medicines Corporation Call
SAGE / Sage Therapeutics, Inc.
SAGE / Sage Therapeutics, Inc. Call
PTCT / PTC Therapeutics, Inc. Call
PTCT / PTC Therapeutics, Inc. Put
CBAY / CymaBay Therapeutics, Inc.
ALKS / Alkermes plc
ALKS / Alkermes plc Call
SLS / SELLAS Life Sciences Group, Inc. Put
CLRB / Cellectar Biosciences, Inc.
ENLV / Enlivex Therapeutics Ltd.
SSKN / STRATA Skin Sciences, Inc.
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
AFMD / Affimed N.V.
NBIX / Neurocrine Biosciences, Inc.
NBIX / Neurocrine Biosciences, Inc. Put
NBIX / Neurocrine Biosciences, Inc. Call
LPCN / Lipocine Inc. Call
LPCN / Lipocine Inc.
DVAX / Dynavax Technologies Corporation Call
DVAX / Dynavax Technologies Corporation
DVAX / Dynavax Technologies Corporation Put
XTLB / XTL Biopharmaceuticals Ltd. - Depositary Receipt (Common Stock)
ESPR / Esperion Therapeutics, Inc.
AKTX / Akari Therapeutics, Plc - Depositary Receipt (Common Stock)
CYTR / LadRx Corp Call
RDHL / RedHill Biopharma Ltd. - Depositary Receipt (Common Stock)
NURO / NeuroMetrix, Inc.
TENX / Tenax Therapeutics, Inc. Call
SRNE / Sorrento Therapeutics, Inc.
CLSN / Imunon Inc Put
ALBO / Albireo Pharma Inc Put
ALBO / Albireo Pharma Inc
LLY / Eli Lilly and Company Call
IWM / iShares Trust - iShares Russell 2000 ETF
SPY / SPDR S&P 500 ETF
SPY / SPDR S&P 500 ETF Put